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Intravitreal slow-release dexamethasone alleviates traumatic proliferative vitreoretinopathy by inhibiting persistent inflammation and Müller cell gliosis in rabbits

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 22-32页

作者： yi-ming zhao Rong-Sha Sun Fang Duan Fang-Yu Wang Yu-Jie Li Xiao-Bing Qian Jie-Ting Zeng Yao Yang Xiao-Feng Lin State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina Xi’an People’s Hospital(Xi’an Fourth Hospital) Shaanxi Eye HospitalXi’an 710004Shaanxi ProvinceChina

AIM:To evaluate the effects of intravitreal slow-release dexamethasone on traumatic proliferative vitreoretinopathy(PVR)and Müller cell gliosis and preliminarily explored the possible inflammatory mechanism in a rabbit model induced by penetrating ocular ***:Traumatic PVR was induced in the right eyes of pigmented rabbits by performing an 8-mm circumferential scleral incision placed 2.5 mm behind the limbus,followed by treatment with a slow-release dexamethasone implant(Ozurdex)or sham *** eyes were used as normal *** intraocular pressure(IOP)was monitored using an iCare *** severity was evaluated via anatomical and histopathological examinations every week for 6wk;specific inflammatory cytokine and proliferative marker levels were measured by quantitative real-time polymerase chain reaction,Western blot,protein chip analysis,or immunofluorescence ***:During the observation period,PVR severity gradually *** Müller cell gliosis was observed in the peripheral retina near the wound and in the whole retina of PVR *** significantly alleviated PVR development and Müller cell ***-traumatic inflammation fluctuated and was *** interleukin-1β(IL-1β)mRNA level was significantly upregulated,peaking on day 3 and increasing again on day 21 after *** expression of nod-like receptor family pyrin domain containing 3(NLRP3)showed a similar trend that began earlier than that of IL-1β*** suppressed the expression of IL-1β,NLRP3,and phosphorylated nuclear factor-kappa B(NF-κB).The average IOP after treatment was within normal ***:The present study demonstrates chronic and fluctuating inflammation in a traumatic PVR rabbit model over *** treatment significantly inhibites inflammatory cytokines expression and Müller cell gliosis,and thus alleviates PVR *** study highlights the important role of IL-1β,and Ozurdex inhibites inflammation pres

关键词： ocular trauma proliferative vitreoretinopathy gliosis Ozurdex inflammation rabbit

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Research progress on metal-organic framework compounds(MOFs)in electrocatalysis

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Journal of Environmental Sciences 2024年第7期141卷 261-276页

作者： Yutong Guo Shunzheng zhao Xiaolong Tang Honghong yi Department of Environmental Science and Engineering School of Energy and Environmental EngineeringUniversity of Science and Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants Beijing 100083China

Metal-organic frameworks(MOFs)have favorable characteristics such as large specific surface area,high porosity,structural diversity,and pore surface modification,giving them great potential for development and attractive prospects in the research area of modern materials ***,unsatisfactory catalytic activity and poor electronic conductivity are the main challenges facing *** review focuses on MOF-based materials used in electrocatalysis,based on the types of catalytic reactions that have used MOF-based materials in recent years along with their applications,and also looks at some new electrocatalytic materials and their future development prospects.

关键词： Metal-organic frame compounds Electrocatalysis Oxidation-reduction Nitrogen fixation to synthesize ammonia Carbon dioxide reduction

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Association of Chronic Kidney Disease with Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus： An Observational Cross-sectional Study in Hangzhou, China

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Chinese Medical Journal 2017年第1期130卷 57-63页

作者： Xue Sun Jie He Xiao-Li Ji yi-ming zhao Han-Yu Lou Xiao-Xiao Song Li-Zhen Shan ying-Xiu Kang Wen-Heng Zeng Xiao-Hong Pang Song-zhao Zhang Yue Ding Yue-Zhong Ren Peng-Fei Shan Department of Endocrinology and Metabolism The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Clinical Laboratory The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China

Background： Chronic kidney disease （CKD） is an independent risk factor for cardiovascular disease （CVD）. However, the association between CKD and CVD risk in patients with type 2 diabetes mellitus （T2DM） in China has not yet been well investigated. This study aimed to determine the association of CKD with the risks of coronary heart disease （CHD） and stroke in a Chinese population with T2DM. Methods： A total of 1401 inpatients with T2DM at the Second Affiliated Hospital of Zhejiang University School of Medicine between April 2008 and November 2013 were included in this study. The CKD-Epidemiology Collaboration equation for Asians was used to classify CKD. The UK Prospective Diabetes Study risk engine was used to estimate the risks of CHD and stroke. Results： CHD risk was significantly increased with CKD stage （20.1%, 24.8%, and 34.3% in T2DM patients with no CKD, CKD Stage 1-2, and Stage 3-5, respectively; P 〈 0.001 for all）. The stroke risk was also increased with CKD stage （8.6%, 12.7%, and 25.4% in T2DM patients with no CKD, CKD Stage 1-2, and Stage 3-5, respectively; P 〈 0.001 for all）. Compared with no-CKD group, the odds ratios （ORs） for high CHD risk were 1.7 （P 〈 0.001） in the CKD Stage 1-2 group and 3.5 （P 〈 0.001） in the CKD Stage 3-5 group. The corresponding ORs for high stroke risk were 1.9 （P 〈 0.001） and 8.2 （P 〈 0.001）, respectively. Conclusion： In patients with T2DM, advanced CKD stage was associated with the increased risks of CHD and stroke.

关键词： Chronic Kidney Disease Coronary Disease Stroke Diabetes Mellitus

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Homologous heterostructure of MoS_(2) and MoO_(2) coupled with carbon layers as cathode catalyst for rechargeable lithium-oxygen batteries

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Rare Metals 2024年第7期43卷 3383-3390页

作者： yi-ming Zhang zhao-Rui Zhou Lan-Ling zhao Ye-Bing Li Rui-Feng Li Ya Zhou Sana Shoukat Abulgasim-Ahmed-Abbaker Adam Jun Wang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJinan 250061China Shenzhen Research Institute of Shandong University Shenzhen 518063China School of Physics Shandong UniversityShenzhen 518063China

Lithium-oxygen batteries tend to experience high overpotentials because of the sluggish oxygen reduction reaction and oxygen evolution reaction during cycling.A potential solution to address this issue is to develop a... 详细信息

关键词： lithium process. kinetics

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Ultrahigh spatiotemporal resolution beam signal reconstruction with bunch phase compensation

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Nuclear Science and Techniques 2024年第5期35卷 99-108页

作者： You-ming Deng Yong-Bin Leng Xing-yi Xu Jian Chen yi-Mei Zhou Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of the Chinese Academy of Sciences Beijing 100049China Shanghai Synchrotron Radiation Facility Chinese Academy of SciencesShanghai 201204China University of Science and Technology of China Hefei 230026China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China

Various electromagnetic signals are excited by the beam in the acceleration and beam-diagnostic elements of a particle *** is important to obtain time-domain waveforms of these signals with high temporal resolution for research,such as the study of beam–cavity interactions and bunch-by-bunch parameter ***,a signal reconstruction algorithm with ultrahigh spatiotemporal resolution and bunch phase compensation based on equivalent sampling is proposed in this *** with traditional equivalent sampling,the use of phase compensation and setting the bunch signal zero-crossing point as the time reference can construct a more accurate reconstructed *** basic principles of the method,simulation,and experimental comparison are also *** on the beam test platform of the Shanghai Synchrotron Radiation Facility(SSRF)and the method of experimental verification,the factors that affect the reconstructed signal quality are analyzed and discussed,including the depth of the sampled data,quantization noise of analog-to-digital converter,beam transverse oscillation,and longitudinal *** results of the beam experiments show that under the user operation conditions of the SSRF,a beam excitation signal with an amplitude uncertainty of 2%can be reconstructed.

关键词： Turn-by-turn bunch phase compensation technique Equivalent sampling Signal reconstruction algorithm Ultrahigh spatiotemporal resolution SSRF

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Construction technology for deep tunnels crossing superhigh-temperature fault zones with high water surges

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Frontiers of Structural and Civil Engineering 2024年第8期18卷 1267-1280页

作者： Yong zhao Tingyu ZHU Li YU ming LU Sichuan–Xizang Railway Co. Ltd.Linzhi 860000China School of Civil Engineering Southwest Jiaotong UniversityChengdu 610036China

The harsh environment in tunnels with high geothermal temperatures and humidity can adversely impact machinery,personnel,and *** main causes of specific problems are the unknown mechanisms of local geothermal formation,inappropriate temperature control measures,and insufficient systematic *** this study,three work sections relating to a high geothermal tunnel are:the tunnel face,middle-of-tunnel section,and outside-oftunnel section.A cooling strategy is proposed to offer technical support in achieving comprehensive cooling,overall as well as for each of the ***,a comprehensive geological survey explores the mechanism and exact location of the heat ***,grouting and centralized drainage measures are used to control the heat release of hot *** ventilation,ice chillers and other applicable measures are used to control the ambient ***,a monitoring and early warning system is established to prevent *** cooling strategy has been applied in the field with good results.

关键词： high geothermal tunnels cooling strategy comprehensive cooling measures safety and security

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Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy:a precise construction of structurally diverse azaspiro polycyclic scaffolds

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Science China Chemistry 2024年第2期67卷 576-586页

作者： Xiao-Bao Wu Jun-Xiu Shi yi-ming Ou Hua-Jie Jiang yi-Jun Fang Qi-ming Wang Quan Gao Jie Yu Department of Applied Chemistry Anhui Province Engineering Laboratory for Green Pesticide Development and ApplicationAnhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Agricultural UniversityHefei230036China

A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic *** diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results(up to 99:1 e.r.,>95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(Ⅲ) complexes.

关键词： asymmetric catalysis post-Ugi transformation anionic stereogenic-at-cobalt(Ⅲ)complex azaspiro polycyclic scaffold one-pot synthesis

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Optical Transient Source AT2021lfa:A Possible“Dirty Fireball”

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Research in Astronomy and Astrophysics 2024年第4期24卷 124-133页

作者： Xue-Mei Ye Da-ming Wei yi-ming Zhu Zhi-Ping Jin Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China National Astronomical Observatories/Nanjing Institute of Astronomical Optics&Technology Chinese Academy of SciencesNanjing 210042China CAS Key Laboratory of Astronomical Optics&Technology Nanjing Institute of Astronomical Optics&TechnologyNanjing 210042China

AT2021lfa,also known as ZTF21aayokph,was detected by the Zwicky Transient Facility on 2021 May 4,a 05:34:48 ***-up observations were conducted using a range of ground-based optical telescopes,as wel as Swift/XRT and VLA ***2021lfa is classified as an“orphan afterglow”candidate due to its rapid flux decline and its reddened color(g-r=0.17±0.14 mag).For an optical transient source without promp gamma-ray detection,one key point is to determine its burst *** we measure the burst time through fitting the initial bump feature of AT2021lfa and obtain its burst time as 2021 May 3,at 22:09:50 *** afterglowpy,we model the multi-band afterglow of AT2021lfa and find that the standard model canno reproduce the late radio observations *** that the microphysical parameters ε_(e),ε_(B)(the energy fraction given to electrons and magnetic field),andξN(the fraction of accelerated electrons)may vary with time we then model the afterglow of AT2021lfa taking into account the temporal evolution of the physical parameters ε_(e),ε^(B),and ξ_(N) and find in this case the multi-wavelength observations can be reproduced *** initial Lorentz factor of AT2021lfa can be estimated from the peak time of the early afterglow,which yields a value of about 18 suggesting that AT2021lfa should be classified as a“dirty fireball.”From the upper limit for the prompt emission energy of AT2021lfa,we obtain that the radiation efficiency is less than 0.02%,which is much smaller than that of ordinary gamma-ray bursts(GRBs).It is also interesting that the fitted values of jet angle and viewing angle are very large,θ_(c)~0.66 rad,θ_(v)~0.53 rad,which may lead to the low Lorentz factor and radiation *** compared with GRB afterglow samples,it is evident that the onset bump timescale of AT2021lfa satisfies the empirical relationships observed in GRB ***,the luminosity of AT2021lfa falls within the range of observations for GRB samples;howeve

关键词： gamma-rays:ISM methods:numerical radiation mechanisms:non-thermal

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Exploring the impacts of major events on the systemic risk of the international energy market

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Petroleum Science 2024年第2期21卷 1444-1457页

作者： ming-Tao zhao Su-Wan Lu Lian-Biao Cui School of Statistics and Applied Mathematics Anhui University of Finance and EconomicsBengbu233030AnhuiChina Anhui Province Key Laboratory of Philosophy and Social Science of Low-Carbon Development and Carbon Finance Anhui University of Finance and EconomicsBengbu233030AnhuiChina

This study examines the systemic risk caused by major events in the international energy market(IEM)and proposes a management strategy to mitigate it. Using the tail-event driven network(TENET)method, this study constructed a tail-risk spillover network(TRSN) of IEM and simulated the dynamic spillover tail-risk process through the cascading failure mechanism. The study found that renewable energy markets contributed more to systemic risk during the Paris Agreement and the COVID-19pandemic, while fossil energy markets played a larger role during the Russia-Ukraine conflict. This study identifies systemically important markets(SM) and critical tail-risk spillover paths as potential sources of systemic risk. The research confirms that cutting off the IEM risk spillover path can greatly reduce systemic risk and the influence of SM. This study offers insights into the management of systemic risk in IEM and provides policy recommendations to reduce the impact of shock events.

关键词： International energy market Tail-risk spillover Cascading failure mechanism Systemic risk management

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Assessment of Wet Season Precipitation in the Central United States by the Regional Climate Simulation of the WRFG Member in NARCCAP and Its Relationship with Large-Scale Circulation Biases

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Advances in Atmospheric Sciences 2024年第4期41卷 619-638页

作者： Yating zhao ming XUE Jing JIANG Xiao-ming HU Anning HUANG School of Atmospheric Sciences Nanjing UniversityNanjing 210023China Center for Analysis and Prediction of Storms and School of Meteorology The University of OklahomaNorman 73072U.S.A

Assessment of past-climate simulations of regional climate models(RCMs)is important for understanding the reliability of RCMs when used to project future regional ***,we assess the performance and discuss possible causes of biases in a WRF-based RCM with a grid spacing of 50 km,named WRFG,from the North American Regional Climate Change Assessment Program(NARCCAP)in simulating wet season precipitation over the Central United States for a period when observational data are *** RCM reproduces key features of the precipitation distribution characteristics during late spring to early summer,although it tends to underestimate the magnitude of *** dry bias is partially due to the model’s lack of skill in simulating nocturnal precipitation related to the lack of eastward propagating convective systems in the *** in reproducing large-scale circulation and environmental conditions is another contributing *** too weak simulated pressure gradient between the Rocky Mountains and the Gulf of Mexico results in weaker southerly winds in between,leading to a reduction of warm moist air transport from the Gulf to the Central Great *** simulated low-level horizontal convergence fields are less favorable for upward motion than in the NARR and hence,for the development of moist convection as ***,a careful examination of an RCM’s deficiencies and the identification of the source of errors are important when using the RCM to project precipitation changes in future climate scenarios.

关键词： NARCCAP Central United States precipitation low-level jet large-scale environment diurnal variation

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