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Individual and joint toxic effects of cadmium sulfate and α-naphthoflavone on the development of zebrafish embryo

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第9期15卷 766-775页

作者： jian yin jian-ming YANG Feng ZHANG Peng MIAO ying LIN Ming-li CHEN CAS Key Lab of Bio-Medical Diagnostics Suzhou Institute of Biomedical Engineering and Technology Chinese Academic of Sciences Suzhou 215163 China Suzhou Xiexin Photovoltaic Technology Co. Ltd. Suzhou 215163 China University of Chinese Academy of Sciences Beijing 100049 China

This paper aims to evaluate the individual and joint toxicities of cadmium sulfate （CdSO4） and α-naphthoflavone （ANF） in zebrafish embryos. As a result, CdSO4 caused both lethal and sub-lethal effects, such as 24 h post-fertilization （hpf） death and 72 hpf delayed hatching. However, ANF only caused sub-lethal effects, including 48 hpf cardiac edema and 72 hpf delayed hatching. Taking 24 hpf death and 48 hpf cardiac edema as endpoints, the toxicities of CdSO4 and ANF were significantly enhanced by each other. Consistently, both CdSO4 and ANF caused significant oxidative stress, including decreases in the reduced glutathione （GSH） level, inhibition of superoxide dis- mutase （SOD） activity, as well as increases in malondialdehyde （MDA） content in zebrafish embryos, but these mixtures produced much more significant alterations on the biomarkers. Co-treatment of CdSO4 and ANF significantly down-regulated the mRNA level of multidrug resistance-associated protein （mrp） 1 and cytochrome P450 （cyp） la, which constituted the protective mechanisms for zebraflsh embryos to chemical toxins. In conclusion, co-treatment of CdSO4 and ANF exhibited a much more severe damage in zebraflsh embryos than individual treatment. Meanwhile, production of oxidative stress and altered expression of mrpl and cypla could be important components of such joint toxicity.

关键词： Joint toxicity Cadmium sulfate α-Naphthoflavone Zebrafish embryo Oxidative stress

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基于A^(2)Π_(1/2)←X^(2)Σ_(1/2)跃迁的CaH分子激光冷却光谱理论研究

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物理学报 2021年第16期70卷 118-127页

作者：尹俊豪杨涛印建平华东师范大学精密光谱科学与技术国家重点实验室上海200062

冷分子是当下物理学的前沿领域和热点研究方向之一,早在2004年就有科学家提出将CaH分子作为激光冷却与磁光囚禁的候选分子.本文首先用三种方法(莫尔斯势法、闭合近似法和RKR反演法)计算CaH分子的弗兰克-康登因子,证实了CaH的X^(2)∑_(1... 详细信息

冷分子是当下物理学的前沿领域和热点研究方向之一,早在2004年就有科学家提出将CaH分子作为激光冷却与磁光囚禁的候选分子.本文首先用三种方法(莫尔斯势法、闭合近似法和RKR反演法)计算CaH分子的弗兰克-康登因子,证实了CaH的X^(2)∑_(1/2)态和A^(2)∏_(1/2)态之间具有高度对角化的弗兰克-康登因子矩阵.随后,采用有效哈密顿量的方法研究了基态X^(2)∑_(1/2)的超精细能级结构和A^(2)∏_(1/2)(J=1/2,+)←X^(2)∑_(1/2)(N=1,-)跃迁的超精细跃迁分支比,并提出可同时覆盖超精细能级的边带调制方案.最后,为探究CaH分子磁光囚禁的相关性质,计算了|X,N=1,->态的塞曼效应和J混合下的朗德g因子.以上工作不仅证明了激光冷却和磁光囚禁CaH分子的可行性,而且对天体物理学中的光谱分析、超冷分子碰撞以及探索基本对称性破缺等基础物理学的相关研究也具有一定的参考意义.

关键词：冷分子激光冷却 CaH分子弗兰克-康登因子

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Late Quaternary palaeoenvironmental changes documented by microfaunas and shell stable isotopes in the southern Pearl River Delta plain,South China

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Journal of Palaeogeography 2013年第4期2卷 344-361页

作者： Liu Chunlian Franz T. Fürsich Wu Jie Dong Yixin Yang Tingting yin jian Department of Earth Sciences Sun Yat-Sen University Geozentrum Nordbayern FG Pal oumwelt der Friedrich-Alexander-Universitt Erlangen Guangdong Provincial Key Laboratory of Mineral Resources and Geological Processes

Ahigh resolution study of sediments,microfaunas(ostracods and foraminifers),and stable isotopes of ostracod shells from core PRD05,sampled from the Da’ao plain of the Pearl River Delta,provides new data about palaeoenvironmental changes during the Late *** basal fluvial gravelly sediments of the core,representing the lowest deposits of the Quaternary at the core site,were possibly formed prior to the transgression associated with the last interglacial *** fluvial setting changed into a marginal marine setting during the last interglacial stage,any record of calcareous fossils were destroyed by subsequent dissolution during the last glacial phase,when the upper part of the deltaic sediments experienced subaerial oxidation,indicated by a mottled clay layer in the *** postglacial sealevel rise in the South China Sea began at16,700 cal yr *** the first phase of sea-level rise(from ~16,700 to 10,100 cal yr B.P.),a swamp environment developed at the core *** ~10,100 cal yr B.P.,marine waters intruded onto the Da’ao plain and reached the core site through the Modaomen *** timing was earlier than in other parts of the Pearl River *** then,a semi-enclosed estuarine environment developed and was maintained until ~5560 cal yr *** this transgressive interval,short-term environmental fluctuations can be recognized based on microfauna and shell geochemical *** ~10,100 to 8630 cal yr B.P.,the sea-level rose,which was followed by a fall from ~8630 to 8520 cal yr *** expanded transgression occurred between ~8520 and 7900 cal yr *** time intervals from ~8520 to 8200 cal yr *** from ~8080 to 7900 cal yr *** marked by peak *** ~7900 to 5560 cal yr B.P.,the core site generally showed a reduced marine influence and enhanced freshwater input.A fluvial environment developed from ~5560 to 3100 cal yr B.P.,and was succeeded by an alluvial plain setting.

关键词： Late Quaternary microfauna shell stable isotopes palaeoenvironment Pearl River Delta

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Singular Stabilization and H_∞ Control of Nonlinear Systems with Ordinary Homogeneous Properties

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Chinese Quarterly Journal of Mathematics 2005年第3期20卷 280-288页

作者： FANG jian-yin MU Xiao-wu Department of Mathematics Zhengzhou University Zhengzhou 450052 China

In this paper, the nonlinear singular stabilization, H∞ control problem of systems with ordinary homogeneous properties is considered. At first, we discuss the stabilization problems of nonlinear systems with homogeneous. Secondly, by vitue of Hamilton-Jacobi-Isaacs equations or inequalities, we solve regular H∞ of nonlinear systems with homogeneous properties. To overcome the H∞ problem of singular nonlinear system, we try to transform inputs of the singular nonlinear system into two parts： regular part input and singular part input. Following the previous results, we solve the singular nonlinear system H∞ control, we give the Lyapunov function and the state feedback controller of the singular nonlinear systems with homogeneous properties.

关键词： stabilization H∞ control homogeneous system singular system regular system feedback state control

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Chemical synthesis of a synthetically useful L-galactosaminuronic acid building block

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Chinese Journal of Natural Medicines 2022年第5期20卷 387-392页

作者： QIN Chun-Jun HOU Hong-Li DING Mei-Ru QI Yi-Kuan TIAN Guang-Zong ZOU Xiao-Peng FU Jun-Jie HU Jing yin jian Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China Wuxi School of Medicine Jiangnan UniversityWuxi 214122China

Most bacterial cell surface glycans are structurally unique, and have been considered as ideal target molecules for the developments of detection and diagnosis techniques, as well as vaccines. Chemical synthesis has been a promising approach to prepare well-defined oligosaccharides, facilitating the structure-activity relationship exploration and biomedical applications of bacterial glycans. L-Galactosaminuronic acid is a rare sugar that has been only found in cell surface glycans of gram-negative bacteria. Here, an orthogonally protected L-galactosaminuronic acid building block was designed and chemically synthesized. A synthetic strategy based on glycal addition and TEMPO/BAIB-mediated C6 oxidation served well for the transformation of commercial L-galactose to the corresponding L-galactosaminuronic acid. Notably, the C6 oxidation of the allyl glycoside was more efficient than that of the selenoglycoside. In addition, a balance between the formation of allyl glycoside and the recovery of selenoglycoside was essential to improve efficiency of the NIS/TfOH-catalyzed allylation. This synthetically useful L-galactosaminuronic acid building block will provide a basis for the syntheses of complex bacterial glycans.

关键词： L-galactosaminuronic acid Chemical synthesis Orthogonal protection Glycal addition C6 oxidation

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钢梁桥竖向弹塑性地震反应分析的非线性位移系数法

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太原理工大学学报 2021年第3期52卷 456-465页

作者：尹剑山西交通科学研究院集团有限公司太原030006

钢梁桥在竖向地震作用下的弹塑性变形在"向下"方向累积,在"向上"方向结构保持弹性。基于此,建立了钢梁桥在竖向地震作用下的非对称滞回模型。采用53条近场竖向强震记录和自编非线性动力反应分析程序,计算了钢梁桥在竖向地震作用下的弹... 详细信息

钢梁桥在竖向地震作用下的弹塑性变形在"向下"方向累积,在"向上"方向结构保持弹性。基于此,建立了钢梁桥在竖向地震作用下的非对称滞回模型。采用53条近场竖向强震记录和自编非线性动力反应分析程序,计算了钢梁桥在竖向地震作用下的弹塑性位移需求。结果表明:钢梁桥等效竖向屈服强度越高,或其屈服后刚度系数越高,钢梁桥的弹塑性位移需求越低,离散性越小。基于计算结果,拟合得到了钢梁桥在竖向地震作用下的弹塑性位移系数公式。采用该方法计算一个钢桁架梁桥在竖向地震作用下的弹塑性反应,所得结果与时程分析结果吻合。对于跨中竖向位移,误差不超过11%;对于屈服构件数量和位置,本文方法与时程分析方法结果一致。

关键词：桥梁结构竖向非线性位移系数非线性地震反应分析钢梁桥竖向非对称滞回

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Effect of Alloying Elements on the Quality of Hard Anodic Oxidation Film in Aluminum Alloy 6061

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稀有金属材料与工程 2011年第S3期40卷 59-62页

作者： Yang yin, Shen jian, Yan Xiaodong, Xu Xiaojing, Li Junpeng, jiang Tao Beijing General Research Institute for Non-ferrous Metals, Beijing 100088, China Beijing Gen Res Inst Nonferrous Met Beijing 100088 Peoples R China

the effect of different Mg/Si and Mn content on uniformity and consistence of anodic films of 6061 aluminum alloy was investigated by using hardness test,coating thickness test, optical microscopy (OM),scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS). The results show that when Mg/Si is in the vicinity of 1.73 and Mn content is 0.14%, the uniformity of the anodic film is the best while the consistence of the anodic film is the best when Mg/Si is 1.88 and Mn content is 0.14%. Superfluous silicon and magnesium have a bad function on the uniformity of anodic films of 6061 aluminum alloy because of secondary phases but magnesium in the base material can be beneficial for the consistence of the anodic film due to formation of a protective, impermeable layer of MgO below the anodic film while plentiful excess silicon result in single Si and w(Cu4Mg5Si4Alx) to gather in the grain boundary, which makes rarefactions and discontinuity present. The uniformity and consistence of anodic films are improved by Mn content rising, which is caused by the decrease of needle-like Fe-rich and Mg2Si phases and the increase of bone-like Fe-rich phases.

关键词： aluminum alloy 6061 uniformity densification anodic oxidation film

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Recent advances in synthetic carbohydrate-based human immunodeficiency virus vaccines

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Virologica Sinica 2016年第2期31卷 110-117页

作者： Zhenyuan Wang Chunjun Qin Jing Hu Xiaoqiang Guo jian yin Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education School of Biotechnology Jiangnan University Wuxi Medical School Jiangnan University

An effective vaccine for human immunodeficiency virus(HIV) is urgently needed to prevent HIV infection and progression to acquired immune deficiency syndrome(AIDS). As glycosylation of viral proteins becomes better understood, carbohydrate-based antiviral vaccines against special viruses have attracted much attention. Significant efforts in carbohydrate synthesis and immunogenicity research have resulted in the development of multiple carbohydrate-based HIV vaccines. This review summarizes recent advances in synthetic carbohydrate-based vaccines design strategies and the applications of these vaccines in the prevention of HIV.

关键词： vaccines carbohydrate advances antiviral epitope vaccination antiretroviral antigenic prevention understood

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P22 Teaching of pharmacology in pharmacy school needs to be different from medical background

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中国药理通讯 2006年第2期23卷 28-29页

作者： Ming yin Ze-jian Wang School of Pharmacy Shanghai Jiao Tong University800 Dong Chuan Road Shanghai 200240

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Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro

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Chinese Medical Journal 2011年第17期000卷 2733-2740页

作者： LI Bing-bing jianG Zhen SHENG jian-yin YAO Kang Department of Anesthesiology Nanjing Drum Tower Hospital Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu 210008 China Department of Anesthesiology and Intensive Care Zhongshan Hospital Fudan University Shanghai 200032 China Department of Cardiology 10th People Hospital of Shanghai Tongji University Shanghai 200072 China Department of Cardiology Zhongshan Hospital Fudan University Shanghai 200032 China

Background Sildenafil is one of the selective phosphodiesterase 5 inhibitors that has been proven by many investigators to suppress growth factor stimulated （e.g. platelet-derived growth factor （PDGF） or epidermal growth factor （EGF）） proliferation and hypertrophy of pulmonary artery smooth muscle cells （PASMCs） via cGMP/cGKla pathway. Serotonin promotes cell cycle progression leading to cell mitogenesis and plays a key role in the pathogenesis of pulmonary artery hypertension. The role of sildenafil in proliferation of PASMCs induced by serotonin has not been investigated so far. In this study we explored the underlying mechanism of the effect of sildenafil on serotonin induced proliferation of porcine PASMCs. Methods PASMCs were cells from primary cultures by the explant method from the pulmonary artery of swine and cells at passage 3-5 were used in this study. MTT colorimetric assay and flow cytometry analysis were used to evaluate the cell proliferation and alterations in cell cycle progression respectively. Western blotting analysis was applied to determine the expression of phosphorylated extracellular signal-regulated kinase （ERK）, proliferating cell nuclear antigen （PCNA） and mitogen activated protein kinase （MAPK） phosphatase-1 （MKP-1）. Results Serotonin （10 IJmol/L） induced the upregulation of phosphorylation of ERK1/ERK2 and PCNA, an increase in the percentage of cells in S phase and subsequent cell proliferation. Pretreatment with 1 μmol/L sildenafil potentiated the phosphorylation of ERK1/ERK2, an increase in the percentage of cells in S phase and cell proliferation, compared with serotonin stimulation alone （P〈0.05）. Furthermore, 30-minute pretreatment with 10 μmol/L U0126, specific antagonist for ERK kinase （MEK） prevented the increase in phosphorylation of ERK1/ERK2 and abolished cell cycle progression and the proliferation of PASMCs induced by sildenafil. Conclusion This study shows that sildenafil potentiated the proliferative effect of serotonin o

关键词： hypertension, pulmonary myocytes smooth muscle sildenafil serotonin MAP kinase signaling system

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