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Emerging trends and hotspots of Nuclear factor erythroid 2-related factor 2 in nervous system diseases

World Journal of Clinical Cases 2023年第32期11卷 7833-7851页

作者： Xue-Qin Chang Ling Xu yi-xuan zuo yi-Guo Liu Jia Li Hai-Tao Chi Department of Neurology Xinhua Hospital Affiliated with Dalian UniversityDalian 116011Liaoning ProvinceChina

BACKGROUND The Nuclear factor erythroid 2-related factor 2(NRF2)transcription factor has attracted much attention in the context of neurological ***,none of the studies have systematically clarified this field's research hotspots and evolution *** To investigate the research hotspots,evolution patterns,and future research trends in this field in recent *** We conducted a comprehensive literature search in the Web of Science Core Collection database using the following methods:(((((TS=(NFE2 L2))OR TS=(Nfe2 L2 protein,mouse))OR TS=(NF-E2-Related Factor 2))OR TS=(NRF2))OR TS=(NFE2L2))OR TS=(Nuclear factor erythroid2-related factor 2)AND(((((((TS=(neurological diseases))OR TS=(neurological disorder))OR TS=(brain disorder))OR TS=(brain injury))OR TS=(central nervous system disease))OR TS=(CNS disease))OR TS=(central nervous system disorder))OR TS=(CNS disorder)AND Language=English from 2010 to *** are just two forms of literature available:Articles and *** were processed with the software Cite-Space(version 6.1.R6).RESULTS We analyzed 1884 articles from 200 schools in 72 countries/*** 2015,the number of publications in this field has increased *** has the largest number of publications,but the articles published in the United States have better centrality and *** the top ten authors with the most published papers,five of them are from China,and the author with the most published papers is Wang *** institution with the most articles was Nanjing *** their credit,three of the top 10 most cited articles were written by Chinese *** keyword co-occurrence map showed that"oxidative stress","NRF2","activation","expression"and"brain"were the five most frequently used *** Research on the role of NRF2 in neurological diseases continues *** in developed countries published more influential papers,while Chinese scholars provided the largest number of a

关键词： Nuclear factor erythroid 2-related factor 2 Nervous system diseases Brain Expression Activation Ferroptosis

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Homologous CoS2 interface with directed electron transfer and strong chloridion repulsion for efficient seawater oxidation

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Science China Chemistry 2025年

作者： Yuan Tian Jiang-Bo Chen Jie ying Ge Tian Yu-xuan Xiao yi Lu Si-Ming Wu Wei Geng Ling Shen Xiao-Yu Yang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and School of Materials Science and Engineering and Shenzhen Research Institute & Laoshan Laboratory Wuhan University of Technology School of Chemical Engineering and Technology Sun Yat-Sen University National Energy Key Laboratory for New Hydrogen-Ammonia Energy Technologies Foshan Xianhu Laboratory

Seawater electrolysis is a highly promising method to produce high energy density hydrogen,especially in dry areas that have scarce freshwater ***,application of seawater electrolysis is confronted by two major problems associated with catalysts employed for the anodic oxygen evolution reaction （OER） including the competitive hypochlorite evolution reaction（HCER） and strong chloridion （Cl–） triggered *** studies aimed at overcoming these problems,a facile method has been developed to synthesize a homologous CoS2heterojunction as an OER *** to a difference in work functions at the interface and increased electron density,this material has directed electron transfer and strong chloridion repulsion properties,*** have shown that CoS2achieves low overpotentials of 289 and 322 mV at 10 mA cm-2current density in respective alkaline （1 M KOH） and alkaline simulated seawater ***,the outstanding stability of CoS2is reflected in a negligible decline in activity during promotion of the OER for 100 *** of density functional theory calculations reveal that the homologous CoS2heterojunction promotes directed electron transport for optimizing adsorption/desorption of reactive species and heightens the Cl-adsorption energy for strongly repulsing Cl-,phenomena that enhance OER performance in alkaline simulated seawater.

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circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

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Science China Life Sciences 2025年

作者： Dan Wang Sicheng zuo Junshang Ge Hongke Qu Jie Wu Na yi Lei Shi Yumin Wang Yongzhen Mo Chunmei Fan yi He Pan Chen Ming Zhou Bo Xiang Wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. In this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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Effects of herding behavior of tradable green certificate market players on market efficiency:insights from heterogeneous agent model

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Frontiers in Energy 2023年第2期17卷 266-285页

作者： yi zuo Xingang ZHAO School of Economics and Management North China Electric Power UniversityBeijing 102206China Beijing Key Laboratory of New Energy and Low-Carbon Development North China Electric Power UniversityBeijing 102206China

Tradable green certificate(TGC)scheme promotes the development of renewable energy industry which currently has a dual effect on economy and *** market efficiency is reflected in stimulating renewable energy investment,but may be reduced by the herding behavior of market *** paper proposes and simulates an artificial TGC market model which contains heterogeneous agents,communication structure,and regulatory rules to explore the characteristics of herding behavior and its effects on market *** results show that the evolution of herding behavior reduces information asymmetry and improves market efficiency,especially when the borrowing is *** addition,the fundamental strategy is diffused by herding evolution,but TGC market efficiency may be remarkably reduced by herding with borrowing ***,the herding behavior may evolve to an equilibrium where the revenue of market players is comparable,thus the fairness in TGC market is improved.

关键词： tradable green certificate herding behavior evolution heterogeneous agent model complex network

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从句子图到篇章图——基于抽象语义表示的篇章级共指标注体系研究

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外语学刊 2025年第1期 19-28页

作者：张艺璇李斌许智星南京师范大学文学院南京210097 南京师范大学语言大数据与计算人文研究中心南京210097

篇章级共指关系是语言学和计算语言学的研究难点之一。本文在梳理共指理论研究与趋势的基础上,回顾共指语料库的构建与自动解析方法,指出共指语料的构建主要存在以下两个问题:共指关系的标注较为粗疏,也基本不考虑与句子语义结构本身的... 详细信息

篇章级共指关系是语言学和计算语言学的研究难点之一。本文在梳理共指理论研究与趋势的基础上,回顾共指语料库的构建与自动解析方法,指出共指语料的构建主要存在以下两个问题:共指关系的标注较为粗疏,也基本不考虑与句子语义结构本身的关系。本文在句子级语义标注体系(中文抽象语义表示)的基础上,设计篇章共指的标注体系,以“概念同一性”为基本原则,从词形的异同和概念的表述角度区分9种篇章共指关系,标注了500个篇章的共指信息。与已完整标注的52种句内语义关系相结合,构建出带有篇章共指信息的篇章抽象语义图库。该语料库选自CTB新闻语料,体裁涵盖经济、体育及生活类,规模为6237句,16万词例。该语料库的构建为篇章级语义分析提供了新框架与数据资源。

关键词：篇章共指抽象语义表示概念同一性篇章语义结构语料库中文信息处理

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Morphology and optical absorption of Bi_2Fe_4O_9 crystals via mineralizer-assisted hydrothermal synthesis

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Particuology 2013年第5期11卷 581-587页

作者： yi Liu Ruzhong zuo Institute of Electro Ceramics & Devices School of Materials Science and EngineeringHefei University of Technology

Submicron-sized Bi2Fe409 crystals were successfully synthesized via the hydrothermal method, while micron-sized Bi2Fe409 crystals with rod-like morphologies were obtained in the presence of the miner- alizer KN03. X-ray diffraction, scanning electron microscopy and transmission electron microscopy were employed to characterize the products. According to a series of time-dependent experiments, it was con- cluded that the likeliest formation mechanism for the microrods was the Ostwald ripening process. It was proposed that the blocking effect of NO3 contributed to the formation of the rod-like powders. Moreover, the optical absorption of the prepared Bi2Fe409 crystals was measured using an UV-vis spec- trophotometer, indicating that Bi2Fe409 powders can be used as effective photocatalysts under visible light.

关键词： Hydrothermal synthesisCrystal growthBi2Fe409 crystals

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Insights into the Payne Effect of Carbon Black Filled Styrene-butadiene Rubber Compounds

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Chinese Journal of Polymer Science 2021年第1期39卷 81-90,I0007页

作者： An Zhao xuan-Yu Shi Shi-Hao Sun Hai-Mo Zhang Min zuo yi-Hu Song Qiang Zheng Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

As a widely used reinforcing filler of rubber, carbon black(CB) often enhances the nonlinear Payne effect and its mechanism still remains controversial. We adopt simultaneous measurement of rheological and electrical behaviors for styrene-butadiene rubber(SBR)/CB compounds and CB gel(CBG) during large deformation/recovery to investigate the contribution of conductive CB network evolution to the Payne effect of the compounds. In the highly filled compounds, the frequency dependence of their strain softening behavior is much more remarkable than that of their CB network breakdown during loading, while during unloading the unrecoverable filler network hardly affects the complete recovery of modulus, both revealing that their Payne effect should be dominated by the disentanglement of SBR matrix. Furthermore,the bound rubber adjacent to CB particles can accelerate the reconstruction of continuous CB network and improve the reversibility of Payne effect. This may provide new insights into the effect of filler network, bound rubber, and free rubber on the Payne effect of CB filled SBR compounds.

关键词： Payne effect Styrene-butadiene rubber Filler network

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Incompressible Limit of the Compressible Q-tensor System of Liquid Crystals

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Acta Mathematicae Applicatae Sinica 2023年第1期39卷 179-201页

作者： yi-xuan WANG University of Pittsburgh PA 15260USA

We study the connection between the compressible Navier-Stokes equations coupled by the Qtensor equation for liquid crystals with the incompressible system in the periodic case, when the Mach number is low. To be more specific, the convergence of the weak solutions of the compressible nematic liquid crystal model to the incompressible one is proved as the Mach number approaches zero, and we also obtain the similar results in the stochastic setting when the equations are driven by a stochastic force. Our approach is based on the uniform estimates of the weak solutions and the martingale solutions, then we justify the limits using various compactness criteria.

关键词： compressible liquid crystal system Q-tensor weak solutions martingale solution stochastic compactness Mach number incompressible limit

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Efficient circularly polarized photoluminescence and electroluminescence of chiral spiro-skeleton-based thermally activated delayed fluorescence molecules

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Science China Chemistry 2022年第7期65卷 1347-1355页

作者： yi-Pin Zhang Shi-Quan Song Meng-Xi Mao Cheng-Hui Li You-xuan Zheng Jing-Lin zuo State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China MaAnShan High-Tech Research Institute of Nanjing University Maanshan 238200China

Chiral thermally activated delayed fluorescence(TADF) molecules showing circularly polarized luminescence(CPL) have great potential in 3D displays. However, the relationships among CPL property, device performance and molecule structure are still not clear. In this article, we develop a strategy to promote dissymmetry factors without sacrifice in device performance and study the impact of molecule structures towards CPL property. Three novel TADF enantiomers are synthesized and studied.(R/S)-SCN with diminutive cyano group as an acceptor shows dissymmetry factor |gPL| ≈ 1.4×10^(-3) and noticeable organic light-emitting diode(OLED) performances with a maximum external quantum efficiency(EQEmax) of 23.0%. For(R/S)-SPHCN, the prolonged electron withdrawing group benzonitrile enhances |gPL| up to 3.6×10^(-3) with decreased device EQEmaxof 15.4%. By further replacing benzonitrile with(trifluoromethyl)pyridine, the enantiomers of(R/S)-SCFPY show similar |gPL| factors of 3.5×10^(-3) and device EQE_(max)up to 23.3%, which represents the highest efficiency among sprio-type TADF materials based OLEDs. Furthermore, the OLEDs also show obvious circularly polarized electroluminescence with gELfactors of-1.4/1.8×10^(-3),-3.6/3.6×10^(-3) and-3.7/3.6×10^(-3), respectively. These results indecate by delicate functional group engineering, high g factor can be achieved while maintaining decent device performances. Besides,(R/S)-SCFPY represents an impressive TADF emitter, which shows promoted g factor and recorded high device EQE_(max)among similar molecules.

关键词： chiral spiro-skeleton thermally activated delayed fluorescence circularly polarized photoluminescence circularly polarized electroluminescence dissymmetry factor

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Excellent dye degradation performance of FeSiBP amorphous alloys by Fenton-like process

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Journal of Environmental Sciences 2021年第7期33卷 116-127页

作者： Mingqing zuo Seonghoon yi Junhyeok Choi Department of Materials Science and Metallurgical Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

Amorphous alloys are being newly applied in wastewater treatment because of their unique atomic packing *** possess excellent degradation efficiency,stability and *** this work,Fe_(80)Si_(10)B_(10) and Fe_(83)Si_(5)B_(8)P_(4) amorphous ribbons exhibited ad-vanced catalytic performance for the degradation of Methyl Blue(MB)and Rhodamine B(RhB)dyes,and the color removal reach nearly 100%within 11 min for both the ***-pared with the Fe_(80)Si_(10)B_(10) amorphous ribbon,the Fe_(83)Si_(5)B_(8)P_(4) ribbon showed higher degra-dation efficiency due to its lower reaction activation energy,higher electron transfer ability and higher Fe content,and the formation of the galvanic cell between the strong Fe-P bonds and the weak Fe-B *** also exhibited high stability and *** degradation ef-ficiency was improved when the appropriate concentration of H_(2)O_(2) is *** regards the pH,high degradation efficiency was observed in acidic MB solution,but it decreased as the pH increased up to pH *** application of the electro-Fenton-like process is discussed,which can effectively improve the degradation performance in a nearly natural *** study presents a high efficiency low-cost catalyst for synthetic dye degradation and expands the functional applications of Fe-based amorphous alloys.

关键词： Metallic glasses Azo dyes Advanced oxidation processes Decolorization Stability

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