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Foveal pit morphological changes in asymptomatic carriers of the G11778A mutation with Leber’s hereditary optic neuropathy

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 766-772页

作者： Xin-Ting Liu Mei-Xiao Shen Chong Chen Sheng-Hai Huang Xi-Ran Zhuang Qing-Kai Ma Qi Chen Fan Lu yi-min yuan School of Ophthalmology and Optometry the Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To investigate the foveal pit morphology changes in unaffected carriers and affected Leber’s hereditary optic neuropathy(LHON)patients with the G11778 A mutation from one ***:This study was a prospective cross-sectional *** eyes from 16 family members(age from 9 to 47 y)with the G11778 A mutation were analyzed and compared with 1 eye from 20 normal control *** family members with the G11778 A mutation but without optic neuropathy were classified as unaffected carriers(n=22 eyes).Five family members(n=10 eyes)expressed the LHON phenotype and were classified as affected *** images of all the subjects were taken by optical coherence tomography(OCT),and an automatic algorithm was used to segment the retina to eight *** and vertical OCT images centered on the fovea were used to measure intra-retinal layer thicknesses and foveal ***:Thicker foveal thickness,thinner foveal pit depth,and flatter foveal slopes were observed in unaffected carriers and affected LHON patients(all P<0.001).Further,the slopes of all four sectors in the LHON were flatter than those in the unaffected carriers(all P<0.001).Compared with the control group,affected LHON patients had a thinner retinal nerve fiber layer(RNFL),ganglion cell layer and inner plexiform layer(GCL+IPL),and total retina(all P<0.01).The retinal nerve fiber layer(RNFL)of affected patients was 38.0%thinner than that of controls while the GCL+IPL was 40.1%***:The foveal pit morphology shows changes in both unaffected carriers and affects *** and GCL+IPL are thinner in affected LHON patients but not in unaffected carriers.

关键词： foveal pit morphology Leber’s hereditary optic neuropathy asymptomatic carriers G11778A

Multi-Stage Voltage Control Optimization Strategy for Distribution Networks Considering Active-Reactive Co-Regulation of Electric Vehicles

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Energy Engineering 2025年第1期122卷 221-242页

作者： Shukang Lyu Fei Zeng Huachun Han HuiyuMiao yi Pan Xiaodong yuan Electric Power Research Institute State Grid Jiangsu Electric Power Co.Ltd.Nanjing211103China

The high proportion of uncertain distributed power sources and the access to large-scale random electric vehicle(EV)charging resources further aggravate the voltage fluctuation of the distribution network,and the existing research has not deeply explored the EV active-reactive synergistic regulating characteristics,and failed to realize themulti-timescale synergistic control with other regulatingmeans,For this reason,this paper proposes amultilevel linkage coordinated optimization strategy to reduce the voltage deviation of the distribution ***,a capacitor bank reactive power compensation voltage control model and a distributed photovoltaic(PV)activereactive power regulationmodel are ***,an external characteristicmodel of EVactive-reactive power regulation is developed considering the four-quadrant operational characteristics of the *** optimization model of the distribution network is then constructed considering the time-series coupling constraints of multiple types of voltage regulators.A multi-timescale control strategy is proposed by considering the impact of voltage regulators on active-reactive EV energy consumption and PV energy ***,a four-stage voltage control optimization strategy is proposed for various types of voltage regulators with multiple time ***-objective optimization is solved with the improvedDrosophila algorithmto realize the power fluctuation control of the distribution network and themulti-stage voltage control *** results validate that the proposed voltage control optimization strategy achieves the coordinated control of decentralized voltage control resources in the distribution *** effectively reduces the voltage deviation of the distribution network while ensuring the energy demand of EV users and enhancing the stability and economic efficiency of the distribution network.

关键词： Electric vehicle(EV) distribution network multi-stage optimization active-reactive power regulation voltage control

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di Zhao Lemei Zhu Zheyu Zhang min yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

Low‑Temperature Fabrication of Stable Black‑Phase CsPbI_(3)Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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Nano-Micro Letters 2025年第3期17卷 232-245页

作者： yingjie Zhao yicheng Sun Chaoxin Pei Xing yin Xinyi Li yi Hao Mengru Zhang Meng yuan Jinglin Zhou Yu Chen Yanlin Song College of Chemistry and Pingyuan Laboratory Zhengzhou UniversityZhengzhou 450001People’s Republic of China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Key Laboratory of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049People’s Republic of China

Flexible wearable optoelectronic devices fabricated fromorganic–inorganic hybrid perovskites significantly accelerate the developmentof portable energy,biomedicine,and sensing fields,but their poor thermal stabilityhinders further ***,all-inorganic perovskites possessexcellent thermal stability,but black-phase all-inorganic perovskite filmusually requires high-temperature annealing steps,which increases energy consumptionand is not conducive to the fabrication of flexible wearable *** this work,an unprecedented low-temperature fabrication of stable blackphaseCsPbI3perovskite films is demonstrated by the in situ hydrolysis reactionof diphenylphosphinic chloride *** released diphenyl phosphateand chloride ions during the hydrolysis reaction significantly lower the phasetransition temperature and effectively passivate the defects in the perovskitefilms,yielding high-performance photodetectors with a responsivity of 42.1 AW−1 and a detectivity of 1.3×10^(14)***,high-fidelity imageand photoplethysmography sensors are demonstrated based on the fabricated flexible wearable *** work provides a newperspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

Natural and human-induced decline and spatio-temporal differentiation of terrestrial water storage over the Lancang-Mekong River Basin

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Journal of Geographical Sciences 2025年第1期35卷 112-138页

作者： CHEN Junxu WANG yuan ZHAO Zhifang FAN Yunjiang LUO Xiaochuan yi Lu FENG Siqi YANG Liang Emlyn Yunnan Key Laboratory of Soil Erosion Prevention and Green Development Yunnan University International Joint Research Center for Karstology Yunnan University School of Engineering Westlake University Department of Geography Ludwig Maximilian University of Munich (LMU)

Due to water conflicts and allocation in the Lancang-Mekong River Basin(LMRB), the spatio-temporal differentiation of total water resources and the natural-human influence need to be clarified. This work investigated LMRB's terrestrial water storage anomaly(TWSA) and its spatio-temporal dynamics during 2002–2020. Considering the effects of natural factors and human activities, the respective contributions of climate variability and human activities to terrestrial water storage change(TWSC) were separated. Results showed that:(1) LMRB's TWSA decreased by 0.3158 cm/a.(2) TWSA showed a gradual increase in distribution from southwest of MRB to middle LMRB and from northeast of LRB to middle LMRB. TWSA positively changed in Myanmar while slightly changed in Laos and China. It negatively changed in Vietnam, Thailand and Cambodia.(3) TWSA components decreased in a descending order of soil moisture, groundwater and precipitation.(4) Natural factors had a substantial and spatial differentiated influence on TWSA over the LMRB.(5) Climate variability contributed 79% of TWSC in the LMRB while human activities contributed 21% with an increasing impact after 2008. The TWSC of upstream basin countries was found to be controlled by climate variability while Vietnam and Cambodia's TWSC has been controlled by human activities since 2012.

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Tunable non-Markovian and quantum coherence in the single-qubit dephasing noise channel

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Science China(Physics,Mechanics & Astronomy) 2025年

作者： Na-Na Zhang Chao-yi Wu Xu Zhou Qi-yuan Liu Cheng-Ge Liu Yong-Rui Guo Ren-Pu Li School of Optoelectronic Engineering Chongqing University of Posts and Telecommunications Department of Physics Applied Optics Beijing Area Major Laboratory Beijing Normal University

In this paper, we construct a single-qubit dephasing noise channel based on the nuclear magnetic resonance（NMR） system by employing the bath-engineering technology, and achieve the construction of the tunable non-Markovian environment in the dephasing noise channel. Our findings indicate that for the single-qubit system, the transition of system dynamics from Markovian to non-Markovian can be achieved by adjusting the base frequency of the noise power spectrum. However, the base frequency corresponding to this phase transition point is not fixed, and there is a certain relationship between it and the total evolution time of the single-qubit system. Through our research, we discovered a fundamental relationship: if the single-qubit system dynamics undergoe a transition from Markovian to non-Markovian at ω0within 0-2t ms, shortening the evolution time to 0-t ms results in an increase of the phase transition point to 2ω0. This insight offers crucial guidance for artificially crafting non-Markovian environments across arbitrary time scales in single-qubit systems, and it is not limited by the type of noise. Apart from system dynamics, quantum coherence is also a focal point of our research. We find that when the system dynamics exhibit non-Markovian behavior, the quantum coherence of the single-qubit system experiences revivals. Notably, the timing of these coherence revivals aligns with the instants of the non-Markovianity enhancement. Therefore, our research also serves as a pivotal foundation for the artificial manipulation and realization of quantum coherence revivals within diverse single-qubit systems.

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Ethyl pyruvate ameliorates the glial microenvironment and promotes spinal cord repair

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Ethyl pyruvate ameliorates the glial microenvironment and pr...

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： yi-min yuan,Zhi-Da SU,ying-Yan PU,Jing-Jing CHEN,Feng ZHU,Yang QIU,Cheng HE~* Institute of Neuroscience and MOE Key Laboratory of Molecular Neurobiology,Second Military Medical University, Shanghai 200433,China

＜正＞Objective After SCI,a series of endogenous processes,including reactive astrogliosis and neuroinflammatory response,are triggered and resulted in the formation of a degenerative microenvironment in the lesion *** many studies,this hostile environment,as well as the intrinsic incapacity of the neuron to regenerate,is regarded as an important contributor to the failure of spontaneous anatomical and functional repair of *** present study is to explore the neuroprotective effect of ethyl pyruvate in the damaged spinal cord using a rat model of SCI. Methods Initially,a scratch-wound model was applied to test reactive astrogliosis in *** vivo,astrogliosis, scar formatting and neuroinflammatory response were further assessed with a spinal cord-hemisectined SCI model. In the damaged spinal cord,survival neurons and regenerative axons was identified by TUNEL staining and BDA anterograde tracing,***,functional recovery was valuated by the Basso,Beattie,and Bresnahan openfield scoring,grid-walk test and foot-print *** In the present study,ethyl pyruvate was found to inhibit reactive astrogliosis in vitro,which was further confirmed in injured spinal *** addition,ethyl pyruvate treatment was also shown to attenuate SCI-induced neuroinflammation by decreasing the Iba-1 or CD11b-positive inflammatory cells at the lesion ***,ethyl pyruvate-treated rats showed a significantly greater number of survival neurons and regenerative axons and their behavioral functions were evidently *** Ethyl pyruvate ameliorates the glial microenvironment and promotes spinal cord repair,suggestive of a potent neuroprotective effect against SCI.

关键词： ethyl pyruvate astrogliosis neuroinflammation glial scar spinal cord injury axon regeneration

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声全息重构卷积计算中混迭问题的研究

数据采集与处理 2004年第3期19卷 346-351页

作者：陈晓东陈心昭陆益民李志远合肥工业大学机械与汽车工程学院合肥230009

分析了实空间离散格林函数的特点和平面声全息重构卷积计算的特殊性 ,推导了在重构条件下二维循环卷积与重构卷积的关系。理论上证明了在全息重构中将二维全息声压序列补零使其成为原序列长度的两倍 ,而二维格林函数序列无需进行补零处... 详细信息

分析了实空间离散格林函数的特点和平面声全息重构卷积计算的特殊性 ,推导了在重构条件下二维循环卷积与重构卷积的关系。理论上证明了在全息重构中将二维全息声压序列补零使其成为原序列长度的两倍 ,而二维格林函数序列无需进行补零处理仍可由二维离散傅氏变换准确地得到全息重构卷积结果 ,而不会产生循环卷积中的混迭现象 ,即不存在所谓的重构“卷绕”误差。同时还证明了实空间格林函数的取值不确定性不会影响重构结果 ,并通过仿真算例进行了验证。

关键词：循环卷积重构卷积格林函数二维离散傅氏变换近场平面声全息声学测量

Modular assembly of complex C-alkyl glycoside enabled via cooperative NHC and photoredox catalysis

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Science China Chemistry 2025年

作者： Rui-Qiang Jiao ming Li Xi Chen Mei-Ze Xu Tian Ding Xiao-Ping Gong Zhuo-Mei Li Xue-yuan Liu Yong-min Liang State Key Laboratory of Applied Organic Chemistry Lanzhou University College of Chemistry and Chemical Engineering Northwest Normal University

C-Alkyl glycosides are found in natural products and are indispensable in drug development programs,owing to their diverse range of medicinal ***-component reactions involving glycosyl radical addition are well documented and proved efficient for the C-alkyl glycosides ***,multicomponent reactions for the rapid and controllable construction of structurally diversified C-alkyl glycosides in a single step remains a significant challenge due to the issues associated with balancing reactivity,compatibility,and ***,we report an NHC and photoredox co-catalyzed three-component method to access complex and valuable C-alkyl *** protocol exhibits broad substrate scope and excellent chemoand ***,nine types of sugars are compatible with this *** addition,the generality of this catalytic strategy was further highlighted by the potential for scalable production,the feasibility of further modifications of the products and its successful application in the late-stage functionalization of pharmaceutical skeletons.

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