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Reproducible Abnormalities and Diagnostic Generalizability of White Matter in Alzheimer’s Disease

Neuroscience Bulletin 2023年第10期39卷 1533-1543页

作者： yida qu Pan Wang Hongxiang Yao Dawei Wang Chengyuan Song Hongwei Yang Zengqiang Zhang Pindong Chen Xiaopeng Kang Kai Du Lingzhong Fan Bo Zhou Tong Han Chunshui Yu Xi Zhang Nianming Zuo Tianzi Jiang Yuying Zhou Bing Liu Ying Han Jie Lu Yong Liu Multi-Center Alzheimer’s Disease Imaging(MCADI)Consortium Brainnetome Center and National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Department of Neurology Tianjin Huanhu HospitalTianjin UniversityTianjin 300222China Department of Radiology Department of Epidemiology and Health StatisticsSchool of Public HealthQilu Hospital of Shandong UniversityJi’nan 250063China Department of Neurology Qilu Hospital of Shandong UniversityJi’nan 250063China Department of Radiology Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Branch of Chinese PLA General HospitalSanya 572022China Department of Neurology The Second Medical CentreNational Clinical Research Centre for Geriatric DiseasesChinese PLA General HospitalBeijing 100089China Department of Radiology Tianjin Huanhu HospitalTianjin 300222China Department of Radiology Tianjin Medical University General HospitalTianjin 300052China Department of Neurology Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Beijing Institute of Geriatrics Beijing 100053China National Clinical Research Center for Geriatric Disorders Beijing 100053China Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijing 100053China State Key Lab of Cognition Neuroscience&Learning Beijing Normal UniversityBeijing 100091China School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China 不详

Alzheimer’s disease(AD)is associated with the impairment of white matter(WM)*** current study aimed to verify the utility of WM as the neuroimaging marker of AD with multisite diffusion tensor imaging datasets[321 patients with AD,265 patients with mild cognitive impairment(MCI),279 normal controls(NC)],a unified pipeline,and independent site *** fiber quantification was used to extract diffusion profiles along ***-effects meta-analyses showed a reproducible degeneration pattern in which fractional anisotropy significantly decreased in the AD and MCI groups compared with *** learning models using tract-based features showed good generalizability among independent site *** diffusion metrics of the altered regions and the AD probability predicted by the models were highly correlated with cognitive ability in the AD and MCI *** highlighted the reproducibility and generalizability of the degeneration pattern of WM tracts in AD.

关键词： Alzheimer’s disease Diffusion tensor imaging White matter tracts Cross-validation

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Convergent Neuroimaging and Molecular Signatures in Mild Cognitive Impairment and Alzheimer’s Disease:A Data-Driven Meta-Analysis with N=3,118

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Neuroscience Bulletin 2024年第9期40卷 1274-1286页

作者： Xiaopeng Kang Dawei Wang Jiaji Lin Hongxiang Yao Kun Zhao Chengyuan Song Pindong Chen yida qu Hongwei Yang Zengqiang Zhang Bo Zhou Tong Han Zhengluan Liao Yan Chen Jie Lu Chunshui Yu Pan Wang Xinqing Zhang Ming Li Xi Zhang Tianzi Jiang Yuying Zhou Bing Liu Ying Han Yong Liu The Alzheimer’s Disease Neuroimaging Initiative The Multi-Center Alzheimer’s Disease Imaging(MCADI)Consortium School of Artificial Intelligence University of Chinese Academy of SciencesBeijing100049China Brainnetome Center and National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing100190China Department of Radiology Qilu Hospital of Shandong UniversityJi’nan250063China Department of Neurology the Second Affiliated Hospital of Air Force Medical UniversityXi’an710032China Department of Radiology Chinese PLA General HospitalBeijing100853China Department of Radiology the Second Medical CentreNational Clinical Research Centre for Geriatric DiseasesChinese PLA General HospitalBeijing100853China School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing100191China Department of Neurology Qilu Hospital of Shandong UniversityJi’nan250063China Department of Radiology Xuanwu Hospital of Capital Medical UniversityBeijing100053China Branch of Chinese PLA General HospitalSanya572013China Department of Neurology the Second Medical CentreNational Clinical Research Centre for Geriatric DiseasesChinese PLA General HospitalBeijing100853China Department of Radiology Tianjin Huanhu HospitalTianjin300222China Department of Psychiatry People’s Hospital of Hangzhou Medical CollegeZhejiang Provincial People’s HospitalHangzhou310014China Department of Radiology Tianjin Medical University General HospitalTianjin300070China Department of Neurology Tianjin Huanhu HospitalTianjin300222China Department of Neurology Xuanwu Hospital of Capital Medical UniversityBeijing100053China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming650201YunnanChina State Key Lab of Cognition Neuroscience&Learning Beijing Normal UniversityBeijing100875China National Clinical Research Center for Geriatric Disorders Beijing100053China Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijing1000

The current study aimed to evaluate the susceptibility to regional brain atrophy and its biological mechanism in Alzheimer’s disease(AD).We conducted data-driven meta-analyses to combine 3,118 structural magnetic resonance images from three datasets to obtain robust atrophy *** we introduced a set of radiogenomic analyses to investigate the biological basis of the atrophy patterns in *** results showed that the hippocampus and amygdala exhibit the most severe atrophy,followed by the temporal,frontal,and occipital lobes in mild cognitive impairment(MCI)and *** extent of atrophy in MCI was less severe than that in AD.A series of biological processes related to the glutamate signaling pathway,cellular stress response,and synapse structure and function were investigated through gene set enrichment *** study contributes to understanding the manifestations of atrophy and a deeper understanding of the pathophysiological processes that contribute to atrophy,providing new insight for further clinical research on AD.

关键词： Alzheimer’s disease Structural magnetic resonance imaging Meta-analysis Brain atrophy Gene set enrichment analysis

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利用弥散张量成像技术观察小血管病所致非痴呆型血管性认知障碍患者白质结构损害与认知下降的关系

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首都医科大学学报 2021年第3期42卷 373-384页

作者：秦琪唐毅曲怡达周爱红丁建平尹筠思刘勇贾建平首都医科大学宣武医院神经疾病高创中心国家老年疾病临床医学研究中心北京市老年病医疗研究中心北京100053 中国科学院自动化研究所模式识别国家重点实验室/脑网络组研究中心北京100190 中国科学院大学人工智能学院北京邮电大学人工智能学院北京100876 老年认知障碍疾病北京市重点实验室首都医科大学神经变性病与记忆障碍疾病临床诊疗与研究中心北京脑重大疾病研究院阿尔茨海默病研究所北京100053

目的非痴呆型血管性认知障碍(vascular cognitive impairment,no dementia,VCIND)是血管性认知障碍最常见亚型,早期诊断是改善预后的关键。神经影像为VCIND早期诊断、严重程度及疗效评价提供依据,但传统结构磁共振(magnetic resonance i... 详细信息

目的非痴呆型血管性认知障碍(vascular cognitive impairment,no dementia,VCIND)是血管性认知障碍最常见亚型,早期诊断是改善预后的关键。神经影像为VCIND早期诊断、严重程度及疗效评价提供依据,但传统结构磁共振(magnetic resonance imaging,MRI)不能较好阐明结构改变与认知损害的关系。本项目利用弥散张量成像技术(diffusion tensor imaging,DTI)探讨VCIND患者脑白质结构改变及其和认知障碍的关系。方法利用DTI对31名VCIND患者和22名正常对照者进行全脑246个脑区的白质连接完整性检测,并对所有受试者进行认知评估。然后分析患者各脑区DTI各向异性程度值(fractional anisotropy,FA)和平均弥散率(mean diffusivity,MD),并与认知评分进行相关性分析及中介分析。结果VCIND患者全脑246个脑区中的部分关键区域发生了显著的白质连接改变,尤其额叶脑区显著。FA值与总体认知评估及记忆、执行功能评分正相关,MD值与总体认知评估及记忆、执行功能评分负相关。中介分析发现VCIND患者白质结构连接的改变介导了神经心理量表评分的改变。结论本研究显示DTI可以为VCIND的早期诊断及认知严重程度的评估提供客观影像学指标。

关键词：弥散张量成像技术非痴呆型血管性认知障碍白质结构损害认知评估

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Dynamic stretching–electroplating metal-coated textile for a flexible and stretchable zinc–air battery

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Carbon Energy 2022年第5期4卷 867-877页

作者： Shengxiang qu Jie Liu Xiaopeng Han yida Deng Cheng Zhong Wenbin Hu Key Laboratory of Advanced Ceramics and Machining Technology(Ministry of Education) School of Materials Science and EngineeringTianjin UniversityTianjinChina Tianjin Key Laboratory of Composite and Functional Materials School of Materials Science and EngineeringTianjin UniversityTianjinChina Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhouFujianChina

A metal electrode is a significant component of a zinc–air battery(ZAB),but the metal material is usually not elastic,which severely restricts the application of flexible and stretchable ZABs in the field of wearable electronic ***,we report a flexible and stretchable metal-coated textile prepared by a dynamic stretching–electroplating based on a wavy spandex textile *** from the unique woven and wavy structure,the metal-coated textile shows a high stretchability of 100%and stable *** situ scanning electron microscope observation during stretching showed that the tensile strain of the metal-coated textile is mainly attributed to the deformation of the microfiber network at the bottom position of the wave *** addition,a sodium carboxymethyl cellulose–polyacrylic acid–potassium hydroxide composite hydrogel has been used as the *** hydrogel shows excellent ionic conductivity,mechanical properties,and water retention properties,which makes it suitable for the semi-open system of ***,a flexible and stretchable sandwich-structure ZAB,assembled using the above-mentioned electrodes and electrolyte,operates stably even under rapid stretching/releasing cycle *** of its facile preparation and low cost,this flexible and stretchable ZAB is suitable for fabrication of large-area batteries to obtain higher output current and power to drive wearable electronic devices.

关键词： dynamic stretching–electroplating hydrogel electrolyte metal-coated textile prestrain–load–recovery zinc–air battery

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The promoting effect of interstitial hydrogen on the oxygen reduction performance of PtPd alloy nanotubes for fuel cells

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Nano Research 2023年第2期16卷 2366-2372页

作者： Tingting Chao Xuan Luo Mengzhao Zhu Yanmin Hu yida Zhang Yunteng qu Hantao Peng Xiaoshuang Shen Xusheng Zheng Liang Zhang Xun Hong Center of Advanced Nanocatalysis(CAN) Department of Applied ChemistryUniversity of Science and Technology of ChinaHefei 230026China Country Center for Combustion Energy and School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China National Synchrotron Radiation Laboratory(NSRL) University of Science and Technology of ChinaHefei 230029China Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China School of Physical Science and Technology Yangzhou UniversityYangzhou 225002China

Highly efficient and stable oxygen reduction reaction(ORR)electrocatalysts are remarkably important but challenging for advancing the large-scale commercialization of practical proton exchange membrane fuel cells(PEMFCs).In this work,we report that the introduction of interstitial hydrogen atoms into PtPd nanotubes can significantly promote ORR performance without scarifying the *** enhanced mass activity was 8.8 times higher than that of commercial Pt/*** accelerated durability test showed negligible activity attenuation after 30,000 ***,H2/O2 fuel cell tests further verified the excellent activity of PtPd-H nanotubes with a maximum power density of 1.32 W·cm^(−2),superior to that of commercial Pt/C(1.16 W·cm^(−2)).Density functional theory calculations demonstrated the incorporation of hydrogen atoms gives rise to the broadening of Pt d-band and the downshift of d-band center,which consequently leads to the weaker intermediates binding and enhanced ORR activity.

关键词： hydrogen atoms incorporation alloy d-band structure regulation oxygen reduction reaction fuel cell

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Promoting the charge separation and photoelectrocatalytic water reduction kinetics of Cu_(2)O nanowires via decorating dual-cocatalysts

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Journal of Materials Science & Technology 2021年第3期62卷 119-127页

作者： Mengmeng Zhang Jiajun Wang Yang Wang Jinfeng Zhang Xiaopeng Han Yanan Chen Yuesheng Wang Zaghib Karim Wenbin Hu yida Deng School of Materials Science and Engineering Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of EducationTianjin UniversityTianjin300072China Center of Excellence in Transformation Electrification and Energy Storage Hydro-Québec1806 Boulevard Lionel-BouletVarennesQuébecJ3X 1S1Canada Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou350207China

Developing high activity and low-cost materials to produce hydrogen by the sustainable way of photoelectrochemical is key to social *** abundance and inexpensive Cu_(2)O has been received increasing research as its suitable energy level for photocatalytic water ***,the fast charge recombination rate and the sluggish catalytic kinetics are the huge challenges facing the Cu_(2)O ***,the highly reactive Cu_(2)O@C-MoS_(2)photocathode is constructed by depositing dual-cocatalysts of the carbon layer and MoS_(2)nanosheets on Cu_(2)O nanowires to realize efficient water *** impressive carrier concentration of 6.59×10^(23)cm^(-3)is received,which is 2.78 times of the bare Cu_(2)O,resulting in remarkable enhancement in photocurrent density of 3.34 times for the Cu_(2)O@CMoS_(2)***,the applied bias photon-to-current conversion efficiency of the bare Cu_(2)O enhanced 4.5 times from 0.16%to 0.72%in the Cu_(2)O@C-MoS_(2)*** analysis shows that the Cu_(2)O as light absorber,the carbon layer as electron transfer promoter,and MoS_(2)nanosheets as catalytic sites,thus facilitating chrage separation and enhancing catalytic *** system paves a feasible strategy for designing other photoelectrodes to realize efficient charge separation and high catalytic activity.

关键词： Photoelectrochemical water reduction Cu_(2)O nanowires Dual-cocatalysts modification Photocathode Charge separation

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实验法在创业研究中的应用:文献综述与未来展望

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外国经济与管理 2019年第5期41卷 31-43,57页

作者：于晓宇渠娴娴陶奕达段锦云叶文平上海大学管理学院上海200444 上海大学创新创业研究中心上海200444 华东师范大学心理与认知科学学院上海200062 暨南大学管理学院广东广州510632

实验法通过操纵、提取创业活动中复杂因素的关键因子,能够更加准确地探索变量间的因果关系,结合实地的研究可以较好地平衡内外部效度,因此日益受到创业学者的关注。目前,既有研究着重探讨如何规范运用实验法开展创业研究,而较少探讨如... 详细信息

实验法通过操纵、提取创业活动中复杂因素的关键因子,能够更加准确地探索变量间的因果关系,结合实地的研究可以较好地平衡内外部效度,因此日益受到创业学者的关注。目前,既有研究着重探讨如何规范运用实验法开展创业研究,而较少探讨如何将实验法和创业领域的研究问题进行有机结合,以更深入地剖析创业情境的独特性和创业活动的内在规律。为了弥补这一空白,本文对发表在14本国际权威管理和创业期刊的65篇创业实验研究文献进行梳理,从发表现状、研究主题、研究范式、实验操纵等方面进行总结。本文指出,创业领域中的实验研究侧重创业准备和机会识别等创业前期以及创业决策等微观层面上的有限领域,而对创业过程以及更广泛的行业和宏观层面考虑不足。未来研究应拓展研究情景和研究层次,将创业研究与神经科学等领域相结合,并进一步提高研究的规范性。本文增进了学者对创业实验研究的认识,为创业研究提供新的研究思路和方法,从而推动创业理论的进一步发展。

关键词：创业实验研究文献综述创业流程研究范式

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表面活性剂在集成电路多层布线CMP工艺中的应用研究

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润滑与密封 2024年第1期49卷 155-162页

作者：占妮牛新环闫晗罗付屈明慧刘江皓邹毅达周建伟河北工业大学电子信息工程学院天津300130 天津市电子材料与器件重点实验室天津300130

随着集成电路(IC)特征尺寸不断缩小,集成电路多层布线加工精度面临更高的要求,而化学机械抛光(CMP)凭借化学腐蚀和机械磨削的耦合协同作用,成为实现晶圆局部和全局平坦化的唯一可靠技术。抛光液作为CMP工艺中关键要素之一,其主要成分表... 详细信息

随着集成电路(IC)特征尺寸不断缩小,集成电路多层布线加工精度面临更高的要求,而化学机械抛光(CMP)凭借化学腐蚀和机械磨削的耦合协同作用,成为实现晶圆局部和全局平坦化的唯一可靠技术。抛光液作为CMP工艺中关键要素之一,其主要成分表面活性剂的选择以及含量会严重影响晶圆的表面质量。介绍表面活性剂的特性及其类型,回顾近年来国内外表面活性剂在集成电路多层布线相关材料CMP中的应用及作用机制,归纳总结得出表面活性剂在CMP过程中可以起到缓蚀保护、增强润湿、分散磨料、去除晶圆表面残留污染等多种作用,具有广泛的应用领域。同时,对表面活性剂在CMP中的应用前景进行了展望。

关键词：表面活性剂化学机械抛光多层布线集成电路抛光液

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吉非替尼治疗非小细胞肺癌脑转移的临床研究

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现代肿瘤医学 2012年第4期20卷 735-738页

作者：曲怡梅廖国清刘鹏辉李亮亮李月敏刘一达解放军309医院肿瘤科北京100091 解放军309医院放疗科北京100091

目的:分析吉非替尼治疗非小细胞肺癌脑转移的疗效、生活质量、预后及其相关因素。方法:对40例资料完整的非小细胞肺癌脑转移患者的临床特点、治疗效果、生活质量及生存时间进行回顾性分析。所有患者发生脑转移后均口服吉非替尼250 mg/天... 详细信息

目的:分析吉非替尼治疗非小细胞肺癌脑转移的疗效、生活质量、预后及其相关因素。方法:对40例资料完整的非小细胞肺癌脑转移患者的临床特点、治疗效果、生活质量及生存时间进行回顾性分析。所有患者发生脑转移后均口服吉非替尼250 mg/天,直到病变进展或发生不可耐受的不良反应。结果:吉非替尼治疗非小细胞肺癌脑转移的颅内病灶的疗效疾病控制率为83%,颅内病变疾病控制率与病理类型具有相关性。全身病变的疾病控制率为78%,全身病变疾病控制率与患者的病理类型、PS评分、脑转移数目(单发或多发)、服药后出现皮疹与否具有相关性(P<0.05)。全组患者中36例患者完成生活质量评价问卷,治疗8周后5种功能状态(躯体、角色、情感、认知、社会)和整体生活质量评分的均值显著增加,且差异均有显著性(P<0.05);2个全身症状(乏力、食欲不振)以及肺癌相关症状(呼吸困难、咳嗽、胸痛)评分的均值降低,其中乏力、呼吸困难、咳嗽的差异有显著性(P<0.05)。本组患者的中位TTP 6个月,TTP与患者的PS评分具有相关性(P=0.000)与服药后是否有皮疹具有相关性(P=0.016)。中位生存期11个月,生存期与PS评分、服药后皮疹情况和脑转移数目具有相关性(P分别为0.000、0.000和0.016)。不良反应可耐受,主要表现为轻度皮疹和腹泻。结论:吉非替尼治疗肺癌脑转移有效,可以改善患者预后,且不良反应轻微。

关键词：非小细胞肺癌脑转移吉非替尼

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