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Dihydromyricetin-mediated inhibition of the Notch1 pathway induces apoptosis in QGY7701 and hep G2 hepatoma cells

World Journal of Gastroenterology 2017年第34期23卷 6242-6251页

作者： Cai-Jie Lu yi-Feng he Wei-Zhuang Yuan Li-Jun xiang Jian Zhang Yan-Rui Liang Juan Duan Yun-he he Ming-yi Li Laboratory of hepatobiliary Surgery Affiliated Hospital of Guangdong Medical University the First Clinical Medical College Southern Medical University Department of Gastrointestinal Surgery. The Second Affiliated Hospital of Guangzhou Medical University TCM-Integrated Hospital Southern Medical University

AIM To investigate whether Dihydromyricetin(DHM) inhibits cell proliferation and promotes apoptosis by downregulating Notch1 *** The correlation between Notch1 and hes1(a Notch1 target molecule) expression in hepatoma samples was confirmed by q RT-PCR. In addition, MTT assays, flow cytometry and TUNEL analysis showed that DHM possessed strong anti-tumor properties, evidenced not only by reduced cell proliferation but also by enhanced apoptosis in QGY7701 and hep G2 hepatocellular carcinoma(HCC) cells. The expressions of Notch1, hes1, Bcl-2 and Bax were determined by Western *** Among the tested samples(n = 64), the expression levels of Notch1(75% of patients) and hes1(79.7% of patients) m RNA in tumor tissues were higher than in the normal liver tissues. There was a negative correlation between the expression of Notch1 and the degree of differentiation and positively correlated with the Alpha Fetal Protein concentration. The viability of HCC cells treated with DHM was significantly inhibited in a dose and time-dependent manner. Apoptosis was induced in hep G2 and QGY7701 cell lines following 24 h of DHM treatment. After treatment with DHM, the protein expression of Notch1 was downregulated, the apoptosis-related protein Bax was upregulated and Bcl2 was downregulated. Notch1 si RNA further enhanced the anti-tumor properties of DHM. CONCLUSION Notch1 is involved in the development of HCC and DHM inhibits cell proliferation and promotes apoptosis by down-regulating the expression of Notch1.

关键词： Dihydromyricetin Apoptosis hepatocellular carcinoma Notch1

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Intrathecal liproxstatin-1 delivery inhibits ferroptosis and attenuates mechanical and thermal hypersensitivities in rats with complete Freund's adjuvant-induced inflammatory pain

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Neural Regeneration Research 2023年第2期18卷 456-462页

作者： yi-Fan Deng Ping xiang Jing-yi Du Jian-Fen Liang xiang Li Department of Anesthesiology The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Medical Quality Management Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Previous studies have confirmed the relationship between iron-dependent ferroptosis and a peripheral nerve injury-induced neuropathic pain ***,the role of fe rroptosis in inflammatory pain remains ***,we aimed to explore whether ferroptosis in the spinal cord and do rsal root ganglion contributes to complete Freund's adjuvant(CFA)-induced painful behaviors in *** results revealed that various biochemical and morphological changes were associated with ferroptosis in the spinal cord and dorsal root ganglion tissues of CFA *** changes included iron overload,enhanced lipid peroxidation,disorders of anti-acyl-coenzyme A synthetase long-chain family member 4 and glutathione peroxidase 4 levels,and abnormal morphological changes in *** treatment of liproxstatin-1(a ferroptosis inhibitor)reve rsed these ferroptosis-related changes and alleviated mechanical and thermal hype rsensitivities in CFA *** study demonstrated the occurrence of fe rroptosis in the spinal cord and do rsal root ganglion tissues in a rodent model of inflammatory pain and indicated that intrathecal administration of fe rroptosis inhibitors,such as liproxstatin-1,is a potential therapeutic strategy for treating inflammatory pain.

关键词： cell death complete Freund's adjuvant dorsal root ganglion ferroptosis inflammatory pain intrathecal delivery liproxstatin-1 spinal cord

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On a BMAP/G/1 G-queue with Setup Times and Multiple Vacations

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Acta Mathematicae Applicatae Sinica 2011年第4期27卷 625-638页

作者： yi PENG xiang-qun YANG School of Mathematical Science and Computing Technology Central South University Changsha 410075 Hunan China College of Mathematics and Computer Science Hunan Normal University Changsha 410081 China

In this paper, we consider a BMAP/G/1 G-queue with setup times and multiple vacations. Arrivals of positive customers and negative customers follow a batch Markovian arrival process （BMAP） and Markovian arrival process （MAP） respectively. The arrival of a negative customer removes all the customers in the system when the server is working. The server leaves for a vacation as soon as the system empties and is allowed to take repeated （multiple） vacations. By using the supplementary variables method and the censoring technique, we obtain the queue length distributions. We also obtain the mean of the busy period based on the renewal theory.

关键词： G-queues batch Markovian arrival process (BMAP) setup times multiple vacations censoring technique Markov chains

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薄板坯连铸连轧的发展现状及应用探讨

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山东冶金 2003年第2期25卷 1-3页

作者：时义祥何绪友王爱霞高艳萍济南钢铁集团总公司山东济南250101

根据薄板坯连铸连轧技术的发展现状及该工艺的关键技术,对其产品的种类和质量做了相应的分析,指出济钢在薄板坯连铸连轧工艺的规划建设中,应重视工艺流程的选择、工序间的衔接及技术装备的引进等问题,以保证达产达标。

关键词：薄板坯连铸连轧工艺规划工艺流程近终型连铸 CSP工艺液芯铸轧

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Influence of cooling rate on phase transformation and precipitation behavior of Ti-bearing steel in continuous cooling process

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Journal of Iron and Steel Research International 2022年第1期29卷 165-174页

作者： Xiao-lin Li Chi Jin Hao-zhe Li Xiao-xiao Hao yi he xiang-tao Deng Zhao-dong Wang State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi’an 710072ShaanxiChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina

The influence of cooling rate on microstructural evolution and precipitation behavior in Ti,Ti–Nb and Ti-Mo low-carbon steels during the continuous cooling process was studied by dilatometer method,optical microscopy,and transmission electron *** results indicated that austenite transformation temperature decreased with the increasing cooling rate in three *** addition of Nb and Mo promoted bainite and martensite transformation and improved the hardenability of *** addition,precipitates formed in deformed austenite and ferrite can be observed *** in the austenite non-recrystallization zone can introduce a large number of deformation bands,and then,the precipitates preferentially nucleated in these deformation *** the following process,randomly distributed precipitates and interphase precipitates will be formed in *** precipitates formed in deformed austenite obey Kurdjumov-Sachs orientation relationship with the matrix,while the precipitates formed in ferrite obey Baker-Nutting orientation relationship with the *** addition of Nb and Mo in Ti-bearing steels decreased the precipitates size and increased the number density of precipitates and then improved the precipitation *** the effect of Mo addition is more obvious than that of Nb addition.

关键词： Ti-microalloyed steel Continuous cooling transformation Precipitation behavior Precipitate-free zone Orientation relationship

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About the Energy of the Universe

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Chinese Physics Letters 1996年第6期13卷 409-411页

作者： FENG Shi-xiang DUAN yi-shi Institute of Nuclear Research Chinese Academy of SciencesShanghai 201800 Institute of Theoretical Physics Lanzhou UniversityLanzhou 730000

We use the general covariant conservation law of energy-momentum,which is general covariant and therefore preferable to the non-covariant conservation laws,to analyse the energy of the universe and obtained vanishing ... 详细信息

关键词： energy vanishing discussions

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iGMDR:Integrated Pharmacogenetic Resource Guide to Cancer Therapy and Research

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 150-160页

作者： xiang Chen yi Guo Xin Chen Institute of Pharmaceutical Biotechnology and the First Affiliated Hospital Department of Radiation Oncology Zhejiang University School of MedicineHangzhou 310058China Department of Polymer Science and Engineering and Key Laboratory of Adsorption and Separation Materials and Technologies of Zhejiang Province Zhejiang UniversityHangzhou 310027China Joint Institute for Genetics and Genome Medicine between Zhejiang University and University of Toronto Zhejiang UniversityHangzhou 310058China

Current pharmacogenetic studies have obtained many genetic models that can predict the therapeutic efficacy of anticancer *** some of these models are of crucial importance and have been used in clinical practice,these very valuable models have not been well adopted into cancer research to promote the development of cancer therapies due to the lack of integration and standards for the existing data of the pharmacogenetic *** this purpose,we built a resource investigating genetic model of drug response(iGMDR),which integrates the models from in vitro and in vivo pharmacogenetic studies with different omics data from a variety of technical *** this study,we introduced a standardized process for all integrations,and described how users can utilize these models to gain insights into *** is freely accessible at https://***.

关键词： Genetic model Pharmacogenetics Anticancer drug Cancer Drug response

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Defect engineering of vanadium-based electrode materials for zinc ion battery

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Chinese Chemical Letters 2023年第7期34卷 78-86页

作者： ying Liu yi Liu xiang Wu School of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China

With the quick development of sustainable energy sources, aqueous zinc-ion batteries(AZIBs) have become a highly potential energy storage technology. It is a crucial step to construct desired electrode materials for improving the total performance of AZIBs. In recent years, considerable efforts have focused on the modification of vanadium-based cathode materials. In this review, we summarized defect engineering strategies of vanadium-based cathodes, including oxygen defects, cation vacancies and heterogeneous doping. Then, we discussed the effect of various defects on the electrochemical performance of electrode materials. Finally, we proposed the future challenges and development directions of V-based cathode materials.

关键词： Aqueous zinc ion batteries Vanadium-based materials Cathodel energy storage devices Defect engineering

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Recent advances of capillary electrophoresis-mass spectrometry instrumentation and methodology

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Chinese Chemical Letters 2017年第8期28卷 1640-1652页

作者： You Jiang Mu-yi he Wen-Jing Zhang Pan Luo Dan Guo xiang Fang Wei Xu National Institute of Metrology Beijing 100013China School of Life Science Beijing Institute of TechnologyBeijing 100081China

Capillary electrophoresis-mass spectrometry（CE-MS） is a powerful separation and analytical technique in the field of analytical chemistry. This review provides an update of instrumentation developments in the methodology of CE-MS systems. A selection of relevant articles covers the literatures published from Jan. 2013 to Feb. 2017. Special attentions were paid to the sample injection and ionization *** of these CE-MS systems were also introduced through representative examples. General conclusions and perspectives were given at the last.

关键词： Capillary electrophoresis Mass spectrometry Instrumentation and methodology developments Interfaces Bio-analytical chemistry

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Role of hydrogen in China's energy transition towards carbon neutrality target:IPAC analysis

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Advances in Climate Change Research 2023年第1期14卷 43-48页

作者： Pian-Pian xiang Chen-Min he Sha CheN Wei-yi JIANG Jia LIU Ke-Jun JIANG College of Energy and Environment Beijing University of TechnologyBeijing 100124China Zhejian Carbon Neutral Innovation Institute Zhejiang University of TechnologyHangzhou 310014China Graduate School of International Studies Yonsei UniversitySeoul 03722South Korea Renm Consulting Co. Beijing 100038China Energy Research Institute Chinese Academy of Macro-Economic ResearchBeijing 100038China

China announced its intention to achieve carbon neutrality by 2060 in 2020,and there is an urgent need to understand the viability of emission pathways to reach this *** study presents the IPAC modelling team's scenario analysis on China's hydrogen utilisation as a key option for carbon neutrality *** contrast to other studies,this study examines the demand for hydrogen as a feedstock and process material in the industrial sector and as a source of energy in the transportation sector in relation to China's energy system *** process of manufacturing hydrogen from carbon-free power generation was also *** finding indicates that the demand for hydrogen could reach 52.4 Mt by 2050 and that the hydrogen will come from renewable power generation and nuclear energy,increasing the demand for electricity by 1884.8 TW *** are several regions in China with abundant renewable energy and low power generation costs,which will make the hydrogen-based industry competitive in these regions after 2035.

关键词： Scenario Hydrogen Carbon neutrality targets CO_(2)mitigation China

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