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Gut microbiota induced abnormal amino acids and their correlation with diabetic retinopathy

International Journal of Ophthalmology(English edition) 2024年第5期17卷 883-895页

作者： Sheng-Qun Jiang Su-Na Ye yin-Hua Huang yi-wen ou Ke-Yang Chen Jian-Su Chen Shi-Bo Tang Aier Eye Hospital Jinan UniversityGuangzhou 510000Guangdong ProvinceChina Aier Eye Institute and Changsha Aier Hospital Changsha 410000Hunan ProvinceChina The First Affiliated Hospital of Bengbu Medical University Bengbu 233000Anhui ProvinceChina School of Public Health Anhui Medical UniversityHefei 230000Anhui ProvinceChina

AIM:To explore the correlation of gut microbiota and the metabolites with the progression of diabetic retinopathy(DR)and provide a novel strategy to elucidate the pathological mechanism of ***:The fecal samples from 32 type 2 diabetes patients with proliferative retinopathy(PDR),23 with nonproliferative retinopathy(NPDR),27 without retinopathy(DM),and 29 from the sex-,age-and BMI-matched healthy controls(29 HC)were analyzed by 16S rDNA gene *** fecal samples from PDR,DM,and HC groups were assayed by untargeted *** metabolites were measured using liquid chromatographymass spectrometry(LC-MS)*** between gut microbiota and fecal metabolites were ***:A cluster of 2 microbiome and 12 metabolites accompanied with the severity of DR,and the close correlation of the disease progression with PDR-related microbiome and metabolites were *** be specific,the structure of gut microbiota differed in four *** and richness of gut microbiota were significantly lower in PDR and NPDR groups,than those in DM and HC groups.A cluster of microbiome enriched in PDR group,including Pseudomonas,Ruminococcaceae-UCG-002,Ruminococcaceae-UCG-005,Christensenellaceae-R-7,was *** analysis showed that the glucose and nicotinate degradations were significantly higher in PDR group than those in HC ***,serine,ornithine,and arachidonic acid were significantly enriched in PDR group,while proline was enriched in HC *** analysis illustrated that arginine biosynthesis,lysine degradation,histidine catabolism,central carbon catabolism in cancer,D-arginine and D-ornithine catabolism were elevated in PDR *** analysis revealed that Ruminococcaceae-UCG-002 and Christensenellaceae-R-7 were positively associated with L-arginine,ornithine levels in fecal ***:This study elaborates the different microbiota structure in the gut from four *** relative abundance of

关键词： proliferative retinopathy gut microbiota Ruminococcaceae amino acid metabolism arginine

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Effects of Scutellaria Baicalensis on Activity and Biofilm Formation of Klebsiella Pneumoniae

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Chinese Medical Sciences Journal 2016年第3期31卷 180-184页

作者： Wei Chen Bei Li Shuai Li yi-wen ou Qin ou The First School of Clinical Medicine Hubei University of Medicine Department of Medical Microbiology Hubei University of Medicine

Objective To explore the effects of Scutellaria baicalensis on activity and biofilm formation of Klebsiella pneumonia(Kp).Methods The broth and agar dilution methods were carried out to determine minimum inhibitory concentration and minimum bactericidal concentration of Scutellaria baicalensis for ***-32 system was used to assay TW518 susceptibility to *** biofilms were formed in vitro and stained with Bac Light Live/Dead *** class integron geneⅠ1 m RNA expression was analyzed with *** The minimum inhibitory concentration of Scutellaria baicalensis on TW518 identified as a Kp colony was 32 mg/ml,and minimum bactericidal concentration was 64 mg/*** baicalensis and broad-spectrum penicillin,cephalosporin,quinolones,or beta-lactamase had synergistic bactericidal *** formation activity of Kp treated with Scutellaria baicalensis was significantly lower than that of the control *** class integron geneⅠ1 m RNA expression of TW518 was significantly inhibited by Scutellaria *** Scutellaria baicalensis has sterilization effect on Kp,and Scutellaria baicalensis could effectively inhibit Kp biofilm formation with prolonged *** baicalensis might inhibit Kp biofilm formation through down-regulating integron geneⅠ1 expression.

关键词： Pneumoniae 生物膜膜形成黄芩活性 RT-PCR方法最小抑菌浓度最低杀菌浓度

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A novel small-animal locomotor activity recording device for biological clock research

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Animal Models and Experimental Medicine 2024年第1期7卷 71-76页

作者： yi-Long Wu Ming Zhong Jun yin Wei-Jie ou Yu-Bin Zhuang Nan-wen Zhang Su Lin Yue-Yong Zhu Endoscopy Center The First Affiliated HospitalFujian Medical UniversityFuzhouChina Department of Endocrinology The First Affiliated HospitalFujian Medical UniversityFuzhouChina Chuangke Workshop Technology Co. LtdShenzhenChina Department of Digestive Nutrition Fujian Children's HospitalFuzhouChina Experimental Animal Center Fujian Medical UniversityFuzhouChina Department of Pharmacology Fujian Medical UniversityFuzhouChina Department of Hepatology Hepatology Research InstituteClinical Research Center for Liver and Intestinal Diseases of Fujian ProvinceThe First Affiliated HospitalFujian Medical UniversityFuzhouChina

The rodent running-wheel recording apparatus is a reliable approach for studying cir-cadian *** study demonstrated how to construct a simple and intelligent running-wheel recording *** running wheel was attached to the cage's base,whereas the Hall sensor was attached to the cage's ***,the RJ25 adaptor relayed the running signal to the main control ***,the main control board was connected to the USB port of the computer with the USB *** were collected using the online-accessible,self-created software *** Magturning,generated data were saved and exported in real ***,the device was validated by collecting data on the locomotor activities of mice under dif-ferent light *** conclusion,this new device can record circadian activity of *** device is appropriate for interdisciplinary investigations related to biological clock research.

关键词： biological clock circadian rhythm intelligent equipment locomotor activity running wheel

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Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy:a precise construction of structurally diverse azaspiro polycyclic scaffolds

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Science China Chemistry 2024年第2期67卷 576-586页

作者： Xiao-Bao Wu Jun-Xiu Shi yi-Ming ou Hua-Jie Jiang yi-Jun Fang Qi-Ming Wang Quan Gao Jie Yu Department of Applied Chemistry Anhui Province Engineering Laboratory for Green Pesticide Development and ApplicationAnhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Agricultural UniversityHefei230036China

A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic *** diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results(up to 99:1 e.r.,>95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(Ⅲ) complexes.

关键词： asymmetric catalysis post-Ugi transformation anionic stereogenic-at-cobalt(Ⅲ)complex azaspiro polycyclic scaffold one-pot synthesis

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Degradation analysis and doping modification optimization for high-voltage P-type layered cathode in sodium-ion batteries

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Journal of Energy Chemistry 2024年第2期89卷 1-9,I0002页

作者： Bao Zhang yi Zhao Minghuang Li Qi Wang Lei Cheng Lei Ming Xing ou Xiaowei Wang National Engineering Laboratory for High-Efficiency Recovery of Refractory Nonferrous Metals School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083HunanChina Zhejiang Power New Energy Co. LTDZhuji 311800ZhejiangChina

Advancing high-voltage stability of layered sodium-ion oxides represents a pivotal avenue for their progress in energy storage *** this,a comprehensive understanding of the mechanisms underpinning their structural deterioration at elevated voltages remains insufficiently *** this study,we unveil a layer delamination phenomenon of Na_(0.67)Ni_(0.3)Mn_(0.7)O_(2)(NNM)within the 2.0-4.3 V voltage,attributed to considerable volumetric fluctuations along the c-axis and lattice oxygen reactions induced by the simultaneous Ni^(3+)/Ni^(4+)and anion redox *** introducing Mg doping to diminished Ni-O antibonding,the anion oxidation-reduction reactions are effectively mitigated,and the structural integrity of the P2 phase remains firmly intact,safeguarding active sites and precluding the formation of novel *** Na_(0.67)Mg_(0.05)Ni_(0.25)Mn_(0.7)O_(2)(NMNM-5)exhibits a specific capacity of100.7 mA h g^(-1),signifying an 83%improvement compared to the NNM material within the voltage of2.0-4.3 *** investigation underscores the intricate interplay between high-voltage stability and structural degradation mechanisms in layered sodium-ion oxides.

关键词： Soidum ion batteries Layer cathode materials P-type High-voltage performance Degradation analysis

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Recent landscape and trends for industry-sponsored pediatric clinical trials in China from 2013 to 2022

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Pediatric Investigation 2024年第1期8卷 12-20页

作者： Chang Liu yi Liu Ling ou Yuenan Qi Jianmin Zhang Drug Clinical Trial Institution Children’s HospitalCapital Institute of PediatricsBeijingChina

Importance:Pediatric medication is a challenging issue *** trials of medications for children and implementing measures to encourage innovation for addressing unmet medical and health needs are ***:To explore the recent landscape of pediatric clinical trials of new investigational drugs conducted by pharmaceutical enterprises in China from 2013 to 2022 to provide insight into pediatric drug development in the pharmaceutical industry and regulatory policy ***:We performed a cross-sectional observational investigation of pediatric clinical trials registered from January 1,2013,to December 31,2022,on the Registration and Information Disclosure Platform for Drug Clinical Trials,the official registration platform established in 2013 for trials of new investigational drugs initiated by biopharmaceutical *** that included pediatric participants(under 18 years old)were retrieved,and their relevant characteristics were extracted and ***:In total,895 pediatric clinical trials were collected,accounting for 5.1%of the total registered clinical trials initiated prior to January 1,*** overall average annual growth rate for the number of pediatric clinical trials was 12%(Pounted for the highest proportion(49.1%,439).Of the 895 trials included,736(82.2%)were domestic trials,and 159(17.8%)were international multicenter *** terms of tested drugs,investigations of biological products accounted for the largest proportion of trials(67.4%,603).Among pediatric clinical trials,studies of vaccines accounted for the largest proportion of trials(41.0%,367),followed by trials for rare diseases(17.2%,154).Furthermore,geographical distribution analysis revealed that the largest and smallest numbers of trials were conducted in North China(35.7%,320)and Northeast China(0.8%,7),***:The growth trends for industry-sponsored clinical trials involving children illust

关键词： Geographic distribution Pediatric clinical trials Pediatric medication Rare disease

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Experimental Analysis of Radial Centrifugal Pump Shutdown

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Fluid Dynamics & Materials Processing 2024年第4期20卷 725-737页

作者： Xiao Sun Jiangbo Tong Yuliang Zhang Haibing Cai wen Zhou Xiaoqi Jia Litao ou School of Mechanical Engineering Hunan University of TechnologyZhuzhou412007China College of Mechanical Engineering Quzhou UniversityQuzhou324000China Zhejiang Testing&Inspection Institute for Mechanical and Electrical Products Quality Co. Ltd.Hangzhou310014China Quzhou Special Equipment Inspection Center Quzhou324000China The Zhejiang Provincial Key Lab of Fluid Transmission Technology Zhejiang Sci-Tech UniversityHangzhou310018China Zhuzhou Nanfang Valve Co. Ltd.Zhuzhou412000China

Centrifugal pumps are widely used in the metallurgy,coal,and building *** order to study the hydraulic characteristics of a closed impeller centrifugal pump during its shutdown in the so-called power frequency and frequency conversion modes,experiments were carried to determine the characteristic evolution of parameters such as speed,inlet and outlet pressure,head,flow rate and shaft power.A quasi-steady-state method was also used to further investigate these transient *** results show that,compared to the power frequency input,the performance parameter curves for the frequency conversion input are less volatile and *** characteristic time is longer and the response to shutdown is *** quasi-steady-state theoretical head-flow curves match the experimental head-flow curves more closely at low flow rates when the frequency conversion input is ***,in this case,the similarity law predicts the hydraulic performance more accurately.

关键词： Centrifugal pump power frequency frequency conversion shutdown external characteristic experimental study

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Long-range asymmetric Cherenkov radiation

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 170-171页

作者： Gang Zhong Qingdong ou Macao Institute of Materials Science and Engineering(MIMSE) Faculty of Innovation EngineeringMacao University of Science and TechnologyTaipaMacao 999078China

Cherenkov radiation(CR)is gaining increasing attention as a high-output power Terahertz radiation source,and it plays a significant role in particle detectors,accelerators,and space science[1].This captivating phenomenon was first observed by Cerenkov in 1934 and was later explained theoretically by Tamm and Frank in 1937,earning them the Nobel Prize in Physics in *** occurs when charged particles move faster than the phase velocity of light in a specific medium.

关键词： asymmetric faster explained

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The low Mach number limit of non-isentropic magnetohydrodynamic equations with large temperature variations in bounded domains

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Science China Mathematics 2024年第4期67卷 787-818页

作者： Min Liang Yaobin ou School of Mathematics Renmin University of ChinaBeijing 100872China

This paper verifies the low Mach number limit of the non-isentropic compressible magnetohydrodynamic(MHD)equations with or without the magnetic diffusion in a three-dimensional bounded domain when the temperature variation is large but *** uniform estimates of strong solutions are established in a short time interval independent of the Mach number,provided that the slip boundary condition for the velocity and the Neumann boundary condition for the temperature are imposed and the initial data is well-prepared.

关键词： low Mach number limit non-isentropic compressible magnetohydrodynamic equations large temperature variations bounded domains

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Knockdown of HE4 suppresses tumor growth and invasiveness in lung adenocarcinoma through regulation of EGFR signaling

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Oncology Research 2024年第6期32卷 1119-1128页

作者： YUE ZHANG wenYU YANG XIAOWANG HAN YUE QIAO HAITAO WANG TING CHEN TIANyiNG LI wen-BIN ou Department of Biopharmaceutics College of Life Sciences and MedicineZhejiang Provincial Key Laboratory of Silkworm Bioreactor and BiomedicineZhejiang Sci-Tech UniversityHangzhou310018China Department of Thoracic Surgery Zhejiang Provincial People’s HospitalHangzhou310014China

It has been shown that the high expression of human epididymis protein 4(HE4)in most lung cancers is related to the poor prognosis of patients,but the mechanism of pathological transformation of HE4 in lung cancer is still *** current study is expected to clarify the function and mechanism of HE4 in the occurrence and metastasis of lung adenocarcinoma(LUAD).Immunoblotting evaluated HE4 expression in lung cancer cell lines and biopsies,and through analysis of The Cancer Genome Atlas(TCGA)*** HE4 overexpression was demonstrated in LUAD,but not in lung squamous cell carcinoma(LUSC),indicating that HE4 can serve as a biomarker to distinguish between LUAD and ***4 knockdown significantly inhibited cell growth,colony formation,wound healing,and invasion,and blocked the G1-phase of the cell cycle in LUAD cell lines through inactivation of the EGFR signaling downstream including PI3K/AKT/mTOR and RAF/MAPK *** first-line EGFR inhibitor gefitinib and HE4 shRNA had no synergistic inhibitory effect on the growth of lung adenocarcinoma cells,while the third-line EGFR inhibitor osimertinib showed additive anti-proliferative ***,we provided evidence that HE4 regulated EGFR expression by transcription regulation and protein interaction in *** findings suggest that HE4 positively modulates the EGFR signaling pathway to promote growth and invasiveness in LUAD and highlight that targeting HE4 could be a novel strategy for LUAD treatment.

关键词： Lung adenocarcinoma Human epididymis protein 4 Epidermal growth factor receptor Biomarker Targeted therapies

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