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Timing analysis of the black hole candidate EXO 1846–031 with Insight-HXMT monitoring

Research in Astronomy and Astrophysics 2021年第3期21卷 193-204页

作者： He-Xin Liu Yue Huang Guang-Cheng Xiao Qing-Cui Bu Jin-Lu Qu Shu Zhang Shuang-Nan Zhang Shu-Mei Jia Fang-Jun Lu Xiang Ma Lian Tao Wei Zhang Li Chen Li-Ming Song Ti-Pei Li Yu-Peng Xu Xue-Lei Cao Yong Chen Cong-Zhan Liu Ce Cai Zhi Chang Gang Chen Tian-Xiang Chen yi-Bao Chen Yu-Peng Chen Wei Cui Wei-Wei Cui Jing-Kang Deng Yong-Wei Dong Yuan-Yuan Du Min-Xue Fu Guan-Hua Gao He Gao Min Gao Ming-Yu Ge Yu-Dong Gu Ju Guan Cheng-Cheng Guo Da-Wei Han Jia Huo Lu-Hua Jiang Wei-Chun Jiang Jing Jin Yong-Jie Jin Ling-Da Kong Bing Li Cheng-Kui Li Gang Li Mao-Shun Li Wei Li Xian Li Xiao-Bo Li Xu-Fang Li yang-Guo Li Zheng-Wei Li Xiao-Hua Liang Jing-Yuan Liao Bai-Sheng Liu Guo-Qing Liu Hong-Wei Liu Xiao-Jing Liu yi-Nong Liu Bo Lu Xue-Feng Lu Qi Luo Tao Luo Bin Meng yi Nang Jian-yin Nie Ge Ou Na Sai Ren-Cheng Shang Xin-ying Song Liang Sun ying Tan You-Li Tuo Chen Wang Guo-Feng Wang Juan Wang Ling-Jun Wang Weng-Shuai Wang Yu-Sa Wang Xiang-yang Wen Bai-yang Wu Bo-Bing Wu Mei Wu Shuo Xiao Shao-Lin Xiong He Xu Jia-Wei yang Sheng yang Yan-Ji yang yi-jung yang Qi-Bin yi Qian-Qing yin Yuan You Ai-Mei Zhang Cheng-Mo Zhang Fan Zhang Hong-Mei Zhang Juan Zhang Tong Zhang Wan-Chang Zhang Wen-Zhao Zhang yi Zhang yi-Fei Zhang Yong-Jie Zhang Yuan-Hang Zhang Yue Zhang Zhao Zhang Zhi Zhang Zi-Liang Zhang Hai-Sheng Zhao Xiao-Fan Zhao Shi-Jie Zheng Yao-Guang Zheng Deng-Ke Zhou Jian-Feng Zhou Yu-Xuan Zhu Ren-Lin Zhuang Yue Zhu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Institut fur Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls Universität72076 TubingenGermany Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China College of Physics Sciences&Technology Hebei UniversityBaoding 071002Hebei ProvinceChina

We present the observational results from a detailed timing analysis of the black hole candidate EXO 1846-031 during its outburst in 2019 with the observations of Insight-HXMT,NICER and *** outburst can be classified roughly into four different ***-C quasi-periodic oscillations(QPOs)observed by NICER(about 0.1-6 Hz)and Insight-HXMT(about 0.7-8 Hz)are also reported in this ***,we study various physical quantities related to QPO *** QPO rms-frequency relationship in the energy band 1-10 keV indicates that there is a turning pointing in frequency around2 Hz,which is similar to that of GRS 1915+105.A possible hypothesis for the relationship above may be related to the inclination of the source,which may require a high inclination to explain *** relationships between QPO frequency and QPO rms,hardness,total fractional rms and count rate have also been found in other transient sources,which can indicate that the origin of type-C QPOs is non-thermal.

关键词： X-ray binaries black hole candidate QPO EXO 1846–031

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A p53 genetic polymorphism of gastric cancer: Difference between early gastric cancer and advanced gastric cancer

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World Journal of Gastroenterology 2006年第40期12卷 6536-6539页

作者： Sun Young yi Woon jung Lee Department of Internal Medicine and Medical Research Center College of Medicine Ewha Womans University Seoul Korea

AIM: To investigate the role of the polymorphism of p53 codon 72 in early gastric cancer (EGC) and advanced gastric cancer (AGC) in Korean patients. METHODS: DNA was extracted from blood samples of gastric cancer patients (n = 291) and controls (n = 216). In the p53 codon 72 genotypes were determined by ***: Patients with gastric cancer had a significantly higher frequency of the homozygous proline (Pro) allele than the control (P = 0.032). Patients with AGC had a significantly higher frequency of the Arg/Arg (arginine) allele (P = 0.038) than EGC and a similar Pro/Pro allele. The signet ring cell type had a higher frequency of the Pro/Pro allele than other types (P = 0.031). The Pro/Pro genotype carries a 3.9-fold increased risk of developing gastric cancer (95% CI, 1.3-15.4, P = 0.039) when compared to Arg/Arg and Arg/Pro genotypes and to develop EGC is a 5.25 fold increased risk (95% CI, 1.8-19.6, P = 0.021). CONCLUSION: The Pro/Pro genotype of the p53 codon 72 polymorphism carries a higher risk for gastric cancer in general and is also associated with a much higher risk for EGC than AGC.

关键词： p53 gene Polymorphism Gastric cancer

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Study on Extended Gate Field Effect Transistor with Nano-TiO-2 Sensing Membrane by Sol-Gel Method

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稀有金属材料与工程 2006年第A3期35卷 252-253页

作者： yi-Hung Liao jung-Chuan Chou Graduate School of Engineering Science and Technology National Yunlin University of Science and TechnologyDouliouTaiwan 640China

The nano-titanium dioxide (nano-TiO_2) sensing membrane,fabricated by sol-gel technology,was used as the pH-sensing layer of the extended gate field effect transistor (EGFET) *** objective of this research is the preparation of titanium dioxide materials by sol-gel method using Ti(OBu)_4 as the *** this study,we fabricated a nano-titanium dioxide sensing layer on the ITO glass by dip *** order to examine the sensitivity of the nano-TiO_2 films applied to the EGFET devices,we adopted the ITO glass as substrate,and measured theⅠ_(DS)-Ⅴ_G curves of the nano-titanium dioxide separative structure EGFET device in the pH buffer solutions that have different pH values by the Keithley 236 *** the experimental results,we can obtain the pH sensitivities of the EGFET with nano-TiO_2 sensing membrane prepared by sol-gel method,which is 59.86mV/pH from pH 1 to pH 9.

关键词： extended gate field effect transistor(EGFET) sol-gel nano-TiO2 sensing membrane buffer solution

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Pancreatic abscess following scrub typhus associated with multiorgan failure

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World Journal of Gastroenterology 2007年第25期13卷 3523-3525页

作者： Sun Young yi jung Hyun Tae Department of Internal Medicine School of Medicine Ewha Womans University Seoul South Korea

Clinical severity of scrub typhus ranges from mild to fatal. Acute pancreatitis with abscess formation is a rare complication among patients with scrub typhus. This paper reports a case of scrub typhus in a 75 years old man with acute pancreatitis with abscess formation and multiorgan failure. Abdominal computed tomography showed multiple infected pancreatic pseudocysts with periopancreatic infiltration. Multiorgan failure was successfully treated with doxycycline, ceftriaxone, and supportive management. The pancreatic abscess was successfully drained percutaneously and the sizes of pseudocysts decreased remarkably.

关键词： Scrub typhus Pancreatitis Pancreaticabscess Multiorgan failure

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Study on the Carbon Nanotube Separative Structure for the Extended Gate H^+-Ion Sensitive Field Effect Transistor

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稀有金属材料与工程 2006年第A3期35卷 225-227页

作者： yi-Hung Liao jung-Chuan Chou Graduate School of Engineering Science and Technology National Yunlin University of Science and TechnologyDouliouYunlinTaiwan 640China

We use the carbon nanotube (CNT) as the material of the pH sensing layer of the separative structure for the extended gate H^+-ion sensitive field effect transistor (EGFET) *** CNT paste was prepared with CNT powder,Ag powder,silicagel,the di-n-butyl phthalate and the toluene solvents by appropriate ratio,then immobilized on the silicon substrate to form the carbon nanotube sensing *** measured theⅠ_(DS)-Ⅴ_G curves of the carbon nanotube separative structure EGFET device in the different pH buffer solutions by the Keithley 236Ⅰ-Ⅴmeasurement *** to the experimental results,we can obtain the pH sensitivities of the carbon nanotube separative structure EGFET device,which is 62.54mV/pH from pH1 to pH13.

关键词： carbon nanotube extended gate field effect transistor pH sensitivity buffer solution

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Zebrafish as a disease model for studying human hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第42期21卷 12042-12058页

作者： Jeng-Wei Lu yi-jung Ho yi-Ju yang Heng-An Liao Shih-Ci Ciou Liang-In Lin Da-Liang Ou Department of Clinical Laboratory Sciences and Medical Biotechnology College of Medicine National Taiwan University Institute of Preventive Medicine National Defense Medical Center Graduate Institute of Life Sciences National Defense Medical Center Institute of Biotechnology National Tsing Hua University Department of Laboratory Medicine National Taiwan University Hospital Graduate Institute of Oncology College of Medicine National Taiwan University

Liver cancer is one of the world's most common cancers and the second leading cause of cancer deaths. Hepatocellular carcinoma(HCC), a primary hepatic cancer, accounts for 90%-95% of liver cancer cases. The pathogenesis of HCC consists of a stepwise process of liver damage that extends over decades, due to hepatitis, fatty liver, fibrosis, and cirrhosis before developing fully into HCC. Multiple risk factors are highly correlated with HCC, including infection with the hepatitis B or C viruses, alcohol abuse, aflatoxin exposure, and metabolic diseases. Over the last decade, genetic alterations, which include the regulation of multiple oncogenes or tumor suppressor genes and the activation of tumorigenesis-related pathways, have also been identified as important factors in HCC. Recently, zebrafish have become an important living vertebrate model organism, especially for translational medical research. In studies focusing on the biology of cancer, carcinogen induced tumors in zebrafish were found to have many similarities to human tumors. Several zebrafish models have therefore been developed to provide insight into the pathogenesis of liver cancer and the related drug discovery and toxicology, and to enable the evaluation of novel smallmolecule inhibitors. This review will focus on illustrativeexamples involving the application of zebrafish models to the study of human liver disease and HCC, through transgenesis, genome editing technology, xenografts,drug discovery, and drug-induced toxic liver injury.

关键词： Cancer model Hepatocellular carcinoma Liver diseas

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Efficacy of telbivudine in HBeAg-positive chronic hepatitis B patients with high baseline ALT levels

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World Journal of Gastroenterology 2010年第32期16卷 4095-4099页

作者： Guo-Cai Lv Wen-Jiang Ma Lin-jung ying Xi Jin Lin Zheng yi-Da yang State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Department of Infectious Diseases First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 Zhejiang ProvinceChina

AIM:To evaluate the efficacy and safety of telbivudine(LDT) in hepatitis B e antigen(HBeAg)-positive chronic hepatitis B(CHB) patients who have high baseline alanine aminotransferase(ALT) levels between 10 and 20 times the upper limit of ***:Forty HBeAg-positive CHB patients with high baseline ALT levels between 10 and 20 times the upper limit of normal were enrolled and received LDT monotherapy for 52 *** forty patients with baseline ALT levels between 2 and 10 times the upper limit of normal were included as *** compared the virological,biochemical,serological and side effect profiles between the two groups at 52 ***:By week 52,the mean decrease in hepatitis B virus(HBV) DNA level compared with baseline was 7.03 log10 copies/mL in the high baseline ALT group and 6.17 log10 copies/mL in the control group,respectively(P < 0.05).The proportion of patients in whom serum HBV DNA levels were undetectable by polymerase chain reaction assay was 72.5% in the high baseline ALT group and 60% in the control group,respectively(P < 0.05).In addition,45.0% of patients in the high baseline ALT group and 27.5% of controls became HBeAg-negative,and 37.5% of those in the high baseline group and 22.5% of controls,respectively,had HBeAg seroconversion(P < 0.05) at week ***,in the high baseline group,4 out of 40 patients(10%) became hepatitis B surface antigen(HBsAg)-negative and 3(7.5%) of them seroconverted(became HBsAg-positive).Only 1 patient in the control group became HBsAg-negative,but had no *** ALT normalization rate,viral breakthrough,genotypic resistance to LDT,and elevations in creatine kinase levels were similar in the two groups over the 52 ***:High baseline ALT level is a strong predictor for optimal results during LDT treatment.

关键词： Chronic hepatitis B Hepatitis B e antigen Serum alanine aminotransferase level Telbivudine

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Efficient page layout analysis on small devices

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第6期10卷 800-804页

作者： Eun-jung HAN Chee-onn WONG Kee-chul jung Kyung-ho LEE Eun-yi KIM Department of Naval Architecture and Ocean Engineering Inha University Human-Centered Interfaces Lab Department of Digital MediaSoongsil University Internet and Media Engineering Konkuk University

Previously we have designed and implemented new image browsing facilities to support effective offiine image contents on mobile devices with limited capabilities： low bandwidth, small display, and slow processing. In this letter, we fulfill the automatic production of cartoon contents fitting small-screen display, and introduce a clustering method useful for various types of cartoon images as a prerequisite stage for preserving semantic meaning. The usage of neural networks is to properly cut the various forms of pages. Texture information that is useful for grayscale image segmentation gives us a good clue for page layout analysis using the multilayer perceptron （MLP） based x-y recursive algorithm. We also automatically frame the segment MLP using agglomerative segmentation. Our experimental results show that the combined approaches yield good results of segmentation for several cartoons.

关键词： Efficient page layout analysis MLP-based segmentation Mobile devices Image segmentation Neural network

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Hydrocarbon pneumonitis following fuel siphonage: A case report and literature review

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World Journal of Emergency Medicine 2019年第2期10卷 69-74页

作者： yi-jung Chen Chien-chin Hsu Kuo-tai Chen Emergency Department Chi-Mei Medical Center Department of Biotechnology Southern Tainan University of Technology Department of Emergency Medicine School of Medicine College of Medicine Taipei Medical University

BACKGROUND: People sometimes siphon fuel to fill their tanks. However, this is a potentially dangerous procedure and may cause hydrocarbon pneumonitis. We present the case of a patient with severe hydrocarbon pneumonitis after siphoning fuel. The patient underwent artifi cial ventilation and was admitted to hospital for 97 days. METHODS: We review the relevant literature for a better understanding of clinical features and management strategies for hydrocarbon pneumonitis following fuel ***: We reviewed 15 articles, which included 3 original articles and 12 case reports that reported the clinical features of fuel siphonage. In addition, we added our presented case for data analysis. A total of 40 cases were included in this review. The literature review found that hydrocarbon pneumonitis caused by fuel siphonage occurs worldwide and that most patients(80%) became symptomatic within 1 day of aspiration. Cough(70%), chest pain(62.5%), dyspnoea(55%), and fever(52.5%) presented in more than half of all patients. The right middle lobe(80%) was the predominantly involved lung fi eld; more than one-third of patients(36.7%) showed the involvement of two ***: Patient history, computed tomographic scans of the chest, and bronchoalveolar lavage are the commonly used diagnostic tools. Supportive care remains the foundation of treatment, whereas antibiotics, steroids, and bronchoalveolar lavage are practical therapies. Patients' clinical improvement precedes the resolution of lesions on chest X-ray. Most complications arise from pulmonary lesions. The prognosis of patients suffering from hydrocarbon pneumonitis following fuel siphonage might be improved by accurate diagnosis and appropriate care.

关键词： Siphonage Diesel Fuel Aspiration Hydrocarbon pneumonitis

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Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages

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Journal of Molecular Cell Biology 2020年第7期12卷 543-555页

作者： yi Rang Na Daun jung Juha Song Jong-Wan Park jung Joo Hong Seung Hyeok Seok Macrophage Lab Department of Microbiology and Immunology and Institute of Endemic DiseaseSeoul National University College of MedicineChongno-guSeoul 03080Republic of Korea Department of Biomedical Science BK21-Plus Education ProgramSeoul National University College ofMedicineJongno-guSeoul 03080Republic of Korea Department of Pharmacology Seoul National University College of MedicineJongno-guSeoul 03080Republic of Korea Cancer Research Institute and Ischemic/Hypoxic Disease Institute Seoul National University College ofMedicineJongno-guSeoul 03080Republic of Korea National Primate Research Center Korea Research Institute of Bioscience and BiotechnologyCheongju 28116Republic of Korea

Interleukin-10(IL-10)is the most potent anti-inflammatory cytokine in the body and plays an essential role in determining outcomes of many inflammatory *** metabolism is a critical determinant of immune cell function;however,it is currently unclear whether metabolic processes are specifically involved in IL-10 *** this study,we aimed to find the central metabolic molecule regulating IL-10 production of macrophages,which are the main producers of *** analysis identified that metabolic changes were predominantly enriched in Kupffer cells at the early inflammatory phase of a mouse endotoxemia *** them,pyruvate dehydrogenase kinase(PDK)-dependent acute glycolysis was negatively involved in IL-10 *** or knockdown of PDK selectively increased macrophage IL-10 ***,PDK inhibition increased IL-10 production via profound phosphorylation of adenosine monophosphate(AMP)-activated protein kinase alpha 1(AMPKα1)by restricting glucose uptake in lipopolysaccharide-stimulated ***α1 consequently activated p38 mitogen-activated protein kinase,c-Jun N-terminal kinase,and cyclic AMP-responsive element-binding protein to regulate IL-10 *** study uncovers a previously unknown regulatory mechanism of IL-10 in activated macrophages involving an immunometabolic function of PDK.

关键词： macrophage pyruvate dehydrogenase kinase AMP-activated protein kinase interleukin-10

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