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Can eradication rate of gastric Helicobacter pylori be improved by killing oral Helicobacter pylori ?

World Journal of Gastroenterology 2013年第39期19卷 6645-6650页

作者： han-yi song Yan Li Department of Gastroenterology Shengjing Hospital of China Medical University

AIM:To evaluate the influence of oral Helicobacter pylori(***)on the success of eradication therapy against gastric ***:A total of 391 patients with dyspepsia were examined for *** using the saliva *** antigen test(HPS),13C-urea breath test(UBT),gastroscopy,and gastric mucosal histopathological *** 40 volunteers without discomfort were subjected to HPS and13C-UBT,and served as the control *** 233 patients who were13C-UBT+were enrolled in this study and divided into 4 *** who were HPS-and13C-UBT+(n=53)received triple therapy *** who were both HPS+and13CUBT+(n=180)were randomly divided into 3 groups:(1)the O+G+t group which received triple therapy alone(n=53);(2)the O+G+tm group which received both triple therapy and mouthrinse treatment(n=65);and(3)the O+G+tmp group which received triple therapy,mouthrinse,and periodontal treatment(n=62).The HPS and13C-UBT were continued for 4 wk after completion of treatment,and the eradication rate of gastric *** and the prevalence of oral *** in the 4 groups were then ***:The eradication rates of gastric *** in the O-G+t group,the O+G+tm group,and the O+G+tmp group were 93.3%,90.0%,and 94.7%respectively;all of these rates were higher than that of the O+G+t group(78.4%)[O-G+t group vs O+G+t group(P=0.039);O+G+tm group vs O+G+t group(P=0.092);O+G+tmp group vs O+G+t group(P=0.012);O+G+tm group vs O-G+t group(P=0.546);O+G+tmp group vs O-G+t group(P=0.765);O+G+tm group vs O+G+tmp group(P=0.924)].The eradication of gastric *** was significantly improved using the combination of triple therapy,mouthrinse,and periodontal *** eradication rates of gastric *** in the peptic ulcer group,chronic atrophic gastritis group and control group were higher than in the duodenitis group and the superficial gastritis *** prevalence rates of oral *** in the O-G+t group,O+G+t group,O+G+tm group and O+G+tmp group following treatmen

关键词： Helicobacter pylori Dental plaque Eradication Periodontal Mouthrinse

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Kinematics and activity of M dwarfs in LAMOST DR1

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Research in Astronomy and Astrophysics 2015年第6期15卷 860-870页

作者： Zhen-Ping yi A-Li Luo Jing-Kun Zhao yi-han song Jing-Chang Pan Yong-Heng Zhao Yong Zhang Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Shandong University Weihai 264209 China University of Chinese Academy of Sciences Beijing 100049 China Nanjing Institute of Astronomical Optics & Technology National Astronomical Observatories Chinese Academy of Sciences Nanjing 210042 China

We report on the first investigation into kinematics and chromospheric activity of M dwarfs from the Guo Shou Jing Telescope （also called the Large Sky Area Multi-Object Fiber Spectroscopic Telescope - LAMOST） data release one （DR1）. The sample comprises 71 304 M dwarfs. Their fundamental parameters such as spectral types, radial velocities, important molecular band indices and magnetic activities are measured. Their distances are determined by a spectroscopic parallax relation. Space motion （U, V, W） and Galactocentric cylindrical coordinates （R, θ, Z） for the M dwarfs are also computed. We examine velocity dispersion as a function of height from the Galactic plane and find that all three components of velocity dispersion in- crease with height as measured with respect to the Galactic plane. The investigation into chromospheric activities along the height from the Galactic plane confirms that M dwarfs closer to the Galactic plane are more likely to be active. We take a pure kinematical approach to select thin disk stars and thick disk stars from our sample, then to investigate the differences in properties between these two populations. Our analysis is in excellent agreement with previous studies and leads to a better understanding of the structure of the Galactic disk.

关键词： stars kinematics -- stars magnetic fields -- stars low-mass, brown dwarfs -- stars fundamental parameters

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Relative flux calibration for the Guoshoujing Telescope (LAMOST)

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Research in Astronomy and Astrophysics 2012年第4期12卷 453-464页

作者： yi-han song A-Li Luo Georges Comte Zhong-Rui Bai Jian-Nan Zhang Wei Du Hao-Tong Zhang Jian-Jun Chen Fang Zuo Yong-Heng Zhao National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100012China Graduate University of Chinese Academy of Sciences Beijing 100049China Observatoire Astronomique Marseille-Provence and Laboratoire d'Astrophysique de Marseille F-13388 Marseille CedexFrance

This paper presents a relative flux calibration method for the Guoshoujing Telescope （LAMOST）, which may be applied to connect a blue spectrum to a red spectrum to build the whole spectrum across the total wavelength range （3700 ～ 9000 A）. In each spectrograph, we estimate the effective temperatures of selected stars using a grid of spectral line indices in the blue spectral range and a comparison with stellar atmosphere models. For each spectrograph, stars of types A and F are selected as pseudo-standard stars, and the theoretical spectra are used to calibrate both the blue （3700 ～ 5900 A） and red spectrograph arms （5700 ～ 9000 A）. Then the spectral response function for these pseudo-standard stars could be used to correct the raw spectra provided by the other fibers of the spectrograph, after a fiber efficiency function has been derived from twilight flat-field exposures. A key problem in this method is the fitting of a pseudo stellar continuum, so we also give a detailed description of this step. The method is tested by comparing a small sample of LAMOST spectra calibrated in this way on stars also observed by the Sloan Digital Sky Survey. The result shows that the T eff estimation and relative flux calibration method are adequate.

关键词： techniques: spectroscopic — calibration: methods:data analysis

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Cardiovascular risk and prevalence of metabolic syndrome by differing criteria

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Chinese Medical Journal 2008年第16期121卷 1532-1536页

作者： LI Wei-ju XUE Hao SUN Kai song Xiao-dong WANG yi-bo ZHEN yi-song han Yun-feng HUI Ru-tai Hypertension Division Fuwai Hospital and Cardiovascular Institute Key Laboratory of Clinical Cardiovascular Genetics Ministry of Education Sino-German Laboratory for Molecular Medicine Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background The prevalence of metabolic syndrome （MetS） in hypertensive population in Chinese countryside is unknown. Firstly, this study compared the prevalence of MetS according to National Cholesterol Education Program （NCEP） ATPIII, revised NCEP and International Diabetes Federation （IDF） definitions. Secondly, it investigated the association between MetS, coronary heart disease （CHD） and stroke in patients with hypertension. Methods In this cross sectional study, the cluster sampling method was used. Three MetS definitions were applied to 1418 normal subjects and 5348 hypertensive patients aged 40-75 years in rural areas in China. The agreement between different MetS definitions was estimated by K statistics. Logistic regression analyses determined the association between MetS defined by the three MetS definitions and CHD and stroke. Results In subjects without hypertension, the prevalence of Mets was 4.1% by NCEP definition, 8.3% revised NCEP definition and 7.8% IDF definition. In hypertensive individuals, the prevalence was 14.0%, 32.9%, and 27.4% in men; 35.6%, 53.1%, and 50.2% in women by the same definitions, respectively. In hypertensive individuals, the agreement was 94.4% in men and 97.0% in women between revised NCEP and IDF definitions. The IDF defined MetS was more strongly associated with CHD than the NCEP or revised NCEP defined MetS （adjusted odds ratio： 1.92 compared with 1.85 and 1.69 in men; 1.64 compared with 1.48 and 1.60 in women）. Conclusions In the patients with hypertension, the revised NCEP and IDF definitions identified more individuals than NCEP definition and their agreement is very high. The IDF defined MetS is more strongly associated with CHD than the NCEP or revised NCEP defined MetS, but weakly or not associated with stroke.

关键词： metabolic syndrome hypertension cardiovascular risk National Cholesterol Education Program,International Diabetes Federation

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M Dwarf catalog of LAMOST general survey data release one

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Research in Astronomy and Astrophysics 2015年第8期15卷 1182-1196页

作者： Yan-Xin Guo Zhen-Ping yi A-Li Luo You-Fen Wang Yu Bai Hai-Feng Yang yi-han song Jian-Jun Chen Xiao-Yan Chen Fang Zuo Bing Du Jian-Nan Zhang yin-Bi Li Xiao Kong Meng-Xin Wang Yue Wu Ke-Fei Wu Yong-Heng Zhao Yong Zhang Yong-Hui Hou Yue-Fei Wang Ming Yang Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of Sciences University of Chinese Academy of Sciences School of Mechanical Electical & Information EngineeringShandong University at Weihai School of Computer Science and Technology Taiyuan University of Science and Technology Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences

We present a spectroscopic catalog of 93 619 M dwarfs from the first data release of the Large Sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST）general survey. During sample selection, M giant contamination was eliminated using2 MASS photometry and Ca H/TiO molecular indices. For each spectrum, the spectral subtype and values are provided including radial velocity, Hα equivalent width, a series of prominent molecular band indices, and the metal–sensitive parameter ζ, as well as distances and the space motions for high S/N objects. In addition, Hα emission lines are measured to examine the magnetic activity properties of M dwarfs and 7179 active ones are found. In particular, a subsample with significant variation in magnetic activity is revealed through observations from different epochs. Finally, statistical analysis for this sample is performed, including the metallicity classification, the distribution of molecular band indices and their errors.

关键词： catalogs—methods: analytical—stars: statistical—stars : late-type—stars: magnetic-activity—stars

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Nearby M subdwarfs from LAMOST data release 2

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Research in Astronomy and Astrophysics 2016年第7期16卷 55-68页

作者： Yu Bai A-Li Luo Georges Comte Jing-Kun Zhao Hai-Feng Yang Yan-Xin Guo You-Fen Wang yin-Bi Li Bing Du Wen Hou Xiao Kong Zhen-Ping yi yi-han song Zhong-Rui Bai Jian-Nan Zhang Meng-Xin Wang Jian-Jun Chen Xiao-Yan Chen Ke-Fei Wu Fang Zuo Yue Wu Zi-Huang Cao Yong-Hui Hou Yue-Fei Wang Yong Zhang Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing100012 China University of Chinese Academy of Sciences Beijing 100049 China Aix-Marseille University CNRS Institut Pytheas L.A.M. UMR 7326 13388 Marseille Cedex France School of Computer Science and Technology Taiyuan University of Science and Technology Taiyuan 030024 China School of Mechanical Electrical & Information Engineering Shandong University at Weihai Weihai 264209 China Nanjing Institute of Astronomical Optics & Technology National Astronomical Observatories Chinese Academy of Sciences Nanjing 210042 China

We identify 108 M subdwarfs（sd Ms） out of more than two hundred thousand M type spectra from the second data release（DR2） of the LAMOST regular survey. This sample, among which 58 members are identified for the first time, includes 33 extreme subdwarfs（esd Ms） and 11 ultra subdwarfs（usd Ms）.The selection is based on the usual ratio of absorption depth of Ca H2, Ca H3 and TiO 5 band *** also emphasize the use of the Ca H1 band. We provide estimates of spectral subtype（SPT）, L′epine metallicity index ζ, effective temperature and [Fe/H]. Both ζ–[Fe/H] and SPT–Teff figures show reasonable consistency; compared to PHOENIX model spectra, average rounded values of [Fe/H] for sd Ms, esd Ms and usd Ms are respectively –0.5, –1 and –1.5. The photometric distances are estimated, indicating that most sources are located within 500 pc of the Sun and 350 pc of the Galactic disk. Velocities and 3D Galactic motions are also briefly discussed. Among the 108 subdwarfs, seven stars appear to be active with a significant Hα emission line. The source LAMOST J104521.52＋482823.3 is a white dwarf- M subdwarf binary, while LAMOST J123045.52＋410943.8, also active, exhibits carbon features in red.

关键词： stars late-type stars statistics subdwarfs

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi han Tang Jianian Hu Siying Kang song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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SFC制备EPA和DHA乙酯过程中上载量和流速的影响

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高校化学工程学报 2007年第2期21卷 189-193页

作者：韩一松任其龙杨亦文张海吴平东浙江大学化学工程与生物工程学系二次资源化工国家专业实验室浙江杭州310027

以超临界CO2为流动相ODS-C18为固定相,以尿素包络法处理后的鱼油乙酯化物为原料,柱温为55℃,柱前压为12.1MPa,改变载量和流动相流速,测定了二十碳五烯酸乙酯(EPA-EE)和二十二碳六烯酸乙酯(DHA-EE)的色谱动态特性。结果表明,EPA-EE与DHA... 详细信息

以超临界CO2为流动相ODS-C18为固定相,以尿素包络法处理后的鱼油乙酯化物为原料,柱温为55℃,柱前压为12.1MPa,改变载量和流动相流速,测定了二十碳五烯酸乙酯(EPA-EE)和二十二碳六烯酸乙酯(DHA-EE)的色谱动态特性。结果表明,EPA-EE与DHA-EE之间的分离良好,但原料中其他脂肪酸乙酯杂质不能分离。适当切割流出物馏分,EPA-EE的纯度可达90%,DHA-EE可达75%。根据实验结果考察了载量和流动相流速对制备色谱效能的影响。色谱柱的生产能力随流速的增大而增大。在EPA-EE纯度一定的前提下,色谱柱的生产能力随载量的增大而增大,但载量过大则生产能力又会减小。当EPA-EE纯度要求在85%以下时,载量对其回收率的影响不大,CO2消耗量(每单位重量产品的消耗)随着载量的增大而减少;纯度要求在90%以上时,回收率随载量的增大而明显减小,CO2消耗量随载量的变化有最低点,在载量为4.076mL·L-1时为最小。EPA-EE纯度要求为90%时,适宜载量为7.13mL·L-1,流动相流速为3.928g·min-1,此时色谱柱的生产能力为2.41g·h-1·L-1,EPA-EE回收率为37.8%。同时得到的DHA-EE的纯度为75%,回收率为88.8%。

关键词：超临界流体色谱(SFC) 二十碳五烯酸乙酯(EPA-EE) 二十二碳六烯酸乙酯(DHA-EE) 色谱效能

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论图书馆服务文化

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农业网络信息 2008年第4期 86-88,91页

作者：韩屹松黑龙江农业经济职业学院黑龙江牡丹江157041

文章认为,读者满意是图书馆服务文化的目标要素,人文关怀是图书馆服务文化的特征要素,馆员素养是图书馆服务文化的载体要素。

关键词：图书馆服务服务文化读者满意人文关怀馆员素养

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The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun Yun Wen-Biao han yi-Yang Guo He Wang Minghui Du hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/hangzhou) University of Chinese Academy of Sciences Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

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