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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 1-11页

作者： Zhiwen Zong Sainan Huai Tianqi Cai Wenyan Jin Ze Zhan Zhenxing Zhang Kunliang Bu Liyang Sui Ying Fei yicong zheng Shengyu Zhang Jianlan Wu Yi Yin Zhejiang Province Key Laboratory of Quantum Technology and Device School of PhysicsZhejiang UniversityHangzhou 310027China Tencent Quantum Laboratory Shenzhen 518057China

As a valid tool for solving ground state problems,imaginary time evolution(ITE)is widely used in physical and chemical *** ITE-based algorithms in their quantum counterpart have recently been proposed and applied to some real *** experimentally realize the variational-based quantum imaginary time evolution(QITE)algorithm to simulate the ground state energy of hydrogen(H_2)and lithium hydride(Li H)molecules in a superconducting qubit *** H_2 molecule is directly simulated using the 3-qubit circuit with unitary-coupled clusters(UCC)*** also combine QITE with the cluster mean-field(CMF)method to obtain an effective *** Li H molecule is correspondingly simulated using the 3-qubit circuit with hardware-efficient *** comparison,the Li H molecule is also directly simulated using the 4-qubit circuit with UCC ansatz at the equilibrium *** the experimental results show a convergence within 4 iterations,with high-fidelity ground state energy *** a more complex system in the future,the CMF may allow further grouping of interactions to obtain an effective Hamiltonian,then the hybrid QITE algorithm can possibly simulate a relatively large-scale system with fewer qubits.

关键词： quantum computation quantum algorithm superconducting qubit

EGFR T790M突变非小细胞肺癌患者的临床病理学、免疫微环境特征及对预后预测的意义

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中国癌症杂志 2024年第4期34卷 368-379页

作者：林艺聪王悦薛倩倩郑强金燕黄子凌李媛复旦大学附属肿瘤医院病理科复旦大学上海医学院肿瘤学系上海200032

背景与目的:表皮生长因子受体20号外显子T790M突变(epidermal growth factor receptor exon 20 threonine-tomethionine substitution mutation at position 790,EGFR T790M)是非小细胞肺癌(non-small cell lung cancer,NSCLC)对第一/二代EGFR酪氨酸激酶抑制剂(EGFR tyrosine kinase inhibitor,EGFR TKI)的获得性耐药机制之一,EGFR T790M突变也可见于未经EGFR TKI治疗的NSCLC,本研究旨在比较原发性和获得性EGFR T790M突变NSCLC中的临床病理学特征和预后差异,进一步探讨NSCLC中获得性T790M突变的免疫微环境特征。方法:本研究回顾性分析复旦大学附属肿瘤医院从2020年4月—2022年9月诊断的3762例NSCLC,其中2070例(55.02%)存在EGFR突变,556例(14.77%)接受EGFR TKI治疗。其中EGFR T790M突变的NSCLC 119例(3.16%),51例(1.35%)为原发性EGFR T790M突变,68例(1.81%)为获得性EGFR T790M突变。收集患者的临床资料,对原发性和获得性T790M突变NSCLC进行比较,采用多重免疫荧光组织化学(multiple immunofluorescence histochemistry,mIHC)探讨获得性T790M突变NSCLC免疫微环境特征。结果:原发性和获得性T790M突变在女性患者中的比例均高于男性;原发性T790M突变患者更为年轻;原发性和获得性T790M突变均更容易出现在差分化癌中;原发性T790M突变NSCLC患者中,程序性死亡受体配体1(programmed death-ligand 1,PD-L1)表达阳性率较高(60.00%);获得性T790M突变NSCLC患者中,PD-L1表达阳性率较低(22.39%)。获得性T790M突变NSCLC往往伴随着TP53改变(39.7%)。单因素Cox回归分析结果显示,间质表皮转化因子(mesenchymal to epithelial transition factor,MET)改变是出现获得性T790M突变的危险因素(P=0.0005)。原发性和获得性T790M突变的平均总生存期(overall survival,OS)差异无统计学意义(分别为35.4和37.3个月)。然而,获得性T790M突变患者复发和转移的比例较高。获得性T790M突变中,间质区域存在更多的免疫细胞浸润,如CD20^(+)B淋巴细胞、CD23^(+)B淋巴细胞、CD8^(+)T淋巴细胞、CD8^(+)程序性死亡受体1(programmed death 1,PD-1)^(-/+)细胞、CD20^(+)PD-1^(-/+)细胞及CD23^(+)PD-1^(-/+)细胞等。此外,研究发现EGFR伴有抑癌基因(tumor suppressor gene,TSG)改变时,肿瘤细胞与CD8+T淋巴细胞、CD20+B淋巴细胞、CD8^(+)PD-1^(+)细胞、CD20^(+)PD-1^(+)细胞和CD23^(+)PD-1^(+)细胞的平均距离较仅有EGFR突变更近。结论:相较于原发性T790M突变,获得性T790M突变的病例中,PD-L1阳性率较低。获得性T790M突变常伴有TP53改变,而MET改变则是引发获得性T790M突变的一个危险因素。虽然获得性T790M突变患者的复发和转移风险较高,但其平均OS与原发性T790M突变患者并无显著差异。获得性T790M突变患者中,伴有TSG突变时可改变免疫细胞的空间分布,有望从免疫治疗中获益。

关键词：非小细胞肺癌 EGFR T790M突变 EGFR TKI 免疫微环境

Layout design and application of 4D-printing bio-inspired structures with programmable actuators

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Bio-Design and Manufacturing 2022年第1期5卷 189-200页

作者： Siyuan Zeng Yixiong Feng yicong Gao Hao zheng Jianrong Tan State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310027China Hangzhou Innovation Institute Beihang UniversityHangzhou 310000China

Four-dimensional(4D)printing is an advanced form of three-dimensional(3D)printing with controllable and programmable shape transformation over *** are used as a controlling factor with multi-stage shape recovery,with emerging opportunities to customize the mechanical properties of bio-inspired *** print pattern of shape memory polymer(SMP)fbers strongly afects the achievable resolution,and consequently infuences several other physical and mechanical properties of fabricated ***,the deformations of bio-inspired structures due to actuator layout are more complex because of the presence of the coupling of multi-directional *** this study,the initial structure was designed from closed-shell behavior and divided into a general unit and actuator unit,the latter responsible for driving the *** stress confrontation between the actuator and the general unit was considered in the layout thermodynamic model,in order to eliminate the transformation produced by the uncontrolled shape memory behavior of the general *** critical and efective strategies for the layout design of actuators were proposed and then applied to achieve the desired accurate deformation of 3D-printed bilayer ***,the proposed approach was validated and adopted for fabricating a complex shell-like gripper structure.

关键词： Bio-inspired structure Layout design Programmable actuators Bilayer structure 4D printing

Cell-based biosensors:Towards the development of cellular monitoring

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Chinese Science Bulletin 2002年第22期47卷 1849-1856页

作者： Gaixia Xu yicong Wu Rong Li Ping Wang Weiming Yan Xiaoxiang zheng Zhejiang Univ Dept Biomed Engn Minist Educ Biosensor Natl Special LabKey Lab BME Hangzhou 310027 Peoples R China

Cell-based biosensors (CBBs), a research hot-spot of biosensors, which treat living cells as sensing elements, can detect the functional information of biologically active analytes. They characterize with high sensitivity, excellent selectivity and rapid response, and have been applied in many fields, such as biomedicine, environmental monitoring and pharmaceutical screening. Recently cell-cultured technology, silicon microfabrication technology and genetic technology have promoted exploration of CBBs dramatically. To elucidate the novel research findings and applications of cell- based biosensors, this paper summarizes various research approaches, presents some challenges and proposes the research trends.

关键词： cell-based biosensors functional analysis cellular microenvironment electrophysiological genetically-engineered.

Comparison of enhancement techniques based on neural networks for attenuated voice signal captured by flexible vibration sensors on throats

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Nanotechnology and Precision Engineering 2022年第1期5卷 1-11页

作者： Shenghan Gao Changyan zheng yicong Zhao Ziyue Wu Jiao Li Xian Huang School of Precision Instruments and Opto-Electronics Engineering Tianjin University92 Weijin RoadTianjin 300072China High-Tech Institute Fan Gong-Ting South Street on the 12thQingzhou 262550China

Wearable flexible sensors attached on the neck have been developed to measure the vibration of vocal cords during ***,highfrequency attenuation caused by the frequency response of the flexible sensors and absorption of high-frequency sound by the skin are obstacles to the practical application of these sensors in speech capture based on bone *** this paper,speech enhancement techniques for enhancing the intelligibility of sensor signals are developed and *** kinds of speech enhancement algorithms based on a fully connected neural network(FCNN),a long short-term memory(LSTM),a bidirectional long short-term memory(BLSTM),and a convolutional-recurrent neural network(CRNN)are adopted to enhance the sensor signals,and their performance after deployment on four kinds of edge and cloud platforms is also *** results show that the BLSTM performs best in improving speech quality,but is poorest with regard to hardware *** improves short-time objective intelligibility(STOI)by 0.18 to nearly 0.80,which corresponds to a good intelligibility level,but it introduces latency as well as being a large *** CRNN,which improves STOI to about 0.75,ranks second among the four neural *** is also the only model that is able to achieves real-time processing with all four hardware platforms,demonstrating its great potential for deployment on mobile *** the best of our knowledge,this is one of the first trials to systematically and specifically develop processing techniques for bone-conduction speed signals captured by flexible *** results demonstrate the possibility of realizing a wearable lightweight speech collection system based on flexible vibration sensors and real-time speech enhancement to compensate for high-frequency attenuation.

关键词： Flexible electronics Vibration sensor Neural network Speech enhancement Deep learning

Cloning of Maize glossy6(gl6) via BSR-Seq and Seq-Walking strategy

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Cloning of Maize glossy6(gl6) via BSR-Seq and Seq-Walking st...

Cloning and characterization of maize ξ-carotene desaturase gene from the Mu-tagged population

第一届全国玉米生物学学术研讨会

作者：李莉 Sanzhen Liu yicong Du Jun zheng Guoying Wang Patrick S Schnable Institute of Crop Sciences Chinese Academy of Agricultural Sciences

The plant cuticle was covered by a layer of waxes which are important to the in vitro regulation of water balance for the plants and the outside *** plays an important role in regulating plant water status and protecting the plants from both biotic and abiotic ***,we cloned the maize waxes related glossy6(gl6)gene by combine the BSR-Seq and the Seq-walking strategy with 12 gl6 alleles.

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Cloning and characterization of maize ξ-carotene desaturase...

第一届全国玉米生物学学术研讨会

作者：陈岩 Jiankun Li Kaijian Fan yicong Du Zhenjing Ren Jun zheng Junjie Fu Dongtao Ren Guoying Wang Institute of Crop Sciences Chinese Academy of Agricultural Sciences State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural University

The maize vp-102 is a Mutator(Mu)induced viviparous mutant,which has white or pale yellow kernels sprouting before *** this study,we reported the cloning of vp-102 gene by a modified digestion-ligation-amplification m...

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单侧涂层浮空器蒙皮材料的近场动力学模型

复合材料学报 2018年第10期35卷 2897-2905页

作者：周毅聪赵海涛陈吉安陈政段登平上海交通大学航空航天学院上海200240

基于近场动力学方法,构建了浮空器蒙皮材料的近场模型。首先阐述了近场动力学的基本理论,表明了蒙皮材料的材料性质及结构。然后将蒙皮材料离散为空间上的质点,基于复合材料的近场模型,分析了编织条件下,质点本构力和应变能密度的组成,... 详细信息

基于近场动力学方法,构建了浮空器蒙皮材料的近场模型。首先阐述了近场动力学的基本理论,表明了蒙皮材料的材料性质及结构。然后将蒙皮材料离散为空间上的质点,基于复合材料的近场模型,分析了编织条件下,质点本构力和应变能密度的组成,推导了质点间的本构力方程及近场参数。最后利用动力松弛法编程模拟了材料的力学性能。结果表明,在该近场模型下,蒙皮材料受力下的拉伸-应变曲线能与其他模拟结果相对应,并且材料的拉伸模量符合实验结果。

关键词：近场动力学蒙皮材料本构力方程近场参数数值模拟

基于性能演化的复杂产品概念设计求解过程研究

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机械工程学报 2018年第9期54卷 214-223页

作者：郑浩冯毅雄高一聪谭建荣浙江大学流体动力与机电系统国家重点实验室

性能约束满足是复杂产品设计的关键因素。传统概念设计求解的研究着重于功构映射及其推理实现,忽略了性能在求解过程中的演化规律,导致性能在设计过程中存在上下文孤立以及无法溯源等问题。为了解决这一问题,提出了基于性能演化的概念... 详细信息

性能约束满足是复杂产品设计的关键因素。传统概念设计求解的研究着重于功构映射及其推理实现,忽略了性能在求解过程中的演化规律,导致性能在设计过程中存在上下文孤立以及无法溯源等问题。为了解决这一问题,提出了基于性能演化的概念设计求解过程模型与实现方法。通过分析概念设计过程中的性能特性,构建集成期望性能、行为性能和结构性能的规范化性能演化模型。以此为基础对模型进行解析计算,主要包括面向期望性能辨识的重要度分析、面向行为性能均衡的单元规划求解以及面向结构性能适配的方案生成,同时建立了性能演化驱动的产品概念设计过程,以支持性能认知、性能优化以及性能计算的设计求解实现。最后以某型号液压机概念设计过程为例验证本方法的可行性与有效性。

关键词：概念设计性能演化解析计算

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下肢康复外骨骼的步态交互设计研究进展

机械工程学报 2023年第17期59卷 175-188页

作者：高一聪王彦坤郑浩魏喆谭建荣浙江大学流体动力与机电系统国家重点实验室杭州310027 浙江大学设计工程及数字孪生浙江省工程研究中心杭州310027 北京航空航天大学杭州创新研究院杭州310000 沈阳工业大学机械工程学院沈阳110870

中国正向深度老龄化社会高速迈进,脑卒中等老年性疾病人群逐年增多,开展面向助老适老的智能产品研究具有广阔的应用前景与重要的学术价值。下肢康复外骨骼是一种与穿戴者肢体交互并为其提供相应运动辅助和训练的人机交互共融智能产品。... 详细信息

中国正向深度老龄化社会高速迈进,脑卒中等老年性疾病人群逐年增多,开展面向助老适老的智能产品研究具有广阔的应用前景与重要的学术价值。下肢康复外骨骼是一种与穿戴者肢体交互并为其提供相应运动辅助和训练的人机交互共融智能产品。利用下肢康复外骨骼进行科学有效的康复运动训练,患者的肌力得以增强,脑神经和患肢之间的传递通路得以重建。根据穿戴者的下肢运动功能缺失或减弱程度生成并调整步态以进行安全有效的康复训练,是目前下肢康复外骨骼的研究前沿与热点。针对下肢运动功能障碍导致的行走方式差异化和康复步态规划个性化问题,结合国内外下肢康复外骨骼步态交互设计的研究进展,围绕下肢康复外骨骼步态性能评价标准、步态生成方法、步态控制策略和典型康复应用进行了重点分析探讨。最后总结并对下肢康复外骨骼的步态交互设计未来发展方向进行了展望,为相关研究人员提供参考。

关键词：交互设计康复步态设计下肢康复外骨骼智能产品