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Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

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The Enhancing Effect of the East Asian Subtropical Westerly Jet on Summer Extreme High-Temperature Events over Central-Eastern China Since the Late 1990s

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ADVANCES IN ATMOSPHERIC SCIENCES 2025年第3期42卷 453-466页

作者： Gao, Chujie niu, Yuyu Li, Gen Sun, Shanlei Lu, Bo Li, Chaofan Xu, Bei Huang, Jinglong Sun, Xiubao Hohai Univ Coll Oceanog Minist Nat Resources Nanjing 210098 Peoples R China Hohai Univ Key Lab Marine Hazards Forecasting Minist Nat Resources Nanjing 210098 Peoples R China Nanjing Univ Informat Sci & Technol Key Lab Meteorol Disaster Minist Educ KLME Nanjing 210044 Peoples R China Nanjing Univ Informat Sci & Technol Collaborat Innovat Ctr Forecast & Evaluat Meteorol Nanjing 210044 Peoples R China Chinese Acad Sci South China Sea Inst Oceanol State Key Lab Trop Oceanog Guangzhou 510301 Peoples R China China Meteorol Adm Natl Climate Ctr Lab Climate Studies Beijing 100081 Peoples R China China Meteorol Adm Natl Climate Ctr CMA NJU Joint Lab Climate Predict Studies Beijing 100081 Peoples R China Xiongan Inst Meteorol Artificial Intellegence Xiongan 071708 Peoples R China Chinese Acad Sci Ctr Monsoon Syst Res Inst Atmospher Phys Beijing 100029 Peoples R China Univ Chinese Acad Sci Coll Earth & Planetary Sci Beijing 100049 Peoples R China Jinling Inst Technol Coll Intelligent Sci & Control Engn Nanjing 211169 Peoples R China

The increase in frequency and intensity of Extreme High-temperature Events (EHEs) over Central-Eastern China (CEC) in recent decades has severely impacted social development and livelihoods. Using observation and reanalysis datasets, this study explores the effect of the East Asian subtropical westerly jet stream (EAJ) on the CEC EHEs for the summers spanning 1979-2020. Considering its general relative location to the right side of the upper-level jet stream exit region, CEC would theoretically suffer more EHEs with a stronger and northwardly-shifted EAJ in summer due to the likelihood of abnormal subsidence induced by the EAJ. However, such an EAJ-EHE connection has been unstable over the past four decades but has displayed an evident interdecadal change. Before the late 1990s, the interannual variation of the EAJ was manifested mainly by its meridional displacement in the northeastern part of East Asia;thus, the atmospheric responses were essentially located to the east of CEC, exerting less of an influence on the CEC EHEs. However, since the late 1990s, the EAJ variation has featured an intensity change in its center over the northwest portion of the CEC, which has resulted in a westward shift in atmospheric responses to cover the CEC region. Therefore, the EAJ could potentially affect the summer CEC EHEs during 2000-21. Our findings offer support for an in-depth understanding of the formation mechanisms of extreme weather/climate events of this nature and thus provide a scientific reference for seasonal climate predictions.

关键词： summer extreme high-temperature events East Asian subtropical jet atmospheric circulation central-eastern China interdecadal change

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Geostatistics-block-based characterization of the relationship between rock mass quality and powder factor and its application on open-pit limit optimization

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International Journal of Mining Science and Technology 2025年第1期35卷 135-147页

作者： Jinduo Li Tianhong Yang Feiyue Liu Shigui Du Wenxue Deng Yong Zhao Honglei Liu Leilei niu Zhiqiang Xu Center for Rock Instability and Seismicity Research School of Resources&Civil EngineeringNortheastern UniversityShenyang 110819China State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and TechnologyHuainan 232001China Institute of Rock Mechanics Ningbo UniversityNingbo 315211China Shuguang Gold and Copper Open Pit Mine Zijin Mining Group Company LimitedHunchun 133300China

Accurately predicting the powder factor during blasting is essential for sustainable production planning in low-grade *** research presents a method for predicting powder factor based on the heterogeneity of rock mass rating(RMR).Considering a low-grade metal mine as an example,this study exploited geostatistical methods to obtain independent RMR for each block unit.A three-dimensional spatial distribution model for the powder factor was developed on the basis of the relationships between the RMR and the powder ***,models for blasting cost and mining value were built and employed to optimize the open-pit *** multi-variable model based on the RMR performed well in predicting the powder factor,achieving a correlation coefficient of 0.88(root mean square error of 4.3)and considerably outperforming the uniaxial compressive strength *** model optimization,the mean size and standard deviation of the fragments in the blast pile decreased by 8.5%and 35.1%,respectively,whereas the boulder yield and its standard deviation decreased by 33.3%and 58.8%,***,optimizing the open-pit limit using this method reduced the amount of rock,increased the amount of ore,and lowered blasting costs,thereby enhancing the economic efficiency of the *** study provides valuable insights for blasting design and mining decisions,demonstrating the advantages and potential applications of powder factor prediction based on the heterogeneity of rock mass quality.

关键词： Geostatistics method Powder factor Open-pit limit optimization Blasting cost Rock mass quality

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Impact of Energy Transition on CO2 Emissions in China's Cities

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Chinese Geographical Science 2025年第02期 250-261页

作者： DANG niu WANG Qiang KWAN Mei-po LIN Jian School of Geographical Sciences Fujian Normal University Key Laboratory for Humid Subtropical Eco-geographical Processes of the Ministry of Education School of Geographical Sciences Fujian Normal University Department of Geography and Resource Management and Institute of Space and Earth Information Science The Chinese University of Hong Kong School of Geography Nanjing Normal University

Reducing global carbon dioxide（CO2） emissions is essential for meeting climate change mitigation goals, especially in urban areas. In this regard, this study used CO2emissions and energy transition data from 296 China's cities in 2020 and the extended Stochastic Impacts by Regression on Population, Affluence, and Technology（STIRPAT） model to explore the relationship between energy transition and CO2emissions at the city-scale. The findings indicate a spatial distribution of energy transition magnitude that is high in the west and low in the east, which does not align with economic status and total CO2emissions, posing significant challenges for China's energy transition and urban CO2reduction. The STIRPAT model reveals that urban CO2emissions are significantly driven by increases in population size, levels of economic development, and the expansion of transportation infrastructure. Conversely, investments in science and education, the expansion of the tertiary sector, and the disruptive effects of the COVID-19（Coronavirus Disease 2019） pandemic are associated with notable reductions in CO2emissions. Specifically, the analysis estimates that a 1.00% increase in the energy transition degree is associated witha 0.90% decrease in urban CO2emissions. However, regional assessments underscore considerable spatial heterogeneity in the energy transition effect, with CO2reduction benefits being less pronounced in central and western cities. These findings suggest that future clean energy initiatives should be strategically concentrated in eastern China, where the demand and potential for CO2mitigation are greater. This study deepens the understanding of the complex relationship between energy transition and urban CO2emissions, offering valuable insights to inform targeted policy interventions for carbon reduction at the city level.

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Surface controllable wettability using amphiphilic rotaxane molecular shuttles

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Chinese Chemical Letters 2025年第2期36卷 422-425页

作者： Dongpu Wu Zheng Yang Yuchen Xia Lulu Wu yingxia Zhou Caoyuan niu Puhui Xie Xin Zheng Zhanqi Cao College of Science Henan Agricultural University

Herein,an alkyne-terminated acid/base responsive amphiphilic [2]rotaxane shuttle was synthesized,and then modified onto the glass surface through “click” *** XPS N 1s spectrum and contactangle measurement were performed to prove the successful *** amphiphilic [2]rotaxane functionalized surface presented controllable wettability responding to external acid-base *** bistable rotaxane modified material system promoted the practical application of molecular machines.

关键词： Amphiphilic rotaxane Controllable wettability Stimuli-responsive

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Medium–Extended Range Forecasting of Meiyu in 2023: Performance of CMA and ECMWF GEPSs

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Journal of Meteorological Research 2025年第01期 193-210页

作者： Ruoyun niu Baiquan ZHOU Wei HUANG Yu GONG Couhua LIU National Meteorological Centre China Meteorological Administration Chinese Academy of Meteorological Sciences China Meteorological Administration Earth System Modeling and Prediction Centre China Meteorological Administration

Meiyu, featuring prolonged periods of rainfall over the Yangtze–Huai River basin(YHRB), not only replenishes water resources and sustains ecological balance, but also poses potential disaster risks. Accurate early forecasting of Meiyu is crucial for effectively implementing flood prevention strategies. To help refine numerical models and providing guidance for operational forecasters, this study explores the capabilities of two global ensemble prediction systems(GEPSs) of the China Meteorological Administration(CMA) and the ECMWF in forecasting the Meiyu characteristics in 2023 over the YHRB. Results show that the ECMWF GEPS reasonably forecasts the Meiyu rainfall, while the CMA GEPS presents a notable underestimation. The predictable lead time of the Meiyu onset date is eight days by the ECMWF GEPS and six days by the CMA GEPS, respectively. Regarding the regional rainstorm processes, the two GEPSs generally provide a predictable lead time of 48–168 h for reasonably forecasting the patterns of the heavy rainfall area. To further examine their strengths and weaknesses in Meiyu forecasting, this paper revisits their abilities in forecasting key influence systems. By verifying against their respective analyses, it is demonstrated that the ECMWF GEPS reasonably forecasts the spatial coverages of the northwestern Pacific subtropical high(NWPSH) and the South Asian high(SAH), whereas the CMA GEPS presents substantial underestimation. Both GEPSs show generally southward deviations for the eastern ridge line position(RLP) of the SAH, and exhibit a northward deviation for the western RLP of the NWPSH during early forecast lead times. The less Meiyu rainfall predicted by the CMA GEPS compared to the ECMWF GEPS can be attributed to its weaker low-level convergence belt and weaker upper-level divergence area. A deeper exploration into these forecast discrepancies in upper-level divergence and lower-level convergence suggests that they likely originate from their initial analys

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Event-triggered leader-follower bipartite consensus control for nonlinear multi-agent systems under DoS attacks

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Science China(Information Sciences) 2025年

作者： Wei SU Chaoxu MU Song ZHU Ben niu Changyin SUN School of Control Science and Engineering Tianjin University School of Mathematics China University of Mining and Technology School of Control Science and Engineering Dalian University of Technology School of Automation Southeast University

Aiming at the consensus control problem of nonlinear multi-agent systems (MASs) under directed topology, a leader-follower bipartite consensus control strategy is proposed. This strategy takes into account the potential for denial-ofservice (DoS) attacks and completely unknown system dynamics. Specifically, the bipartite consensus dynamics describes the cooperation and competition relationship between followers and the leader, that is, the follower chooses to move in accordance with or opposite to the leader according to its trajectory. In order to optimize the communication bandwidth and mitigate the impact of DoS attacks, the proposed consensus control scheme integrates the DoS attack detection mechanism and eventtriggered mechanism. In addition, neural networks (NNs) are used to solve the nonlinear problem, and a speed function is designed to achieve the desired tracking performance, ensuring that all agents’ tracking errors converge to a predefined set in a finite time. With the help of backstepping, graph theory, and Lyapunov stability theory, sufficient conditions for achieving bipartite consensus without Zeno behavior are established. Finally, the accuracy and feasibility of the theoretical analysis are verified by simulation cases.

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Vertical variations in planar lamination of marine shale: Elucidating hydrodynamic changes during the Ordovician-Silurian transition on the Upper Yangtze Block

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Journal of Palaeogeography 2025年第01期14卷 221-244页

作者： Zhen-Sheng Shi Tian-Qi Zhou Hui-Bo Song Yong-Bin niu Sha-Sha Sun Department of Unconventional Oil and Gas Research Institute of Petroleum Exploration and DevelopmentPetroChina College of Resources and Environment Henan Polytechnic University

The hydrodynamics and their evolution on the Upper Yangtze Block during the Ordovician-Silurian transition period remain unclear. The present study is an assessment of how regional and global events may have influenced the hydrodynamic evolution based on a planar lamination investigation of the shales from the Upper Yangtze Block. Analyses of large thin sections and argon-ion polished thin sections using field emission-scanning electron microscopy(FE-SEM) showed that there are four types of planar lamination, namely, silty graded planar lamination(SGPL), silt-clay graded planar lamination(SCGPL), silt-clay interlaminated planar lamination(SCIPL), and paper-like planar lamination(PPL). SGPL is formed by turbidity current with a flow speed less than 15 cm/s. SCGPL is formed by turbidity currents with a flow speed less than 15 cm/s for normal grading type and 15-25 cm/s for alternating grading type. SCIPL has a continuum of sparsely spaced type, closely spaced type, and alternating type, which is formed by bottom current with an increasing flow speed from 15 to 25 cm/s to above 25 cm/s. PPL can be divided into normal grading and composite grading types. The former is formed by vertical settling, while the latter is formed by bottom current with a flow speed of 5-15 cm/s. Vertically, types of planar lamination varied from SGPL to PPL and then SCIPL manifesting the waxing and waning of flow speed with a positive excursion at graptolite biozone Metabolograptus extraordinarius(WF4) and a negative excursion at graptolite biozone Persculptograptus persculptus(LM1). The sudden decrease in flow speed across Linxiang and graptolite biozone Paraorthograptus pacificus(WF3) and the subsequent progressive increase from graptolite biozone Akidograptus ascensus(LM2)to graptolite biozone Demirastrites triangulatus(LM6) and to graptolite biozone Stimulograptus sedgwickii(LM8) during deposition of the Ordovician-Silurian transition succession on the Upper Yangtze Block were linked to th

关键词： Planar lamination Wufeng Formation Longmaxi Formation Ocean circulation Black shale

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Insights into novel indium catalyst to kW scale low cost,high cycle stability of iron-chromium redox flow battery

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Green Energy & Environment 2025年第2期10卷 410-421页

作者： yingchun niu yinping Liu Tianhang Zhou Chao Guo Guangfu Wu Wenjie Lv Ali Heydari Bo Peng Chunming Xu Quan Xu State Key Laboratory of Heavy Oil Processing China University of Petroleum(Beijing)Beijing102249China Department of Applied Physics Aalto UniversityFI-00076AaltoFinland

Iron-chromium flow batteries(ICRFBs)have emerged as an ideal large-scale energy storage device with broad application prospects in recent *** of the Cr^(3+)/Cr^(2+)redox reaction activity and inhibition of the hydrogen evolution side reaction(HER)are essential for the development of ICRFBs and require a novel catalyst ***,elucidating the underlying mechanisms for modulating catalyst behaviors remains an unresolved ***,we show a novel precisely controlled preparation of a novel thermal-treated carbon cloth electrode with a uniform deposit of low-cost indium catalyst *** density functional theory analysis reveals the In catalyst has a significant adsorption effect on the reactants and improves the redox reaction activity of Cr^(3+)/Cr^(2+).Moreover,H+is more easily absorbed on the surface of the catalyst with a high migration energy barrier,thereby inhibiting the occurrence of *** assembled ICRFBs have an average energy efficiency of 83.91%at 140 mA cm^(-2),and this method minimizes the electrodeposition process and cleans the last obstacle for industry long cycle operation *** ICRFBs exhibit exceptional long-term stability with an energy efficiency decay rate of 0.011%per cycle at 1000 cycles,the lowest ICRFBs reported so ***,this study provides a promising strategy for developing ICRFBs with low costs and long cycle life.

关键词： Iron-chromium flow batteries In catalyst Hydrogen evolution side reaction Cycle stability Industry usage

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The current status and influencing factors of the coexistence of multiple frailty domains in patients with chronic heart failure

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Chinese Journal of Nursing 2025年第3期60卷 311-318页

作者： Wang, Sipei Wang, Yan niu, Weihua Yang, Huifeng 天津中医药大学护理学院天津市300167 天津市第一中心医院心内科

Objective To investigate the status and influeneing factors of the eoexistenee of multiple frailty domains in patients with chronic heart failure(CHF), and to provide a reference for formulating targeted intervention measures. Methods The patients with CHF hospitalized in the cardiovascular department of a tertiary general hospital in Tianjin from November 2021 to December 2022 were conveniently selected as the study subjects. The self-designed general information questionnaire, FRAIL scale, Montreal Cognitive Assessment (MoCA) scale, HALFT Scale, Social Support Rating Scale and Self-Rating Depression Scale were used to investigate the coexistence of physical, cognitive and social frailty in CHF patients, and single factor analysis and binary logistic regression analysis were used to analyze the influencing factors. Results A total of 275 questionnaires were issued and 269 valid questionnaires were collected. Among 269 patients with CHF, 12(4.5%), 67(24.9%), 122(45.4%) and 68(25.3%) patients had 0, 1, 2 and 3 frailty domains, respectively. According to the patients with CHF whether coexists physical, cognitive, social frailty, divided into coexistence and non-coexistence group. In univariate analysis, there were statistically significant differences in education, residence, family history of cardiovascular disease, NYHA cardiac function grade, atrial fibrillation, BMI, social support score and depression score(P<0.05). Binary logistic regression analysis showed that high education level(OR =0.567, 95%CI 0.397-0.810, P=0.002) was the protective factor for multiple frailty domains in CHF patients, and atrial fibrillation(OR=1.904, 95%CI 1.054-3.442, P=0.033) and depression(OR=1.038, 95%CI 1.006-1.071, P=0.018) were risk factors. Conclusion The prevalence of the coexistence of multiple frailty domains in CHF patients is high. Education level, atrial fibrillation and depression are potential intervention targets for multiple frailty domains in CHF patients. Targeted int

关键词： Chronic Heart Failure Frailty Nursing Care Root Cause Analysis

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