检索结果-南通市图书馆

COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2020年第5期41卷 517-526页

作者： Ling Xu Dan-Dan Yu Yu-Hua Ma Yu-Lin Yao Rong-Hua Luo Xiao-Li Feng Hou-Rong Cai jian-Bao Han Xue-Hui Wang Ming-Hua Li Chang-wen Ke Yong-Tang Zheng Yong-Gang Yao Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming National High-level Biosafety Research Center for Non-Human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academic of SciencesKunmingYunnan 650107China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Department of Respiratory and Critical Care Medicine the Affiliated Drum Tower Hospital of Nanjing UniversityNanjingJiangsu 210008China Medical Key Laboratory for Repository and Application of Pathogenic Microbiology Guangdong Provincial Center for Disease Control and PreventionGuangzhouGuangdong 510440China CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 2Q0Q3AChina

Thecoronavirusdisease2019(COVID-19)pandemic continues to pose a global threat to the human population. Identifying animal species susceptible to infection with the SARS-CoV-2/HCoV-19 pathogen is essential for controlling the outbreak and for testing valid prophylactics or therapeutics based on animal model studies. Here,different aged Chinese tree shrews(adult group, 1 year old;old group, 5–6 years old), which are close relatives to primates, were infected with SARS-CoV-2. X-ray, viral shedding, laboratory, and histological analyses were performed on different days postinoculation(dpi). Results showed that Chinese tree shrews could be infected by SARS-CoV-2. Lung infiltrates were visible in X-ray radiographs in most infected animals. Viral RNA was consistently detected in lung tissues from infected animals at 3,5, and 7 dpi, along with alterations in related parameters from routine blood tests and serum biochemistry, including increased levels of aspartate aminotransferase(AST) and blood urea nitrogen(BUN). Histological analysis of lung tissues from animals at 3 dpi(adult group) and 7 dpi(old group) showed thickened alveolar septa and interstitial hemorrhage. Several differences were found between the two different aged groups in regard to viral shedding peak. Our results indicate that Chinese tree shrews have the potential to be used as animal models for SARS-CoV-2 infection.

关键词： SARS-CoV-2/HCoV-19 Treeshrews Animal model Susceptibility COVID-19

Desorption corona beam ionisation(DCBI) mass spectrometry for in-situ analysis of adsorbed phenol in cigarette acetate fiber filter

在线全文

学校读者我要写书评

暂无评论

Desorption corona beam ionisation(DCBI) mass spectrometry fo...

作者： wen Du Li-Juan Tang jian-Hui wen Ke-Jun Zhong jian-Hui jiang Hua Wang Bo Chen Ru-Qin Yu Technology Center of China Tobacco Hunan Industrial Co. Ltd. State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Key Laboratory of Phytochemical R&D of Hunan Province Hunan Normal University

The study of spatial distribution characteristics of the adsorbed compounds for absorbent materials has significant importance in understanding the behaviors of aerosols while they migrating in the absorbent materials. Herein, for the first time, desorption corona beam ionization–mass spectrometry(DCBI–MS)has proposed for direct in-situ analysis of adsorbed aerosol for absorbent materials. DCBI is a novel atmospheric pressure chemical ionization(APCI)-related technique developed by our group in recent years. It can facilitate accurately localizing sampling by forming a visible thin corona beam and avoid the risk of sample contamination and matrix interference compared with other similar techniques. The advantages of DCBI–MS allow rapid screening of the spatial distribution characteristics of the adsorbed compounds for absorbent materials. The distribution characteristic of phenol in cigarette filter tip filled with cellulose acetate fiber was studied as a model case for demonstrating the feasibility of the developed method. As a comparison, conventional HPLC was also used for the study of the distribution characteristic of phenol. The results revealed DCBI–MS had highly improved assay simplicity in spatial distribution characteristic analysis of phenol for the acetate fiber tip, therefore, exhibiting a great potential for convenient, rapid and cost-efficient analysis of the spatial distribution characteristic investigation of adsorbed compounds for adsorbent materials.

关键词： Absorbent material Spatial distribution characteristic In-situ analysis Desorption corona beam ionization Mass spectrometry Ambient ionization

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

辉光放电聚合物薄膜的红外性质研究

光谱学与光谱分析 2016年第4期36卷 939-942页

作者：温成伟尹剑余铭铭李海容夏立东何智兵梁建华中国工程物理研究院核物理与化学研究所四川绵阳621900 中国工程物理研究院激光聚变研究中心四川绵阳621900

为了实现惯性约束聚变(ICF)点火,需要制备出均匀的高密度燃料靶。对于氘氘(DD)冰层,红外均化技术可用于改善其内表面粗糙度。本文利用红外光谱仪和红外显微镜研究了辉光放电聚合物(GDP)薄膜和靶球的红外吸收性质,得到了GDP薄膜材料特定... 详细信息

为了实现惯性约束聚变(ICF)点火,需要制备出均匀的高密度燃料靶。对于氘氘(DD)冰层,红外均化技术可用于改善其内表面粗糙度。本文利用红外光谱仪和红外显微镜研究了辉光放电聚合物(GDP)薄膜和靶球的红外吸收性质,得到了GDP薄膜材料特定波长处的红外吸收系数。通过比较薄膜材料和靶球的红外吸收,证实了热处理可以降低GDP材料中的氧化位点,从而抑制羟基(—OH)峰的形成,优化DD冰层的红外均化效果。利用所得实验数据对DD均化实验中红外均化积分球所需要的红外功率和国家点火装置(national ignition facility,NIF)标准靶的红外透射率进行了估算,计算结果对DD冰红外均化实验具有重要指导作用。

关键词：惯性约束聚变辉光放电聚合物红外吸收系数

基于AHP和GC-TOPSIS的山区桥型方案比选

在线全文

学校读者我要写书评

暂无评论

公路交通科技 2019年第3期36卷 102-108页

作者：谢全敏殷建强杨文东武汉理工大学土木工程与建筑学院湖北武汉430070 中国市政工程西北设计研究院有限公司甘肃兰州730000

最优桥型方案的确定是桥梁初步设计阶段的关键内容,决策结果的科学与否直接关系到整个工程建设的开展和实施。目前山区桥型方案的确定主要以经验判断为主,可采用的理论方法相对较少,为此,基于层次分析法、灰色关联分析和逼近理想解法的... 详细信息

最优桥型方案的确定是桥梁初步设计阶段的关键内容,决策结果的科学与否直接关系到整个工程建设的开展和实施。目前山区桥型方案的确定主要以经验判断为主,可采用的理论方法相对较少,为此,基于层次分析法、灰色关联分析和逼近理想解法的基本理论,建立了一种山区桥型方案综合评价模型。该模型首先从经济、技术、社会3大方面综合考虑影响桥型选取的多种因素,选定12个评价指标,构建山区桥型方案综合评价体系,通过层次分析法计算桥型评价指标权重以降低人为主观因素的影响,然后运用模糊数学理论和灰色关联分析方法构造加权灰色关联系数决策矩阵,并采用逼近理想解法计算各备选桥型方案与灰色关联理想解的相对贴近度,最后以相对贴近度的大小作为评判依据进行优劣排序确定最优桥型方案。运用该评价模型对贵州普安县山区某公路3个备选桥型方案(A_1～A_3)进行比较,获得装配式预应力混凝土连续T梁桥(A_1)、预应力混凝土连续刚构桥(A_2)和预应力混凝土矮塔斜拉桥(A_3)3个方案的贴近度分别为0.597 7,0.315 6,0.400 3,优劣排序为A_1>A_3>A_2,即第1方案为最优方案。将该桥型方案应用于实际桥梁建造,取得了良好的经济和社会价值。实践结果表明,该评价模型为山区桥型方案的决策提供了一种可行的理论方法。

关键词：桥梁工程方案比选灰色关联分析逼近理想解法山区桥型层次分析法

Minitab软件在多杀菌素发酵条件优化中的应用

在线全文

学校读者我要写书评

暂无评论

中国抗生素杂志 2008年第11期33卷 659-662,688页

作者：梁艳卢文玉闻建平天津大学化工学院生物工程系天津300072

利用Minitab软件,采用响应面方法(response surface methods,RSM)对多杀菌素发酵条件进行优化。通过Plackeet-Burman设计实验,从培养基中筛选出显著性影响因子:葡萄糖、棉籽粉、玉米浆的浓度以及初始pH,并确定非显著影响因素的水平;采... 详细信息

利用Minitab软件,采用响应面方法(response surface methods,RSM)对多杀菌素发酵条件进行优化。通过Plackeet-Burman设计实验,从培养基中筛选出显著性影响因子:葡萄糖、棉籽粉、玉米浆的浓度以及初始pH,并确定非显著影响因素的水平;采用中心组合设计,对四个显著影响因素进一步的优化,根据建立的多元二次方程确定其最佳水平,得到最佳的培养条件(g/L):葡萄糖68.5,麦芽糖10,棉籽粉26.0,玉米浆17.8,牛肉膏2.0,硫酸锌0.2,硫酸铵1.5,CaCO35;接种量10%,初始pH7.0,摇床转速220r/min,培养7d。在此条件下,多杀菌素的产量为175mg/L,比优化前(120mg/L)产量提高了45.8%。

关键词：多杀菌素 Minitab软件响应面方法(RSM) 优化

Dynamic design of a nonlinear energy sink with NiTiNOL-steel wire ropes based on nonlinear output frequency response functions

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2019年第12期40卷 1791-1804页

作者： Yewei ZHANG Kefan XU jian ZANG Zhiyu NI Yunpeng ZHU Liqun CHEN College of Aerospace Engineering Shenyang Aerospace UniversityShenyang 110136China Department of Automatic Control and Systems Engineering Sheffield UniversityMapping Street Sheffield S13JDU.K. Shanghai Institute of Applied Mathematics and Mechanics Shanghai UniversityShanghai 200072China School of Mechanics and Engineering Science Shanghai UniversityShanghai 200444China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai UniversityShanghai 200072China

A novel vibration isolation device called the nonlinear energy sink(NES)with NiTiNOL-steel wire ropes(NiTi-ST)is applied to a whole-spacecraft *** NiTi-ST is used to describe the damping of the NES,which is coupled with the modified Bouc-wen model of *** NES with NiTi-ST vibration reduction principle uses the irreversibility of targeted energy transfer(TET)to concentrate the energy locally on the nonlinear oscillator,and then dissipates it through damping in the NES with *** generalized vibration transmissibility,obtained by the root mean square treatment of the harmonic response of the nonlinear output frequency response functions(NOFRFs),is first used as the evaluation index to analyze the whole-spacecraft system in the *** optimization analysis of the impact of system responses is performed using different parameters of NES with NiTi-ST based on the transmissibility of ***,the effects of vibration suppression by varying the parameters of NiTi-ST are analyzed from the perspective of energy *** results indicate that NES with NiTi-ST can reduce excessive vibration of the whole-spacecraft system,without changing its natural ***,the NES with NiTi-ST can be directly used in practical engineering applications.

关键词： nonlinear energy sink(NES) vibration isolation NiTiNOL-steel wire rope (NiTi-ST) nonlinear output frequency response function(NOFRF) root mean square transmissibility

Femtosecond Reflections of Bulk GaAs and GaAs/AlGaAs Multiple Quantum Wells

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 1996年第3期13卷 237-240页

作者： LI Wei-liang QIU Zhi-ren PENG wen-ji HUANG Xu-guang ZHOU jian-ying YU Zhen-xin State Key Laboratory of Ultrafast Laser Spectroscopy Zhongshan UniversityGuangzhou 510275

We present room temperature femtosecond rejection studies on the photocarrier dynamics of GaAs and GaAs/AlGaAs multiple quantum wells(MQW).A rising wing with a time constant of about.5 ps and an increased amplitude per carrier is observed for the MQW sample at carrier densities lower than 5×10^(11) cm^(-2).This phenomenon is explained as the saturation of the excitonic transitions.

关键词： GaAs/AlGaAs Femto Quantum

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于GIS的降雨侵蚀力计算器实现研究

水土保持研究 2014年第4期21卷 123-126,132,322页

作者：殷兵吴健平章文波华东师范大学地理信息科学教育部重点实验室上海200241 北京师范大学地理学与遥感科学学院北京100875

降雨侵蚀力是土壤流失模型的一个基本因子,在收集和处理降雨数据时耗时耗力,且以文本格式保存的降雨数据存在诸多缺失问题。为此,将逐日、半月、累月及累年降雨侵蚀力计算模型与组件式GIS平台ArcGIS Engine及.NET平台结合,开发一种降雨... 详细信息

降雨侵蚀力是土壤流失模型的一个基本因子,在收集和处理降雨数据时耗时耗力,且以文本格式保存的降雨数据存在诸多缺失问题。为此,将逐日、半月、累月及累年降雨侵蚀力计算模型与组件式GIS平台ArcGIS Engine及.NET平台结合,开发一种降雨侵蚀力因子计算器,并利用多种空间插值方法对数据进行不同的空间插值。结果表明:该计算器可快速、有效地的管理数据;对计算的降雨侵蚀力数据,使用插值方法可获得栅格数据,且能进一步进行单一或批量掩膜、重采样;同时也可对降雨侵蚀力因子进行统计分析、专题图制作等。为结果的可视化及保存提供应用基础。

关键词：降雨侵蚀力空间分析统计分析空间显示

Current progress of source control in the management of intra-abdominal infections

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Traumatology 2020年第6期23卷 311-313页

作者： Xiu-wen Wu Tao Zheng Zhi-Wu Hong Hua-jian Ren Lei Wu Ge-Fei Wang Guo-Sheng Gu jian-An Ren Research Institute of General Surgery Jinling HospitalMedical School of Nanjing UniversityNanjingChina Lab for Trauma and Surgical Infection Jinling HospitalNanjingChina

Intra-abdominal infection(IAI)is a deadly condition in which the outcome is associated with urgent diagnosis,assessment and management,including fluid resuscitation,antibiotic administration while obtaining further laboratory results,attaining precise measurements of hemodynamic status,and pursuing source *** last item makes abdominal sepsis a unique treatment *** or inadequate source control is an independent predictor of poor outcomes and recognizing source control failure is often difficult or *** complicating issue in the debate is surrounding the timing,adequacy,and procedures of source *** review evaluated and summarized the current approach and challenges in IAI management,which are the future research directions.

关键词： Source control Intra-abdominal infection Open abdomen Source control failure