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ADRC BASED INPUT DISTURBANCE REJECTION FOR MINIMUM-PHASE PLANTS WITH UNKNOWN ORDERS AND/OR UNCERTAIN RELATIVE DEGREES

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Journal of Systems Science & Complexity 2012年第4期25卷 625-640页

作者： Chunzhe ZHAO yi huang School of Computer Science and Engineering Chongqing Three Gorges University Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of Sciences

The capability of ADRC is studied for linear time-invariant SISO minimum-phase systems with unknown orders, uncertain relative degrees, and unknown input disturbances. It is proved that ADRC can reject the unknown input disturbance and guarantee the close-loop stability for the plants with unknown but bounded relative degrees. Meanwhile, some close-loop performances can be achieved. The influence of the sensor noise is also discussed. And it is demonstrated by numerical examples that one ADRC with fixed parameters can be applied to a group of plants of different orders, relative degrees, and parameters.

关键词： ADRC frequency performance sensor noise uncertain relative degree unknown input disturbance unknown order.

Epitranscriptomics:Toward A Better Understanding of RNA Modifications

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Genomics, Proteomics & Bioinformatics 2017年第3期15卷 147-153页

作者： Xushen xiong Chengqi yi Jinying Peng State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Synthetic and Functional Biomolecules Center College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Ever since the first RNA nucleoside modification was charac- terized in 1957 [1], over 100 distinct chemical modifications have been identified in RNA to date [2]. Most of these modi- fications were characterized in non-coding RNAs （ncRNAs）, including tRNA, rRNA, and small nuclear RNA （snRNA） [3]. Studies in the past few decades have located various mod- ifications in these ncRNAs and revealed their functional roles [3]. For instance, NLmethyladenosine （mlA）, which is typically found at position 58 in the tRNA T-loop of eukaryotes, func- tions to stabilize tRNA tertiary structure [4] and affect transla- tion by regulating the associations between tRNA and polysome [5]. Pseudouridine （tp） in snRNA can fine-tune branch site interactions and affect mRNA splicing [6].

关键词： of on or is as with Epitranscriptomics:Toward A Better Understanding of RNA Modifications RNA

Tuning of Sampled-Data ADRC for Nonlinear Uncertain Systems

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Journal of Systems Science & Complexity 2016年第5期29卷 1187-1211页

作者： XUE Wenchao huang yi Key Laboratory of Systems and Control Academy of Mathematics and Systems Science Chinese Academy of Sciences

This paper concerns with the parameters tuning of active disturbance rejection control(ADRC) for a class of nonlinear systems with sampling rate not fast enough. The theoretical results show the quantitative relationship between the sampling rate, the parameters of ADRC, the size of uncertainties in system and the properties of the closed-loop system. Furthermore, the capability of the sampled-data ADRC under given sampling rate is quantitatively discussed.

关键词： Active disturbance rejection control (ADRC) extended state observer nonlinear uncertain systems parameters tuning sampled-data control.

Zircon from Orogenic Peridotite: An Ideal Indicator for Mantle-Crust Interaction in Subduction Zones

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Journal of Earth Science 2019年第3期30卷 666-678页

作者： yi Zhao Jianping Zheng Qing xiong School of Earth Sciences China University of GeosciencesWuhan 430074 China State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Wuhan 430074 China

The orogenic peridotites can be subdivided into crust-and mantle-derived types. They record complex geological processes in subduction and collision zones. The crust-derived peridotites are derived from cumulates crystallized from ultramafic-mafic magmas in deep continental crust, an early mantle-crust interaction, prior to subduction. The mantle-derived orogenic peridotites are originated from subcontinental lithospheric mantle(SCLM) wedge and other mantle domains, and are later involved in the subduction channel and orogenic system. The mantle-derived peridotites usually record complex metasomatism, ultra-high pressure(UHP) metamorphism and mantle-crust interaction during the orogenic processes. Zircons are rarely found in orogenic peridotites. These zircons in orogenic peridotites are generally formed during metasomatism, they can be divided into old zircons(mainly the cores of residual magmatic and recrystallized) and newly grown zircons. Three key factors for zircon formation in orogenic peridotites are that:(1) zircon has strong crystallization ability, and Zr is easier to exchange Si in zircon crystal structure than other elements in the mantle;(2) metamorphic destruction of Zr-bearing minerals and precipitation of intergranular melts during the high-grade metamorphism can nucleate zircon under sub-solidus conditions;(3) the melts/fluids released from the subducted crust can metasomatize the mantle wedge to form zircons. In-situ studies on zircons and zircon inclusions enclosed in mantle minerals indicate that zircon can be an ideal indicator for mantle-crust interaction in subduction zones. The inclusions in zircons and Hf-O isotope of zircons are effective to reflect the composition of the melts/fluids, source properties, and the physical and chemical conditions. Dating of the zircons has been widely used in the studies of lithospheric evolution and crust-mantle interaction. During the complex processes of plate convergence, the orogenic peridotites can be

关键词： orogenic peridotite zircon mantle-crust interaction subduction zone

The role of ribosomal proteins in the regulation of cell proliferation, tumorigenesis, and genomic integrity

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Science China(Life Sciences) 2016年第7期59卷 656-672页

作者： Xilong Xu Xiufang xiong yi Sun Institute of Translational Medicine Zhejiang University School of Medicine Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease Zhejiang University Division of Radiation and Cancer Biology Department of Radiation Oncology University of Michigan

Ribosomal proteins （RPs）, the essential components of the ribosome, are a family of RNA-binding proteins, which play prime roles in ribosome biogenesis and protein translation. Recent studies revealed that RPs have additional extra-ribosomal func- tions, independent of protein biosynthesis, in regulation of diverse cellular processes. Here, we review recent advances in our understanding of how RPs regulate apoptosis, cell cycle arrest, cell proliferation, neoplastic transformation, cell migration and invasion, and tumorigenesis through both MDM2/p53-dependent and p53-independent mechanisms. We also discuss the roles of RPs in the maintenance of genome integrity via modulating DNA damage response and repair. We further discuss mutations or deletions at the somatic or gennline levels of some RPs in human cancers as well as in patients of Diamond-Blackfan ane- mia and 5q- syndrome with high susceptibility to cancer development. Moreover, we discuss the potential clinical application, based upon abnormal levels of RPs, in biomarker development for early diagnosis and/or prognosis of certain human cancers. Finally, we discuss the pressing issues in the field as future perspectives for better understanding the roles of RPs in human cancers to eventually benefit human health.

关键词： ribosomal protein tumorigenesis genomic integrity ribosomal stress p53 MDM2

Reinforcement of Self-Healing Polyacrylic Acid Hydrogel with Acrylamide Modified Microcrystalline Cellulose

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Chinese Journal of Chemistry 2020年第5期38卷 494-500页

作者： Changzhuang Bai Qiuhua huang Xiaopeng xiong Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamenFujian 361005China

Self-healing hydrogel such as polyacrylic acid(PAA)hydrogel has attracted increasing attention based on its promising potential ***,it usually suffers from low strength especially as mechanical ***,a commercial microcrystalline cellulose(MCC)was modified with acrylamide to graft polyacrylamide(PAM)chains on the particle *** acrylamide-modified MCC(AM-MCC)was then dispersed in monomer solution of acrylic acid to prepare composite *** mechanical properties of the obtained composite hydrogels and the self-healed hydrogels were carefully measured by compressive and tensile tests,and by dynamic mechanical *** results demonstrate that introduction of a small amount of AM-MCC such as 3 wt%can not only reinforce the original hydrogel and the healed hydrogel markedly,but also improve self-healing efficiency *** analyses indicate that in addition to the reversible multi-interactions such as hydrogen bonding and ionic interactions,the entanglements between the PAA chains of the hydrogel matrix and the PAM chains grafted on the MCC particles have also played an important role on the improvement in mechanical performances and the healing ability of the ***,the responsiveness to exterior ion has been tested to indicate potential application of the composite hydrogel as self-healable sensor.

关键词： surface. chains acrylic

Hole mobility enhancement in monolayer WSe2 p-type transistors through molecular doping

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Science China(Information Sciences) 2024年第6期67卷 207-213页

作者： Shiyuan LIU xiong xiong Xin WANG Xinhang SHI Ru huang Yanqing WU School of Integrated Circuits and Beijing Advanced Innovation Center for Integrated Circuits Peking University Wuhan National High Magnetic Field Center and School of Integrated Circuits Huazhong University of Science and Technology

Two-dimensional （2D） transition metal dichalcogenide （TMDC） semiconductor materials exhibit extraordinary electrical properties,holding promise for the realization of next-generation complementary metal-oxide-semiconductor （CMOS） devices at ultimate ***,constrained by effective device doping strategies,the hole mobility and device performance of tungsten diselenide （WSe2） p-type transistors,especially monolayer chemical vapor deposition （CVD）-grown WSe2,have not met *** this paper,an effective performance enhancement of monolayer WSe2p-type transistor was achieved through a molecular doping *** monolayer WSe2directly on SiO2back-gated substrates and leveraging energy band alignment design,4-nitrobenzenediazonium tetrafluoroborate （4-NBD） molecular dopant with a concentration of 10 m M was utilized to modulate the Fermi level position of monolayer WSe2for hole *** devices demonstrated a more than 98%increase in hole mobility,reaching up to 97 cm2·V-1·s-1while maintaining the current on/off ratio of *** p-type WSe2transistors with 1μm channel length exhibit a high drive current surpassing 176μA·μm-1,exceeding previous CVD-WSe2devices with similar channel *** straightforward and effective approach to improving the electrical performance of WSe2transistors paves the way for advanced logic technologies based on transition metal dichalcogenide semiconductors.

关键词： CVD-grown WSe$_2$ molecular doping 4-NBD p-type transistors hole mobility

有氧运动调节转化生长因子β/Smad通路缓解db/db糖尿病小鼠的肝脏纤维化

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中国组织工程研究 2025年第14期29卷 2951-2957页

作者：黄朝露黄毅吴昌燕李芳菲李海燕黔东南民族职业技术学院临床医学系贵州省凯里市556000 贵州医科大学基础医学院贵州省贵阳市550000 贵州中医药大学基础医学院贵州省贵阳市550000 温州医科大学附属第一医院康复科浙江省温州市325000

背景:有氧运动可抑制糖尿病小鼠肝纤维化,但具体作用机制尚未阐明。目的:基于转化生长因子β/Smad信号通路探讨有氧运动改善db/db小鼠肝纤维化的作用机制。方法:将8周龄雄性db/db小鼠和年龄匹配的m/m小鼠随机分为m/m对照组、m/m+运动组... 详细信息

背景:有氧运动可抑制糖尿病小鼠肝纤维化,但具体作用机制尚未阐明。目的:基于转化生长因子β/Smad信号通路探讨有氧运动改善db/db小鼠肝纤维化的作用机制。方法:将8周龄雄性db/db小鼠和年龄匹配的m/m小鼠随机分为m/m对照组、m/m+运动组、db/db对照组、db/db+运动组,每组10只,运动组小鼠接受12周有氧运动。运动结束后检测各组小鼠空腹血糖,进行葡萄糖耐量测试和胰岛素耐量测试;摘取肝脏计算肝脏指数,摘眼球取血检测生化指标;苏木精-伊红染色、油红O染色和Masson染色观察小鼠肝组织的病理变化,免疫组化检测肝组织中转化生长因子β1、p-Smad3的表达;Western blot检测肝组织中转化生长因子β1、Smad3、p-Smad3、α-平滑肌肌动蛋白、Ⅰ型胶原蛋白和Ⅲ型胶原蛋白表达水平。结果与结论:①与m/m组和m/m+运动组小鼠相比,db/db组小鼠体质量、肝质量、肝脏指数、空腹血糖、三酰甘油、总胆固醇、低密度脂蛋白和肌酶水平均显著升高(P<0.01);高密度脂蛋白水平显著降低(P<0.01);转化生长因子β1、p-Smad3、α-平滑肌肌动蛋白、Ⅰ型胶原蛋白和Ⅲ型胶原蛋白表达水平显著升高(P<0.01);葡萄糖、胰岛素耐量测试的曲线下面积显著增加(P<0.01);肝组织病理染色显示大量炎症细胞浸润,脂滴增多,明显纤维化;②与db/db组相比,db/db+运动组小鼠体质量、肝质量、肝脏指数、空腹血糖、三酰甘油、总胆固醇、低密度脂蛋白和肌酶水平显著降低(P<0.05或P<0.01);高密度脂蛋白水平显著升高(P<0.05);转化生长因子β1、p-Smad3、α-平滑肌肌动蛋白、Ⅰ型胶原蛋白和Ⅲ型胶原蛋白表达显著降低(P<0.05或P<0.01);此外,糖耐量、胰岛素耐量测试的曲线下面积明显减少(P<0.01,P<0.05),肝脏病理损伤得到明显改善;③结果表明,有氧运动有效减轻了糖尿病小鼠肝纤维化,其机制可能与调控转化生长因子β/Smad信号通路有关。

关键词：有氧运动转化生长因子β Smad 信号通路 db/db 肝纤维化

Multiple Bifurcations of Critical Period for a Quartic Kolmogorov Model

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Acta Mathematicae Applicatae Sinica 2021年第4期37卷 673-681页

作者： Chao-xiong DU Wen-tao huang School of Mathematics Changsha Normal UniversityChangsha410100China School of Mathematics and Statistics Guangxi Normal UniversityGuilin541001China

Our work is concerned with the bifurcation of critical period for a quartic Kolmogorov *** computing the periodic constants carefully,we show that point(1,1)can be a weak center of fourth order,and the weak centers condition is ***,point(1,1)can bifurcate 4 critical periods under a certain *** terms of multiple bifurcation of critical periodic problem for Kolmogorov model,studied results are less seen,our work is good and interesting.

关键词： singular values weak center periodic constants bifurcation of critical period