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Qili Qiangxin, a compound herbal medicine formula, alleviates hypoxia-reoxygenation-induced apoptotic and autophagic cell death via suppression of ROS/AMPK/mTOR pathway in vitro

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Journal of Integrative Medicine 2022年第4期20卷 365-375页

作者： cai-lian Fan Wan-jun cai Meng-nan Ye Miao Chen yi Dai Department of Cardiology the First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou 510632Guangdong ProvinceChina College of Pharmacy Jinan UniversityGuangzhou 510632Guangdong ProvinceChina

Objective: Qili Qiangxin(QLQX), a compound herbal medicine formula, is used effectively to treat congestive heart failure in China. However, the molecular mechanisms of the cardioprotective effect are still unclear. This study explores the cardioprotective effect and mechanism of QLQX using the hypoxiareoxygenation(H/R)-induced myocardial injury ***: The main chemical constituents of QLQX were analyzed using high-performance liquid chromatography-evaporative light-scattering detection. The model of H/R-induced myocardial injury in H9c2 cells was developed to simulate myocardial ischemia–reperfusion injury. Apoptosis, autophagy,and generation of reactive oxygen species(ROS) were measured to assess the protective effect of QLQX. Proteins related to autophagy, apoptosis and signalling pathways were detected using Western ***: Apoptosis, autophagy and the excessive production of ROS induced by H/R were significantly reduced after treating the H9c2 cells with QLQX. QLQX treatment at concentrations of 50 and 250 μg/mL caused significant reduction in the levels of LC3Ⅱ and p62 degradation(P < 0.05), and also suppressed the AMPK/mTOR signalling pathway. Furthermore, the AMPK inhibitor Compound C(at 0.5 μmol/L),and QLQX(250 μg/mL) significantly inhibited H/R-induced autophagy and apoptosis(P < 0.01), while AICAR(an AMPK activator, at 0.5 mmol/L) increased cardiomyocyte apoptosis and autophagy and abolished the anti-apoptotic effect of QLQX. Similar phenomena were also observed on the expressions of apoptotic and autophagic proteins, demonstrating that QLQX reduced the apoptosis and autophagy in the H/R-induced injury model via inhibiting the AMPK/mTOR pathway. Moreover, ROS scavenger,N-Acetyl-L-cysteine(NAC, at 2.5 mmol/L), significantly reduced H/R-triggered cell apoptosis and autophagy(P < 0.01). Meanwhile, NAC treatment down-regulated the ratio of phosphorylation of AMPK/AMPK(P < 0.01), which showed a similar effect to ***: QLQX plays a

关键词： Herbal medicine Qili Qiangxin formula Hypoxia–reoxygenation Reactive oxygen species Autophagy Apoptosis AMPK/mTOR pathway

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Potential effects of subduction rate in the key ocean on global warming hiatus

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Acta Oceanologica Sinica 2018年第3期37卷 63-68页

作者： CHEN Xingrong LIU Shan cai yi ZHANG Shouwen National Marine Environmental Forecasting Center State Oceanic Administration Key Laboratory of Research on Marine Hazards Forecasting National Marine Environmental Forecasting CenterState Oceanic Administration

In this study, the possible effects of subduction rate on global warming hiatus were investigated using Simple Ocean Data Assimilation（SODA） data. This study first analyzed the characteristics of the temporal and spatial distribution of global subduction rate, which revealed that the North Atlantic meridional overturning circulation region and the Antarctic Circumpolar Current region are the two main sea areas with great subduction *** this basis, four key areas were selected to explore the relationship between the local subduction rate and the global mean sea surface temperature. In addition, the reason for the variations in subduction rate was preliminarily explored. The results show good correspondence of the subduction of the key areas in the North Atlantic meridional overturning the circulation region and the Antarctic Circumpolar Current region to the global warming hiatus, with the former leading by about 10 years. The subduction process may be a physical mechanism by which the North Atlantic overturning circulation and the Antarctic Circumpolar Current act on the stagnation of global warming. Advection effect plays an important role in the variations in subduction in the key regions. In the Antarctic Circumpolar Current region, the magnitude of sea surface wind stress is closely related to the local changes in subduction.

关键词： global warming hiatus sea surface temperature inter-decadal variation subduction rate

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Power outage and environmental justice in Winter Storm Uri: an analytical workflow based on nighttime light remote sensing

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International Journal of Digital Earth 2023年第1期16卷 2259-2278页

作者： Jinwen Xu yi Qiang Heng cai Lei Zou GIS Center Florida International UniversityMiamiFLUSA School of Geosciences University of South FloridaTampaFLUSA Department of Geography Texas A&M UniversityCollege StationTXUSA

The intensity of extreme weather events has been increasing,posing a unique threat to society and highlighting the importance of our electrical power system,a key component in our *** severe weather events,quickly identifying power outage impact zones and affected communities is crucial for informed disaster ***,a lack of household-level power outage data impedes timely and precise *** address these challenges,we introduced an analytical workflow using NASA’s Black Marble daily nighttime light(NTL)images to detect power outages from the 2021 Winter Storm *** workflow includes adjustments to mitigate viewing angle and snow reflection *** outage is detected by comparing storm-time and baseline(normal condition)NTL images using an empirical adjusted *** outcomes of the workflow are 500-meter resolution power outage maps,which have the optimal correlation with real outage tracking data when NTL intensity is reduced by 26%.With the resultant power outage maps,we analyzed the relations between power outages and disadvantaged populations in 126 Texas counties and 4182 census tracts to evaluate environmental justice in the *** results show that Latino/Hispanic communities tend to suffer more from power outages at both the county and census tract levels.

关键词： Nighttime light disaster resilience natural disaster spatial analysis environmental justice power outage

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Risk Factors of Enternal Nutrition Intolerance in Septic Patients:A Case-control Study

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Current Medical Science 2024年第2期44卷 328-332页

作者： Li-zhu WANG Yan xiang Qian LI yi-rong ZHU Jue FANG Xiao-dan LU Zhao-cai ZHANG Department of Nursing The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Critical Care Medicine The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Key Laboratory of the Diagnosis and Treatment for Severe Trauma and Burn of Zhejiang Province Hangzhou 310009China Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine Hangzhou 310009China

Objective:This study aimed to investigate the incidence of enteral nutrition intolerance(ENI)in patients with sepsis and explore potential risk ***:A case-control study was conducted in patients with sepsis who were receiving enteral nutrition(EN)at a tertiary hospital in *** included patients were divided into the ENI group and the non-ENI *** and multivariate analyses were performed to identify the risk factors for ***:A total of 859 patients were included in the *** them,288(33.53%)patients experienced symptoms of ENI,including diarrhea,vomiting,bloating,and gastric *** regression analysis revealed that the Acute Physiology and Chronic Health Evaluation H(APACHE H)score,thoracocentesis,and usage of cardiotonic drugs(namely,inotropes)were independent predictors of the ***:The incidence of ENI is relatively high in patients with sepsis,especially in those who have higher APACHE H scores,have undergone thoracocentesis,and have received inotropes.

关键词： sepsis enteral nutrition intolerance influencing factor

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Rational engineering of homospermidine synthase for enhanced catalytic efficiency toward spermidine synthesis

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Synthetic and Systems Biotechnology 2024年第3期9卷 549-557页

作者： Wenjing Liu Xiaoxiang Hu yi Yan Yujie cai The Key Laboratory of Industrial Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan University1800 Lihu RoadWuxiJiangsu214122China

Spermidine is a naturally occurring polyamine widely utilized in the prevention and treatment of various *** spermidine biosynthetic methods have problems such as low efficiency and complex multi-enzyme *** on sequence-structure-function relationships,we engineered the widely studied homospermidine synthase from Blastochloris viridis(BvHSS)and obtained mutants that could catalyze the production of spermidine from 1,3-diaminopropane and *** specific activities of BvHSS and the mutants D361E and E232D+D361E(E232D-D)were 8.72,46.04 and 48.30 U/mg,*** optimal pH for both mutants was 9.0,and the optimal temperature was 50◦*** docking and dynamics simulations revealed that mutating aspartic acid at position 361 to glutamic acid narrowed the substrate binding pocket,promoting stable spermidine ***,mutating glutamic acid at position 232 to aspartic acid enlarged the substrate channel entrance,facilitating substrate entry into the active pocket and enhancing spermidine *** whole-cell catalysis lasting 6 h,D361E and E232D-D synthesized 725.3 and 933.5 mg/L of spermidine,*** study offers a practical approach for single-enzyme catalyzed spermidine synthesis and sheds light on the crucial residues influencing homospermidine synthase catalytic activity in spermidine production.

关键词： Homospermidine synthase Polyamine Site-directed mutagenesis Spermidine Structural analysis

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Antioxidant Activities of Aqueous Extract from Cultivated Fruit-bodies of Cordyceps militaris （L.） Link In Vitro

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Journal of Integrative Plant Biology 2006年第11期48卷 1365-1370页

作者： Yu Zhan cai-Hong Dong yi-Jian Yao Key Laboratory of Systematic Mycology and Lichenology Institute of Microbiology the Chinese Academy of Sciences Beijing 100080 China Graduate University of the Chinese Academy of Sciences Beijing 100049 China

Biological antloxldants extracted from plants and fungi have potential abilities to scavenge free radicals and Inhibit lipid peroxldatlon, playing Important roles in preventing diseases, for example, cancer, and aging Induced by reactive oxygen species, which may cause oxidative damage to DNA, proteins and other macromolecules. The antloxldant potency of cultivated fruit-bodies of Cordyceps militarls （L.） Link was investigated In this study. Five established In vitro systems were employed, including the 1,1-dlphenyl-2- plcryldrazyl （DPPH） free radical scavenging, hydroxyl radical eliminating, iron chelating, Inhibition of Ilnolelc acid lipid peroxldatlon and reducing power. The aqueous extract from cultivated fruit-bodies was subjected to the test of amino acid, polysaccharlde and mannitol. Ascorblc acid （Vc）, butylated hydroxytoluene （BHT） and ethylenedlamlnetetraacetlc acid （EDTA） were used as positive controls for comparisons. Among the assays, the aqueous extract of C. mllltarls frult-bodles shows a significant scavenging effect on DPPH, eliminating the capability on hydroxyl radicals and the chelating effect on ferrous Iron. The extract also shows positive results of Inhibiting Ilnoleic acid lipid peroxldatlon and reducing power.

关键词： antioxidation aqueous extract Cordyceps militaris free radicals in vitro.

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A review of unmanned vehicle distribution optimization models and algorithms

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Journal of Traffic and Transportation Engineering(English Edition) 2023年第4期10卷 548-559页

作者： Jiao Zhao Hui Hu yi Han Yao cai College of Transportaion Engineering Chang'an UniversityXian 710064China School of Automobile Chang'an UniversityXi'an 710064China Yushi Technology(Beijing)Co. Ltd.Beijing 100027China

With the development of globalization and artificial intelligence,as well as the outbreak of COVID-19,unmanned vehicles have played an important role in cargo *** order to better analyze the research directions of unmanned vehicle distribution,this paper summarizes the models and algorithms of unmanned vehicle distribution *** research results show that most of the studies have established the goal of optimizing the total costs or travel *** researchers have begun to study multi-objective optimization problems,but there are certain limitations,so some studies convert these problems into single-objective optimization for solving,such as converting time and energy consumption into cost,waiting time into distance,and time delay into penalty *** the development of unmanned vehicle distribution technology,in future research,a multi-objective model with the lowest cost,the shortest distance and the best security should be established and *** studies have proposed heuristic algorithms for solving the unmanned vehicle distribution problem,and improved optimization solutions have been *** order to ensure the diversity of solution methods,and give consideration to solution time and solution quality,hybrid methods with other algorithms will be a future research direction,for example,the combination of heuristic algorithm and exact *** the gradual deepening of research,integrated distribution of multiple types of unmanned equipment will become the focus of future research.

关键词： Unmanned vehicle Distribution optimization Mathematical model Optimization algorithm

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A 3D-PSF Space Size Selection Method Based on Inflection Point

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Chinese Journal of Electronics 2017年第1期26卷 160-165页

作者： YANG Fengjuan CHEN Hua cai yi LIANG Riliu HE Shuangyan School of Computer and Electronics Information Guangxi University

In the three-dimensional microscopic biological image restoration processing of digital confocal microscopy, the selection of three-Dimensional Point spread function(3D-PSF) space size determines the restoration effect and restoration time. Based on 3D-PSF double funnelshaped structure and analyzing the relationship of 3DPSF space size to the image restoration effect and restoration time, it proposed the comprehensive image restoration evaluation criteria based on restoration efficiency,and also proposed the 3D-PSF selection method based on restoration efficiency curve inflection point. Three groups of 3D-PSF with different layer distances were used for image restoration experiments, the relationship between the3D-PSF space sizes of different diameter and the image restoration effect and restoration time was built, and the restoration efficiency curve was obtained. Based on the curve inflection point, the selection of optional minimum space 3D-PSF and 3D-PSF was determined. Experimental results showed the method has good feasibility.

关键词： Microscopic image Three-Dimensional Point spread function(3D-PSF) Selection method Restoration efficiency Inflection point

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Selection of dopants and doping sites in semiconductors:the case of AlN

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Journal of Semiconductors 2024年第11期45卷 46-50页

作者： yi-Feng Zheng Xuefen cai Su-Huai Wei Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Physics Eastern Institute of TechnologyNingbo 315200Chin

The choices of proper dopants and doping sites significantly influence the doping *** this work,using doping in Al N as an example,we discuss how to choose dopants and doping sites in semiconductors to create shallow defect *** comparing the defect properties of C_(N),O_(N),Mg_(Al),and Si_(Al)in AlN and analyzing the pros and cons of different doping approaches from the aspects of size mismatch between dopant and host elements,electronegativity difference and perturbation to the band edge states after the substitution,we propose that Mg_(Al)and Si_(Al)should be the best dopants and doping sites for p-type and n-type doping,*** first-principles calculations verify our predictions as these defects present lower formation energies and shallower defect *** defect charge distributions also show that the band edge states,which mainly consist of N-s and p orbitals,are less perturbed when Al is substituted,therefore,the derived defect states turn out to be delocalized,opposite to the situation when N is *** approach of analyzing the band structure of the host material and choosing dopants and doping sites to minimize the perturbation on the host band structure is general and can provide reliable estimations for finding shallow defect levels in semiconductors.

关键词： defect control band structure analysis wide-bandgap semiconductor

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Structural abnormalities of trigeminal root with neurovascular compression revealed by high resolution diffusion tensor imaging

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Asian Pacific Journal of Tropical Medicine 2012年第9期5卷 749-752页

作者： Jing Chen Zi-yi Guo Qi-Zhou Liang Hai-Yan Liao Wen-Rui Su cai-xiang Chen Shui-Xi Fu xiang-Jun Han Radiology Department Municipal Hospital of Haikou

Objective:To detect neurovascular compression-induced structural abnormalities of trigeminal nerves(TGN) by diffusion tensor imaging(DTI).Methods:The affected ipsilateral TGN(iTGN) and unaffected contralateral TGN(cTGN) of 20 trifacial neuralgia(TIM) patients as well as the bilateral TGN of 10 normal controls(nTGN) were examined by DTI and 3D high resolution MR] using a 3.0 T MRI *** fractional anisotropy and apparent diffusion coefficieiil(ADC) were ***:Compared with the cTGN and nTGN,the *** significantly lower fraction of anisotropy(FA),significantly higher *** significantly smaller volume and crosssectional area(P<0.05).Conclusions:The increase in ADC and decrease in FA has a close relationship with morphological changes of TGN,and the DTI could provide valuable diagnostic information on TGN structure forTN patients.

关键词： Trigeminal nerves Diffusion tensor imaging Trifacial neuralgia Apparent diffusion coefficient Fraction of anisotropy

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