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Constitutive aryl hydrocarbon receptor facilitates the regenerative potential of mouse bone marrow mesenchymal stromal cells

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World Journal of Stem Cells 2023年第8期15卷 807-820页

作者： Jing Huang yi-ning wang yi Zhou State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhan 430079Hubei ProvinceChina

BACKGROUND Bone marrow mesenchymal stromal cells(BMSCs)are the commonly used seed cells in tissue *** hydrocarbon receptor(AhR)is a transcription factor involved in various cellular ***,the function of constitutive AhR in BMSCs remains *** To investigate the role of AhR in the osteogenic and macrophage-modulating potential of mouse BMSCs(mBMSCs)and the underlying *** Immunochemistry and immunofluorescent staining were used to observe the expression of AhR in mouse bone marrow tissue and *** overexpression or knockdown of AhR was achieved by lentivirus-mediated *** osteogenic potential was observed by alkaline phosphatase and alizarin red *** mRNA and protein levels of osteogenic markers were detected by quantitative polymerase chain reaction(qPCR)and western *** coculture with different mBMSCs,the cluster of differentiation(CD)86 and CD206 expressions levels in RAW 264.7 cells were analyzed by flow *** explore the underlying molecular mechanism,the interaction of AhR with signal transducer and activator of transcription 3(STAT3)was observed by co-immunoprecipitation and phosphorylation of STAT3 was detected by western *** AhR expressions in mouse bone marrow tissue and isolated mBMSCs were *** overexpression enhanced the osteogenic potential of mBMSCs while AhR knockdown suppressed *** ratio of CD86+RAW 264.7 cells cocultured with AhR-overexpressed mBMSCs was reduced and that of CD206+cells was *** directly interacted with *** overexpression increased the phosphorylation of *** inhibition of STAT3 via stattic,the promotive effects of AhR overexpression on the osteogenic differentiation and macrophage-modulating were partially *** AhR plays a beneficial role in the regenerative potential of mBMSCs partially by increasing phosphorylation of STAT3.

关键词： Aryl hydrocarbon receptor Bone marrow mesenchymal stromal cells Osteogenesis Macrophage Signal transducer and activator of transcription 3 Interaction

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Phosphine-Catalyzed [4+3] Annulation Reaction of Indole Derivatives with MBH Carbonates:A Facile Access to Indole-1,2-fused 1,4-Diazepinones and Azepines

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Chinese Journal of Chemistry 2024年第3期42卷 271-275页

作者： Yannan Zhu Haoran Jiang yi-ning wang Faculty of Chemistry and Chemical Engineering Yancheng Institute of TechnologyYanchengJiangsu224051 China

A phosphine-catalyzed [4+3] annulation between dinucleophilic indole derivatives and Morita−Baylis−Hillman (MBH) carbonates was discovered by using the N1 and N4′/C4′ nucleophilicities of the indole precursors,in which indoles act as four atom synthons. This protocol provides an efficient and facile access to indole-1,2-fused 1,4-diazepinones and azepines in good to high yields in one step,which illustrates potential synthetic utilities in drug discovery.

关键词： Phosphine catalysis [4+3]Annulation Indole derivatives Nitrogen heterocycles Organocatalysis

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Evaluation of the osseointegration of dental implants coated with calcium carbonate:an animal study

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International Journal of Oral Science 2017年第3期9卷 133-138页

作者： yi Liu yi Zhou Tao Jiang You-De Liang Zhen Zhang yi-ning wang Department of Stomatology Huangshi Central HospitalAffiliated Hopsital of Hubei Polytechnic UniversityEdong Healthcare GroupHuangshiChina The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of EducationSchool and Hospital of StomatologyWuhan UniversityWuhanChina

In an attempt to overcome the limitations of titanium in dental and orthopaedic clinical applications, a new method has been developed to prepare calcium carbonate coatings on sandblasted and acid-etched （SA） titanium implants. The purpose of this study was to investigate the effect of calcium carbonate-SA （CC-SA） implants on osseointegration in vivo. The surfaces of SA and CC-SA implants were characterised for surface morphology and surface chemistry. Subsequently, these two kinds of implants were implanted in the femoral condyles of rabbits. The implants were retrieved and prepared for histological and histomorphometric evaluation 1, 2, 4, 8 and 12 weeks after implantation. Significantly higher values of bone-to-implant contact of the entire implant except the gap area （BIC_ALL） and the bone-to-implant contact of the gap area （BIC_GAP） were found in animals with the CC-SA implants than in those with the SA implants at 4 weeks. Higher values of total gap bone were found in those with the CC-SA implants than in those with the SA implants at 1, 2 and 4 weeks. In conclusion, the current findings demonstrate that the calcium carbonate coating can improve and accelerate the early ingrowth of bone and osseointegration at the early healine phase. This may reduce clinical healinE times and thus improve implant success rates.

关键词： calcium carbonate histomorphometry in vivo osseointegration titanium

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Fe_(3)O_(4)@Angelica sinensis polysaccharide nanoparticles as an ultralow-toxicity contrast agent for magnetic resonance imaging

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Rare Metals 2021年第9期40卷 2486-2493页

作者： Kai wang Xiao-Guang Xu ying-Li Ma Chun-Rui Sheng Li-Na Li Li-ying Lu Jian wang yi-ning wang Yong Jiang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China School of Instrumentation Science and Optoelectronics Engineering Beihang UniversityBeijing 100191China School of Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China School of Chemistry and Biological Engineering University of Science and Technology BeijingBeijing 100083China Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical SciencesBeijing 100730China

Although iron oxide(Fe_(3)O_(4)) nanoparticles have broad application prospects as magnetic resonance imaging(MRI) contrast agent, their biocompatibility and biotoxicity still need to be improved. In this study, we prepared Fe_(3)O_(4)@Angelica sinensis polysaccharide nanoparticles(Fe_(3)O_(4)@ASP NPs) with a 9 nm Fe_(3)O_(4) core and ASP as the coating material. The Fe_(3)O_(4)@ASP NPs are superparamagnetic, can be taken up by liver and spleen macrophages in the circulatory system in vivo, and are a good-biocompatibility and low-toxicity transverse relaxation time(T_(2)) and T_(2)-star(T_(2)^(*)) magnetic resonance imaging(MRI) contrast agent for the liver. The cytotoxicity assessment using HeLa cells and the pathological tests in mice validate that Fe_(3)O_(4)@ASP NPs have low toxicity and good biocompatibility in vivo, which can be attributed to the ASP as a natural polysaccharide with good biocompatibility and its function of protecting the liver. Fe_(3)O_(4)@ASP NPs are a potential new MRI contrast agent with high signal intensity in vivo.

关键词： Superparamagnetic nanoparticles Fe_(3)O_(4) Angelica sinensis polysaccharide Magnetic resonance imaging Ultralow toxicity

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Wild type transthyretin amyloidosis,a reason not to be forgotten for heart failure of preserved ejection fraction in the elderly

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Journal of Geriatric Cardiology 2020年第12期17卷 793-796页

作者： Zhuang TIAN Chao REN Li HUO Xiao LI yi-ning wang Lun HUANG Ran TIAN Shu-Yang ZHANG Department of Cardiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Nuclear Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Jilin Central HospitalJilinChina

Amyloidosis is a multisystem disease that is characterized by deposition of fibrils in extracellular tissue,which mainly involves the kidney,heart,and autonomic nervous *** types of amyloidosis typically infiltrate the heart,including immunoglobulin light-chain(AL)and amyloid transthyretin(ATTR).ATTR is further subdivided into wild-type ATTR and variant ATTR caused by point mutations in the TTR gene.[1]Wild-type ATTR is considered as not uncommon in older patients with heart ***,a comprehensive set of consensus recommendations for the suspicion and diagnosis of ATTR was published,with particular focus on the combined application of noninvasive methods.[2]We present here a case of wild-type TTR cardiac amyloidosis(ATTRwt-CA),which was diagnosed by noninvasive modalities,and provide an overview of the recommended diagnostic approach of ***,to the best of our knowledge,this is the first Chinese case of ATTRwt-CA reported to date.

关键词： Amyloidosis Cardiomyopathy Heart failure Wild-type transthyretin 99mTC-Pyrophosphate scintigraphy

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Machine learning models for outcome prediction of Chinese uveal melanoma patients: A 15-year follow-up study

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Cancer Communications 2022年第3期42卷 273-276页

作者： Yu-ning Chen yi-ning wang Meng-Xi Chen Kai Zhang Rong-Tian Chen Rui Fang Heng wang Hai-Han Zhang yi-ning Huang Yu Feng Jing-Ting Luo yin-Jun Lan Yue-Ming Liu Yang Li Wen-Bin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100730P.R.China InferVision Healthcare Science and Technology Limited Company Shanghai 200030P.R.China

Dear Editor Uveal melanoma(UM)is the most frequent primary malig-nant intraocular tumor in adults with an estimated inci-dence of 4-5 per million per year in western countries[1].About 50%of UM patients eventually develop *** a previous study,the prognosis of Chinese UM was mainly correlated with visual clinical features and gene sequencing *** designed to predict UM prognosis have been previously described[2],but these studies were based on Caucasians,not Chinese.

关键词： melanoma patients prognosis

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ASSESSMENT OF MYOCARDIAL VIABILITY WITH CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING AND COMPARISON WITH SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY

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Chinese Medical Sciences Journal 2006年第4期21卷 239-244页

作者： yi-ning wang Zheng-yu Jin Zhu-hua Zhang Ling-yan Kong Li-bo Chen Lu Zhou Hong-yi Sun Heng Zhang Qi Miao Department of Radiology Department of Nuclear Medicine Department of CardiacSurgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730

Objective To compare contrast-enhanced magnetic resonance imaging （ceMRI） with nuclear metabolic imaging for the assessment of myocardial viability in patients with chronic ischemic heart disease. Methods Twenty patients with suspected chronic ischemic heart disease underwent ceMRI and technetium-99m sestamibi single-photon emission computed tomography （SPECT）. Patients with positive SPECT results also underwent 18 F-fluorodeoxyglucose （FDG） SPECT. In a 17-segment model, the segmental extent of hyperenhancement （SEH） by ceMRI was compared with segmental FDG and sestamibi uptake by SPECT. Correlation between the extent of hyperenhancement by ceMRI and left ventricular function was analyzed. Seven patients got negative results both in ceMRI and technetium-99m sestamibi SPECT. The rest 13 patients with positive results then underwent ^18F-FDG SPECT. In 221 segments of 13 patients, SEH was （2. 1±8.2）%, （25.0±13.7 ）%, and （57. 7±23.6 ）% in segments with normal metabolism/perfusion, metabolism/perfusion mismatch, and matched defects, respectively, and there were significant differences between either two of them （ all P 〈 0.05）. By receiver operating characteristic curve analysis, the area under the curve was 0. 95 for the differentiation between viable and non-viable segments. At the cutoff value of 34%, SEH optimally differentiated viable from non-viable segments defined by SPECT. Using this threshold, the sensitivity and specificity of ceMRI to detect non-viable myocardium as defined by SPECT were 92% and 93%, respectively. Hyperenhancement size by ceMRI was correlated negatively with the left ventricular ejection fraction （ r = - 0.90, P 〈 0.01 ） and positively with left ventricular volumes （ r = 0. 62 for end-diastolic volume, r = 0.75 for end-systolic volume, both P 〈 0.05 ）. Conclusion CeMRI allows assessment of myocardial viability with a high accuracy in patients with chronic ischemic heart disease.

关键词： magnetic resonance imaging single-photon emission computed tomography myocardialviability

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基于双因素wang转换方法的长寿风险债券定价研究

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财经理论与实践 2017年第4期38卷 32-38页

作者：樊毅张宁王耀中中南林业科技大学经济学院湖南长沙410004 湖南大学经济与贸易学院湖南长沙410079 湖南大学金融与统计学院湖南长沙410079

在比较国外经典债券设计的基础上,基于离散型死亡率模型假设,设计一种可调整上触碰点的触发型长寿债券,运用带永久跳跃的APC模型和双因素wang转换定价方法对长寿债券进行定价,实证结果表明:在不同的参数组合下的风险溢价均处在一个合理... 详细信息

在比较国外经典债券设计的基础上,基于离散型死亡率模型假设,设计一种可调整上触碰点的触发型长寿债券,运用带永久跳跃的APC模型和双因素wang转换定价方法对长寿债券进行定价,实证结果表明:在不同的参数组合下的风险溢价均处在一个合理的范围,由于模型参数多、可用死亡率数据年限短,风险溢价的结果对无风险利率等参数敏感性较高。

关键词：长寿风险债券双因素wang转换死亡率定价

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128-slice Dual-source Computed Tomography Coronary Angiography in Patients with Atrial Fibrillation: Image Quality and Radiation Dose of Prospectively Electrocardiogram-triggered Sequential Scan Compared with Retrospectively Electrocardiogram-gated Spiral

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Chinese Medical Sciences Journal 2012年第4期27卷 195-200页

作者： Lu Lin yi-ning wang Ling-yan Kong Zheng-yu Jin Guang-ming Lu Zhao-qi Zhang Jian Cao Shuo Li Lan Song Zhi-wei wang Kang Zhou Ming wang Department of Radiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Department of Radiology Nanjing General Hospital of Nanjing Military Command Department of Radiology Anzhen Hospital Affiliated to the Capital Medicine of University

Objective To evaluate the image quality （IQ） and radiation dose of 128-slice dual-source computed tomography （DSCT） coronary angiography using prospectively electrocardiogram （ECG）-triggered sequen- tial scan mode compared with ECG-gated spiral scan mode in a population with atrial fibrillation. Methods Thirty-two patients with suspected coronary artery disease and permanent atrial fibrilla- tion referred for a second-generation 128-slice DSCT coronary angiography were included in the prospec- tive study. Of them, 17 patients （sequential group） were randomly selected to use a prospectively ECG.~triggered sequential scan, while the other 15 patients （spiral group） used a retrospectively ECG-gated spiral scan. The IQ was assessed by two readers independently, using a four-point grading scale from excel- lent （grade 1） to non-assessable （grade 4）, based on the American Heart Association 15-segment model. IQ of each segment and effective dose of each natient were comDared between the two groups. Results The mean heart rate （HR） of the sequential group was 96±27 beats per minute （bpm） with a variation range of 73±25 bpm, while the mean HR of the spiral group was 86±22 bpm with a variationrange of 65±24 bpm. Both of the mean FIR （t= 1.91, P=0.243） and HR variation range （t=0.950, P=0.350） had no significant difference between the two groups. In per-segment analysis, IQ of the sequential group vs. spiral group was rated as excellent （grade 1） in 190/244 （78%） vs. 177/217 （82%） by readerl and 197/245 （80%） vs. 174/214 （81%） by reader2, as non-assessable （grade 4） in 4/244 （2%） vs. 2/217 （1%） by readerl and 6/245 （2%） vs. 4/214 （2%） by reader2. Overall averaged IQ per-patient in the sequential and spiral group showed equally good （1.27＋0.19 vs. 1.25＋0.22, Z=-0.834, P=0.404）. The effective radiation dose of the sequential group reduced significantly compared with the spiral group （4.88±1.77 mSv vs. 10.20±3.64 mSv; t=-5.372, P=0.000）. Conclusion Compared with retrospectively E

关键词： atrial fibrillation computed tomography coronary angiography prospectivelyelectrocardiogram-triggered sequential scan

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Catalytic Asymmetric Diastereodivergent Synthesis of 2-Alkenylindoles Bearing both Axial and Central Chirality

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Precision Chemistry 2024年第5期2卷 208-220页

作者： Shuang Yang Jia-Bo Huang Da-Hua wang ning-yi wang Yu-Yu Chen Xin-Yan Ke Hao Chen Shao-Fei Ni Yu-Chen Zhang Feng Shi Research Center of Chiral Functional Heterocycles School of Chemistry and Materials ScienceJiangsu Normal UniversityXuzhou 221116China Department of Chemistry Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong ProvinceShantou UniversityShantou 515063China Department of Otolaryngology Xuzhou First People’s HospitalAffiliated Xuzhou Municipal Hospital of Xuzhou Medical UniversityXuzhou 221002China School of Petrochemical Engineering Changzhou UniversityChangzhou 213164China

The catalytic asymmetric diastereodivergent synthesis of axially chiral 2-alkenylindoles was established via chiral phosphoric acid-catalyzed addition reactions of C3-unsubstituted 2-alkenylindoles with o-hydroxybenzyl alcohols under different reaction *** this strategy,two series of 2-alkenylindoles bearing both axial and central chirality were synthesized in a diastereodivergent fashion with moderate to high yields and good stereoselectivities(up to 99%yield,95:5 er,>95:5 dr).Moreover,theoretical calculations were performed on the key transition states leading to different stereoisomers,which provided an in-depth understanding of the origin of the observed stereoselectivity and diastereodivergence of the products under different reaction *** importantly,these 2-alkenylindoles were utilized in asymmetric catalysis as chiral organocatalysts and in medicinal chemistry for evaluation of their cytotoxicity,which demonstrated their potential *** study has not only established the catalytic atroposelective synthesis of axially chiral 2-alkenylindoles,but also provided an efficient strategy for catalytic asymmetric diastereodivergent construction of indole-based scaffolds bearing both axial and central chirality.

关键词： 2-Alkenylindole Axial chirality Central chirality Diastereodivergent synthesis Chiral phosphoric acid

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