检索结果-南通市图书馆

公共地下空间主导的地下空间精细化立体管控——以广州市为例

在线全文

学校读者我要写书评

暂无评论

城市发展研究 2024年第5期31卷 72-79页

作者：方舟何健张皇林逸风广州市交通规划研究院有限公司

当前我国已建立从城市地下空间总体开发利用规划到地下空间建设规划的规划编制体系，详细规划阶段的地下空间建设规划逐步纳入法定规划体系，但是在地下空间管控方面仍缺乏完善的、有效的、上下协同的技术框架体系，也难以纳入各大城市... 详细信息

当前我国已建立从城市地下空间总体开发利用规划到地下空间建设规划的规划编制体系，详细规划阶段的地下空间建设规划逐步纳入法定规划体系，但是在地下空间管控方面仍缺乏完善的、有效的、上下协同的技术框架体系，也难以纳入各大城市国土空间资源“一张图”平台，导致管理缺位、管控不足等问题。本次研究以广州市为例，在深入分析近十年城市重点地区地下空间规划编制、设计、实施全过程的基础上，提出了以公共地下空间作为主导，构建国土空间详细规划阶段地下空间规划编制和精细化立体管控的“三个层级”技术框架，明确了地下空间详细规划编制“三个范围”的内容深度要求，以及立体分层管控的“六大核心要素”和刚弹结合管控原则，为广州市地下空间详细规划编制融入法定规划构建了完善的技术框架体系，并实现纳入到广州市国土空间资源“一张图”平台进行管控，进一步提升地下空间规划管理水平，并纵向传导和衔接后续工程设计、实施、运营。

关键词：公共地下空间详细规划立体管控刚弹结合

基于多元统计分析的法语动词屈折研究——以第三组动词为例

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

法语国家与地区研究（中法文） 2024年第3期 49-57,92页

作者：林义丰巴黎第十大学

本文主要研究法语直陈式现在时第三组动词的屈折变化。通过对数据的标注以及使用聚类分析、多维尺度分析等多元统计分析的方法,对法语动词的屈折类别、能产性以及词形差异距离展开研究。结果发现,法语直陈式现在时第三组动词共计29个屈... 详细信息

本文主要研究法语直陈式现在时第三组动词的屈折变化。通过对数据的标注以及使用聚类分析、多维尺度分析等多元统计分析的方法,对法语动词的屈折类别、能产性以及词形差异距离展开研究。结果发现,法语直陈式现在时第三组动词共计29个屈折类别,其中13个较为能产。此外,通过屈折词形差异距离,这些类别共分成6组。本研究将有利于法语学习者更好地解决法语动词变位这一难点,也将有助于深化法语屈折形态学的理论研究。

关键词：动词变位屈折法语语法多元统计分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

孔内深层强夯复合地基桩土应力比试验研究

华南地震 2024年第1期44卷 119-125页

作者：吕文龙林逸峰付强广东省建筑科学研究院集团股份有限公司广州510500 广州大学土木工程学院广州510006

通过开展孔内深层强夯单桩复合地基现场静载试验和桩土应力测试,获取了不同荷载作用下孔内深层强夯复合地基的平均桩顶应力、桩间土应力、桩土应力比、荷载分担比及其变化规律。试验结果表明:孔内深层强夯复合地基的桩间土承担了主要的... 详细信息

通过开展孔内深层强夯单桩复合地基现场静载试验和桩土应力测试,获取了不同荷载作用下孔内深层强夯复合地基的平均桩顶应力、桩间土应力、桩土应力比、荷载分担比及其变化规律。试验结果表明:孔内深层强夯复合地基的桩间土承担了主要的上部荷载,约占50%~63%,随着荷载增大,桩间土承担的荷载比例逐步增大;对于孔内深层强夯复合地基,随着荷载的增大,桩土应力比随荷载的增大而减小,数值介于2~5之间;对粘性素填土地基,孔内深层强夯复合地基在处理后的桩间土地基承载力比处理前可提高220%。

关键词：孔内深层强夯复合地基桩土应力比桩间土应力地基承载力荷载分担比

Deletion of CHD8 in cerebellar granule neuron progenitors leads to severe cerebellar hypoplasia,ataxia,and psychiatric behavior in mice

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2022年第9期49卷 859-869页

作者： Xiang Chen Tong Chen Chen Dong Huiyao Chen Xinran Dong lin Yang Liyuan Hu Huijun Wang Bingbing Wu Ye Yao Yu Xiong Man Xiong yifeng lin Wenhao Zhou Departments of Neonatology Children's Hospital of Fudan UniversityNational Children's Medical CenterShanghai201102China Institutes of Biomedical Sciences Fudan UniversityShanghai200032China Key Laboratory of Birth Defects Children's Hospital of Fudan UniversityNational Children's Medical CenterShanghai201102China Department of Biostatistics School of Public HealthFudan UniversityShanghai200032China Department of Obstetrics Obstetrics and Gynecology Hospital of Fudan UniversityShanghai200090China Stem Cell Center Children's Hospital of Fudan UniversityShanghai201102China MOE Frontiers Center for Brain Science Fudan UniversityShanghai201102China

CHD8 is a candidate gene for autism spectrum disorders and neurological development *** has been reported to be essential for neurogenesis in the cerebral cortex,but the function of CHD8 in cerebellum has not been comprehensively *** potential relationship of cerebellum dysplasia with psychiatric disorders in patients with CHD8 mutations is still not *** this study,we establish different conditional knockout mouse models to investigate the roles of CHD8 in cerebellar *** with neural stem cell-specific Chd8 deletion exhibit significant reduction of cerebellum volume and no layering structure is *** deletion of Chd8 in cerebellar granule neuron progenitors(GNPs)leads to cerebellar hypoplasia,absent of proliferation layer and ectopic of Purkinje ***,no substantial cerebellar dysplasia is detected in mice with Purkinje neuron-or oligodendrocyte-specific Chd8 ***-cell RNA sequencing indicates that ribosome-related genes and pathways are most significantly disrupted in GNPs,indicating the potential ***,in addition to the ataxia phenotype,mice with GNPspecific Chd8 ablation present a neuropsychiatric phenotype in three-chamber and light/dark *** together,our results provide insights not only into the function of CHD8 in cerebellar development,but also the pathogenesis of neuropsychiatric disorders in patients with CHD8 mutations.

关键词： Cerebellum Granule neuron CHD8 Autism spectrum disorder

Multilevel Micro Structures of the Clam Make the Sealing Even Tighter

在线全文

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2024年第3期21卷 1442-1452页

作者： Daobing Chen Xiaolong Zhang Junqiu Zhang Zhiwu Han Ruteng Wang Zhen lin yifeng Lei Longjian Xue Sheng Liu The Institute of Technological Science Wuhan UniversityWuhan430072China School of Power and Mechanical Engineering Wuhan UniversityWuhan430072China The Key Laboratory of Bionic Engineering(Ministry of Education) Jilin UniversityChangchun130022China Institute of Structured and Architected Materials Liaoning Academy of MaterialsShenyang110167China

Excellent fluid sealing performance is crucial to ensuring the safety of important equipment,especially in aerospace field,such as space capsule and fuel *** frequently opening and closing of the sealing devices is particularly *** by this background,clams(Mactra chinensis)which can open and close their double shells with superior sealing performance,are studied in this ***,we show that the clam’s sealing ability is the result of its unique multilevel intermeshing microstructures,including hinge teeth and *** microstructures,which resemble gear teeth,engage with each other when the shell closes,forming a tight structure that prevents the infiltration of water from the ***,the presence of micron blocks prevents the penetration of finer *** simulation results of the bionic end seal components show that the multilevel microstructure has a superior sealing *** research is expected to be applied to undersea vehicles that require frequent door opening and closing.

关键词： Multilevel micro structures Opening and closing components Clam Sealing Bionic

Bifidobacterium adolescentis orchestrates CD143^(+)cancer-associated fibroblasts to suppress colorectal tumorigenesis by Wnt signaling-regulated GAS1

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2023年第9期43卷 1027-1047页

作者： Shujie Chen lina Fan yifeng lin Yadong Qi Chaochao Xu Qiwei Ge Ying Zhang Qiwen Wang Dingjiacheng Jia Lan Wang Jianmin Si Liangjing Wang Department of Gastroenterology Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangP. R. China Institute of Gastroenterology Zhejiang UniversityHangzhouZhejiangP. R. China Cancer Center Zhejiang UniversityHangzhouZhejiangP. R. China Research Center of Prevention and Treatment of Senescent Disease School of Medicine Zhejiang UniversityHangzhouZhejiangP. R. China Department of Gastroenterology Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiangP. R. China

Background The interplay between gut microbiota and tumor microenvironment(TME)in the pathogenesis of colorectal cancer(CRC)is not well ***,we elucidated the functional role of Bifidobacterium adolescentis(B.a)on CRC and investigated its possible mechanism on the manipulation of cancer-associated fibroblasts(CAFs)in *** Different CRC animal models and various cell line models were established to explore the function of B.a on *** single-cell RNA sequencing(scRNA-seq)or flow cytometry was used to detect the cell subsets in the TME of *** blot,quantitative real-time polymerase chain reaction(qRT-PCR),or immunofluorescence staining were performed to examine the activation of Wnt signaling and growth arrest specific 1(GAS1)on CD143+*** immunoprecipitation quantitative real-time PCR(CHIP-qPCR)was performed to investigate the regulation of transcription factor 4(TCF4)on ***-immunofluorescence assay examined the expression level of CD143 and GAS1 on tissue *** We found that B.a abundance was significantly reduced in CRC patients from two independent cohorts and the bacteria database of *** with B.a suppressed ApcMin/+spontaneous or AOM/DSS-induced tumorigenesis in ***-seq revealed that B.a facilitated a subset of CD143+CAFs by inhibiting the infiltration of Th2 cells,while promoting the TNF-alpha+B cells in ***143+CAFs highly expressed GAS1 and exhibited tumor suppressive ***,GAS1 was activated by the Wnt/β-catenin signaling in CD143+CAFs.B.a abundance was correlated with the expression level of CD143 and *** level of CD143+CAFs predicted the better survival outcome in CRC *** These results highlighted that B.a induced a new subset of CD143+CAFs by Wnt signaling-regulated GAS1 to suppress tumorigenesis and provided a novel therapeutic target for probiotic-based modulation of TME in CRC.

关键词： Bifidobacterium adolescentis cancer-associated fibroblast colorectal cancer GAS1 microbiota single-cell RNA sequencing Wnt/β-catenin signaling

Fish Skin-Inspired Janus Hydrogel Coating for Drag Reduction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2024年第8期42卷 867-872页

作者： Yurong Zhang Lijun Li Ruteng Wang Junwei Liu Zhen lin Gang Li Hongtao Liu yifeng Lei Yunhe Xiong Yan Zhao Longjian Xue The Institute of Technological Science School of Power and Mechanical EngineeringWuhan UniversitySouth Donghu Road 8WuhanHubei430072 China Hubei Key Laboratory of Electronic Manufacturing and Packaging Integration(Wuhan University) Wuhan UniversityWuhanHubei430072 China Department of Urology Renmin Hospital of Wuhan UniversityZhangzhidong Road 99WuhanHubei430060 China Department of Urology Renmin Hospital of Wuhan UniversityZhangzhidong Road 99WuhanHubei 430060China

Comprehensive Summary,In nature,fishes have evolved functional skins with effective hydrodynamic performance and anti-fouling,facilitating predation and escaping from *** a large number of fish scale-inspired structured surfaces have been explored,the incorporation of mucus on the structured surfaces has been largely *** by the skin of Osteichthyes fishes,a Janus hydrogel coating(JHC)is successfully prepared by a two-step UV light irradiation at room *** bottom side of JHC(STH)achieves a shear adhesive strength of 103.3±17.5 kPa and can strongly adhere to a large variety of surfaces,including metals,ceramic and *** top surface of JHC(SLH)replicates the structure of cycloid scales,while the nature of hydrogel mimics the mucus on fish *** possesses prominent mechanical,anti-swelling,anti-fouling and drag reduction *** design strategy for JHC has potential applications in numerous fields,like,pipeline transportation,bioengineering,and shipping industry.

关键词： Fish skin-inspired Artificial coating Hydrogel Drag reduction Antibacterial

Confined Mn^(2+) enables effective aerobic oxidation catalysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第5期67卷 1545-1553页

作者： Desheng Yuan Sicong Ma Xiao Kong Chi Zhang lin Chen Chengsheng Yang Lihua Wang Zhen Liu lin Ye Yongmei Liu Rui Ma Zhi-Pan Liu yifeng Zhu Yong Cao Xinhe Bao Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsCollaborative Innovation Center of Chemistry for Energy MaterialsFudan UniversityShanghai 200438China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Institute of Advanced Fluorine-Containing Materials Zhejiang Normal UniversityJinhua 321004China State Key Laboratory of Catalysis National Laboratory for Clean EnergyCollaborative Innovation Center of Chemistry for Energy MaterialsDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Effective and mild activation of O_(2) is essential but challenging for aerobic oxidation. In heterogeneous catalysis, high-valence manganese oxide(e.g., +4) is known to be active for the oxidation, whereas divalent MnO is ineffective due to its limited capacity to supply surface oxygen and its thermodynamically unstable structure when binding O_(2) in reaction conditions. Inspired by natural enzymes that rely on divalent Mn^(2+), we discovered that confining Mn^(2+) onto the Mn_(2)O_(3) surface through a dedicated calcination process creates highly active catalysts for the aerobic oxidation of 5-hydroxymethylfurfural, benzyl alcohol, and *** Mn_(2)O_(3)-confined Mn^(2+) is undercoordinated and efficiently mediates O_(2) activation, resulting in 2–3 orders of magnitude higher activity than Mn_(2)O_(3) alone. Through low-temperature infrared spectroscopy, we distinguished low-content Mn^(2+) sites at Mn_(2)O_(3) surface, which are difficult to be differentiated by X-ray photoelectron spectroscopy. The combination of in-situ energydispersive X-ray absorption spectroscopy and X-ray diffraction further provides insights into the formation of the newly identified active Mn^(2+) sites. By optimizing the calcination step, we were able to increase the catalytic activity threefold *** finding offers promising frontiers for exploring active oxidation catalysts by utilizing the confinement of Mn^(2+)and oftenignored calcination skills.

关键词： confinement catalysis manganese oxide aerobic oxidation divalent Mn^(2+) operando spectroscopies

Efficacy of Biological and Physical Enhancement on Targeted Muscle Reinnervation

在线全文

学校读者我要写书评

暂无评论

Cyborg and Bionic Systems 2022年第1期2022卷 55-63页

作者： Siyang Zhong Zijun Zhang Huan Su Chenyang Li yifeng lin Wei Lu Zhendong Jiang lin Yang Department of Basic Education Zhuhai Campus of Zunyi Medical UniversityZhuhaiChina School of Resources Environmental and Chemical EngineeringNanchang UniversityChina CAS Key Laboratory of HumanMachine InteligenceSymergy Systems Shenzhen Insttutes of Advanced TechnologyChinese Academy of Sciences(CAS)Shenzhen 518055China

Targeted muscle reinnervation(TMR)is a microsurgical repair technique to reconstruct the anatomical structure between thedistal nerve and the muscle stump to provide more myoelectric information to the artificially intlligent *** functional electrical stimulation treatment of the patient's denervated muscle or proximal nerve stump as well asnerve growth factor injection is effective in promoting nerve regeneration and muscle function *** this experiment,wesuccessfully established a TMR rat model and divided Sprague-Dawley(SD)adult male rats into IMR group,TMR+FESgroup,and TMR+NGF group acording to TMR and whether they received FES treatment or NGF injection after *** the recovery ffect of rat neuromuscular function was assessed by analyzing EMG *** the experiments,weconfrmed that growth factor supplementation and lowfrequency electrical stimulation can efectively promote theregeneration of the transplanted nerve as well as signifcantly enhance the motor function of the target muscle and have a positive effect on the regeneration of the transplanted nerve.

关键词： injection function treatment