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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 380-390页

作者： yishuang Yu Jingxiao Zhao Xuelin Wang Hui guo Zhenjia Xie Chengjia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China

This work reveals the significant effects of cobalt(Co)on the microstructure and impact toughness of as-quenched highstrength steels by experimental characterizations and thermo-kinetic *** results show that the Co-bearing steel exhibits finer blocks and a lower ductile-brittle transition temperature than the steel without ***,the Co-bearing steel reveals higher transformation rates at the intermediate stage with bainite volume fraction ranging from around 0.1 to *** improved impact toughness of the Co-bearing steel results from the higher dense block boundaries dominated by the V1/V2 variant ***,the addition of Co induces a larger transformation driving force and a lower bainite start temperature(BS),thereby contributing to the refinement of blocks and the increase of the V1/V2 variant *** findings would be instructive for the composition,microstructure design,and property optimization of high-strength steels.

关键词： high-strength steel cobalt transformation kinetics crystallography impact toughness

Astrocyte polarization in glaucoma: a new opportunity

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Neural Regeneration Research 2022年第12期17卷 2582-2588页

作者： yi-xin Liu Hao Sun Wen-yi guo Department of Ophthalmology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology ShanghaiChina

Astrocyte polarization is a new concept which is similar to microglia polarization and in which astrocytes are classified as A1(neurotoxic)and A2(neuroprotective).Several studies on astrocyte polarization have focused mainly on neurodegenerative diseases,trauma,and ***,the role of astrocyte polarization in glaucoma,a neurodegenerative disease,has not been fully *** this review,we first describe the characteristics of astrocyte astrogliosis in glaucoma,including morphological,molecular,proliferative and functional *** then summarize understanding of astrocyte polarization in other diseases,and show that A1 astrocytes are involved in the death of retinal ganglion cells in glaucoma,and that their neurotoxins kill only damaged retinal ganglion *** on this,we propose new interesting conjecture on astrocyte polarization in glaucoma:(1)That the neurotoxin from A1 astrocytes is a product of the complement system(membrane-attacking complex),since this system is known to mediate synaptic elimination and the C3 expression is clearly increased in A1 astrocytes;(2)that reactive scar-forming astrocytes in the optic nerve head may be classified as A2 astrocytes since their ablation leads to a worse prognosis in ***,current therapeutic research progress on astrocyte polarization in other diseases is also *** of astrocyte polarization can be achieved by extracellular microglia-related and intracellular *** A1 or increased A2 astrocytes can rescue the *** example,glucagon-like peptide-1 receptor agonist rescues retinal ganglion cells by reducing A1 astrocytes via the extracellular microglia-related pathway in an ocular hypertension model,suggesting that regulation of astrocyte polarization as a therapeutic target in glaucoma is feasible.

关键词： astrocytes glaucoma heterogeneity microglia neurodegenerative disease neuroinflammation neuroprotection optic nerve retina therapy

Numerical study of the influence of the atmospheric pressure on the thermal environment in the passenger cabin

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Building Simulation 2024年第2期17卷 253-265页

作者： xin Su Yu guo Zhengwei Long yi Cao Tianjin Key Lab.of Indoor Air Environmental Quality Control School of Environmental Science and EngineeringTianjin UniversityTianjin300072China Shanghai Aircraft Design and Research Institute Jinke RoadPudong DistrictShanghai201210China

The cabin air pressure remains lower than the horizontal atmospheric pressure when the airplane is in *** pressure is one of the parameters that must be taken into consideration while studying the thermal environment of an airplane *** are still no reference values for aircraft cabins despite the fact that numerous studies on low pressure heat transfer have demonstrated the connection between convective heat transfer coefficient(CHTC)and air *** this paper,a correction method for CHTC under low pressure conditions was established by using the dummy heat dissipation in the low-pressure cabin *** this basis,a thermal environment simulation model was developed,then was applied to the simulation of a seven-row aircraft cabin containing 42 passengers,and the CHTC and heat loss of dummy surface in the cabin were ***,the results of PMV calculated by using heat dissipation and air parameters at sampling points were *** results show that the modified CHTC can accurately reflect the cabin thermal environment under low pressure conditions,and the correction of CHTC can be realized by adjusting the turbulent Prandtl number,which is nonlinear correlated with the *** simulation results of the thermal environment in the seven-row cabin show that the CHTC changes by about 42%before and after *** air pressure decreases during take-off,which reduces the average CHTC of the crew surface from 5.09 W/(m^(2)·K)to 4.56 W/(m^(2)·K),but the air temperature rises by about 0.2°C as a *** deviation of PMV results calculated by using simulated heat loss data and using air parameters of measuring points in space is up to 0.5,but the latter is representative for calculating the thermal comfort level of the whole cabin.

关键词： low pressure aircraft cabin simulation heat dissipation convective heat transfer coefficient

Forward and backward models for fault diagnosis based on parallel genetic algorithms

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第10期9卷 1420-1425页

作者： yi LIU ying LI yi-jia CAO Chuang-xin guo School of Electrical Engineering Zhejiang University Hangzhou 310027 China

In this paper, a mathematical model consisting of forward and backward models is built on parallel genetic algorithms (PGAs) for fault diagnosis in a transmission power system. A new method to reduce the scale of fault sections is developed in the forward model and the message passing interface (MPI) approach is chosen to parallel the genetic algorithms by global sin-gle-population master-slave method (GPGAs). The proposed approach is applied to a sample system consisting of 28 sections, 84 protective relays and 40 circuit breakers. Simulation results show that the new model based on GPGAs can achieve very fast computation in online applications of large-scale power systems.

关键词： Forward and backward models Fault diagnosis Global single-population master-slave genetic algorithms (GPGAs) Parallel computation

基于半导体制冷的太阳能多功能遮阳伞设计及实验测试

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节能 2018年第6期37卷 31-34页

作者：周宇鸿周东一袁信国李想邵阳学院机械与能源工程学院湖南邵阳422000 中国铁塔股份有限公司邵阳市分公司湖南邵阳422000

设计了一种以太阳能电池板作为太阳能的收集装置。通过利用半导体制冷原理的太阳能多功能遮阳伞,本设计利用蓄电池储存太阳能电池板的发电,驱动半导体制冷片制冷和冷风扇运转从而给伞下创造出一个凉爽通风的环境,经实验测试,可使站在伞... 详细信息

设计了一种以太阳能电池板作为太阳能的收集装置。通过利用半导体制冷原理的太阳能多功能遮阳伞,本设计利用蓄电池储存太阳能电池板的发电,驱动半导体制冷片制冷和冷风扇运转从而给伞下创造出一个凉爽通风的环境,经实验测试,可使站在伞下人的体表温度最大降低约5.6℃。本设计还可用作手机电源及晚上用于遮阳伞的照明与美化,且结构简单、节能环保,可为别墅花园、露台茶座、草坪沙滩、商贩摊位、交警站台等户外场所提供低温环境。

关键词：半导体制冷太阳能风扇节能

Interface reaction during titanium alloys investment casting by residue gas in ceramic mold

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Rare Metals 2019年第4期38卷 327-335页

作者： Ya-Meng Wei Zhi-Gang Lu xin-yi Li xin guo Department of Mechanical Engineering Tsinghua University Beijing 100084 China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084 China Academy of Opto-Eletronics Chinese Academy of Sciences Beijing 100094 China

The chemical reaction between mold material and titanium melt during investment casting was studied intensively. However, the in fluence of residue gas in ceramic mold on interface reaction remains unclear. In this investigation, the effect of residue gas in Y2O3-silica sol shell mold on interface reaction during Ti-6A1-4V alloy investment casting was investigated. Two groups of shell molds were prepared by adding different kinds of pore formers, i.e., spherical starch particles or nylon fibers, respectively. Ti-6Al-4V alloy was cast under vacuum by gravity casting through cold crucible induction melting (CCIM) method. Porosity of different shell molds was measured based on Archimedean method. Scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS) were employed to characterize the micromorphology and composition of the reaction area, respectively. White light interferometer (WLI) was used to obtain the surface topography of the shell mold. The results show that the direct chemical reaction is very weak for all specimens. The release of residue gas in closed pores is the key factor influencing surface defects. However, open pores make nearly no difference on the interface reaction.

关键词： Titanium alloy Investment casting Residue gas Y2O3: Silica sol

玉米茎腐、鞘腐、穗腐病中不同镰孢菌间关系研究

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西南农业学报 2017年第6期30卷 1340-1345页

作者：袁丁何鹏飞吴毅歆郭力维袁远何月秋云南农业大学农业生物多样性应用技术国家工程研究中心云南昆明650201 滨州职业学院山东滨州256603 微生物菌种筛选与应用国家地方联合工程研究中心云南昆明650217 云南农业大学农学与生物技术学院云南昆明650201

【目的】为了明确不同镰孢菌对玉米茎腐病、鞘腐病和穗腐病的致病性。【方法】采用土壤接菌、穿刺接菌和孢子悬浮液接菌的方法。【结果】证明层出镰孢菌(Fusarium proliferatum)、轮枝镰孢菌(***)可引起玉米茎腐病,禾谷镰孢菌(***)可引... 详细信息

【目的】为了明确不同镰孢菌对玉米茎腐病、鞘腐病和穗腐病的致病性。【方法】采用土壤接菌、穿刺接菌和孢子悬浮液接菌的方法。【结果】证明层出镰孢菌(Fusarium proliferatum)、轮枝镰孢菌(***)可引起玉米茎腐病,禾谷镰孢菌(***)可引起穗腐病、鞘腐病,而尖孢镰孢菌(***)则通过复合侵染引起病害。【结论】将各类镰孢菌分别接种不同生育期的玉米植株,观察株高、病斑大小、玉米发育程度和籽粒的形成情况,研究各镰孢菌菌株对玉米植株的影响程度,分析各菌株的致病力,最佳侵染时期及茎腐、鞘腐、穗腐之间的侵染关系,证明玉米茎腐、鞘腐、穗腐之间病原菌侵染部位没有特异性,不同时期侵染引起的茎腐、鞘腐及穗腐发病程度不同。

关键词：玉米镰孢菌致病性关系

Bandgap characteristics analysis and graded design of a novel metamaterial for flexural wave suppression

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 1-24页

作者： Fan YANG Zhaoyang MA xingming guo Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai University Shanghai Institute of Aircraft Mechanics and Control

A novel elastic metamaterial is proposed with the aim of achieving lowfrequency broad bandgaps and bandgap regulation. The band structure of the proposed metamaterial is calculated based on the Floquet-Bloch theorem, and the boundary modes of each bandgap are analyzed to understand the effects of each component of the unit cell on the bandgap formation. It is found that the metamaterials with a low elastic modulus of ligaments can generate flexural wave bandgaps below 300 Hz. Multi-frequency vibrations can be suppressed through the selective manipulation of bandgaps. The dual-graded design of metamaterials that can significantly improve the bandgap width is proposed based on parametric studies. A new way that can regulate the bandgap is revealed by studying the graded elastic modulus in the substrate. The results demonstrate that the nonlinear gradient of the elastic modulus in the substrate offers better bandgap performance. Based on these analyses, the proposed elastic metamaterials can pave the way for multi-frequency vibration control, low-frequency bandgap broadening, and bandgap tuning.

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Asking one mechanism in glial cells during neuroinflammation

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Neural Regeneration Research 2025年第4期20卷 1077-1078页

作者： Xiaoli guo Chikako Harada Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

Multiple sclerosis(MS),which is characterized by inflammatory demyelination in the central nervous system(CNS),is the most common neurological disease in the young adult *** autoimmune encephalomyelitis(EAE),an animal model of MS,is often used in preclinical *** data indicate that in addition to immune cells such as T cells and dendritic cells,CNS resident microglia and astrocytes play important roles in demyelinating neuroinflammation(Healy et al.,2022).In particular,microglia are key immune-competent cells that can respond to environmental *** depletion of transforming growth factor-β-activated kinase 1,a mitogen-associated protein kinase kinase kinase,in microglia is reported to reduce CNS inflammation and diminish axonal and myelin damage *** suggests that elucidating the mechanisms of microglia-specific responses during pathologies may help in the development of treatments that reduce EAE/MS disease severity(Goldmann et al.,2013).

关键词： inflammation clinical

Epileptic brain network mechanisms and neuroimaging techniques for the brain network

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Neural Regeneration Research 2024年第12期19卷 2637-2648页

作者： yi guo Zhonghua Lin Zhen Fan xin Tian Department of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Sichuan Provincial Center for Mental Health Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Geriatrics Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurology Chongqing Key Laboratory of NeurologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Epilepsy can be defined as a dysfunction of the brain network,and each type of epilepsy involves different brain-network changes that are implicated diffe rently in the control and propagation of interictal or ictal *** more detailed information on brain network alterations can help us to further understand the mechanisms of epilepsy and pave the way for brain network-based precise therapeutic approaches in clinical *** increasing number of advanced neuroimaging techniques and electrophysiological techniques such as diffusion tensor imaging-based fiber tra ctography,diffusion kurtosis imaging-based fiber tractography,fiber ball imagingbased tra ctography,electroencephalography,functional magnetic resonance imaging,magnetoencephalography,positron emission tomography,molecular imaging,and functional ultrasound imaging have been extensively used to delineate epileptic *** this review,we summarize the relevant neuroimaging and neuroelectrophysiological techniques for assessing structural and functional brain networks in patients with epilepsy,and extensively analyze the imaging mechanisms,advantages,limitations,and clinical application ranges of each technique.A greater focus on emerging advanced technologies,new data analysis software,a combination of multiple techniques,and the construction of personalized virtual epilepsy models can provide a theoretical basis to better understand the brain network mechanisms of epilepsy and make surgical decisions.

关键词： electrophysiological techniques epilepsy functional brain network functional magnetic resonance imaging functional near-infrared spectroscopy machine leaning molecular imaging neuroimaging techniques structural brain network virtual epileptic models