检索结果-南通市图书馆

Numerical and physical simulations of array laterolog in deviated anisotropic formation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2022年第5期19卷 2107-2119页

作者： yi-zhi wu Zhen-Guan wu yi-Ren Fan Tao Xing Chao-Liu Li Chao Yuan School of Geosciences China University of PetroleumQingdao266580ShandongChina Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao266071ShandongChina CNPC Key Laboratory for Well Logging China University of PetroleumQingdao266580ShandongChina Research Institute of Petroleum Exploration and Development PetroChinaBeijing100083China

Due to the tremendous amount of high-resolution measurement information,array laterolog is widely used in evaluations of deviated anisotropic ***,the precision of a complementary numerical simulation should be improved as high as the core of fine-scale reservoir ***,the 3D finite element method(3D-FEM)is presented to simulate the array laterolog ***,a downscaled physical simulation system is introduced to validate and calibrate the precision of the ***,the size of the downscaled system is determined by ***,the surrounding and investigated beds are represented by a sodium chloride solution and planks soaked in solution,***,a half-space measurement scheme is presented to improve the experimental ***,the corresponding sensitivity function and separation factor are established to analyze the effects of the formation anisotro py and dipping angle on the array laterolog *** numerical and experimental results indicate that the half-space method is practical,and the mean relative error between the numerical and experimental results is less than 5%,which indicates that the numerical simulation is *** the proposed approach,the reversal angle of array laterolog response curves in anisotropic formations can be observed,and this range is determined to be 50°-62°.

关键词： Anisotropic formation Array laterolog Downscaled physical simulation Sensitivity function Reversal angle

Gene therapy for monogenic disorders: challenges, strategies, and perspectives

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第2期51卷 133-143页

作者： yi Zhang zhi-ying wu Department of Medical Genetics and Center for Rare Diseases Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Key Laboratory of Medical Neurobiology of Zhejiang Province HangzhouZhejiang 310009China

Monogenic disorders refer to a group of human diseases caused by mutations in single genes. While disease-modifying therapies have offered some relief from symptoms and delayed progression for some monogenic diseases, most of these diseases still lack effective treatments. In recent decades, gene therapy has emerged as a promising therapeutic strategy for genetic disorders. Researchers have developed various gene manipulation tools and gene delivery systems to treat monogenic diseases. Despite this progress, concerns about inefficient delivery, persistent expression, immunogenicity, toxicity, capacity limitation, genomic integration, and limited tissue specificity still need to be addressed. This review gives an overview of commonly used gene therapy and delivery tools, along with the challenges they face and potential strategies to counter them.

关键词： Gene therapy Monogenic diseases Geneediting Genedelivery Challenges

Numerical simulation and dimension reduction analysis of electromagnetic logging while drilling of horizontal wells in complex structures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2020年第3期17卷 645-657页

作者： Zhen-Guan wu Shao-Gui Deng Xu-Quan He Runren Zhang yi-Ren Fan Xi-Yong Yuan yi-zhi wu Qing Huo Liu School of Geosciences China University of PetroleumQingdao 266580ShandongChina Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071Shandong.China CNPC Key Laboratory for Well Logging China University of PetroleumQingdao 266580ShandongChina Research Institute of Exploration and Development PetroChina Southwest Oil and Gas Field CompanyChengdu 610041SichuanChina Duke University DurhamNC 27705USA

Electromagnetic logging while drilling(LWD)is one of the key technologies of the geosteering and formation evaluation for high-angle and horizontal *** this paper,we solve the dipole source-generated magnetic/electric fields in 2D formations efficiently by the 2.5D finite diff erence ***,by leveraging the field’s rapid attenuation in spectral domain,we propose truncated Gauss–Hermite quadrature,which is several tens of times faster than traditional inverse fast Fourier *** applying the algorithm to the LWD modeling under complex formations,e.g.,folds,fault and sandstone pinch-outs,we analyze the feasibility of the dimension reduction from 2D to *** the formations with smooth lateral changes,like folds,the simplified 1D model’s results agree well with the true responses,which indicate that the 1D simplification with sliding window is ***,for the formation structures with drastic rock properties changes and sharp boundaries,for instance,faults and sandstone pinch-outs,the simplified 1D model will lead to large errors and,therefore,2.5D algorithms should be applied to ensure the accuracy.

关键词： Complex formation structures Horizontal wells Electromagnetic logging while drilling 2.5D algorithm-Model simplification

Chinese patients with adult onset leukodystrophy caused by CST3 variants

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第7期51卷 778-780页

作者： yi Zhang zhi-ying wu Department of Medical Genetics and Center for Rare Diseases Zhejiang Key Laboratory of Rare Diseases for Precision Medicine and Clinical TranslationSecond Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Nanhu Brain-computer Interface Institute HangzhouZhejiang 314050China Department of Neurology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China MOE Frontier Science Center for Brain Science and Brain-machine Integration School of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang 310012China

Leukodystrophies represent a group of cerebral white matter disorders that mainly affect axon-glia *** disorders are clinically diverse and display significant genetic *** is challenging to differentiate hereditary leukodystrophies,particularly those that present in adulthood,from acquired leukodystrophies and other genetic disorders,such as multiple sclerosis(MS)or hereditary spastic paraplegia(HSP)(Wei et al.,2021).Over the past few decades,a series of causative genes associated with leukodystrophies have been identified(Kohler et al.,2018).Nevertheless,a significant proportion of patients still lack a precise molecular diagnosis.

关键词： al. patients Kohler

Single-atom Ag-loaded carbon nitride photocatalysts for efficient degradation of acetaminophen:The role of Ag-atom and O_(2)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第5期139卷 12-22页

作者： yi Yuan Wen-Long Wang zhi-Wei Wang Jin Wang Qian-Yuan wu Key Laboratory of Microorganism Application and Risk Control of Shenzhen Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental SafetyInstitute of Environment and EcologyShenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Shenzhen Environmental Science and New Energy Technology Engineering Laboratory Tsinghua-Berkeley Shenzhen InstituteShenzhen 518055China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071China

Carbon nitride has been extensively used as a visible-light photocatalyst,but it has the disadvantages of a low specific surface area,rapid electron-hole recombination,and relatively low light *** this study,single-atom Ag was successfully anchored on ultrathin carbon nitride(UTCN)via thermal polymerization,the catalyst obtained is called *** Ag hardly changed the carbon nitride's layered and porous physical *** exhibited efficient visible-light photocatalytic performances in the degradation of various recalcitrant pollutants,eliminations of 85% were achieved by visible-light irradiation for *** with Ag improved the photocatalytic performance of UTCN by narrowing the forbidden band gap from 2.49 to 2.36 e V and suppressing electron-hole pair *** addition,Ag doping facilitated O_(2) adsorption on UTCN by decreasing the adsorption energy from -0.2 to -2.22 e V and favored the formation of O_(2)^(·-).Electron spin resonance and radical-quenching experiments showed that O_(2)^(·-)was the major reactive species in the degradation of Acetaminophen(paracetamol,APAP).

关键词： Ag single atom Carbon nitride Photocatalysis Visible light Adsorption energy Reactive species

Characteristics of high-sulfate wastewater treatment by two-phase anaerobic digestion process with Jet-loop anaerobic fluidized bed

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2007年第3期19卷 264-270页

作者： WEI Chao-hai, WANG Wen-xiang, DENG zhi-yi, wu Chao-fei School of Environmental Science and Engineering, South China University of Technology, Guangzhou 510640, China. School of Environmental Science and Engineering South China University of Technology Guangzhou 510640 China

A new anaerobic reactor, Jet-loop anaerobic fluidized bed （JLAFB）, was designed for treating high-sulfate wastewater. The treatment characteristics, including the effect of influent COD/SO42 ratio and alkalinity and sulfide inhibition in reactors, were discussed for a JLAFB and a general anaerobic fiuidized bed （AFB） reactor used as sulfate-reducing phase and methane-producing phase, respectively, in two-phase anaerobic digestion process. The formation of granules in the two reactors was also examined. The results indicated that COD and sulfate removal had different demand of influent COD/SO4^2- ratios. When total COD removal was up to 85%, the ratio was only required up to 1.2, whereas, total sulfate removal up to 95% required it exceeding 3.0. The alkalinity in the two reactors increased linearly with the growth of influent alkalinity. Moreover, the change of influent alkalinity had no significant effect on pH and volatile fatty acids （VFA） in the two reactors. Influent alkalinity kept at 400-500 mg/L could meet the requirement of the treating process. The JLAFB reactor had great advantage in avoiding sulfide and free-H2S accumulation and toxicity inhibition on microorganisms. When sulfate loading rate was up to 8. 1 kg/（m^3.d）, the sulfide and free-H2S concentrations in JLAFB reactor were 58.6 and 49.7 mg/L, respectively. Furthermore, the granules, with offwhite color, ellipse shape and diameters of 1.0-3.0 mm, could be developed in JLAFB reactor. In granules, different groups of bacteria were distributed in different layers, and some inorganic metal compounds such as Fe, Ca, Mg etc. were found.

关键词： Jet-loop anaerobic fluidized bed reactor sulfate wastewater two-phase anaerobic digestion process granule sludge

Cutting performance of saw blades with microtextured rougher and finisher sawteeth

在线全文

学校读者我要写书评

暂无评论

Advances in Manufacturing 2024年第2期12卷 317-334页

作者： Yang Lu Jian-Xin Deng zhi-Hui Zhang Jia-Xing wu Ran Wang yi-Chen Bao Key Laboratory of High Efficiency and Clean Mechanical Manufacture of MOE School of Mechanical EngineeringShandong UniversityJinan250061People’s Republic of China

The problems of severe sawtooth wear,harsh sawing noise,and low surface quality during the processing of circular saw blades need to be *** improve the cutting performance of TiC-based cermet saw blades,microtextures parallel to the cutting edge were fabricated on rough and fine sawteeth by laser *** cutting tests were performed on a sawing platform under lubricated *** of the sawing arc length and working sawtooth cutting force variations were developed for sawing steel pipes,and the accuracy of the sawing force model was verified *** results indicate that the variations in the sawing force are proportional to the sawing arc *** circular saw blades with microtextures that did not penetrate the sawtooth rake face exhibited the lowest cutting force,sawing noise,and highest machined surface ***,the worn-out distance of the rougher and finisher sawteeth was reduced by approximately 7.4%and 44.1%,respectively,compared with conventional circular saw *** main failure modes of sawteeth were tip wear,rake face adhesion,and oxidative *** addition,the mechanism by which the textures improve the cutting and wear properties of TiC-based circular saw blades was *** study provided a significant concept for enhancing the cutting performance of circular saw blades and improving the machined surface quality.

关键词： Circular saw blades Micro textures Cutting performance Wear performance

The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research 2024年第2期2023卷 373-387页

作者： Di wu yi Sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

Relationship between seismic structures and the diverse rupture processes of the 2023 Türkiye earthquake doublet

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第9期67卷 2810-2823页

作者： zhi WANG yi FU Shunping PEI CAS Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Recent geodetic and seismological observations of two major earthquakes in southeastern Türkiye in February 2023 have revealed complex rupture initiation,propagation,and segmentation along the East Anatolian Fault Zone(EAFZ)and surrounding ***,the role of upper crust structures along the EAFZ in determining the diverse rupture processes of this earthquake doublet remains *** further investigate this,we employed double-difference location and seismic tomography techniques to determine high-resolution seismic velocities(V_(P),V_(S))and Poisson’s ratio(σ)structures using a multiparameter joint tomographic *** dataset includes 100,833 high-quality source-receiver travel-time pairs of P-and *** find that the unique rupture processes of this earthquake doublet were primarily influenced by contrasting crustal seismic structures and localized geological *** M_(w)7.8 mainshock was initiated within a transitional edge zone characterized by a rigid part(asperity)of the seismogenic zone with sharp contrast variations in rock strength ranging from low to high along the *** comparison,the M_(w)7.6 rupture originated in a ductile belt featuring fluid saturation with low-VP,low-VS,and high-σvalues that extended parallel to the Cardak *** pronounced contrast structures observed along the former rupture can be attributed to the oblique collision system between the weakened section of the east Anatolian plateau and the brittle Arabian platform,while the latter rupture was initiated within the ductile structure associated with fluid intrusion caused by the northward subduction of the Cyprus slab and subsequent ***,the occurrence of the first earthquake(E1)serves to alleviate shear stress on the second earthquake(E2)fault,potentially impeding the initiation of an E2 *** the contrary,this event also significantly reduces the normal stress acting on the E2 fault due to a double left-lateral strike-slip system

关键词： 2023 Turkiye earthquake doublet Joint seismic tomography Tomographic transition edge Seismic rupture process Strong fault coupling