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Role of Leptin in Immunity

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Cellular & Molecular Immunology 2007年第1期4卷 1-13页

作者： Queenie lai Kwan Lam Department of Pathology and Center of Infection and Immunology The University of Hong Kong

Leptin, a protein hormone produced by the adipocytes, has long been recognized to regulate metabolism, neuroendorine and other physiological functions. Early findings of increased leptin production during infection and inflammation and dysregulated immune response in leptin signaling-deficient mice provide strong evidence for the involvement of leptin in the immune responses. Recent data have established the regulatory function for leptin in immunity similar to the function of a pro-inflammatory cytokine, while gene-targeting studies also demonstrated an essential role of leptin in regulating hematopoiesis and lymphopoiesis. Moreover, there has been increasing evidence that leptin is involved in the pathogenesis of various autoimmune diseases. This review discusses recent advances in understanding the role of leptin in immunity and leptin-signaling pathways involved in modulating immune homeostasis and autoimmune pathogenesis. Cellular ＆ Molecular Immunology. 2007;4（1）：1-13.

关键词： leptin leptin signaling pro-inflammatory cytokine immune response autoimmune disease

Synthesis, Characterization and Control of Proportion of Polymorph C in ITQ-16 and ITQ-17 Films

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Chemical Research in Chinese Universities 2016年第6期32卷 895-901页

作者： CHEN Yanli FENG lai College of Physics Optoelectronics and Enevgy Soochow University Suzhou 215006 P. R. China School of Materials Science and Engineering Tianjin University of Technology Tianjin 300384 P. R. China

Continuous ITQ-16 and ITQ-17 films on silicon wafer were prepared in fluoride media using TEAOH asorganic structure-directing agent. The proportion ofpolymorph C in the as-synthesized ITQ-16 and ITQ-17 films wasdetermined via X-ray diffraction characterization. The proportion of polymorph C in the ITQ-16 and 1TQ-17 filmswas controlled via optimizing the compositions of the reaction mixtures and reaction conditions, such as varyingthe Si/Ge molar ratio and adding n-propyl alcohol as a solvent in the reaction mixture, The Ge atoms in the reactionmedia strongly increased the crystallization of polymorph C in ITQ-16 and ITQ-17 films. Moreover, the stabilizingand buffering effect of n-propyl alcohol on crystal growth further enhanced the proportion of polymorph C in theITQ-16 and ITQ-17 films. For potential catalytic applications, A1 was incorporated into the framework ofpolymorphC, and a pure phase of polymorph C in Al-ITQ-17 film was achieved from the synthesis gel in the n-propyl alcohol phase.

关键词： Zeolite beta ITQ-16 ITQ-17 Polymorph C

DNA-chip-based dynamic broadcast encryption scheme with constant-size ciphertexts and decryption keys

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Science China(Information Sciences) 2014年第9期57卷 126-135页

作者： FANG XiWen lai XueJia Department of Computer Science and Engineering Shanghai Jiao Tong University

In this paper we present DNA-DBE,a DNA-chip-based dynamic broadcast encryption *** our scheme,new users can join dynamically without modification of other users’decryption *** the ciphertext or the decryption key is of *** secrecy is achieved in DNA-DBE:if new users join the system dynamically,they will not be able to retrieve past *** security of our scheme relies on hard biological problems,which are immune to attacks of new computing technologies in the *** exists a special feature in DNA–based cryptosystems,*** set of encryption keys and the set of decryption keys have a many-to-many *** implementation of more complicated DNA cryptosystems taking advantage of this special feature has been previously left as an open *** DNA-DBE system is a solution to this open problem,which is also the first exploration of DNA based group-oriented encryption system.

关键词： DNA cryptography dynamic broadcast encryption group oriented cryptography DNA chip cryptology

Robust N−k Security-constrained Optimal Power Flow Incorporating Preventive and Corrective Generation Dispatch to Improve Power System Reliability

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CSEE Journal of Power and Energy Systems 2023年第1期9卷 351-364页

作者： Liping Huang Chun Sing lai Zhuoli Zhao Guangya Yang Bang Zhong Loi Lei lai School of Automation Guangdong University of TechnologyGuangzhou 510006China School of Automation Guangdong University of TechnologyGuangzhou 510006Chinaand also with the Department of Electronic and Electrical EngineeringBrunel University LondonLondonUB83PHUK Center for Electric Power System and Energy Department of Electrical EngineeringTechnical University of DenmarkKongens Lyngby 2800Demark Zhaoqing Power Supply Bureau Guangdong Power Grid CompanyChina Southern Power GridZhaoqing 526020China

As extreme weather events have become more frequent in recent years,improving the resilience and reliability of power systems has become an important area of *** this paper,a robust preventive-corrective security-constrained optimal power flow(RO-PCSCOPF)model is proposed to improve power system reliability under N−k *** the short-term emergency limit(STL)and the long-term operating limit(LTL)of the post-contingency power flow on the branch are *** with the existing robust corrective SCOPF model that only considers STL or LTL,the proposed ROPCSCOPF model can achieve a more reliable generation dispatch *** addition,this paper also summarizes and compares the solution methods for solving the N−k SCOPF *** computational efficiency of the classical Benders decomposition(BD)method,robust optimization(RO)method,and line outage distribution factor(LODF)method are investigated on the IEEE 24-bus Reliability Test System and 118-bus *** results show that the BD method has the worst computation *** RO method and the LODF method have comparable ***,the LODF method can only be used for the preventive SCOPF and not for the corrective *** RO method can be used for both.

关键词： Benders cut bender decomposition line outage distribution factor N−k security criterion optimal power flow power system reliability resilience robust optimization

U-Pb Ages and Hf Isotope of Zircons from a Carbonatite Dyke in the Bayan Obo Fe-REE Deposit in Inner Mongolia: its Geological Significance

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Acta Geologica Sinica(English Edition) 2019年第6期93卷 1783-1796页

作者： lai Xiaodong YANG Xiaoyong School of Environmental and Chemical Engineering Foshan UniversityFoshanGuangdong 528225China CAS Key Laboratory of Crust-Mantle Materials and Environments University of Science and Technology of ChinaHefei 230026China

Detailed studies on U-Pb ages and Hf isotope have been carried out in zircons from a carbonatite dyke associated with the Bayan Obo giant REE-Nb-Fe deposit,northern margin of the North China Craton(NCC),which provide insights into the plate tectonic in *** of small amounts of zircons extracted from a large sample of the Wu carbonatite dyke have yielded two ages of late Archaean and late Paleoproterozoic(with mean 207 Pb/206 Pb ages of 2521±25 Ma and 1921±14 Ma,respectively).Mineral inclusions in the zircon identified by Raman spectroscopy are all silicate minerals,and none of the zircon grains has the extremely high Th/U characteristic of carbonatite,which are consistent with crystallization of the zircon from silicate,and the zircon is suggested to be derived from trapped basement *** isotopes in the zircon from the studied carbonatite are different from grain to grain,suggesting the zircons were not all formed in one single *** ofεHf(t)values are compatible with ancient crustal sources with limited juvenile *** Hf data and their TDM2 values also suggest a juvenile continental growth in Paleoproterozoic during the period of 1940–1957 *** data demonstrate the major crustal growth during the Paleoproterozoic in the northern margin of the NCC,coeval with the assembly of the supercontinent Columbia,and provide insights into the plate tectonic of the NCC in Paleoproterozoic.

关键词： crustal growth zircon U-Pb age Hf isotope Bayan Obo North China Craton

A higher order lattice BGK model for simulating some nonlinear partial differential equations

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Science China(Physics,Mechanics & Astronomy) 2009年第7期52卷 1053-1061页

作者： lai HuiLin MA ChangFeng School of Mathematics and Computer Science Fujian Normal UniversityFuzhou 350007China

In this paper, we consider a one-dimensional nonlinear partial differential equation that has the form ut + αuux + βunux - γuxx + δuxxx = F(u). A higher order lattice Bhatnager-Gross-Krook (BGK) model with an amending-function is proposed. With the Chapman-Enskog expansion, different kinds of nonlinear partial differential equations are recovered correctly from the continuous Boltzmann equation. The numerical results show that this method is very effective.

关键词： nonlinear partial differential equation lattice Boltzmann model multi-scale technique Taylor series expansion Chapman-Enskog expansion

Genetically Modified Pig Models for Human Diseases

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Journal of Genetics and Genomics 2013年第2期40卷 67-73页

作者： Nana Fan Liangxue lai Key Laboratory of Regenerative Biology South China Institute for Stem Cell Biology and Regenerative MedicineGuangzhou Institutes of Biomedicine and HealthChinese Academy of Sciences School of Life Sciences University of Science and Technology of China

Genetically modified animal models are important for understanding the pathogenesis of human disease and developing therapeutic strategies. Although genetically modified mice have been widely used to model human diseases, some of these mouse models do not replicate important disease symptoms or pathology. Pigs are more similar to humans than mice in anatomy, physiology, and genome. Thus, pigs are considered to be better animal models to mimic some human diseases. This review describes genetically modified pigs that have been used to model various diseases including neurological, cardiovascular, and diabetic disorders. We also discuss the development in gene modification technology that can facilitate the generation of transgenic pig models for human diseases,

关键词： Pig Transgene Gene targeting Human disease model

Effect of anodic dissolution and passivation on X80 steel in NaHCO_(3) solution

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Petroleum Science 2021年第1期18卷 285-294页

作者： lai-Shun Yang Chao Yang College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdao 266590ShandongChina Technology Inspection Center of Shengli Oilfield SINOPECDongying 257000ShandongChina China University of Petroleum(East China) Qingdao 266580ShandongChina

The effects of extreme stray current on the anodic dissolution and passivation of X80 steel in NaHCO3 solution were investigated using measurements of polarization curves and EIS,AFM and SEM *** the interference of anodic current(i=0~200 A/m2),main constituents of corrosion products of X80 steel were FeO(OH)and Fe3 O4.A double-layer film formed at i=00 A/m2,in which FeOOH was in outer and Fe3 O4 lied in *** formation mechanism of Fe3 O4 was confirmed and described by the electrochemical reaction in various regions on anodic potentiodynamic polarization curve.

关键词： Anodic current Passivation X80 steel Fe3O4 Near-neutral solution

Intercellular and inter-organ crosstalk in browning of white adipose tissue:molecular mechanism and therapeutic complications

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Journal of Molecular Cell Biology 2021年第7期13卷 466-479页

作者： lai Yee Cheong Aimin Xu The State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina

Adipose tissue(AT)is highly plastic and heterogeneous in response to environmental and nutritional *** development of heat-dissipating beige adipocytes in white AT(WAT)through a process known as browning(or beiging)has garnered much attention as a promising therapeutic strategy for obesity and its related metabolic *** is due to its inducibility in response to thermogenic stimulation and its association with improved metabolic *** consists of adipocytes,nerves,vascular endothelial cells,various types of immune cells,adipocyte progenitor cells,and *** cells contribute to the formation of beige adipocytes through the release of protein factors that significantly influence browning *** addition,inter-organ crosstalk is also important for beige adipocyte ***,we summarize recent findings on fat depot-specific differences,secretory factors participating in intercellular and inter-organ communications that regulate the recruitment of thermogenic beige adipocytes,as well as challenges in targeting beige adipocytes as a potential anti-obese therapy.

关键词： adipose tissue browning circulating factors energy homeostasis adipose biology obesity