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Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing Sun Xue-Ting Bai Qian zhang Zi-Han Li yi-Xin zhang Rong-xuan Xu Wei Wu Zhi-Han Yao Chun-Wen Pu Xiao-Feng Li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

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Edge-aware Feature Aggregation Network for Polyp Segmentation

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Machine Intelligence Research 2025年第1期22卷 101-116页

作者： Tao Zhou yizhe zhang Geng Chen yi Zhou Ye Wu Deng-Ping Fan PCA Lab Key Laboratory of Intelligent Perception and Systems for High-dimensional Information of Ministry of EducationSchool of Computer Science and EngineeringNanjing University of Science and TechnologyNanjing210094China School of Computer Science and Engineering Northwestern Polytechnical University(NPU)Xi’an710129China School of Computer Science and Engineering Southeast UniversityNanjing211189China Computer Vision Lab ETH ZürichZürich8092Switzerland

Precise polyp segmentation is vital for the early diagnosis and prevention of colorectal cancer(CRC)in clinical ***,due to scale variation and blurry polyp boundaries,it is still a challenging task to achieve satisfactory segmentation performance with different scales and *** this study,we present a novel edge-aware feature aggregation network(EFA-Net)for polyp segmentation,which can fully make use of cross-level and multi-scale features to enhance the performance of polyp ***,we first present an edge-aware guidance module(EGM)to combine the low-level features with the high-level features to learn an edge-enhanced feature,which is incorporated into each decoder unit using a layer-by-layer ***,a scale-aware convolution module(SCM)is proposed to learn scale-aware features by using dilated convolutions with different ratios,in order to effectively deal with scale ***,a cross-level fusion module(CFM)is proposed to effectively integrate the cross-level features,which can exploit the local and global contextual ***,the outputs of CFMs are adaptively weighted by using the learned edge-aware feature,which are then used to produce multiple side-out segmentation *** results on five widely adopted colonoscopy datasets show that our EFA-Net outperforms state-of-the-art polyp segmentation methods in terms of generalization and *** implementation code and segmentation maps will be publicly at https://***/taozh2017/EFANet.

关键词： Colorectal cancer polyp segmentation edge-aware guidance module scale-aware convolution module cross-level fusion module

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Insight into the sorption and desorption pattern of pyrrolizidine alkaloids and their N-oxides in acidic tea(Camellia sinensis)plantation soils

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Journal of Environmental Sciences 2025年第2期148卷 350-363页

作者： Yuting Lu Haolei Han Yuexing yi Yunfeng Chai ChenWang Xiangchun zhang Xiangde Yang Hongping Chen Tea Research Institute Chinese Academy of Agricultural SciencesHangzhou 310008China Graduate School of Chinese Academy of Agricultural Sciences Beijing 100081China School of Chemical Engineering and Materials Zhejiang University of TechnologyHangzhou 310008China Key Laboratory of Tea Quality and Safety&Risk Assessment Ministry of AgricultureHangzhou 310008China Key Laboratory of Tea Quality and Safety Control Ministry of Agriculture and Rural AffairsHangzhou 310000China

Pyrrolizidine alkaloids(PAs)and their N-oxides(PANOs)are phytotoxins produced by various plant species and have been emerged as environmental *** sorption/desorption behaviors of PAs/PANOs in soil are crucial due to the horizontal transfer of these natural products from PA-producing plants to soil and subsequently absorbed by plant *** study firstly investigated the sorption/desorption behaviors of PAs/PANOs in tea plantation soils with distinct *** amounts for seneciphylline(Sp)and seneciphylline-N-oxide(SpNO)in three acidic soils ranged from 2.9 to 5.9μg/g and 1.7 to 2.8μg/g,*** percentages for Sp and SpNO were from 22.2%to 30.5%and 36.1%to 43.9%.In the mixed PAs/PANOs systems,stronger sorption of PAs over PANOs was occurred in tested ***,the Freundlich models more precisely described the sorption/desorption *** exchange capacity,sand content and total nitrogen were identified as major influencing factors by linear regression ***,the soils exhibiting higher sorption capacities for compounds with greater *** were more likely to migrate within soils and be absorbed by tea *** contributes to the understanding of environmental fate of PAs/PANOs in tea plantations and provides basic data and clues for the development of PAs/PANOs reduction technology.

关键词： Pyrrolizidine alkaloids Sorption-desorption behavior Tea plantation system Acidic soil Linear regression model

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Chemical Composition and Heavy Metal Content of Radix Notoginseng from Different Sources

Chemical Composition and Heavy Metal Content of Radix Notogi...

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第十四届全国中药和天然药物学术研讨会

作者： Lin-Lin Chen Xin Zhou yi-xuan zhang Jia-Bo Wang Xiao-He Xiao Yung-Chi Cheng Yale University School of Medicine HuBei University of Chinese Medicine Longhua Hospital affiliated to Shanghai University of Traditional Chinese Medicine Shenyang Pharmaceutical University 302 Hospital of People's Liberation Army

＜正＞Panax notoginseng is traditionally cultivated in Wenshan and Baise *** resource ts becoming a serious issue because of succession cropping *** over 80%planting soil in Wenshan area is no more suitable for the co...

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H_(2)S and NIR light-driven nanomotors induce disulfidptosis for targeted anticancer therapy by enhancing disruption of tumor metabolic symbiosis

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Chinese Chemical Letters 2025年第1期36卷 427-432页

作者： Shangqian zhang Jiaxuan Li xuan Hu Zelong Chen Junliang Dong Chenhao Hu Shuang Chao yinghua Lv Yuxin Pei Zhichao Pei College of Chemistry&Pharmacy Northwest A&F UniversityYangling 712100China

Disulfidptosis,a novel mechanism of programmed cell death through the disruption of tumor metabolic symbiosis(TMS),has showed tremendous potential in cancer ***,the efficacy of disulfidptosis is limited by poor permeability of drugs in solid ***,hydrogen sulfide(H_(2)S)and nearinfrared(NIR)light-driven nanomotors(denoted as HGPP)have been constructed to efficiently penetrate tumors and induce *** demonstrate glutathione(GSH)-responsive release of H_(2)S,which combined with NIR light-induced photothermal effect drive HGPP movement to facilitate deep tumor *** released H_(2)S induces tumor acidosis and disrupts TMS,where disulfide accumulation following cell starvation leads to *** addition,HGPP induce hepatoma specific cellular uptake and catalyze the conversion of glucose and oxygen to produce hydrogen peroxide(H_(2)O_(2)),leading to glucose ***,this study has developed a multifunctional Janus nanomotor that provides a novel strategy for disulfidptosis-based solid tumor therapy.

关键词： H_(2)S NIR light Nanomotors Disulfidptosis Tumor metabolic symbiosis

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Influencing factors of early post-traumatic stress disorder in young and middle-aged individuals with open globe injuries in west China:a cross-sectional study

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 146-153页

作者： yi-Man Li Xin zhang Ji-Hong Zeng Hong-Mei Luo Department of Ophthalmology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM:To evaluate the prevalence of early post-traumatic stress disorder(PTSD)among young and middle-aged patients who have suffered open globe injuries,and to identify the psychosocial factors influencing PTSD in these ***:A total of 280 patients who underwent ocular trauma surgery between January 2023 and January 2024 were selected through convenience *** were collected using a custom-designed demographic questionnaire,the Connor-Davidson Resilience Scale(CDRISC),the Cognitive Emotion Regulation Questionnaire(C-ERRI),and the PTSD Checklist-Civilian Version(PCL-C).Univariate analysis and stepwise multiple linear regression analysis were performed to determine the factors affecting PTSD in these ***:The average PTSD score for the patients was 33.22±*** scores for individual PTSD dimensions,ranked from highest to lowest,were recurrent traumatic experiences,heightened arousal,avoidance reactions,and social *** PTSD symptoms were observed in 85 patients(30.36%).Univariate analysis indicated that gender,postoperative vision,marital status,psychological resilience,and rumination were significant factors affecting PTSD symptoms(χ^(2)/t=6.53,17.88,8.83,2.17,and 14.1,respectively;all P<0.05).Pearson correlation analysis showed a positive correlation between rumination and PTSD symptoms(r=0.73,P<0.01)and a negative correlation between psychological resilience and PTSD symptoms(r=-0.14,P<0.05).Stepwise multiple linear regression analysis identified postoperative vision(notably eye removal),rumination levels,and psychological resilience(optimism)as major factors influencing PTSD in these patients(R^(2)=0.57,P<0.001).CONCLUSION:Young and middle-aged patients with open globe injuries have a high incidence of *** risk factors for early PTSD include primary enucleation,high levels of rumination,and low psychological resilience(optimism).Conversely,patients with good postoperative vision recovery,low rumination l

关键词： young and middle-aged open globe injuries post-traumatic stress disorder rumination psychological resilience

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The Microbial Change Trend Relevant to Panax notoginseng Root Rot Diseases

The Microbial Change Trend Relevant to Panax notoginseng Roo...

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第十四届全国中药和天然药物学术研讨会

作者： Jun Xie Meng-Yue zhang Tian-Yuan zhang Huan Xu Xue-Song Xiang Xiao-Yu Deng Jin-yu zhang Yung-Chi Cheng yi-xuan zhang Shenyang Pharmaceutical University Institute of Medicinal Plants in Yunnan Academy of Agricultural Sciences Yale University School of Medicine

＜正＞The variations of microbes associated with Panax notoginseng root rot diseases have not been *** this study,27 notoginseng rhizosphere soil samples were collected from 3farms of Wenshan,Yunnan *** soil samples included soils before notoginseng cultivation;1,2,3 years during cultivation and 1 year after crop rotation.18 plant samples

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Self-assembled supramolecular materials for photocatalytic reactions

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cMat 2024年第3期1卷 54-72页

作者： Xin-Gang Tan Ponmani Jeyakkumar yi-xuan zhang Lin-Wang Chu Yu-Ru Hao Sheng-Ke Li Kai-Ya Wang Xiao-Yu Hu College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjingChina Macao Centre for Research and Development in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoChina

The modern lifestyle necessitates significant energy consumption,which con-tinues to increase as human development *** energy presents an attractive alternative resource that can meet the global demand for energy in light of the limited availability of fossil *** nature,photosynthetic organelles utilize solar energy to convert inorganic matter into organic matter through *** energy can be converted into chemical energy through a natural process,and humans can replicate this technology through artificial *** photosynthesis is an emerging discipline that imitates the mechanism of photosynthesis found in living *** ad-vancements have been made in this field,and this review specifically focuses on the self-assembly process of supramolecular nanomaterials through non-covalent *** self-assembly process of photosensitizer molecules combined with catalysts and substrates for photocatalytic reactions is of particular *** review presents three categories of photocatalytic reactions,followed by a brief discussion of the prospects and challenges within this field.

关键词： artificial photosynthesis non-covalent interactions photocatalytic reactions self-assembly solar energy

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Heat transfer prediction modeling method combining threedimensional high-precision and one-dimensional real-time dynamic simulations

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Science China Technological Sciences 2025年第3期68卷 86-100页

作者： xuanang zhang Ping YUAN Gequn SHU xuan WANG Hua TIAN State Key Laboratory of Engines Tianjin University Department of Thermal Science and Energy Engineering University of Science and Technology of China

Heat exchangers are the core components of energy transfer and conversion and are widely used in the energy,chemical, and other fields. In an actual operational process, load changes lead to variations in the operating conditions of the heat exchanger. Evaluating the heat-transfer performance is crucial for the safe and efficient operation of the system. To realize high-precision heat transfer prediction through simulations, instead of using traditional solid equipment, this study proposed a heat transfer prediction modeling method that combines three-dimensional high-precision and one-dimensional real-time dynamic simulations. This method combines the high-precision advantage of three-dimensional simulation with the real-time advantage of one-dimensional simulation. To verify the feasibility of the modeling method, a heat transfer prediction model was constructed based on the heat transfer channel structure of a CO2mixture heat transfer characteristic experimental test *** steady-state and dynamic heat transfer characteristics of CO2/R32 mixtures were simulated and experimentally ***, the real-time operational capability of the heat transfer prediction model was verified using a real-time simulator. The results showed that the heat transfer prediction model modeling method proposed in this study could improve the accuracy by 1.75–4.64 times compared with the conventional one-dimensional dynamic model. The established heat transfer prediction model exhibited good accuracy for both dynamic and steady-state processes. The average relative errors with the experimental results were in the range of 0.91%–2.83% under six sets of experimental tests. Thus, the proposed heat transfer prediction model can predict the heat transfer process in real-time under all experimental heat source conditions.

关键词： heat transfer prediction model CO2 mixture heat exchanger real-time simulation

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Iron-nitrogen-doped porous carbon absorbers constructed from hypercrosslinked ferrocene polymers for efficient electromagnetic wave absorption

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International Journal of Minerals,Metallurgy and Materials 2025年第3期32卷 578-590页

作者： yi Hu yijia Zhou Lijia Liu Qiang Wang Chunhong zhang Hao Wei Yudan Wang Key Laboratory of Superlight Materials&Surface Technology of Ministry of Education College of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China Yantai Research Institute of Harbin Engineering University Yantai 264006China Qingdao Innovation and Development Base of Harbin Engineering University Qingdao 266404China

Herein,an external crosslinker facilitated the hypercrosslinking of ferrocene and a nitrogen heterocyclic compound(either melamine or imidazole)through a direct Friedel-Crafts reaction,which led to the formation of nitrogen-containing hypercrosslinked fer-rocene polymer precursors(HCP-FCs).Subsequent carbonization of these precursors results in the production of iron-nitrogen-doped por-ous carbon absorbers(Fe-NPCs).The Fe-NPCs demonstrate a porous structure comprising aggregated nanotubes and *** porosity of this structure can be modulated by adjusting the iron and nitrogen contents to optimize impedance *** uniform dis-tribution of Fe-N_(x)C,N dipoles,andα-Fe within the carbon matrix can be ensured by using hypercrosslinked ferrocenes in constructing porous carbon,providing the absorber with numerous polarization sites and a conductive *** electromagnetic wave absorption performance of the specially designed Fe-NPC-M_(2)absorbers is satisfactory,revealing a minimum reflection loss of-55.3 dB at 2.5 mm and an effective absorption bandwidth of 6.00 GHz at 2.0 *** utilizing hypercrosslinked polymers(HCPs)as precursors,a novel method for developing highly efficient carbon-based absorbing agents is introduced in this research.

关键词： hypercrosslinked polymers porous carbon iron-nitrogen doping annealing

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