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Predictors for partial suppression of spermatogenesis of hormonal male contraception

Asian Journal of Andrology 2008年第5期10卷 723-730页

作者： Jing-Wen Li yi-qun gu peking Union Medical College Postgraduate School Beijing 100730 China National Research Institute for Family Planning Beijing 100081 China

Aim： To analyze factors influencing the efficacy of hormonal suppression of spermatogenesis for male contraception. Methods： A nested case-control study was conducted, involving 43 subjects, who did not achieve azoospermia or severe oligozoospermia when given monthly injections of 500 mg testosterone undecanoate （TU）, defined as partial suppressors compared with 855 subjects who had suppressed spermatogenesis （complete suppressors）. Sperm density, serum testosterone, luteinizing hormone （LH） and follicle stimulating hormone （FSH） concentrations at the baseline and the suppression phase were compared between partial and complete suppressors. Polymorphisms of androgen receptor （AR） and three single nucleotide variants and their haplotypes of FSH receptor （FSHR） genes determined by polymerase chain reaction （PCR） and DNA sequencing technique were compared between 29 partial and 34 complete suppressors. Results： Baseline serum LH level was higher and serum LH as well as FSH level during the suppression phase was less suppressed in partial suppressors. Additionally, in a logistic regression analysis larger testis volume, higher serum FSH concentrations alone, or interaction of serum LH, FSH, testosterone and sperm concentrations were associated with degree of suppression. The distribution of polymorphisms of AR or FSH receptor genes did not differ between partial and complete suppressors. In cases with incomplete FSH suppression （FSH 〉 0.2 IU/L）, the chances of reaching azoospermia were 1.5 times higher in the subjects with more than 22 CAG triplet repeats. Conclusion： Partial suppression of spermatogenesis induced by 500 mg TU monthly injections is weakly influenced by hormonal and clinical features but not polymorphism in AR and FSHR genes.

关键词： male contraception genetic polymorphism androgen receptor CAG repeats follicle stimulating hormone receptor single nucleotide polymorphism sperm concentration

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Testosterone replacement therapy： dilemmas and challenges in China and Asia

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Asian Journal of Andrology 2018年第2期20卷 149-151页

作者： Qi An yi-qun gu Graduate School Peking Union Medical College Beijing 100730 China Nationa Health and Family Planning Key Laboratory of Male Reproductive Health National Research Institute for Family Planning Beijing 100081 China

Late-onset hypogonadism （LOH） has been described as a clinical syndrome comprising symptoms consistent with androgen deficiency and a circulating concentration of testosterone in the low-to-normal range in some middle-aged and elderly men. The presence of symptoms may affect the health and quality of life in aging men and it has become a hot spot in global medical research, diagnosis, and treatment in the recent years.

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Insights into semen analysis： a Chinese perspective on the fifth edition of the WHO laboratory manual for the examination and processing of human semen

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Asian Journal of Andrology 2010年第4期12卷 605-606页

作者： Wen-Hong Lu yi-qun gu National Research Institute for Family Planning Beijing 100081 China

We are very glad to see that the Asian Journal of Andrology published a Special Issue on Semen Analysis in 21st Century Medicine, which well revealed some behind-the-scene controversies of the 5th edition of the WHO laboratory manual for the examination and processing of human semen [1]. Three articles from the special issue, two on the reference values of semen parameters [2, 3] and another presenting the investigation results of 118 laboratories performing semen analysis in China's Mainland [4], are very thoughtprovoking and we would like to share some of our views on these topics.

关键词： WHO laboratory examination semen

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Prevalence of late-onset hypogonadism among middle-aged and elderly males in China:results from a national survey

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Asian Journal of Andrology 2021年第2期23卷 170-177页

作者： yi-Jun Liu Xu-Bo Shen Na Yu Xue-Jun Shang yi-qun gu Lian-Dong Zuo Cheng-Liang Xiong Zhen Ye Yuan-Zhong Zhou School of Public Health Zunyi Medical UniversityZunyi 563000China Scientific Research Center The Third Affiliated Hospital of Guang Dong Medical University(Long Jiang Hospital of Shunde District Foshan City)Foshan 528318China Department of Andrology Eastern Theater General HospitalNanjing 210002China Institute of Science and Technology National Research Institute for Family PlanningBeijing 100081China guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhou 510632China Family Planning Research Institute Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Urology and Andrology Wuhan Tongji Reproductive Medicine HospitalWuhan 430013China

This study aimed to propose an operational definition of late-onset hypogonadism(LOH)that incorporates both clinical symptoms and serum testosterone measurements to evaluate the prevalence of LOH in aging males in China.A population-based sample of 6296 men aged 40 years-79 years old was enrolled from six representative provinces in *** total testosterone(TT),sex hormone-binding globulin(SHBG),and luteinizing hormone(LH)were measured and free testosterone(cFT)was *** Aging Males’Symptoms(AMS)scale was used to evaluate the LOH ***,5078 men were included in this *** TT levels did not decrease with age(P=0.59),and had no relationship with AMS symptoms(P=0.87 for AMS total score,P=0.74 for≥3 sexual symptoms).The cFT levels decreased significantly with age(P<0.01)and showed a negative association with the presence of≥3 sexual symptoms(P=0.03).The overall estimated prevalence of LOH was 7.8%(395/5078)if a cFT level<210 pmol l−1 combined with the presence of≥3 sexual symptoms was used as the criterion of *** them,26.1%(103/395)and 73.9%(292/395)had primary and secondary hypogonadism,*** adjustment for confounding factors,primary and secondary hypogonadism was positively related to age and *** mass index was an independent risk factor for secondary *** results suggest that the AMS total score is not an appropriate indicator for decreased testosterone,and that the cFT level is more reliable than TT for LOH *** hypogonadism is the most common form of LOH.

关键词： Aging Males'Symptoms calculated free testosterone late-onset hypogonadism middle-aged and elderly male total testosterone

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The current situation of semen analysis in China,based on a survey of 296 laboratories

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Asian Journal of Andrology 2024年第2期26卷 220-221页

作者： Long-Long Fu ying Liu Xiao-Wei Wang Fang Zhou ying guo Wen-Hong Lu yi-qun gu National Health Commission Key Laboratory of Male Reproductive Health Reproductive Health Research CenterNational Research Institute for Family PlanningBeijing 100081China Institute of Pediatric Research Children's Hospitalof Soochow UniversitySuzhou 215025China

Dear Editor,Semen analysis is a basic test to assess male fertility and is a fundamental test in assisted reproductive *** the first publication of World Health Organization(WHO)Laboratory Manual of Human Semen and Sperm-Cervical Mucus Interaction in 1980,to the publication of the WHO Manual,6th edition in 2021,these 40 years have been recognized as providing a global standard that is widely used in research and clinical laboratories *** WHO Manual,6th edition in Chinese,which we have been authorized by the WHO to translate,will be published soon.

关键词： technology. analysis translate

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Is serum sex hormone-binding globulin a dominant risk factor for metabolic syndrome？

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Asian Journal of Andrology 2015年第6期17卷 991-995,I0010页

作者： yi-Hong Yang Ming-Jia Zhao Shan-Jie Zhou Wen-Hong Lu Xiao-Wei Liang Cheng-Liang Xiong Chang-Chun Wan Xue-Jun Shang yi-qun gu Graduate School of Peking Union Medical College Beijing 100730 China National Health and Family Planning Key Laboratory of Male Reproductive Health Department of Male Clinical Research National Research Institute for Family Planning Beijing 100081 China Department of Reproduction and Genetics Maternity and Child Health Care Hospital Tangshan 063000 China Tianjin United Family Hospital and Clinics Tianjin 300221 China Family Planning Research Institute Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China People's Hospital of Jinhu Huaian 211600 China Department of Andrology Nanjing Genera/Hospital of Nanjing Command PLA.Nanjing 210002 China

This multi-center, cross-sectional study investigated the association between serum testosterone （T） levels, serum sex hormone-binding globulin （SHBG） levels, and the risk of metabolic syndrome （MS） in 3332 adult Chinese men. The prevalence of MS was 34.7%, and men with MS had lower serum levels of total T （TT） and SHBG than those without MS （P 〈 0.001）. There was no significant difference in serum free T （FT） levels between subjects with and without MS （P = 0.627）. In logistic regression analysis, the association between MS and serum SHBG levels persisted after adjusting for age, body mass index （BMI）, smoking and drinking status, and serum TT （odds ratio [OR] 0.962, 95% confidence interval [95% CI] 0.954-0.969, P 〈 0.01）. However, the association between serum TT level and the risk of MS was weak after adjusting for age, BMI, SHBG level, and smoking and drinking status （OR 0,981, 95% CI 0.960-1.007）. Our study reveals that both serum TT and SHBG levels, but not serum FT, are inversely associated with the prevalence of MS and that serum SHBG is an independent and dominant risk factor for *** multi-center, cross-sectional study investigated the association between serum testosterone （T） levels, serum sex hormone-binding globulin （SHBG） levels, and the risk of metabolic syndrome （MS） in 3332 adult Chinese men. The prevalence of MS was 34.7%, and men with MS had lower serum levels of total T （TT） and SHBG than those without MS （P 〈 0.001）. There was no significant difference in serum free T （FT） levels between subjects with and without MS （P = 0.627）. In logistic regression analysis, the association between MS and serum SHBG levels persisted after adjusting for age, body mass index （BMI）, smoking and drinking status, and serum TT （odds ratio [OR] 0.962, 95% confidence interval [95% CI] 0.954-0.969, P〈 0.01）. However, the association between serum TT level and the risk of MS was weak after adjusting for age, BMI, SHBG level, and smoking and drinking status （OR 0,98

关键词： metabolic syndrome sex hormone-binding globulin testosterone

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A randomized, controlled, multicenter contraceptive efficacy clinical trial of the intravas device, a nonocclusive surgical male sterilization

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Asian Journal of Andrology 2014年第3期16卷 432-436页

作者： Wen-Hong Lu Xiao-Wei Liang yi-qun gu Wei-Xiong Wu Li-Wei Bo Tian-gui Zheng Zhen-Wen Chen Key Laboratory of Male Reproductive Health National Health and Family Planning Commission National Research Institute for Family Planning and WHO Collaborating Centre for Research in Human Reproduction Beijing Institute for Family Planning of guangzhou city Guangzhou Institute for Family Planning of Henan Province Zhengzhou Institute for Family Planning of Putian City Putian China.

Because of unavoidable complications of vasectomy, this study was undertaken to assess the efficacy and safety of male sterilization with a nonobstructive intravas device （IVD） implanted into the vas lumen by a mini-surgical method compared with no-scalpel vasectomy （NSV）. IVDs were categorized into two types： IVD-B has a tail used for fixing to the vas deferens （fixed wing） whereas IVD-A does not. A multicenter prospective randomized controlled clinical trial was conducted in China. The study was comprised of 1459 male volunteers seeking vasectomy who were randomly assigned to the IVD-A （n = 487）, IVD-B （n = 485） or NSV （n = 487） groups and underwent operation. Follow-up included visits at the 3rd-6TM and 12~ postoperative months, The assessments of the subjects involved regular physical examinations （including general and andrological examinations） and semen analysis. The subjects＇ partners also underwent monitoring for pregnancy by monthly interviews regarding menstruation and if necessary, urine tests, There were no significant differences in pregnancy rates （0.65% for IVD-A, 0 for IVD-B and 0.21% for NSV） among the three groups （P 〉 0.05）. The cumulative rates of complications at the 12th postoperative month were zero, 0.9% and 1.7% in the three groups, respectively. In conclusion, IVD male sterilization exhibits a low risk of long-term adverse events and was found to be effective as a male sterilization method, similar to the NSV technique. IVD male sterilization is expected to be a novel contraceptive method.

关键词： complication male sterilization nonobstructive intravas device no-scalpel vasectomy

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Congenital Giant Epignathus with Intracranial Extension in a Fetal

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Chinese Medical Journal 2017年第19期130卷 2386-2387页

作者： Ai-Chun Wang yi-qun gu Xiu-Yun Zhou Department of Pathology Haidian Maternal and Children Health Hospital Beijing 100080 China Department of Ultrasonography Haidian Maternal and Children Health Hospital Beijing 100080 China

Epignathus is a rare congenital orofacial teratoma. The incidence of epignathus is between 1：35,000 and 1：200,000 live births with a female predominance. We reported an uncommon male fetal case of epignathus origina... 详细信息

关键词： Congenital Epignathus Fetal

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Altered microRNA expression profiles of human spermatozoa in normal fertile men of different ages

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Asian Journal of Andrology 2023年第6期25卷 737-744页

作者： Ming-Jia Zhao Yao-Nan Zhang Yong-Ping Zhao Xian-Bing Chen Bao-Sheng Han Ning Ding yi-qun gu Shu-Song Wang Jing Ma Mei-Ling Liu Graduate School of Peking Union Medical College Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China National Health Commission Key Laboratory of Male Reproductive Health National Research Institute for Family PlanningBeijing 100081China Department of Reproduction and Genetics Maternity and Child Health Care HospitalTangshan 063000China Department of Family Planning and Reproductive Medicine Peking University People’s HospitalBeijing 100081China Hebei Key Laboratory of Reproductive Medicine Hebei Institute of Reproductive Health Science and TechnologyShijiazhuang 050071China

MicroRNAs(miRNAs)are mediators of the aging *** purpose of this work was to analyze the miRNA expression profiles of spermatozoa from men of different ages with normal ***-seven donors were divided into three groups by age(Group A,n=8,age:20–30 years;Group B,n=10,age:31–40 years;and Group C,n=9,age:41–55 years)for high-throughput sequencing *** from 65 individuals(22,22,and 21 in Groups A,B,and C,respectively)were used for validation by quantitative real-time polymerase chain reaction(qRT-PCR).A total of 2160 miRNAs were detected:1223 were known,937 were newly discovered and unnamed,of which 191 were expressed in all donors.A total of 7,5,and 17 differentially expressed microRNAs(DEMs)were found in Group A vs B,Group B vs C,and Group A vs C comparisons,***-two miRNAs were statistically correlated with *** miRNAs were identified as age-associated miRNAs,including hsa-miR-127-3p,mmu-miR-5100_L+2R-1,efu-miR-9226_L-2_1ss22GA,cgr-miR-1260_L+1,hsa-miR-652-3p_R+1,pal-miR-9993a-3p_L+2R-1,hsa-miR-7977_1ss6AG,hsa-miR-106b-3p_R-1,hsa-miR-186-5p,PC-3p-59611_111,hsa-miR-93-3p_R+1,and aeca-mir-8986ap5_*** were 9165 target genes of age-associated *** Ontology(GO)analysis of the target genes identified revealed enrichment of protein binding,membrane,cell cycle,and so *** Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis of age-related miRNAs for target genes revealed 139 enriched pathways,such as signaling pathways regulating stem cell pluripotency,metabolic pathways,and the Hippo signaling *** suggests that miRNAs play a key role in male fertility changes with increasing age and provides new evidence for the study of the mechanism of age-related male fertility decline.

关键词： age fertility microRNA spermatozoa

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Andrology in China： current status and 10 years＇ progress

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Asian Journal of Andrology 2011年第4期13卷 512-518页

作者： Kai Hong Qing-Quan Xu Yong-Ping Zhao yi-qun gu Hui Jiang Xiao-Feng Wang Ji-Chuan Zhu Urology Department Peking University 3rd Hospital Beijing 100191 China Department of Urology Peking University People＇s Hospital Beijing 100044 China Department of Male Clinic Research National Research Institute for Family Planning Beijing 100081 China

Andrology has a long history in traditional Chinese medicine. There are records of male sexual health, male sexual dysfunction and male infertility from over thousands of years ago. Modern andrology in China had a late start, with the Chinese Androlo~ Association founded in 1995. Within last decade, andrology in China has grown rapidly. In this review article, we summarized the progress of androlo~ in last 10 years and outlined the current status of Chinese andrology with a special focus on progress in male erectile dysfunction, prostate diseases, male infertility and male hormonal contraception.

关键词： andrology benign prostatic hyperplasia Chinese contraception erectile dysfunction male infertility prostate cancer prostatitis

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