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Journal of Geriatric Cardiology 2024年第6期21卷 658-668页

作者： Wen-Jie WANG Ke-Xin WANG Jia-Long NIU yi-xuan liu Hai-Long GE Hua SHEN On behalf of CCC-ACS investigators Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina

BACKGROUND Stress hyperglycemia ratio(SHR)could provide accurate information on the acute status of *** relationship between SHR and acute coronary syndrome(ACS)prognosis remains *** study was conducted to identity the association between SHR and in-hospital outcomes in patients with *** A total of 12,010 patients were eventually enrolled in the *** relationship between SHR and in-hospital major adverse cardiovascular events(MACEs)was then modeled by restricted cubic spline(RCS)curves,and all patients were divided into three groups according to the *** multivariate logistic regression analysis was used to determine the associations between the SHR and in-hospital outcomes,described as odds ratios(ORs)and 95%confidence intervals(CIs).Subgroup analyses were also performed on different *** The median age of this cohort was 63(54,71)years old,and 8942(74.5%)were *** 1 was defined as SHR1(n=5763).Compared with Group 2,Group 1(OR=1.891,95%CI:1.028-3.479,P<0.001)and Group 3(OR=1.868,95%CI:1.434-2.434,P<0.001)had higher risks of suffering from in-hospital *** was associated with higher risks of in-hospital MACEs in the subgroups of DM[OR=2.282,95%CI:1.477-3.524).CONCLUSIONS Both low and high SHR levels were independently associated with in-hospital *** males with DM,hypertension,and decreased renal function had much higher risks of suffering from SHR-correlated MACEs.

关键词： acute cardiovascular finding

Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis

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Zoological Research 2024年第3期45卷 617-632页

作者： Jing-Hang Jiang yi-Fu Wang Jie Zheng yi-Ming Lei Zhong-Yuan Chen yi Guo Ya-Jie Guo Bing-Qian Guo Yu-Fang Lv Hong-Hong Wang Juan-Juan Xie yi-xuan liu Ting-Wei Jin Bi-Qi Li Xiao-Shu Zhu Yong-Hua Jiang Zeng-Nan Mo Center for Genomic and Personalized Medicine Guangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Medical UniversityNanningGuangxi 530021China Department of Urology First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Reproductive Medicine Center Jingmen People’s HospitalJingChu University of Technology Affiliated Central HospitalJingmenHubei 448000China School of Computer Science and Engineering Yulin Normal UniversityYulinGuangxi 537000China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Department of Pathology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China Department of Obstetrics and Gynecology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China

The Chinese tree shrew(Tupaia belangeri chinensis)has emerged as a promising model for investigating adrenal steroid synthesis,but it is unclear whether the same cells produce steroid hormones and whether their production is regulated in the same way as in ***,we comprehensively mapped the cell types and pathways of steroid metabolism in the adrenal gland of Chinese tree shrews using single-cell RNA sequencing,spatial transcriptome analysis,mass spectrometry,and *** compared the transcriptomes of various adrenal cell types across tree shrews,humans,macaques,and *** showed that tree shrew adrenal glands expressed many of the same key enzymes for steroid synthesis as humans,including CYP11B2,CYP11B1,CYB5A,and *** analysis confirmed the production of aldosterone,cortisol,and dehydroepiandrosterone but not dehydroepiandrosterone sulfate in the tree shrew adrenal ***,genes in adrenal cell types in tree shrews were correlated with genetic risk factors for polycystic ovary syndrome,primary aldosteronism,hypertension,and related disorders in humans based on genome-wide association ***,this study suggests that the adrenal glands of Chinese tree shrews may consist of closely related cell populations with functional similarity to those of the human adrenal *** comprehensive results(publicly available at http://***:16245/scAGMap/)should facilitate the advancement of this animal model for the investigation of adrenal gland disorders.

关键词： Tree shrew Adrenal gland Dehydroepiandrosterone Genome-wide association studies Disease model

Improving Parameter Estimation and Defensive Ability of Latent Dirichlet Allocation Model Training Under Rényi Differential Privacy

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Journal of Computer Science & Technology 2022年第6期37卷 1382-1397页

作者： Tao Huang Su-Yun Zhao Hong Chen yi-xuan liu Key Laboratory of Data Engineering and Knowledge Engineering(Renmin University of China) Ministry of Education Beijing 100087China School of Information Renmin University of ChinaBeijing 100087China

Latent Dirichlet allocation(LDA)is a topic model widely used for discovering hidden semantics in massive text *** Gibbs sampling(CGS),as a widely-used algorithm for learning the parameters of LDA,has the risk of privacy ***,word count statistics and updates of latent topics in CGS,which are essential for parameter estimation,could be employed by adversaries to conduct effective membership inference attacks(MIAs).Till now,there are two kinds of methods exploited in CGS to defend against MIAs:adding noise to word count statistics and utilizing inherent *** two kinds of methods have their respective *** sampled from the Laplacian distribution sometimes produces negative word count statistics,which render terrible parameter estimation in *** inherent privacy could only provide weak guaranteed privacy when defending against *** is promising to propose an effective framework to obtain accurate parameter estimations with guaranteed differential *** key issue of obtaining accurate parameter estimations when introducing differential privacy in CGS is making good use of the privacy budget such that a precise noise scale is *** is the first time that R′enyi differential privacy(RDP)has been introduced into CGS and we propose RDP-LDA,an effective framework for analyzing the privacy loss of any differentially private ***-LDA could be used to derive a tighter upper bound of privacy loss than the overestimated results of existing differentially private CGS obtained byε-*** RDP-LDA,we propose a novel truncated-Gaussian mechanism that keeps word count statistics *** we propose distribution perturbation which could provide more rigorous guaranteed privacy than utilizing inherent *** validate that our proposed methods produce more accurate parameter estimation under the JS-divergence metric and obtain lower precision and recall when defending against MIAs.

关键词： latent Dirichlet allocation parameter estimation membership inference attack Rényi differential privacy

A predictive model for differential diagnosis between rosacea and sensitive skin:a cross-sectional study

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Chinese Medical Journal 2020年第17期133卷 2132-2134页

作者： Xiao-Yan Wang Yun-yi liu yi-xuan liu Wei-Wei Ma Jia-Wen Zhang Zi-Jing liu Juan liu Bing-Rong Zhou Yang Xu Department of Dermatology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China

To the Editor:Rosacea is a common chronic inflammatory skin disease of the central facial skin,with typical manifestations such as flushing,erythema,papules,pustules,and phymatous changes.[1]Erythema is the most common manifestation among all types of *** skin(SS)is commonly defined as the occurrence of unpleasant sensations(pruritus,burning,pain,and tingling)upon exposure to certain physical,thermal,or chemical stimuli that normally cause no such sensations on healthy *** was reported that erythema might also be present in 74%of SS patients.[2]The pathogenesis,medication,and prognosis of rosacea and SS are quite different,so it is necessary to find reliable non-invasive methods to differentiate between the two conditions.

关键词： sensation diagnosis facial

(K, Na)NbO3-based lead-free piezoceramics: one more step to boost applications

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National Science Review 2022年第10期9卷 13-15页

作者： Huan liu yi-xuan liu Aizhen Song Qian Li Yang yin Fang-Zhou Yao Ke Wang Wen Gong Bo-Ping Zhang Jing-Feng Li State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University School of Materials Science and Engineering University of Science and Technology Center of Advanced Ceramic Materials and Devices Yangtze Delta Region Institute of Tsinghua University

Piezoelectric materials, as a conversion medium between mechanical and electrical energies, are widely used in actuators, sensors and sonar ***-based materials represented by lead zirconate titanate(PZT) have dominate...

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Lipase and photodecarboxylase coexpression: A potential strategy for alkane-based biodiesel production from natural triglycerides

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Chinese Journal of Chemical Engineering 2024年第3期67卷 238-246页

作者： Yong-yi Zeng Xin-yi Xu Jin-xuan Xie Wen-Li Chen Lan liu Xin-Jian yin Bi-Shuang Chen School of Marine Sciences Sun Yat-Sen UniversityZhuhai 519080China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China

Alkane-based biodiesel is considered the next generation of biodiesel owing to its potential environmental benefits and the fact that it exhibits much higher specific caloric values than traditional ***,the formidable obstacle impeding the commercialization of this cutting-edge fuel alternative lies in the cost associated with its *** this study,an engineered strain Escherichia coli(***)showcasing harmonized coexpression of a lipase(from Thermomyces lanuginosus lipase,TLL)and a fatty acid photodecarboxylase(from Chlorella variabilis,CvFAP)was first constructed to transform triglycerides into *** potential of *** BL21(DE3)/pRSFDuet-1-TLL-CvFAP for alkane synthesis was evaluated with tripalmitin as a model substrate under various process *** a comprehensive examination of the reaction parameters,the scope of the biotransformation was expanded to‘real’substrates(vegetable oils).The results showed that bioderived oils can be transformed into alkanes with high yields(0.80-10.20 mmol·L^(-1))under mild conditions(35℃,pH 8.0,and 36 h)and blue light *** selected processes were performed on an increased lab scale(up to 100 ml)with up to 24.77 mmol·L^(-1) tripalmitin,leading to a yield of 18.89 mmol·L^(-1) *** the employment of a method for efficiently producing alkanes under mild conditions and a simple procedure to isolate alkanes from the reaction system,the utilization of sustainable biomass as a fundamental feedstock emerges as the primary solution to lower the cost of alkane-based ***,this study proposes a readily implementable and highly effective approach for alkane-based biodiesel production.

关键词： Alkane-based biodiesel Renewable biomass Co-overexpression Lipase Photodecarboxylase

Determination of polarization states in(K,Na)NbO3 lead-free piezoelectric crystal

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Journal of Advanced Ceramics 2020年第2期9卷 204-209页

作者： Mao-Hua ZHANG Chengpeng HU Zhen ZHOU Hao TIAN Hao-Cheng THONG yi xuan liu Xing-Yu XU Xiao-Qing XI Jing-Feng LI Ke WANG State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Physics Harbin Institute of TechnologyHarbin 150001China

Polarization switching in lead-free(K0.40Na0.60)NbO3(KNN)single crystals was studied by switching spectroscopy piezoresponse force microscopy(SS-PFM).Acquisition of multiple hysteresis loops on a closely spaced square grid enables polarization switching parameters to be mapped in real *** amplitude and phase hysteresis loops show collective symmetric/asymmetric characteristics,affording information regarding the switching behavior of different *** such,the out-of-plane polarization states of the domains,including amplitudes and phases can be *** results could contribute to a further understanding of the relationships between polarization switching and polarization vectors at the nanoscale,and provide a feasible method to correlate the polarization hysteresis loops in a domain under an electric field with the polarization vector states.

关键词： piezoelectrics lead-free (K0.40Na0.60)NbO3(KNN) switching spectroscopy piezoresponse force microscopy(SS-PFM) ferroelectric domain

Sodium lithium niobate lead-free piezoceramics for high-power applications:Fundamental,progress,and perspective

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Journal of Advanced Ceramics 2023年第1期12卷 1-23页

作者： Chen-Bo-Wen LI Zhao LI Juan WANG yi-xuan liu Jing-Tong LU Ze XU Pak-Sheng SOON Ke BI Chuan CHEN Ke WANG State Key Laboratory of Information Photonics and Optical Communications School of ScienceBeijing University of Posts and TelecommunicationsBeijing 100876China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Stomatology Beijing Jishuitan HospitalBeijing 100035China Department of Electric Power Sensing Technology State Grid Smart Grid Research Institute Co.Ltd.Beijing 102211China

With the capability of interconversion between electrical and mechanical energy,piezoelectric materials have been revolutionized by the implementation of perovskite-piezoelectric-ceramic-based studies over 70 *** particular,the market of piezoelectric ceramics has been dominated by lead zirconate titanate for ***,the research on piezoelectric ceramics is largely driven by cutting-edge technological demand as well as the consideration of a sustainable ***,environmental-friendly lead-free piezoelectric materials have emerged to replace lead-based Pb(Zr,Ti)O_(3)(PZT)*** to the inherent high mechanical quality factor(Q_(m))and low energy loss,(Li,Na)NbO_(3)(LNN)materials have recently drawn increasing attention and brought advantages to high-power piezoelectric *** the crystallographic structures of LNN materials were intensively investigated for decades,the technical strategies for electrical performance are still *** a result,the property enhancement appears to have approached a *** review traces the progress in the development of LNN materials,starting from the polymorphism in terms of the crystal structures,phase transitions,and local structural ***,the key milestone works on the functional tunability of LNN are reviewed with emphasis on involved engineering *** exceptional performance at a large vibration velocity makes LNN ceramics promising for high-power applications,such as ultrasonic welding(UW)and ultrasonic osteotomes(UOs).The remaining challenges and some strategic insights for synergistically engineering the functional performance of LNN piezoceramics are also suggested.

关键词： sodium lithium niobate lead-free piezoelectric performance high-power applications

Systematic adsorption process of petroleum hydrocarbon by immobilised petroleum-degradation bacteria system in degradation pathways

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Petroleum Science 2021年第5期18卷 1543-1550页

作者： Xin-Ge Fu Ke Shi Jian-Liang Xue Chuan Chen Yu Bai Yan-Lu Qiao yi-xuan liu Xiang-Ming Hu Yu Gao Hao Yu College of Safety and Environmental Engineering Shandong University of Science and TechnologyQingdaoShandong266590China School of Environment Harbin Institute of TechnologyHaerbinHeilongjiang150001China Chinaunicom System Integration Co LtdNo.131Xidan North RoadBeijing100085China College of Chemical and Biological Engineering Shandong University of Science and TechnologyQingdaoShandong266590China

In order to effectively control petroleum hydrocarbon pollution by immobilisation technology,it is necessary to understanding the degradation pathways of petroleum hydrocarbon in immobilised petroleum-degradation bacteria ***,the adsorption in degradation process is rarely *** this study,adsorption process of petroleum hydrocarbon was synergistically studied by means of the surface properties,adsorption thermodynamics and molecular *** results indicate that the immobilised petroleum-degradation bacteria have many holes for the bacteria to *** diesel adsorption by immobilised petroleum-degradation bacteria is a spontaneous,entropy-increasing and endothermic *** is first adsorbed to the surface of immobilised petroleum-degradation bacteria through hydrogen bonding,and then is *** study provided substantial knowledge of immobilised technology in controlling petroleum hydrocarbon pollution.

关键词： Petroleum hydrocarbon pollution Immobilisation Adsorption-biodegradation Molecular simulation Bioremediation

Corrosion behavior of Al_(2)O_(3)-C bricks in MnO-containing mold slag

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Journal of Iron and Steel Research International 2024年第6期31卷 1486-1492页

作者： yi-jiang Zhao Guang-qiang Li Yang Wu Cheng Yuan Ze Meng Xiao-xuan Deng Yu liu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan 430081HubeiChina Research Institute of Technology Shougang Group Co.Ltd.Beijing 100043China

In order to explore the corrosion mechanism of Al_(2)O_(3)-C refractories in the mold flux bearing MnO,the immersion test of Al_(2)O_(3)-C refractories in CaO-SiO2-CaF2-MnO slag with different MnO contents was carried out at 1550℃.The results show that Mn particles were observed in the slag after experiment,due to the reduction of MnO by graphite in *** amounts of graphite were observed at the interface between refractories and slag,indicating that the oxidation of graphite is limited by the poor contact between graphite and molten ***,the oxidation of graphite is not the main cause of damage to refractories.A small quantity of CaO·2Al_(2)O_(3)(CA_(2))and CaO·6Al_(2)O_(3)(CA_(6))adjacent to Al_(2)O_(3) grain was detected at the slag/reaction layer ***_(2) and CA_(6) possess relatively high melting points,which is beneficial to hindering the further penetration of ***,the dissolution of Al_(2)O_(3) into slag is still the main cause for refractories *** increase in the MnO content of mold slag decreases the viscosity and then results in the severe corrosion of Al_(2)O_(3)-C bricks.

关键词： Al_(2)O_(3)-C refractory MnO-containing slag Graphite Corrosion