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RETROSPECTIVE ANALYSIS OF MAGNETIC RESONANCE MYOCARDIAL DELAYED ENHANCEMENT

Chinese Medical Sciences Journal 2006年第4期21卷 245-251页

作者： Zhu-hua Zhang Qi Miao Song-bai Lin Shu-yang Zhang Li-bo Chen Heng Zhang yi-ning wang Lu Zhou Lin-yan Kong Feng Feng Hui You Hong-yi Sun Wen-min Zhao Li-ren Zhang Zheng-yu Jin Department of Radiology Department of Cardiac Surgery Special Medical Care Center Department of Cardiology Department of Nuclear Medicine Peking Union Medical CollegeHospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To explore the imaging and related clinical characteristics of magnetic resonance （MR） delayed enhancement in patients with ischemic or nonischemic heart disease. Methods Thirty-two cases who underwent MR myocardial cine and delayed enhancement imaging from January 2004 to October 2006 were retrospectively analyzed. The cine sequence imaging included the four-chamber view and the left ventricular short axis view. The delayed enhancement imaging was taken 10 minutes after the infusion of gadolinium from the antecubital vein with a segmented inversion-recovery-prepared Tl-weighted fast gradient echo sequence. Patients underwent coronary computed tomography angiography （CTA） two weeks before or after the MR imaging examination. Combined with clinical history, the clinical and MR imaging characteristics of the patients who had delayed enhancement were analyzed. Results MR delayed enhancement could be found in 16 cases. Among them, 12 cases had ischemic heart disease. Their coronary CTA showed one to three vessel diseases. The delayed enhancement was transmural or subendocardium, and the area of delayed enhancement corresponded well with one or more coronary arteries which had severe stenosis or occlusion. Four cases had nonischemic heart diseases One case was dilated cardiomyopathy, with diffuse small midwall spots in delayed enhancemen and only 30% stenosis of the anterior descending coronary artery in coronary CTA. One case was hypertrophic cardiomyopathy, with delayed enhancement of strip- and patch-shaped at midwall of the hypertrophic myocardiurn. One case was restrictive cardiomyopathy, and the delayed enhancement was located in the area of subendocardium of both the right and left ventricles. Coronary CTA of these two cases were normal The other case was a mass of the lateral wall of the left ventricle, and the delayed enhancement with a clumpy shape was located in the lateral wall of the left ventricle. Conclusions MR myocardial delayed enhancement

关键词： cardiac imaging magnetic resonance imaging contrast enhancement

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CORONARY ANGIOGRAPHY WITH DUAL SOURCE COMPUTED TOMOGRAPHY:INITIAL EXPERIENCE

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Chinese Medical Sciences Journal 2007年第4期22卷 205-210页

作者： Zhu-hua Zhang Zheng-yu Jin Shu-yang Zhang Song-bai Lin Dong-jing Li Ling-yan Kong yi-ning wang Lan Song Yun wang Wen-min Zhao Wen-bin Mou Li-ren Zhang Wen-ling Zhu Qi Miao Qi Fang Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Department of Cardiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Special Medical Care Center Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Department of Cardiac Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To explore the scan technique and image quality of coronary angiography with dual source computed tomography(CT) without oral metoprolol *** Plain and enhanced dual source CT coronary angiography without oral metoprolol preparation was prospectively performed in 600 *** scoring with plain scan images as well as multi-planar reconstruction(MPR),maximum intensity projection(MIP),and volume rendering technique(VRT) reconstruction with enhanced scan images were performed in all *** scan technique and post-reconstruction experience was *** image quality was classified as 1 to 4 points,and coronary segments classified according to the American Heart Association standards were *** The average calcium score of the 600 cases was 213.6±298.7(0-3 216.5).The average heart rate of the enhanced scan was 82.1±16.2(47-139) *** post-reconstruction methods with which coronary segments could be shown as best as possible consisted of single phase reconstruction method,two or more phases supplemented method,and electrocardiogram editing *** 8 457 coronary segments were evaluated,among which 97.2% were evaluated as point 1,1.7% point 2,0.5% point 3,and 0.6% point *** coronary segments in 261 cases were completely normal,while 360 segments were diagnosed with <50% stenosis and 625 segments with ≥50% *** Excellent coronary artery image can be obtained with dual source CT in patients with any heart rate without oral metoprolol *** rate is not a major source of the artifact,coronary segments can be well shown with single or multiple-phase reconstruction method.

关键词： computed tomography coronary angiography coronary heart disease

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二氧化钛-活性炭纤维混合材料净化室内甲醛污染

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四川大学学报（工程科学版） 2004年第4期36卷 41-44页

作者：侯一宁王安王燕四川大学建筑与环境学院四川成都610065

将常温吸附和光催化降解两种作用相结合,寻求一种简单有效的治理室内空气中低浓度甲醛污染的方法。分别选用活性炭纤维(ACF)和二氧化钛(TiO2)作为吸附剂和光催化剂,取室内甲醛的浓度0.3mg/m3作为初始浓度,测定出在25℃时ACF、TiO2和(ACF... 详细信息

将常温吸附和光催化降解两种作用相结合,寻求一种简单有效的治理室内空气中低浓度甲醛污染的方法。分别选用活性炭纤维(ACF)和二氧化钛(TiO2)作为吸附剂和光催化剂,取室内甲醛的浓度0.3mg/m3作为初始浓度,测定出在25℃时ACF、TiO2和(ACF+TiO2)混合材料(ACF/TiO2的质量比为1∶0.5)3种净化剂的动态等温净化量随时间的变化规律。结果表明:在太阳光照下,TiO2和(ACF+TiO2)混合材料均有相应的饱和净化量,而用紫外灯照射之后,两者的净化量都有明显增加。ACF、TiO2和(ACF+TiO2)混合材料3种净化剂的饱和净化量由大到小的排列为:(ACF+TiO2)混合材料>ACF>TiO2且有(ACF+TiO2)混合材料>ACF+TiO2;TiO2在太阳光照下具有降解活性,紫外光照可明显增强其活性。新(ACF+TiO2)混合材料比ACF或TiO2单独作用的效果更好。ACF与TiO2的质量比为1∶0.5时去除效果最好。

关键词：二氧化钛活性炭纤维光催化氧化甲醛

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Chinese expert consensus on the non-invasive imaging examination pathways of stable coronary artery disease

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Journal of Geriatric Cardiology 2018年第1期15卷 30-40页

作者： Yun-Dai CHEN Wei-yi FANG Ji-Yan CHEN Zhan-Ming FAN Chuan-Yu GAO Jun-Bo GE Zuo-Xiang HE Yong HUO Lang LI Si-Jin LI Xi-Lie LU Bin LV Ju-ying QIAN Ya-Jun SHI Zhu-Jun SHEN Jing wang yi-ning wang Lei XU Li YANG Bo YU Mei ZHANG Jun-Jie YANG Shu-Yang ZHANG Xiao-Li ZHANG Shi-Hua ZHAO Yang ZHENG Yu-Chi HAN Guang ZHI Chinese PLA General Hospital Beijing China Shanghai Chest Hospital Shanghai Jiaotong University Shanghai China Guangdong General Hospital Guangzhou China Beijing Anzhen Hospital Capital Medical University Beijing China Henan Provincial People's Hospital Zhengzhou China Zhongshan Hospital Fudan University Shanghai China Fuwai Hospital Chinese Academy of Medical Sciences Beijing China The First Hospital of Peking University Beijing China The First Affiliated Hospital of Guangxi Medical University Nanning China The First Affiliated Hospital of Shanxi Medical University Taiyuan China Peking Union Medical College Hospital Beijing China The 2^nd Affiliated Hospital of Harbin Medical University Harbin China Qilu Hospital of Shandong University Jinan China The First Bethune Hospital of Jilin University Changchun China University of Pennsylvania United States

1 Introduction Early detection and diagnosis of stable coronary artery disease （SCAD） is essential for proactive secondary prevention of myocardial infarction （MI）, control of disease progress, and reduction of mortality. Clinical decision-making in modem medicine is increasingly dependent on cardiovascular imaging techniques. 2012 ACCF/AHA/ACP/AATS/ PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease has been issued by American Heart Association （AHA）. European Society of Cardiology （ESC） has issued 2013 ESC guidelines on the management of stable coronary artery disease.

关键词： Expert consensus Clinical pathway Coronary artery disease Non-invasive imaging examination Pre-test probabilities

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The pivotal role of microglia in injury and the prognosis of subarachnoid hemorrhage

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Neural Regeneration Research 2025年第7期20卷 1829-1848页

作者： Wenjing ning Shi Lv Qian wang Yuzhen Xu Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina Department of Central Laboratory The Affiliated Taian City Central Hospital of Qingdao UniversityTaianShandong ProvinceChina

Subarachnoid hemorrhage leads to a series of pathological changes,including vascular spasm,cellular apoptosis,blood–brain barrier damage,cerebral edema,and white matter ***,which are the key immune cells in the central nervous system,maintain homeostasis in the neural environment,support neurons,mediate apoptosis,participate in immune regulation,and have neuroprotective *** evidence has shown that microglia play a pivotal role in the pathogenesis of subarachnoid hemorrhage and affect the process of injury and the prognosis of subarachnoid ***,microglia play certain neuroprotective roles in the recovery phase of subarachnoid *** approaches aimed at modulating microglia function are believed to attenuate subarachnoid hemorrhage *** provides new targets and ideas for the treatment of subarachnoid ***,an in-depth and comprehensive summary of the role of microglia after subarachnoid hemorrhage is still *** review describes the activation of microglia after subarachnoid hemorrhage and their roles in the pathological processes of vasospasm,neuroinflammation,neuronal apoptosis,blood–brain barrier disruption,cerebral edema,and cerebral white matter *** also discusses the neuroprotective roles of microglia during recovery from subarachnoid hemorrhage and therapeutic advances aimed at modulating microglial function after subarachnoid ***,microglia in subarachnoid hemorrhage are targeted with TLR inhibitors,nuclear factor-κB and STAT3 pathway inhibitors,glycine/tyrosine kinases,NLRP3 signaling pathway inhibitors,Gasdermin D inhibitors,vincristine receptorαreceptor agonists,ferroptosis inhibitors,genetic modification techniques,stem cell therapies,and traditional Chinese ***,most of these are still being evaluated at the laboratory *** clinical studies and data on subarachnoid hemorrhage are required to improve the treatment of subarachnoid hemor

关键词： apoptosis blood–brain barrier brain edema microglia neuroinflammation neuron neuroprotection subarachnoid hemorrhage vasoconstriction white matter injury

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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu yi-Hua wang yi-Xin Liu Lu Xu Lin Fu ning yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

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Assessment of Coronary Stents by 64-slice Computed Tomography: In-stent Lumen Visibility and Patency

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Chinese Medical Sciences Journal 2009年第3期24卷 156-160页

作者： Ling-yan Kong Zheng-yu Jin Shu-yang Zhang Zhu-hua Zhang yi-ning wang Lan Song Xiao-na Zhang Yun-qing Zhang Department of Radiology Department of Cardiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To assess lumen visibility of coronary stents by 64-slice computed tomography （CT） coronary angiography, and determine the value of 64-slice CT in non-invasive detecting of in-stent restenosis after coronary artery stent implantation. Methods Totally, 60 patients （54 males, aged 57.0±12.7 years） and /05 stents were investigated by 64-slice CT at a mean interval of 20.0±16.6 months after coronary stents implantation. Axial multi-planar reconstruction images of the stents and curved-planar reconstruction images through the median of the stents were reconstructed for evaluating stent image quality on a 5-point scale （1=excellent, 5=nonassessable）, and stent lumen diameter was detected. Conventional coronary angiography was performed in 18 patients, and 32 stents were evaluated. Results Image quality was good to excellent on average （score 1.71±0.76）. Stent image quality score was correlated to heart rate （r=0. 281, P〈0.01） and stent diameter （r=-0.480, P〈0.001）. All the stents were assessable in lumen visibility with an average visible lumen diameter percentage of 60.7%±13.6%. Visible lumen diameter percentage was correlated to heart rate （r=-0.193, P〈0.05）, stent diameter （r=0.403, P〈0.001）, and stent image quality score （r=-0.500, P〈0.001）. Visible lumen diameter percentage also varied depending on the stent type. In comparison with the conventional coronary angiography, 4 of 6 in-stent stenoses were correctly detected. The sensitivity and specificity for the detection of in-stent stenosis were 66.7% and 84.6%, respectively. Conclusions Using a 64-slice CT, the stent lumen is partly visible in most of the stents. And 64-slice CT may be useful in the assessment of stent patency.

关键词： coronary artery in-stent restenosis computed tomography

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泪小管塞栓治疗重度慢性眼移植物抗宿主病的安全性和有效性

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国际眼科杂志 2023年第7期23卷 1218-1224页

作者：王贺阴小月张照委王仡宁张玲赵颖奕李明新徐州医科大学附属医院眼科中国江苏省徐州市221000 徐州医科大学研究生学院中国江苏省徐州市221004

目的:评估泪小管塞栓治疗重度慢性眼移植物抗宿主病(coGVHD)的安全性和有效性。方法:回顾性研究。纳入2022-06/09就诊于徐州医科大学附属医院干眼门诊的重度coGVHD患者9例,均行双眼下泪小管塞栓术。观察术前、术后1、3mo眼表疾病指数(OS... 详细信息

目的:评估泪小管塞栓治疗重度慢性眼移植物抗宿主病(coGVHD)的安全性和有效性。方法:回顾性研究。纳入2022-06/09就诊于徐州医科大学附属医院干眼门诊的重度coGVHD患者9例,均行双眼下泪小管塞栓术。观察术前、术后1、3mo眼表疾病指数(OSDI)评分、泪河高度(TMH)、角膜荧光素染色评分(CFS)、结膜丽丝胺绿染色评分(CLGS)、非接触式泪膜破裂时间(NIBUT)、SchirmerⅠ试验(SⅠt)和使用共聚焦角膜显微镜检测角膜浅基质层浸润的朗格汉斯细胞密度,记录并发症发生情况。结果:术后3mo,患者OSDI评分为21.89±6.07分,较术前(67.33±12.64分)下降(P<0.01);TMH术后3mo为0.21±0.03mm较术前0.09±0.02mm上升(P<0.05);NIBUT术后3mo为6.77±2.05s较术前2.24±0.68s上升(P<0.01)。CFS和CLGS术后3mo为2.22±0.67、2.56±0.88分较术前(9.11±1.45、6.33±1.00分)下降(均P<0.01)。朗格汉斯细胞密度术后3mo为39.67±9.75cells/mm~2较术前140.22±38.18cells/mm~2下降(P<0.01)。SⅠt手术前后无差异(F=0.059,P=0.943)。随访期间未观察到栓子脱落等并发症发生。结论:泪小管塞栓治疗重度coGVHD安全有效,可显著改善干眼患者症状体征,减轻炎症反应。

关键词：泪小管塞栓移植物抗宿主病干眼

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离散平面Voronoi图的光栅图形算法

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四川大学学报（自然科学版） 2003年第3期40卷 596-599页

作者：罗以宁王开平四川大学计算机学院成都610064

The data structure and the raster graphics algorithm for producing the Voronoi in discrete plane preseted. Delaunay triangulation can be realized on the basis of the data structure. The algorithm after simply expanded... 详细信息

关键词：计算机图形学 Voronoi图光栅图形生成算法离散二维平面数据结构

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Factors Influencing Pregnancy Outcome Following Slow Cooling Cryoembryo Transfer and Risk of Multiple Conception

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Journal of Reproduction and Contraception 2008年第2期19卷 93-100页

作者： Su-ying LIU Jin-lan HAN Bin TENG Zhu-di LU Yu ZHENG ying CAO Xiang CAO ning-yi wang Bin HUANG Jing-ming YAN Shanghai Jiai Genetics ＆ IVF Institute Obstetrics ＆ Gynecology Hospital Fudan University Shanghai 200011 China

Objective To investigate the factors that influence the potential for cryoembryo implantation and multiple pregnancy. Methods In this retrospective study, a total of 93 7 thawing cycles （859 couples） in which 3286 d 3-embryos were thawed. Rates of implantation, clinical pregnancy and multiple conception following FET were observed. Results There were significant differences in female age （P〈0.05） and number of good quality embryos （P〈0. 05） between cycles that resulted in pregnancy and those did not. There was a trend toward decreasing rates of implantation, clinical pregnancy and multiple pregnancy with increasing female age. Compared with transferring 1 good quality embryo, clinical pregnancy rate of transferring 2 and 3 good quality embryos was increased significantly （P〈0. 001）, there was no significant difference in clinical pregnancy rate between transferring 2 and 3 good quality embryos. Multiple pregnancy rate was increased significantly in the group of transferring 3 good quality embryos （P〈0.05）,but there was no significant differences in multiple pregnancy rate between transferring 1 and 2 good quality embryos. Younger women （≤ 30 years） also had a significantly higher multiple pregnancy rates （28.13%） than the older ones（〉35 years）（13.64%）. With an increase in age from ≤ 30 years to〉40 years, clinical pregnancy rate declined from 47 61% to 25.00%.Conclusion Female age and the number of gooa quality embryos transferred are important factors influencing the clinical and multiple pregnancy rate, reducing the number of good quality embryos transferred may decrease the rate of multiple pregnancy but do not affect the clinical pregnancy rate.

关键词： in vitro fertilization cryopreservation embryo transfer clinical pregnancy multiple pregnancy

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