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Application of Natural Medicinal Plants Active Ingredients in Oral Squamous Cell Carcinoma

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Chinese Journal of Integrative Medicine 2024年第9期30卷 852-864页

作者： REN Qun-li LI Xiao-lan tian tian LI Shuang SHI Rong-yi WANG Qian zhu Yuan WANG Miao HU Huan LIU Jian-guo School of Stomatology Zunyi Medical UniversityZunyiGuizhou Province563000China Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution Zunyi Medical UniversityZunyiGuizhou Province563000China School of Basic Medicine Zunyi Medical UniversityZunyiGuizhou Province563000China

Oral squamous cell carcinoma(OSCC)is the most common malignant cancer of the head and neck,with high morbidity and mortality,ranking as the sixth most common cancer in the *** treatment of OSCC is mainly radiotherapy,chemotherapy and surgery,however,the prognosis of patients is still poor and the recurrence rate is *** paper reviews the range of effects of natural medicinal plant active ingredients(NMPAIs)on OSCC cancer,including the types of NMPAIs,anti-cancer mechanisms,involved signaling pathways,and clinical *** NMPAIs include terpenoids,phenols,flavonoids,glycosides,alkaloids,coumarins,and volatile *** active ingredients inhibit proliferation,induce apoptosis and autophagy,inhibit migration and invasion of OSCC cells,and regulate cancer immunity to exert anti-cancer *** mechanism involves signaling pathways such as mitogen-activated protein kinase,phosphatidylinositol 3 kinase/protein kinase B,nuclear factor kappa B,miR-22/WNT1/β-catenin and Nrf2/***,NMPAIs can inhibit the growth of OSCC,and the combined drug is more *** medicinal plants are promising candidates for the treatment of OSCC.

关键词： natural medicinal plant active ingredients oral squamous cell carcinoma mechanism signaling pathway review

Accelerating the Control and Elimination of Major Parasitic Diseases in China—On World NTD Day 2024

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China CDC weekly 2024年第6期6卷 95-99页

作者： Yuwan Hao tian tian Zelin zhu yijun Chen Jing Xu Shuai Han Menbao Qian yi Zhang Shizhu Li Qiang Wang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute of Parasitic DiseasesChinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)Key Laboratory on Parasite and Vector BiologyMinistry of HealthWHO Centre for Tropical Diseases National Center for International Research on Tropical Diseases Ministry of Science and TechnologyShanghaiChinaSchool of Global HealthChinese Center for Tropical Diseases Research-Shanghai Jiao Tong University School of MedicineShanghaiChina

Neglected tropical diseases(NTDs)are a group of diseases associated with poverty that affect over 1 billion people worldwide(1).On May 31,2021,the World Health Assembly(WHA)officially recognized January 30 as World Neglected Tropical Diseases Day through decision WHA74(18).This designation aims to raise awareness about the severe impact of NTDs on disadvantaged populations and to mobilize support for control,elimination,and eradication efforts.

关键词： Diseases diseases disadvantage

Cisplatin pretreatment enhances anti-tumor activity of cytokine-induced killer cells

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World Journal of Gastroenterology 2011年第25期17卷 3002-3011页

作者： Xiang Huang yi-tian Chen Hai-zhu Song Gui-Chun Huang Long-Bang Chen Department of Medical Oncology MedicalSchool of Nanjing University Jinling Hospital 305 ZhongshanEast Road Nanjing 210002 Jiangsu Province China

AIM： To investigate whether cisplatin （DDP） enhances the anti-tumor activity of cytokine- induced killer （CIK） cells in a murine colon adenocarcinoma model. METHODS： Tumor size and weight served as indicators of therapeutic response. Immunohistochemistry was performed to observe intratumoral lymphocyte infiltration and tumor microvessel density. Changes in the percentage of regulatory T （Treg） cells within the spleens of tumor-bearing mice preconditioned with DDP were monitored using flow cytometry. RESULTS： A marked T cell-dependent, synergistic anti- tumor effect of the combined therapy was observed （1968 ± 491 mm3 ys 3872 ＋ 216 mm3; P = 0,003）, Preconditioning chemotherapy with DDP augmented the infiltration of CD3＋ T lymphocytes into the tumor mass and reduced the percentage of both intratumoral and splenic Treg cells. CONCLUSION： Preconditioning with DDP markedly enhances the efficacy of adoptively transferred CIK cells, providing a potential clinical modality for the treatment of patients with colorectal cancer.

关键词： Colorectal cancer Preconditioning chemo-therapy Cytokine-induced killer cells Regulatory Tcells Immunomodulation

Revealing the anti-sintering phenomenon on silica-supported nickel catalysts during CO_(2)hydrogenation

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Journal of Environmental Sciences 2024年第6期140卷 270-278页

作者： Liuqingqing Yang tiancheng Pu Feixiang tian Yulian He Minghui zhu State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China University of Michigan-Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong UniversityShanghai 200240China School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The CO_(2)catalytic hydrogenation represents a promising approach for gas-phase CO_(2)utilization in a direct *** to its excellent hydrogenation ability,nickel has been widely studied and has shown good activities in CO_(2)hydrogenation reactions,in addition to its high availability and low ***,Ni-based catalysts are prone to sintering under elevated temperatures,leading to unstable catalytic *** the present study,various characterization techniques were employed to study the structural evolution of Ni/SiO_(2)during CO_(2)*** anti-sintering phenomenon is observed for both 9%Ni/SiO_(2)and 1%Ni/SiO_(2)during CO_(2)hydrogenation at 400℃.Results revealed that Ni species were re-dispersed into smaller-sized nanoparticles and formed Ni^(0)active *** interestingly,this anti-sintering phenomenon leads to distinct outcomes for two catalysts,with a gradual increase in both reactivity and CH_(4)selectivity for 9%Ni/SiO_(2)presumably due to the formation of abundant surface Ni°from redispersion,while an apparent decreasing trend of CH_(4)selectivity for 1%Ni/SiO_(2)sample,presumably due to the formation of ultra-small nanoparticles that diffuse and partially filled the mesoporous pores of the silica support over ***,the redispersion phenomenon was found relevant to the H_(2)gas in the reaction environment and enhanced as the H_(2)concentration *** finding is believed to provide in-depth insights into the structural evolution of Ni-based catalysts and product selectivity control in CO_(2)hydrogenation reactions.

关键词： Carbon dioxide utilization CO_(2)hydrogenation Nickel-based catalysts Anti-sintering Structural evolution

Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine

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Chinese Journal of Integrative Medicine 2024年第5期30卷 468-479页

作者： ZHONG yi LI Xin-yue LIANG tian-jun DING Bao-zhu MA Ke-xin REN Wen-xuan LIANG Wen-jie College of Integrated Traditional Chinese and Western Medicine Hebei University of Chinese MedicineHebei Key Laboratory of Integrated Traditional Chinese and Western Medicine in Liver and Kidney DiseasesInstitute of Integrated Traditional Chinese and Western MedicineShijiazhuang 050200China Department of Cardiovascular Internal Medicine the Second Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi Province 332000China Graduate School Hebei Medical UniversityShijiazhuang 050017China Rural Physician College Hebei Medical UniversityShijazhuang 050017China Medical Department the First Hospital of Hebei Medical UniversityShijiazhuang 050030China

Activation of the NOD-like receptor protein 3(NLRP3)inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases(CVDs),such as diabetic cardiomyopathy,ischemia/reperfusion injury,myocardial infarction,heart failure and *** RNAs(nc RNAs)are important regulatory *** Chinese medicine(CM)compounds,including their effective components,can regulate pyroptosis and exert myocardium-protecting *** mechanisms underlying this protection include inhibition of inflammasome protein expression,Toll-like receptor 4–NF-κB signal pathway activation,oxidative stress,endoplasmic reticulum stress(ERS),and mixed lineage kinase 3 expression and the regulation of silent information regulator *** NLRP3 protein is an important regulatory target for CVD prevention and treatment with *** the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.

关键词： pyroptosis cardiovascular diseases Chinese medicine NOD-like receptor protein 3 mechanisms

Can the integration between urban and rural areas be realized?A new theoretical analytical framework

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Journal of Geographical Sciences 2024年第1期34卷 3-24页

作者： WANG yi LU Yuqi zhu yingming Research Base of Jiangsu Industrial Cluster School of Economics and ManagementNanjing University of Science and TechnologyNanjing 210094China School of Geography Nanjing Normal UniversityNanjing 210023China

Urban-rural integration is an advanced form resulting from the future evolution of urban-rural ***,little research has explored whether urban and rural areas can move from dual segmentation to integrated development from a theoretical or empirical *** on the research framework of welfare economics,which offers an appealing paradigm to frame the underlying game between cities and villages,this study clarifies the ideal state of urban-rural *** then proposes a series of basic assumptions,and constructs a corresponding objective function and its ***,it assesses the possibility of seeing the transmutation from division to integration between urban and rural areas with continuous socio-economic *** authors argue that the ideal state of urban-rural integration should be a Pareto-driven optimal allocation of urban-rural resources and outputs,and the maximization of social welfare in the entire *** on a systematic demonstration using mathematical models,the study proposes that urban and rural areas can enter this ideal integrated development pattern when certain parameter conditions are *** general,this study demonstrates the theoretical logic and scientific foundations of urban-rural integration,enriches theoretical studies about urban-rural relationships,and provides basic theoretical support for large developing countries to build a coordinated and orderly urban-rural community with a shared future.

关键词： urban-rural integration development ideal state parameter conditions welfare economics theoretical framework

NFHP-RN:AMethod of Few-Shot Network Attack Detection Based on the Network Flow Holographic Picture-ResNet

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 929-955页

作者： Tao yi Xingshu Chen Mingdong Yang Qindong Li yi zhu School of Cyber Science and Engineering Sichuan UniversityChengdu610065China CyberScience Research Institute Sichuan UniversityChengdu610065China Chengdu Fengwei Technology Co. Ltd.Chengdu610041China

Due to the rapid evolution of Advanced Persistent Threats(APTs)attacks,the emergence of new and rare attack samples,and even those never seen before,make it challenging for traditional rule-based detection methods to extract universal rules for effective *** the progress in techniques such as transfer learning and meta-learning,few-shot network attack detection has ***,challenges in few-shot network attack detection arise from the inability of time sequence flow features to adapt to the fixed length input requirement of deep learning,difficulties in capturing rich information from original flow in the case of insufficient samples,and the challenge of high-level abstract *** address these challenges,a few-shot network attack detection based on NFHP(Network Flow Holographic Picture)-RN(ResNet)is ***,leveraging inherent properties of images such as translation invariance,rotation invariance,scale invariance,and illumination invariance,network attack traffic features and contextual relationships are intuitively represented in *** addition,an improved RN network model is employed for high-level abstract feature extraction,ensuring that the extracted high-level abstract features maintain the detailed characteristics of the original traffic behavior,regardless of changes in background ***,a meta-learning model based on the self-attention mechanism is constructed,achieving the detection of novel APT few-shot network attacks through the empirical generalization of high-level abstract feature representations of known-class network attack *** results demonstrate that the proposed method can learn high-level abstract features of network attacks across different traffic detail *** state-of-the-artmethods,it achieves favorable accuracy,precision,recall,and F1 scores for the identification of unknown-class network attacks through cross-validation onmultiple datasets.

关键词： APT attacks spatial pyramid pooling NFHP(network flow holo-graphic picture) ResNet self-attention mechanism meta-learning

Dark Matter Search in Dwarf Irregular Galaxies with Ten Years of Data from the Ice Cube Neutrino Observatory

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Research in Astronomy and Astrophysics 2024年第3期24卷 75-82页

作者： yi-Fei Lü Ben-Yang zhu Rong-Lan Li Xue-Kang Guo tian-Ci Liu Yong-Bo Huang Yun-Feng Liang Guangxi Key Laboratory for Relativistic AstrophysicsSchool of Physical Science and TechnologyGuangxi University Nanning 530004China

Dwarf irregular galaxies(dIrrs),as rotationally supported systems,have more reliable J-factor measurements than dwarf spheroidal galaxies and have received attention as targets for dark matter detection in recent *** this paper,we use 10 yr of IceCube muon-track data and an unbinned maximum-likelihood-ratio method to search for neutrino signals beyond the background from the directions of seven dIrrs,aiming to detect neutrinos produced by heavy annihilation dark *** do not detect any significant *** on such null results,we calculate the upper limits on the velocity-averaged annihilation cross section for 1 TeV–10 PeV dark *** limits,although weaker than the strictest constraints in the literature in this mass range,are also a good complement to the existing results considering the more reliable J-factor measurements of dIrrs.

关键词： (cosmology) dark matter-cosmology theory-galaxies dwarf

Enhancing Deep Learning Semantics:The Diffusion Sampling and Label-Driven Co-Attention Approach

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Computers, Materials & Continua 2024年第5期79卷 1939-1956页

作者： ChunhuaWang Wenqian Shang Tong yi Haibin zhu State Key Laboratory of Media Convergence and Communication Communication University of ChinaBeijing100024China School of Computer and Cyber Sciences Communication University of ChinaBeijing100024China School of Computer Science and Engineering Guangxi Normal UniversityGuilin541004China Department of Computer Science Nipissing UniversityNorth BayON P1B 8L7Canada

The advent of self-attention mechanisms within Transformer models has significantly propelled the advancement of deep learning algorithms,yielding outstanding achievements across diverse ***,self-attention mechanisms falter when applied to datasets with intricate semantic content and extensive dependency *** response,this paper introduces a Diffusion Sampling and Label-Driven Co-attention Neural Network(DSLD),which adopts a diffusion sampling method to capture more comprehensive semantic information of the ***,themodel leverages the joint correlation information of labels and data to introduce the computation of text representation,correcting semantic representationbiases in thedata,andincreasing the accuracyof semantic ***,the model computes the corresponding classification results by synthesizing these rich data semantic *** on seven benchmark datasets show that our proposed model achieves competitive results compared to state-of-the-art methods.

关键词： Semantic representation sampling attention label-driven co-attention attention mechanisms