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Safety of fecal microbiota transplantation in Chinese children: A single-center retrospective study

World Journal of Clinical Cases 2018年第16期6卷 1121-1127页

作者： Xin-Yue Zhang yi-zhong wang Xiao-Lu Li Hui Hu Hai-Feng Liu Dan Li Yong-Mei Xiao Ting Zhang Department of Gastroenterology Hepatology and Nutrition Shanghai Children's Hospital Shanghai Jiao Tong University

BACKGROUND Fecal microbiota transplantation(FMT) is the administration of fecal bacterial liquid from healthy donors to a recipient's digestive tract, which is recommended as a therapeutic method for recurrent Clostridium difficile infection(CDI). Many clinical trials focusing on different diseases are in progress. To date, scarce research and long-term follow-up have been conducted on FMT in children or on the proper guidelines. Our center first performed FMT to treat a 13-month-old boy with severe CDI in 2013. Until February 2018, our center had performed 114 pediatric FMT procedures in 49 subjects. AIM To investigate the safety of FMT in children. METHODS A retrospective study was conducted on 49 patientswho underwent 114 FMT treatments at our hospital. All FMT processes followed uniform standards. Adverse events(AEs) related to FMT were divided into shortterm(48 h post-FMT) and long-term(3 mo). All potential influencing factors for AEs, such as gender, age, time of FMT infusion, route of administration, disease type, immune function state, and donor relative genetic background, were analyzed as independent factors. The significant independent factors and risk ratio with 95% confidence interval(CI) were assessed by multivariate logistic regression *** Forty-nine patients(mean age 68.1 mo, range 4 to 193 mo) were recruited. Their average follow-up time after the first FMT was 23.1 mo. The incidence of short-term AEs was 26.32%(30/114). The most common shortterm AEs were abdominal pain, diarrhea, fever, and vomiting, which were all self-limited and symptom-free within 48 h. Two severe AEs occurred, and one patient died in the fourth week after FMT. All-cause mortality was 2.04%. As independent factors, age(P = 0.006) and immune state(P = 0.002) had significant effects. Age greater than 72 mo seemed to be correlated with more AEs than age 13 to 36 mo(P = 0.04). In multivariate logistic regression analysis, immune state was an independent risk factor for

关键词： Safety Fecal microbiota transplantation Pediatrics Adverse event Immune system diseases Age factors

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Altered gut microbiota composition in children and their caregivers infected with the SARS‑CoV‑2 Omicron variant

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World Journal of Pediatrics 2023年第5期19卷 478-488页

作者： yi‑zhong wang Jian‑Guo Zhou Yan‑Ming Lu Hui Hu Fang‑Fei Xiao Ting Ge Xing wang Lu Zheng Lian‑Hu Yu Jun Le Hui Yu Guang‑Jun Yu Qiang Xia Ting Zhang Wen‑Hao Zhou Department of Gastroenterology Hepatologyand NutritionShanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong University355 Luding RoadShanghai 200062China Gut Microbiota and Metabolic Research Center Institute of Pediatric InfectionImmunity and Critical Care MedicineSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neonatology Children’s Hospital of Fudan UniversityShanghaiChina Department of Pediatrics Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityShanghaiChina Department of Liver Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Birth Defects Department of NeonatologyMolecular Medical CenterChildren’s Hospital of Fudan University399 Wanyuan RoadShanghai 201101China

Background Gut microbiota alterations have been implicated in the pathogenesis of coronavirus disease 2019(COVID-19).This study aimed to explore gut microbiota changes in a prospective cohort of COVID-19 children and their asymptomatic caregivers infected with the severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2)Omicron *** A total of 186 participants,including 59 COVID-19 children,50 asymptomatic adult caregivers,52 healthy children(HC),and 25 healthy adults(HA),were recruited between 15 April and 31 May *** gut microbiota composition was determined by 16S rRNA gene sequencing in fecal samples collected from the *** microbiota functional profling was performed by using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States(PICRUSt)*** The gut microbiota analysis of beta diversity revealed that the fecal microbial community of COVID-19 children remained far distantly related to *** relative abundances of the phyla Actinobacteria and Firmicutes were decreased,whereas Bacteroidetes,Proteobacteria,and Verrucomicrobiota were increased in COVID-19 *** from COVID-19 children exhibited notably lower abundances of the genera Blautia,Bifdobacterium,Fusicatenibacter,Streptococcus,and Romboutsia and higher abundances of the genera Prevotella,Lachnoclostridium,Escherichia-Shigella,and Bacteroides than those from *** enterotype distributions of COVID-19 children were characterized by a high prevalence of enterotype *** changes in gut microbiota compositions were observed in asymptomatic ***,the microbial metabolic activities of KEGG(Kyoto Encyclopedia of Genes and Genomes)and COG(cluster of orthologous groups of proteins)pathways were perturbed in feces from subjects infected with the SARS-CoV-2 Omicron *** Our data reveal altered gut microbiota compositions in both COVID-19 children and their asymptomatic caregivers infected with

关键词： Caregivers Children Coronavirus disease 2019(COVID-19) Gut microbiota Severe acute respiratory syndrome coronavirus type 2(SARS-CoV-2)

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An Intelligent Agency Framework to Realize Adaptive System Management

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International Journal of Plant Engineering and Management 2007年第1期12卷 29-35页

作者： FU Yu SHEN Jun-yi FENG zhong-hui wang Yong Department of Computer Science and Technology Xi＇an Jiaotong University Xi＇an 710049 P. R. China

In order to realize the required scalable and adaptive system management, an interactive intelligent agency framework, iSMAcy （intelligent System Management Agency） , is proposed as an integrated solution to realize distributed autonomoas system management. Firstly, it is a multiagent platform that supports inter-agent communication and cooperation. Secondly, the functional agents are based on intentional agent architecture that achieves balance between goal-directed behavior and situated reactive action. An example of applying the iSMAcy system to a network management environment has been described to illustrate and validate the scalable and adaptive management capability of the intelligent agency framework.

关键词： intelligent agent muhiagent system adaptive system management

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Emergence of H5N8 avian influenza virus in domestic geese in a wild bird habitat,yishui Lake,north central China

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Virologica Sinica 2023年第1期38卷 157-161页

作者： Cheng Zhang zhong-yi wang Huan Cui Li-Gong Chen Chun-Mao Zhang Zhao-Liang Chen Shi-Shan Dong Kui Zhao ying-ying Fu Ju-Xiang Liu Zhen-Dong Guo Changchun Veterinary Research Institute at Chinese Academy of Agriculture Sciences Changchun 130122China Beijing Institute of Biotechnology Beijing 100071China College of Veterinary Medicine at Jilin University Changchun 130062China College of Veterinary Medicine at Hebei Agricultural University Baoding 071000China

Dear Editor,China is located in the eastern part of the Eurasian continent,with a large north–south range,resulting in a large temperature *** birds migrate two times annually along with the north–south range,including eastern,central and western routes in *** birds are reported to carry influenza viruses from multiple sources,causing the virus to spread across a wide range of regions,which present great challenges for the prevention and control of avian influenza viruses(AIVs)(He et al.,2021;Shi and Gao,2021).

关键词： north annually habitat

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Photoluminescence from neodymium silicide thin films formed by MEVVA ion source

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Nuclear Science and Techniques 2001年第1期12卷 21-23页

作者： XIAO Zhi-Song XU Fei CHENG Guo-An ZHANG Tong-He yi zhong-Zhen wang Shui-Feng (Key Laboratory in University for Radiation Beam Technology and Materials Modification, Institute of Low Energy Nuclear Physics, Beijing Normal University Beijing Radiation 北京师范大学低能核物理所教育部射线束技术与材料改性开放实验室北京 100875 南昌大学材料科学与工程系江西南昌 530047 南昌大学物理系江西南昌 530047

Neodymium silicides were synthesized by Nd ion implant6d into Si substrates with the aid of a metal vapor vacuum arc (MEVVA) ion source. The blender of Nd5Si4 and NdSi2 was formed in a neodymium-implanted silicon thin film during the as-implanted state, but there was only single neodymium silicide compound in the postannealed state, and the phase changed from NdSi2 to Nd5Si4 with increasing annealing temperature. The blue-violet luminescence excited by ultra-violet was observed at the room temperature (RT), and the intensity of photoluminescence (PL) increased with increasing the neodymium ion fluence. Moreover, the photoluminescence was closely dependent on the temperature of rapid thermal annealing (RTA). A mechanism of photoluminescence was discussed.

关键词： MEVVA离子源离子移殖薄膜光致发光

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The Efficient Transformation of Wheat in Planta by Agrobacterium tumefaciens

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Agricultural Sciences in China 2003年第11期2卷 1187-1191页

作者： HE Dao-yi, LI zhong-cun and wang Hong-gang(Agronomy College , Shandong Agricultural University, Tai’an 271000 , P.R.China) Agronomy College Shandong Agricultural University Tai'an 271000 P. R. China

Transformation of wheat was performed by pipetting spikelets with Agrobacterium tumefaciens which contained expression vectors using Npt II as reporter gene. Transformants were identified through kana-mycin resistance, PCR and Southern blot. The results showed that transformation efficiency was within 2.0 to 3. 2% in all tested varieties of wheat. Then the simple and efficient protocol of wheat transformation by Agrobacterium tumefaciens in planta was primarily established.

关键词： Agrobacterium tumefaciens Transformation Wheat

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Effect of Gardenia extract ZG on the adsorption quantity of herpes simplex virus type 1 (HSV-1)

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Journal of Microbiology and Immunology 2006年第4期4卷 272-277页

作者： SHAN SHAN GUO yi zhong wang XIU KUN wang yiNG JIE GAO YA HONG JIN DE FENG LI GUI DONG YUAN yi ZHANG GUI ZHEN ZONG YE ZHAO XIAO LAN CUI Institute of Chinese Meteria Medica China Academy of Chinese Medical Sciences Beijing P. R.China Aerospace Central Hospital Beijing P. R. China

To observe the effect of Gardenia extract ZG on the adsorption quantity of herpes simplex virus type 1 （HSV-1） so as to explore the mechanism of its antiviral activity, fluorescein isothiocyanate （FITC） was used as the fluorescent probe to label viruses and heparin sodium was used as control. Meanwhile, the effect of Gardenia extract ZG on the adsorption quantity on the surface of Hep-2 cells was determined by flow cytometry. It was demonstrated that adsorption of HSV-1 on the surface of Hep-2 cells exhibited the character of saturation and specificity and heparin sodium could prevent attachment of viruses on these ceils. These results are in accord with those reported previously. It was also proved that the manner of drug-use prior to adsorption or simultaneous use of drug and adsorption was better than adsorption prior to drug-use, and the inhibition rates of the former and latter manner were 84.76% and 82.92% respectively. Three manners of drug-use with Gardenia extract ZG were all effective to reduce the adsorption quantity of viruses, especially the manner of simultaneous use of drug and adsorption with an adsorption inhibition rate of 68.46%. From the above observation, it is apparent that the mechanism of anti-viral activity of Gardenia extract ZG may be via several steps involved in the HSV-1 adsorption.

关键词： Gardenia extract ZG Herpes simplex virus type 1 (HSV-1) Adsorption quantity Flow cytometry (FCM) Fluorescein isothiocyanate (FITC)

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Probiotics for Prevention and Treatment of Respiratory Tract Infections in Children A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Probiotics for Prevention and Treatment of Respiratory Tract...

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第十三届江浙沪儿科学术会议暨2016年浙江省医学会儿科学学术年会

作者： yi zhong wang Xiao lu Li Ting Ge Yong mei Xiao Yang Liao Ting Zhang Department of Gastroenterology Hepatologyand NutritionShanghai Children’s HospitalShanghai Jiao Tong University Pediatric Intensive Care Unit Shanghai Children’s HospitalShanghai Jiao Tong University

Background:Respiratory tract infections(RTIs)represent one of the main health problems in *** are viable bacteria that colonize the intestine and affect the host intestinal microbial *** evidences suggest that probiotics consumption may decrease the incidence of or modify *** authors systematically reviewed data from randomized controlled trials(RCTs)to investigate the effect of probiotics

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集装箱班轮运价协议收益优化与仿真研究

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系统仿真学报 2010年第3期22卷 765-770页

作者：殷明丁以中王学锋上海海事大学

考虑数量折扣、追加订购等实际因素,对经典报童模型进行改进。以激励相容原理作为基本指导思想,以集装箱班轮运输企业与无船承运业务经营人双方的收益优化为目标,建立一系列数学模型,并进行数值仿真,比较并分析影响双方决策的主要因素,... 详细信息

考虑数量折扣、追加订购等实际因素,对经典报童模型进行改进。以激励相容原理作为基本指导思想,以集装箱班轮运输企业与无船承运业务经营人双方的收益优化为目标,建立一系列数学模型,并进行数值仿真,比较并分析影响双方决策的主要因素,为相关产业的经营管理提供了科学的决策依据与方法。

关键词：报童模型激励相容数量折扣追加订购收益优化仿真

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乳剂型凝胶剂预混辅料的初步研制

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中国中药杂志 2017年第3期42卷 498-504页

作者：邱仁杰黄艺钟王秀丽北京中医药大学中药学院北京100102

该实验旨在研究乳剂型凝胶剂预混辅料。以最为常用、成本低廉和工艺简单等为标准筛选辅料和设计配方。采用星点设计-效应面法进行实验设计,以主观评分为指标,使用Design-Expert 8.0.6 Trial进行数据拟合与分析,绘制三维效应曲面图和二... 详细信息

该实验旨在研究乳剂型凝胶剂预混辅料。以最为常用、成本低廉和工艺简单等为标准筛选辅料和设计配方。采用星点设计-效应面法进行实验设计,以主观评分为指标,使用Design-Expert 8.0.6 Trial进行数据拟合与分析,绘制三维效应曲面图和二维等高线图。结果确定最佳范围为A(卡波姆940):0.05~0.065 g;B(蓖麻油):1.00~1.12 m L;C[聚氧乙烯脱水山梨醇单油酸酯(吐温-80)]:0.15 m L。选取最佳配方为卡波姆0.057 5 g,蓖麻油1.1 m L,吐温-80 0.15 m L。对制得的基质进行了初步稳定性评价和一些流变学特性如黏度、触变性的考察。并以此最佳配方为基质,分别以98%芦丁、98%盐酸小檗碱和98%盐酸小檗胺为主药制备乳剂型凝胶制剂,以0.9%生理盐水为接收液,1 h内3种制剂的透皮量均在1%以下。可见,该基质具有发展成为预混辅料的潜力。该配方制得的乳剂型凝胶基质具有较好外观,具有一定的稳定性、较好黏度和触变性,在1 h内无皮肤刺激性。

关键词：预混辅料乳剂型凝胶剂星点设计-效应面法体外透皮性实验

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