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On the resonance analysis for compliant bionic jellyfishes

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Science China Technological Sciences 2010年第11期53卷 2976-2982页

作者： hsieh Wen-Hsiang CHEN Tsung-I Department of Automation Engineering Formosa University Institute of Mechanical & Electro-Mechanical Engineering Formosa University

A bionic jellyfish is a robot that can mimic the swimming of a real jellyfish. In practical application, the volume and the capacity of its carrying power are limited, hence its power consumption is a crucial factor for continuous swimming. The purpose of this paper is to propose an approach for the resonance analysis of bionic jellyfishes in order to investigate their energy efficiency in swimming. First, a suitable rigid-body bionic jellyfish was chosen from the previous study, and then its design approach was presented, Then, it was transformed into a compliant design, by the proposed method, in order to mimic the motion of a real jellyfish. Furthermore, its solid model was drawn, and the approach of modal analysis by using ANSYS software was addressed. After that, two terms, specific energy and energy ratio, were defined in order to evaluate its energy efficiency. Finally, a design example was given for illustration, and its motion simulations with and without resonance input were conducted by using ADAMS software. Additionally, their specific energies and energy ratios were found. The simulation results showed that the required input energy would be significantly reduced if a bionic jellyfish swims at its resonance frequency.

关键词： bionic robot jellyfish compliant mechanism resonance analysis

PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance

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Asian Journal of Andrology 2014年第3期16卷 378-386页

作者： Merritt P Edlind Andrew C hsieh Perelman School of Medicine University of Pennsylvania Philadelphia PA USA Division of Hematology/Oncology and Department of Internal Medicine University of California San Francisco CA USA.

Prostate cancer （PCa） is the second most common malignancy among men in the world. Castration-resistant prostate cancer （CRPC） is the lethal form of the disease, which develops upon resistance to first line androgen deprivation therapy （ADT）. Emerging evidence demonstrates a key role for the PI3K-AKT-mTOR signaling axis in the development and maintenance of CRPC. This pathway, which is deregulated in the majority of advanced PCas, serves as a critical nexus for the integration of growth signals with downstream cellular processes such as protein synthesis, proliferation, survival, metabolism and differentiation, thus providing mechanisms for cancer cells to overcome the stress associated with androgen deprivation. Furthermore, preclinical studies have elucidated a direct connection between the PI3K-AKT-mTOR and androgen receptor （AR） signaling axes, revealing a dynamic interplay between these pathways during the development of ADT resistance. Thus, there is a clear rationale for the continued clinical development of a number of novel inhibitors of the PI3K pathway, which offer the potential of blocking CRPC growth and survival. In this review, we will explore the relevance of the PI3K-AKT-mTOR pathway in PCa progression and castration resistance in order to inform the clinical development of specific pathway inhibitors in advanced PCa. In addition, we will highlight current deficiencies in our clinical knowledge, most notably the need for biomarkers that can accurately predict for response to PI3K pathway inhibitors.

关键词： androgen receptor CRPC kinase inhibitors mTOR prostate cancer PI3K resistance

Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第5期23卷 876-884页

作者： Ai-Ru hsieh Cathy SJ Fann Chau-Ting Yeh Hung-Chun Lin Shy-yi Wan yi-Cheng Chen Chia-Lin Hsu Jennifer Tai Shi-Ming Lin Dar-In Tai Graduate Institute of Biostatistics China Medical University Institute of Biomedical Sciences Academia Sinica Division of Hepatology Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital Kaohsiung Medical University College of Medicine

AIM To explore factors associated with persistent hepatitis B virus (HBV) infection in a cohort of hepatocellular carcinoma (HCC)-affected families and then investigate factors that correlate with individual viral load among hepatitis B surface antigen (HBsAg)-positive relatives. METHODS questionnaire. Demographics, relationship to index case, HBsAg status of mothers and index cases were evaluated for association with the HBV persistent infection or viral load by generalized estimating equation analysis. RESULTS Among 729 relatives enrolled, parent generation (P = 0.0076), index generation (P = 0.0044), mothers positive for HBsAg (P = 0.0007), and HBsAg-positive index cases (P = 5.98 x 10(-8)) were associated with persistent HBV infection. Factors associated with HBV viral load were evaluated among 303 HBsAg-positive relatives. Parent generation (P = 0.0359) and sex (P = 0.0007) were independent factors associated with HBV viral load. The intra-family HBV viral load was evaluated in families clustered with HBsAg-positive siblings. An intra-family trend of similar HBV viral load was found for 27 of 46 (58.7%) families. Male offspring of HBsAg-positive mothers (P = 0.024) and older siblings were associated with high viral load. CONCLUSION Sex and generation play important roles on HBV viral load. Maternal birth age and nutritional changes could be the reasons of viral load difference between generations.

关键词： Familial generation Sex Hepatitis B virus Perinatal infection Viral replication

WATER WAVES IN AN ELASTIC VESSEL

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Acta Mechanica Sinica 1997年第4期13卷 289-303页

作者： D. Y. hsieh Department of Mathematics Hong Kong University of Science and Technology Hong Kong

Linear and nonlinear analyses of water waves in an elastic vessel are carried out to study the dramatic phenomena of Dragon Wash as well as related controllable experiments. It is proposed that the capillary edge waves are generated by parametric resonance, which is shown to be a possible mechanism for both rectangular an circular vessels. For circular vessel, the normal geometric resonance is also operating, thus greatly. enhance the dramatic effect. The mechanism of nonlinear mode-mode interaction is proposed far the generation of axisymmetric low-frequency gravity waves by the high-frequency external excitation. A simple model system is studied numerically to demonstrate explicitly this interaction mechanism.

关键词： water waves elastic vessel Dragon Wash

Long-term Effects of Antihypertensive Drug Use and New-onset Osteoporotic Fracture in Elderly Patients： A Population-based Longitudinal Cohort Study

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Chinese Medical Journal 2016年第24期129卷 2907-2912页

作者： Hung-yi Chen Kai-Yan Ma Pei-Ling hsieh yi-Sheng Liou Gwo-Ping Jong Institute of Pharmacy China Medical University Taichung Taiwan 40402 China Department of Pharmacy China Medical University Beigang Hospital Yunlin County Taiwan 65152 China Department of Endocrinology and Metabolism Shangluo Central Hospital Shangluo Shaanxi 726000 China Department of Family Medicine and Geriatrics School of Public Health National Defense Medical Center Taichung Veteran General Hospital Taichung Taiwan 40705 China Division of Internal Cardiology Chung Shah Medical University Hospital Chung Shan Medical University Taichung Taiwan 40201 China Department of Basic Science Central Taiwan University of Science and Technology Taichung Taiwan 40601 China

Background： Antihypertensive drugs have been linked to new-onset osteoporotic fracture （NOF）, and different classes of antihypertensive drugs may alter the risk for the development of NOF; however, the classic effect of different antihypertensive drugs on the development of NOF in the elderly has not been well studied during long-term follow-up. Methods： In this study, we investigated the association between different classic antihypertensives and the development of NOF in the elderly. This was a longitudinal cohort study performed using data from claim forms submitted to the Taiwan Bureau of National Health Insurance in Central Taiwan, China including case patients with NOF aged 65–80 years from January 2002 to December 2012 and non-NOF controls. Prescriptions for antihypertensives before the index date were retrieved from a prescription database. We estimated the hazard ratios （HR s） of NOF associated with antihypertensive use. Non-NOF controls served as the reference group. Results： A total of 128 patients with NOF were identified from among 1144 patients with hypertension during the study period. The risk of NOF after adjusting age, sex, comorbidities, and concurrent medications was higher among the users of angiotensin-converting enzyme （ACE） inhibitors （HR, 1.64; 95% confidence interval [CI], 1.01–2.66） than among nonusers. Patients who took calcium channel blockers （CCBs）（HR, 0.70; 95% CI, 0.49–0.99） were at a lower risk of developing NOF than nonusers. Loop diuretics, thiazide diuretics, angiotensin receptor blocker, beta-blocker, and alpha-blocker were not associated with the risk of NOF. Conclusions： Elderly with hypertension who take CCBs are at a lower risk of NOF and that the use of ACE inhibitors was associated with a significantly increased risk of developing NOF during the 11-year follow-up.

关键词： Antihypertensive Drugs Elderly New-onset Osteoporosis Fracture

Multi-frame speckle reduction in OCT using supercontinuum pumped by noise-like pulses

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Journal of Innovative Optical Health Sciences 2019年第2期12卷 86-92页

作者： Chengming Wang yi-Jing You Shengnan Ai Wenxin Zhang Wenchao Liao Xiao Zhang Juicheng hsieh Ning Zhang Bihua Tang Ci-Ling Pan Ping Xue State Key Laboratory of Low-Dimensional Quantum Physics Department of Physics Tsinghua University Collaborative Innovation Center of Quantum Matter BeijingP.R.China Department of Physics National Tsing Hua University No.101Sec.2Kuang-Fu RdHsinchuTaiwan Department of Physics and Institute of Photonics Technologies National Tsing Hua University Taiwan School of Life Science Beijing Institute of Technology BeijingP.R.China Institute of Forensic Science Ministry of Public Security Beijing P.R.China Southwest Medical University Luzhou Sichuan ProvinceP.R.China Nuctech Company Limited BeijingP.R.China

In most coherent imaging modality,speckle noise is a major cause that blurs the boundary of tissues and degrades the image *** utilizing the unique properties of supercontinuum(SC)generated by noise-like pulses(NLPs)and a simple multi-frame averaging technique,we achieved significant speckle reduction in spectral domain optical coherence tomography(SD-OCT).We quantitatively compared the speckle of our proposed method with those of conventional swept source OCT(SS-OCT)and SD-OCT based on commercial light *** experimental results show that SC pumped by NLPs combined with noncoherent averaging method achieves better denoising performance in terms of contrast to noise ratio(CNR).

关键词： Noise-like pulses supercontinuum generation speckle reduction optical coherence tomography

Quercetin exerts anti-inflammatory effects via inhibiting tumor necrosis factor-α-induced matrix metalloproteinase-9 expression in normal human gastric epithelial cells

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World Journal of Gastroenterology 2022年第11期28卷 1139-1158页

作者： Hsi-Lung hsieh Ming-Chin Yu Li-Ching Cheng Mei-yi Chu Tzu-Hao Huang Ta-Sen Yeh Ming-Ming Tsai Department of Nursing Division of Basic Medical SciencesChang-Gung University of Science and TechnologyTaoyuan 333TaiwanChina Research Center for Chinese Herbal Medicine College of Human EcologyChang Gung University of Science and TechnologyTaoyuan 333TaiwanChina Department of Neurology Chang Gung Memorial HospitalTaoyuan 333TaiwanChina Department of General Surgery New Taipei Municipal TuCheng HospitalNew Taipei 236TaiwanChina College of Medicine Chang Gung UniversityTaoyuan 333TaiwanChina Department of General Surgery Chang Gung Memorial HospitalTaoyuan 333TaiwanChina

BACKGROUND Gastric injury is the most common digestive system disease worldwide and involves inflammation,which can lead to gastric ulcer or gastric cancer(GC).Matrix metallopeptidase-9[MMP-9(gelatinase-B)]plays an important role in inflammation and GC *** and quercetin-rich diets represent potential food supplements and a source of medications for treating gastric injury given their anti-inflammatory ***,the effects and mechanisms of action of quercetin on human chronic gastritis and whether quercetin can relieve symptoms remain *** To assess whether tumor necrosis factor-α(TNF-α)-induced MMP-9 expression mediates the anti-inflammatory effects of quercetin in normal human gastric mucosal epithelial *** The normal human gastric mucosa epithelial cell line GES-1 was used to establish a normal human gastric epithelial cell model of TNF-α-induced MMP-9 protein overexpression to evaluate the antiinflammatory effects of *** cell counting Kit-8 assay was used to evaluate the effects of varying quercetin doses on cell viability in the normal GES-1 cell *** migration was measured using Transwell *** expression of proto-oncogene tyrosine-protein kinase Src(cSrc),phospho(p)-c-Src,extracellular-signal-regulated kinase 2(ERK2),p-ERK1/2,c-Fos,p-c-Fos,nuclear factor kappa B(NF-κB/p65),and p-p65 and the effects of their inhibitors were examined using Western blot analysis and measurement of luciferase activity.p65 expression was detected by ***-9 m RNA and protein levels were measured by quantitative reverse transcription polymerase chain reaction(q RT–PCR)and gelatin zymography,*** q RT-PCR and gelatin zymography showed that TNF-αinduced MMP-9 m RNA and protein expression in a dose-and time-dependent *** effects were reduced by the pretreatment of GES-1 cells with quercetin or a TNF-αantagonist(TNFR inhibitor)in a dose-and timedependent *** and TNF-αa

关键词： Anti-inflammatory Quercetin Matrix metallopeptidase-9 Tumor necrosis factor-α Normal human gastric epithelial cells

A diagnostic dilemma:acute abdomen presenting as segmental arterial mediolysis masked by a ruptured hepatocellular carcinoma

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Gastroenterology Report 2017年第3期5卷 244-246,I0003页

作者： Chen-yi Liao Wu-Hsien Kuo En-Hua Huang An-Tie hsieh Ching-Chang Le Chi-Chang Tsai Chao-Wen Hsueh Department of Medicine Kaohsiung Armed Forces General HospitalKaohsiungTaiwan

A 65-year-old male was brought to our hospital with right upper abdominal fullness sensation and recent body weight loss of about 3 *** patient had developed episodes of melena following progressive abdominal muscular guarding and drop of haemoglobin level to 6.3 g/*** abdominal computed tomography scan disclosed a ruptured hepatocellular cell carcinoma.A segmental arterial mediolysis was found on the superior mesenteric artery in the process of repairing the ruptured right hepatic artery with the assistance of *** embolization was carried out and permanent haemostasis was achieved.

关键词： segmental arterial mediolysis hepatocellular carcinoma

Factor analysis for the statistical modeling of earthquake-induced landslides

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Frontiers of Structural and Civil Engineering 2020年第1期14卷 123-126页

作者： Jeng-Wen LIN Meng-Hsun hsieh Yu-Jen LI Department of Civil Engineering Feng Chia UniversityTaichung 40724China School of Management Fujian University of TechnologyFuzhou 350118China Ruentex Engineering&Construction Co. Ltd.Taipei 10492China

Earthquake-induced landslides are difficult to assess and predict owing to the inherent unpredictability of *** most existing studies,the landslide potential is statistically assessed by collecting and analyzing the data of historical landslide events and earthquake observation *** rainfall-induced landslides,earthquake-induced landslides cannot be predicted in advance using real-time monitoring systems,and the development of the models for these landslides should instead depend on early earthquake warnings and ***,in this study,factor analysis was performed and the frequency distribution method was employed to investigate the potential risk of the landslides caused by *** such as the slope gradient,lithology(geology),aspect,and elevation were selected and classified as influential factors to facilitate the construction of a landslide database for the area of study.

关键词： earthquake factor analysis slope landslides statistical modeling