检索结果-南通市图书馆

Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期68卷 263-271页

作者： Siyi He Zhiyi Zhang Guohui song Zhenhai Wang Chunyun Dai Shipeng Yan Kun Jiang Bingbing song He Li Maomao Cao Dianqin Sun Fan Yang Xinxin Yan Shaoli Zhang yi Teng Qianru Li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute Linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrend<0.001). Four predictors, including male, ≥60 years, smoking, and limited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

关键词： stomach neoplasms precancerous conditions cancer screening cumulative incidence risk stratification

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

开放性数学课堂教学之我见

怀化师专学报 2001年第5期20卷 85-87页

作者：易松华张斌怀化师专初等教育系湖南怀化418008

开放性教学是针对传统的封闭式教学而言的 ,更注重学生素质和能力的培养开放性教学包括教学观念。

关键词：数学教学开放性教学课堂教学教学观念教学内容教学形式能力培养素质教育

精准扶贫视野下苗族村寨发展策略思考——基于怀化学院对口扶贫明中村的个案研究

在线全文

学校读者我要写书评

暂无评论

科技视界 2018年第6期 99-100,42页

作者：易松华颜娟怀化学院湖南怀化418008

通过精确识别,明中村致贫既有自然条件和天灾的原因,也有因病缺乏劳动力因素,更有"等、靠、要"思想与因循守旧观念严重的深层次问题;如何做好精确帮扶,怀化学院根据学校传统教育资源和专业优势,确定了"扶‘志’与扶‘智’相结合"、"科... 详细信息

通过精确识别,明中村致贫既有自然条件和天灾的原因,也有因病缺乏劳动力因素,更有"等、靠、要"思想与因循守旧观念严重的深层次问题;如何做好精确帮扶,怀化学院根据学校传统教育资源和专业优势,确定了"扶‘志’与扶‘智’相结合"、"科学研究与产业发展相结合"以及"文化引领与旅游打造相结合"的策略;这些策略对于贫困的苗族村寨发展具有重要的启迪意义。

关键词： “精准扶贫” 苗族村寨教育扶贫专业扶贫文化扶贫

在线全文

学校读者我要写书评

暂无评论

基于单线圈斜向磁化的钢管漏磁检测方法

无损检测 2008年第11期30卷 800-803页

作者：孙燕华康宜华宋凯武新军华中科技大学武汉430074

针对目前钢管纵、横向缺陷采用漏磁方法分开检测的不足,依据单线圈磁场特性,提出并分析了基于同轴单线圈、斜置单线圈、辅以聚磁器的斜置单线圈和辅以聚磁器的同轴单线圈的四种钢管磁化方法。得出了单线圈斜置是钢管产生斜向磁化的必要... 详细信息

针对目前钢管纵、横向缺陷采用漏磁方法分开检测的不足,依据单线圈磁场特性,提出并分析了基于同轴单线圈、斜置单线圈、辅以聚磁器的斜置单线圈和辅以聚磁器的同轴单线圈的四种钢管磁化方法。得出了单线圈斜置是钢管产生斜向磁化的必要条件,聚磁器能增强斜向磁场的结论。在此结论基础上建立了基于斜向磁化的,可同时检测出纵、横向缺陷的钢管漏磁检测方法。

关键词：漏磁检测钢管单线圈斜向磁化

Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu yi-hua Wang yi-Xin Liu Lu Xu Lin Fu Ning yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

短切高性能纤维增强三聚氰胺甲醛泡沫性能研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

塑料工业 2017年第1期45卷 28-31,60页

作者：蒋洁林义王桦宋巧丽顾迎春陈胜高技术有机纤维四川省重点实验室四川成都610072 四川大学轻纺与食品学院四川成都610065

采用短切芳纶纤维和短切玄武岩纤维分别作为增强材料制备了纤维增强三聚氰胺甲醛泡沫。通过对样品进行形貌分析、力学性能测试以及热重分析等,对比分析了两种短切纤维对三聚氰胺甲醛泡沫增强效果的影响。结果表明,短切玄武岩纤维和短切... 详细信息

采用短切芳纶纤维和短切玄武岩纤维分别作为增强材料制备了纤维增强三聚氰胺甲醛泡沫。通过对样品进行形貌分析、力学性能测试以及热重分析等,对比分析了两种短切纤维对三聚氰胺甲醛泡沫增强效果的影响。结果表明,短切玄武岩纤维和短切芳纶纤维的加入降低了泡沫材料的粉化率,提高了压缩比强度;短切芳纶纤维明显提高了泡沫材料的比模量,这将有利于提高材料的缓冲性能和吸声性能;短切玄武岩和短切芳纶纤维增强泡沫材料均有利于提高泡沫复合材料的热稳定性。

关键词：三聚氰胺甲醛泡沫短切芳纶纤维短切玄武岩纤维增强

在线全文

学校读者我要写书评

暂无评论

基于ARM处理器的地下输水管道渗漏检测仪

计算机应用研究 2005年第4期22卷 198-199页

作者：孙天泽袁文菊王越峰易松华清华大学计算机与信息管理中心北京100084 中国地质大学地下信息探测技术与仪器教育部重点实验室北京100083 北京麦克泰软件技术有限公司北京100094

根据相关检测的基本原理,提出使用相关检测方法进行漏水检测。结合ARM嵌入式处理器的低功耗特性,设计了一种低功耗、便携式地下输水管道渗漏检测仪方案。

关键词：嵌入式数据采集相关 ARM

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan huang yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-yian Guo Jian-Gang Shen Su-hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

在线全文

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-Li Kang yi Jiang hua-Wei Zhang Xiao-Mei song Yu-Ze Li Wen-Li huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC