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Development of a new Cox model for predicting long-term survival in hepatitis cirrhosis patients underwent transjugular intrahepatic portosystemic shunts

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 491-502页

作者： yi-Fan Lv bing Zhu Ming-Ming Meng yi-Fan Wu Cheng-bin Dong Yu Zhang Bo-Wen liu Shao-Li You Sa Lv Yong-Ping Yang Fu-Quan liu Liver Disease Minimally Invasive Diagnosis and Treatment Center Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Liver Vascular Disease Diagnosis and Treatment Center The Fifth Medical Center of Chinese People's Liberation Army General HospitalBeijing 100039China

BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)placement is a procedure that can effectively treat complications of portal hypertension,such as variceal bleeding and refractory ***,there have been no specific studies on predicting long-term survival after TIPS *** To establish a model to predict long-term survival in patients with hepatitis cirrhosis after *** A retrospective analysis was conducted on a cohort of 224 patients who un-derwent TIPS *** univariate and multivariate Cox regression analyses,various factors were examined for their ability to predict survival at 6 years after ***,a composite score was formulated,encompassing the indication,shunt reasonability,portal venous pressure gradient(PPG)after TIPS,percentage decrease in portal venous pressure(PVP),indocyanine green retention rate at 15 min(ICGR15)and total bilirubin(Tbil)***,the performance of the newly developed Cox(NDC)model was evaluated in an in-ternal validation cohort and compared with that of a series of existing *** The indication(variceal bleeding or ascites),shunt reasonability(reasonable or unreasonable),ICGR15,post-operative PPG,percentage of PVP decrease and Tbil were found to be independent factors affecting long-term survival after TIPS *** NDC model incorporated these parameters and successfully identified patients at high risk,exhibiting a notably elevated mortality rate following the TIPS procedure,as observed in both the training and validation ***,in terms of predicting the long-term survival rate,the performance of the NDC model was significantly better than that of the other four models[Child-Pugh,model for end-stage liver disease(MELD),MELD-sodium and the Freiburg index of post-TIPS survival].CONCLUSION The NDC model can accurately predict long-term survival after the TIPS procedure in patients with hepatitis cirrhosis,help identify high-risk patients

关键词： Transjugular intrahepatic portosystemic shunt Long-term survival Predictive model

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Suppressing the phase transition of ZrP_(2)O_(7), by defect and entropy regulation for high-temperature wave-transparent material application

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Journal of Advanced Ceramics 2024年第8期13卷 1164-1177页

作者： Peng liu Zhilin Tian Zhilin Chen Shuping Wen Liya Zheng bin Li School of Materials Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China

ZrP_(2)O_(7) is a promising wave-transparent material due to its low dielectric constant and low dielectric loss,but its inherent phase transition characteristic at approximately 300℃ limits its high-temperature ***,suppressing the phase transition is necessary for ZrP_(2)O_(7),to serve in extremely harsh *** this work,introducing Ti and Hf into ZrP_(2)O_(7) causes significant lattice distortion and an increase in entropy,both of which synergistically limit the crystal structure *** addition,enhanced phonon scattering by mismatch of atomic mass and local distortion leads to a reduction in the thermal *** distortions also cause changes in both bond length and tilting angle,so that(Ti_(1/3)Zr_(1/3)Hf_(1/3))P_(2)O_(7) does not undergo sudden expansion as does ZrP_(2)O_(7).(Ti_(1/3)Zr_(1/3)Hf_(1/3))ZrP_(2)O_(7) maintains excellent dielectric properties,which highlights it as a promising high-temperature wave-transparent material.

关键词： wave-transparent material medium-entropy ceramics phase transition dielectric constant thermal expansion thermal conductivity

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Multidomain Hybrid Direct DG and Central Difference Methods for Viscous Terms in Hyperbolic-Parabolic Equations

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Numerical Mathematics(Theory,Methods and Applications) 2024年第1期17卷 1-36页

作者： Weixiong Yuan Tiegang liu bin Zhang Kui Cao Kun Wang LMIB and School of Mathematical Sciences Beihang UniversityBeijing 100191China

A class of multidomain hybrid methods of direct discontinuous Galerkin(DDG)methods and central difference(CD)schemes for the viscous terms is pro-posed in this *** conservative and nonconservative coupling modes are *** treat the shock wave,the nonconservative coupling mode automatically switch to conservative coupling mode to preserve the conservative property when discontinuities pass through the artiﬁcial *** maintain the accuracy of the hybrid methods,the Lagrange interpolation polynomials and their derivatives are reconstructed to handle the coupling cells in the DDG subdomain,while the values of ghost points for the CD subdomain are calculated by the approximate polynomials from the DDG *** linear stabilities of these methods are demonstrated in detail through von-Neumann *** multidomain hybrid DDG and CD meth-ods are then extended to one-and two-dimensional hyperbolic-parabolic *** results validate that the multidomain hybrid methods are high-order ac-curate in the smooth regions,robust for viscous shock simulations and capable to save computational cost.

关键词： Direct discontinuous Galerkin central difference schemes multidomain hybrid methods viscous terms hyperbolic-parabolic equations

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Adaptive Algorithms on Maximizing Monotone Nonsubmodular Functions

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Journal of the Operations Research Society of China 2024年第2期12卷 428-445页

作者： bin liu Hui Su Shu-Fang Gong Qi-Zhi Fang School of Mathematical Sciences Ocean Universityof ChinaQingdao266100ShandongChina

Submodular optimization is widely used in large *** order to speed up the problems solving,it is essential to design low-adaptive algorithms to achieve acceleration in *** general,the function values are given by a value oracle,but in practice,the oracle queries may consume a lot of ***,how to strike a balance between optimizing them is *** this paper,we focus on maximizing a normalized and strictly monotone set function with the diminishing-return ratio under a cardinality constraint,and propose two algorithms to deal with *** apply the adaptive sequencing technique to devise the first algorithm,whose approximation ratio is arbitrarily close to 1-e^(-γ)in O(logn·log(log k/γ)) adaptive rounds,and requires O(logn^(2)·log(log k/γ)) *** by adding preprocessing and parameter estimation steps to the first algorithm,we get the second *** second algorithm trades a small sacrifice in adaptive complexity for a significant improvement in query *** the same approximation and adaptive complexity,the query complexity is improved *** the best of our knowledge,this is the first paper of designing adaptive algorithms for maximizing a monotone function using the diminishing-return ratio.

关键词： Approximation algorithm Adaptivity Nonsubmodular maximization Cardinality constraint

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Improving landscape connectivity through habitat restoration:application for Asian elephant conservation in Xishuangbanna Prefecture,China

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Integrative Zoology 2024年第2期19卷 319-335页

作者： bin WAN Wenwen LI Peng liu Nian YANG Shang CHEN Xianming GUO bin WANG Li ZHANG Key Laboratory for Biodiversity Science and Ecological Engineering Ministry of EducationCollege of Life SciencesBeijing Normal UniversityBeijingChina Research Center for Coastal Zone Science and Marine Development Strategy First Institute of OceanographyMinistry of Natural ResourcesQingdaoChina School of Biological Sciences The University of Hong KongPokfulamHong KongChina Research Institute of Xishuangbanna National Nature Reserve JinghongChina Xishuangbanna Asian Elephant Conservation and Management Center JinghongChina

Habitat restoration is an effective method for improving landscape connectivity,which can reduce habitat *** landscape connectivity could promote connections between habitat,which is extremely essential to preserve gene flow and population *** study proposes a methodological framework to analyze landscape connectivity for Asian elephant habitat conservation,aiming to provide practical options for reducing habitat fragmentation and improving habitat *** approach involved combining a species distribution model using MaxEnt and landscape functional connectivity models using graph theory to assess the impact on connectivity improvement via farmland/plantation restoration as *** results showed that:(1)there were 119 suitable habitat patches of Asian elephant covering a total area of 1952.41 km^(2).(2)The connectivity between habitats improved significantly after vegetation restoration and the gain first decreased and then increased with the increase of dispersal distance.(3)The first few new habitat patches that were identified played an important role in improving connectivity,and the variation rate of connectivity gradually leveled off as the number of new habitats increased.(4)Prioritization of the 25 best new habitat patches increased connectivity from 0.54%to 5.59%as the dispersal distance increased and mainly was located between two Asian elephant distribution regions and two *** of new habitat patches was effective for improving or restoring *** findings can be used as guidance for improving the studied fragmented Asian elephant habitats,and they can also be used as a reference for the habitat restoration of other endangered species heavily affected by habitat fragmentation.

关键词： Asian elephant connectivity habitat restoration habitat suitability landscape graphs

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Oxidative cyclization of allyl compounds and isocyanide: A facile entry to polysubstituted 2-cyanopyrroles

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Chinese Chemical Letters 2024年第4期35卷 330-335页

作者： Yaping Zhang Wei Zhou Mingchun Gao Tianqi liu bingxin liu Chang-Hua Ding bin Xu Department of Chemistry Affiliated Nantong Hospital of Shanghai University(The Sixth People's Hospital of Nantong)Shanghai Engineering Research Center of Organ RepairInnovative Drug Research CenterSchool of MedicineShanghai UniversityShanghai 200444China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

A facile Tf OH-catalyzed oxidative cyclization of allyl compounds and isocyanide has been developed with the assistance of DDQ, where isocyanide is used as the crucial "N" and "CN" sources. Highly functionalized 2-cyanopyrroles are constructed efficiently through a new formal [3 + 2] mode, demonstrating diverse reactivity and synthetic utility in organic chemistry. 2-Cyanopyrrole is converted into a nucleobase analogue of Remdesivir and 5H-pyrrolo[2,1-a]isoindole through a three-step or a two-step sequence, respectively. This protocol features broad substrate scope, operational simplicity and good functional group tolerance.

关键词： Isocyanide Cyanopyrrole Insertion Allyl compound Bronsted acid catalysis

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Antibonding orbital tailor and stress relief engineering for FeS2 complex toward superior sodium storage

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Rare Metals 2024年第10期43卷 5048-5059页

作者： You-bin Zhang Zhen-Guo Qi Fu-Sheng liu Guo-Hui Qin State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and Technology Shandong Synergetic Innovation Center of Ecological and Chemical Engineering

The sluggish kinetics behaviors and vast volume variations of Na+hosts to FeS2anode involved intercalation,and conversion reactions plague its applicability of sodium-ion batteries （SIBs）.Here,a significantly expedited kinetics via cation intercalation and considerably relieved stress accumulation by constructing the concave scaffold protector are approached for *** Mn2+intercalation into FeS2,a new stable Mn–FeS2was generated with distorted coordination;elevated antibonding orbital occupancy and lowed d band center to the release of more free Na+were achieved,which was further encapsulated by hollow bowl-like carbon spheres （BC）This cation intercalation and concave morphology strategies confer Mn–FeS2@BC significantly enhanced electron ion transport kinetics via reversed electron transfer to FeS2fast desolvation kinetics,and evidently depressed structural deformation during Na+insertion and ***,Mn–FeS2@BC delivers the longevity and stable Na+storage capacity in both half and full cell ***,Mn–FeS2@BC also displays excellen adaptability in a wider temperature *** work proposes new views into the deep regulation of electrochemical performance of transition metal anodes via intercalation chemistry and concave engineering.

关键词： Concave engineering FeS2 Intercalation chemistry Sodium capture

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Iridoids modulate inflammation in diabetic kidney disease: A review

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Journal of Integrative Medicine 2024年第3期22卷 210-222页

作者： Tong-yi Zhou Na Tian liu Li Rong Yu The First Clinical College of Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Provincial Key Laboratory of Translational Research in Traditional Chinese Medicine Prescriptions and Zheng Changsha 410208Hunan ProvinceChina

In recent years,preclinical research on diabetic kidney disease (DKD) has surged to the forefront of scientific and clinical *** has become a pervasive complication of type 2 *** the complexity of its etiology and pathological mechanisms,current interventions,including drugs,dietary modifications,exercise,hypoglycemic treatments and lipid-lowering methods,often fall short in achieving desired therapeutic ***,primarily derived from the potent components of traditional herbs,have been the subject of long-standing *** data suggest that iridoids possess notable renal protective properties;however,there has been no summary of the research on their efficacy in the management and treatment of *** article consolidates findings from in vivo and in vitro research on iridoids in the context of DKD and highlights their shared anti-inflammatory activities in treating this ***,it explores how certain iridoid components modify their chemical structures through the regulation of intestinal flora,potentially bolstering their therapeutic *** review provides a focused examination of the mechanisms through which iridoids may prevent or treat DKD,offering valuable insights for future research endeavors.

关键词： Diabetic kidney disease Iridoids Gut-kidney axis Traditional Chinese medicine monomer Inflammation

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Systematic and long-term technical validity of toxicity determination and early warning of heavy metal pollution based on an automatic water-toxicity-determination-system

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Frontiers of Environmental Science & Engineering 2024年第8期18卷 59-71页

作者： Yue yi Baoguo Wang Xuemei yi Fan Zha Haisen Lin Zhijun Zhou Yanhong Ge Hong liu School of Life Science Beijing Institute of TechnologyBeijing 100081China Institute of Environmental Biology and Life Support Technology School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China Infore Environment Technology Group Foshan 528000China Jiangmen Ecological Environment Monitoring Station Jiangmen 529000China Guangzhou Sub-branch of Guangdong Ecological and Environmental Monitoring Center Guangzhou 510000China

Water toxicity determination with electrochemically active bacteria(EAB)shows promise for providing early warnings for heavy metal pollution in ***,thus far,only idealized tests with a few types of heavy metals have been *** this study,an automatic water-toxicitydetermination system with high technical maturity was established,and the toxicological properties of common heavy metals were systematically *** results demonstrated that the common heavy metals linearly inhibited EAB currents in the range of 0.1 mg/L to 0.5 mg/*** toxicity ranking of the tested heavy metals was Pb^(2+)>Tl^(3+)>Cu^(2+)>Cd^(2+)>Zn^(2+)>Ni^(2+)>Hg^(2+)>As^(3+).The toxicity interaction mainly exhibited an antagonistic effect in binary heavy metal *** system can accurately determine surface water toxicity and rapidly monitor heavy metal pollution,with good repeatability and a long ***,this study demonstrates that EAB are capable of long-term(>60 d)surface water quality monitoring and on-site early warning of heavy metal pollution.

关键词： Biological early warning system Electrochemically active bacteria Water toxicity determination Biosensor Heavy metal pollution Early warning

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COVID-19 vaccine updates for people under different conditions

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Science China Life Sciences 2024年第11期67卷 2323-2343页

作者： yijiao Huang Weiyang Wang Yan liu Zai Wang bin Cao National Center for Respiratory Medicine State Key Laboratory of Respiratory Health and Multimorbidity National Clinical Research Center for Respiratory Diseases Institute of Respiratory Medicine Chinese Academy of Medical Sciences Department of Pulmonary and Critical Care Medicine Center of Respiratory Medicine China-Japan Friendship Hospital School of Basic Medical Sciences Tsinghua Medicine Tsinghua University Tsinghua University-Peking University Joint Centre for Life Sciences Tsinghua University Peking Union Medical College Chinese Academy of Medical Sciences Department of Infectious Disease The Affiliated Yantai Yuhuangding Hospital of Qingdao University Institute of Clinical Medical Sciences China-Japan Friendship Hospital Changping Laboratory Department of Respiratory Medicine Capital Medical University New Cornerstone Science Laboratory China-Japan Friendship Hospital

SARS-Co V-2 has caused global waves of infection since December 2019 and continues to persist today. The emergence of SARS-Co V-2variants with strong immune evasion capabilities has compromised the effectiveness of existing vaccines against breakthrough ***, it is important to determine the best utilization strategies for different demographic groups given the variety of vaccine options available. In this review, we will discuss the protective efficacy of vaccines during different stages of the epidemic and emphasize the importance of timely updates to target prevalent variants, which can significantly improve immune protection. While it is recognized that vaccine effectiveness may be lower in certain populations such as the elderly, individuals with chronic comorbidities(e.g., diabetes with poor blood glucose control, those on maintenance dialysis), or those who are immunocompromised compared to the general population,administering multiple doses can result in a strong protective immune response that outweighs potential risks. However, caution should be exercised when considering vaccines that might trigger an intense immune response in populations prone to inflammatory flare or other complications. In conclusion, individuals with special conditions require enhanced and more effective immunization strategies to prevent infection or reinfection, as well as to avoid the potential development of long COVID.

关键词： SARS-CoV-2 vaccine variants of concern elderly immunocompromised

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