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Polymorphisms in HIF-1a gene are not associated with diabetic retinopathy in China

World Journal of Diabetes 2021年第8期12卷 1304-1311页

作者： Yue-Hong Liu Chang Guo yi-qiong sun Qiang Li Department of Endocrinology Hainan Cancer HospitalHaikou 570312Hainan ProvinceChina Department of Endocrinology Shenzhen University General HospitalShenzhen 518055Guangdong ProvinceChina

BACKGROUND It has been reported that vascular endothelial growth factor(VEGF)is a susceptibility gene for both type 2 diabetes mellitus(T2DM)and diabetic retinopathy(DR).In response to hypoxia,VEGF mRNA levels are increased,which is mainly mediated by the binding of hypoxia-inducible factor-1(HIF-1)and hypoxia response element upstream of the transcriptional start site of ***,HIF-1a is supposed to be involved in pathology of *** To investigate whether the polymorphisms in HIF-1a gene are associated with *** Two hundred and ninety-nine type 2 diabetic patients(128 males and 171 females)and 144 healthy volunteers were *** age was 56.04±21.05 *** to the results of fundus fluorescein angiography and examination of ophthalmoscopy,patients were divided into two groups,DNR group(diabetes without retinopathy)and DR group(diabetes with retinopathy).There are 150 cases in DNR group and 149 cases in DR *** single nucleotide polymorphisms(SNP)of the HIF-1a gene were tested using matrix-assisted laser desorption/Ionization time of flight mass *** frequency of genotypes and alleles,and odds ratio were *** The mean age of the cases with diabetes was 55.84±3.66 years,the mean age of the cases with DR was 55.97±4.66 years and that of controls was 56.32±4.70 *** variations were found in 76 ***11549465 is the change of C-T base,rs11549467 is the change of G-A *** rs11549467 G/A genotype was 5.33%in diabetes and 6.04%in DR patients,*** rs11549465 C/T genotype was 10%and 12.75%in patients with diabetes and *** rs11549467 A allele frequencies and rs11549465 T frequencies was similar to that of *** SNP linkage disequilibrium analysis indicated that rs11549467 was in linkage disequilibrium with *** association analysis denoted that the haplotype association exhibited similar distribution in the patients compared to the normal *** This s

关键词： Diabetic retinopathy Single nucleotide polymorphisms HIF1a Vascular endothelial growth factor Diabetes Mutation

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Application of the improved dung beetle optimizer,muti-head attention and hybrid deep learning algorithms to groundwater depth prediction in the Ningxia area,China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 18-23页

作者： Jiarui Cai Bo sun Huijun Wang yi Zheng Siyu Zhou Huixin Li Yanyan Huang Peishu Zong Collaborative Innovation Center on forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina China Meteorological Administration Key Laboratory of Transportation MeteorologyNanjingChina Jiangsu Meteorological Observatory NanjingChina

Due to the lack of accurate data and complex parameterization,the prediction of groundwater depth is a chal-lenge for numerical *** learning can effectively solve this issue and has been proven useful in the prediction of groundwater depth in many *** this study,two new models are applied to the prediction of groundwater depth in the Ningxia area,*** two models combine the improved dung beetle optimizer(DBO)algorithm with two deep learning models:The Multi-head Attention-Convolution Neural Network-Long Short Term Memory networks(MH-CNN-LSTM)and the Multi-head Attention-Convolution Neural Network-Gated Recurrent Unit(MH-CNN-GRU).The models with DBO show better prediction performance,with larger R(correlation coefficient),RPD(residual prediction deviation),and lower RMSE(root-mean-square error).Com-pared with the models with the original DBO,the R and RPD of models with the improved DBO increase by over 1.5%,and the RMSE decreases by over 1.8%,indicating better prediction *** addition,compared with the multiple linear regression model,a traditional statistical model,deep learning models have better prediction performance.

关键词： Groundwater depth Multi-head attention Improved dung beetle optimizer CNN-LSTM CNN-GRU Ningxia

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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing yin Hongyin Ma Yang Qu Jiaxin Ren yingying sun Zhen-Ni Guo yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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Low-Temperature Fabrication of Stable Black-Phase CsPbI₃ Perovskite Flexible Photodetectors Toward Wearable Health Monitoring

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NANO-MICRO LETTERS 2025年第1期17卷 1-14页

作者： Zhao, yingjie sun, yicheng Pei, Chaoxin yin, Xing Li, Xinyi Hao, yi Zhang, Mengru Yuan, Meng Zhou, Jinglin Chen, Yu Song, Yanlin Zhengzhou Univ Coll Chem Zhengzhou 450001 Peoples R China Zhengzhou Univ Pingyuan Lab Zhengzhou 450001 Peoples R China Chinese Acad Sci Inst Chem Key Lab Green Printing Beijing 100190 Peoples R China Chinese Acad Sci Tech Inst Phys & Chem Key Lab Bioinspired Mat & Interfacial Sci Beijing 100190 Peoples R China Chinese Acad Sci Inst High Energy Phys Beijing 100049 Peoples R China

Low-temperature fabrication of black-phase CsPbI3 perovskite films is first demonstrated by using diphenylphosphinic chloride additive under 30-50 degrees C, arising from the steric effect and chloride insertion ***-area high-quality all-inorganic perovskite films with fewer defects enhanced crystallographic orientation, and excellent environmental stability is *** record performances are demonstrated for flexible wearable photodetectors with a responsivity of 42.1 A W-1, a detectivity of 1.3 x 1014 Jones, high-fidelity image, photoplethysmography sensor functions, and high mechanical stability. Flexible wearable optoelectronic devices fabricated from organic-inorganic hybrid perovskites significantly accelerate the development of portable energy, biomedicine, and sensing fields, but their poor thermal stability hinders further applications. Conversely, all-inorganic perovskites possess excellent thermal stability, but black-phase all-inorganic perovskite film usually requires high-temperature annealing steps, which increases energy consumption and is not conducive to the fabrication of flexible wearable devices. In this work, an unprecedented low-temperature fabrication of stable black-phase CsPbI3 perovskite films is demonstrated by the in situ hydrolysis reaction of diphenylphosphinic chloride additive. The released diphenyl phosphate and chloride ions during the hydrolysis reaction significantly lower the phase transition temperature and effectively passivate the defects in the perovskite films, yielding high-performance photodetectors with a responsivity of 42.1 A W-1 and a detectivity of 1.3 x 1014 Jones. Furthermore, high-fidelity image and photoplethysmography sensors are demonstrated based on the fabricated flexible wearable photodetectors. This work provides a new perspective for the low-temperature fabrication of large-area all-inorganic perovskite flexible optoelectronic devices.

关键词： In situ hydrolyzation Low-temperature processing All-inorganic perovskite Flexible photodetectors Health monitoring

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Inter-Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding, Sensing and Thermal Management

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： Li, Xufeng Chen, Chunyan Li, Zhenyang yi, Peng Zou, Haihan Deng, Gao Fang, Ming He, Junzhe sun, Xin Yu, Ronghai Shui, Jianglan Pan, Caofeng Liu, Xiaofang Beihang Univ Sch Mat Sci & Engn Beijing 100191 Peoples R China Beihang Univ Inst Atom Mfg Beijing 100191 Peoples R China Tianmushan Lab Xixi Octagon City Hangzhou 310023 Peoples R China Beijing Inst Environm Features Sci & Technol Electromagnet Scattering Lab Beijing 100854 Peoples R China

Unique inter-skeleton conductive films are constructed in polymer *** resistance change of the foam can reach four orders of magnitude under *** foam exhibits strain-adaptive electromagnetic interference shielding performance, anti-interference pressure sensor with high sensitivity over a wide pressure range and compression-regulated Joule heating function. Conductive polymer foam (CPF) with excellent compressibility and variable resistance has promising applications in electromagnetic interference (EMI) shielding and other integrated functions for wearable electronics. However, its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during deformation. Here, an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under compression. Unique inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton (denoted as AMLM-PM foam). Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive films. Therefore, the resistance change of AMLM-PM reaches four orders of magnitude under compression. Moreover, the inter-skeleton conductive films can improve the mechanical strength of foam, prevent the leakage of liquid metal and increase the scattering area of EM wave. AMLM-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness, solving the problem of traditional CPFs upon compression. The upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam Liquid metal Electromagnetic interference shielding

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Improved utilization of active sites for phosphorus adsorption in FeOOH/anion exchanger nanocomposites via a glycol-solvothermal synthesis strategy

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Journal of Environmental Sciences 2022年第1期34卷 313-323页

作者： yi Zhang qiong Tang yifan sun Chenxu Yao Zhen Yang Weiben Yang School of Chemistry and Materials Science Jiangsu Provincial Key Laboratory of Material Cycling and Pollution ControlNanjing Normal UniversityNanjing 210046China

Metal oxide/hydroxide-based nanocomposite adsorbents with porous supporting matrices have been recognized as efficient adsorbents for phosphorus *** at satisfying increasingly restrictive environmental requirements involving improving metal site utilization and lowering metal leakage risk,a glycol-solvothermal confined-space synthesis strategy was proposed for the fabrication of Fe OOH/anion exchanger nanocomposites(Fe/900s)with enhanced metal site utilization and reduced metal leakage *** to composites prepared using alkaline precipitation methods,Fe/900s performed comparably,with a high adsorption capacity of 19.05 mg-P/g with an initial concentration of 10 mg-P/L,a high adsorption selectivity of 8.2 mg-P/g in the presence of 500 mg-SO_(4)^(2-)/L,and high long-term resilience(with a capacity loss of~14%after five cycles),along with substantially lower Fe loading amount(4.11 wt.%)and Fe leakage *** investigation demonstrated that contribution of the specific Fe OOH sites to phosphate adsorption increased substantially(up to 50.97%under the optimal conditions),in which Fe(Ⅲ)-OH was the dominant efficient *** side effects of an excessively long reaction time,which included quaternary ammonium decomposition,Fe OOH aggregation,and Fe(Ⅲ)reduction,were discussed as guidance for optimizing the synthesis *** glycol-solvothermal strategy provides a facile solution to environmental problems through nanocrystal growth engineering in a confined space.

关键词： Phosphate adsorption Nanocomposite adsorbent Metal site utilization Metal hydroxides/oxides Ethylene glycol-solvothermal confined-space synthesis

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基于乐观阴影集的荧光分子断层成像优化策略

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郑州大学学报（理学版） 2025年第1期57卷 40-45页

作者：张钦然国栋凯易黄建谢琼西北大学信息与科学技术学院陕西西安710127 湖南中医药大学第一附属医院湖南长沙410208

荧光分子断层成像(fluorescence molecular tomography,FMT)是一种很有潜力的光学分子影像技术,由于光在生物组织内传输时会产生大量随机的强散射,传播过程极其复杂,使得荧光分子断层成像重建具有高度的病态性。为了获得准确的重建结果... 详细信息

荧光分子断层成像(fluorescence molecular tomography,FMT)是一种很有潜力的光学分子影像技术,由于光在生物组织内传输时会产生大量随机的强散射,传播过程极其复杂,使得荧光分子断层成像重建具有高度的病态性。为了获得准确的重建结果,提出了一种基于乐观阴影集的FMT优化策略。首先,定义了一种基于阴影集的情绪决策—乐观决策和悲观决策。然后,提出了一种基于乐观决策的FMT优化策略,该策略将荧光产额信息转换为模糊信息样本,通过阴影集计算当前模糊信息样本的最佳阈值,对样本的划分采取乐观决策。最后,筛选出荧光目标的预测位置。实验结果表明,所提算法能够有效提高FMT重建的精度。

关键词：阴影集三支决策荧光分子断层成像乐观决策

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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye Yan sun Jing Cai Fubing Yu Haiping Wen Xiuwei yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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Seismic design analysis of the country masonry school buildings in the meizoseismal area

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Earthquake Engineering and Engineering Vibration 2011年第3期10卷 359-367页

作者： Feng Yuan yi Dan Bi qiong China Southwest Architecture Design ＆ Research Institute Chengdu 610042 China

Several reinforcing schemes are illustrated that are based on the loading characteristics of typical country masonry school buildings with sparsely spaced transversal walls and large depth. From the seismic damage observed following the Wenchuan Earthquake, the effects of reinforcing schemes, tie-columns and tie-beams on the seismic resistance of masonry buildings are analyzed. The concept of improving the ductility of these types of buildings is presented. Finally, some suggestions are proposed for the design of masonry buildings with sparsely spaced transversal walls and large depth.

关键词： masonry school buildings tie-columns tie-beams ductility wall between the windows Wenchuan earthquake seismic damage

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Source-less density measurement using an adaptive neutron-induced gamma correction method

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Nuclear Science and Techniques 2023年第8期34卷 115-130页

作者： qiong Zhang yi Ge Yu-Lian Li University of Electronic Science and Technology of China Chengdu 610000China

The use of radioactive isotopes,such as Cs-137,to measure formation density is a common practice;however,it poses high risks such as environmental contamination from lost *** address these challenges,the use of pulsed neutron sources for density measurements,also known as“source-less density”,has emerged as a promising *** collecting gamma counts at different time gates according to the duty cycle of the pulsed sequence,the inelastic gamma component can be isolated to obtain more accurate density ***,the collection of gamma rays during the neutron burst-on period often contains a proportion of capture gamma rays,which can reduce the accuracy of density *** proportion can vary depending on the formation environment and neutron duty *** address these challenges,an adaptive capture gamma correction method was developed for density *** method distinguishes between“burst-on”and“burst-off”periods based on the gamma time spectra,and derives the capture ratio in the burst-on period by iteratively fitting the capture gamma time spectra,resulting in a more accurate net inelastic *** method identifies the end of the pulse by automatically calculating the differential,and fits the capture gamma time spectra using Gaussian process regression,which considers the differences in formation attenuation caused by different *** method was verified through simulations with errors of below 0.025 g/cm3,demonstrating its adaptability and feasibility for use in formation density ***,the proposed method has the potential to minimize the risks associated with radioactive isotopes and improve the accuracy of density measurements in various duty cycles and formation environments.

关键词： Neutron-induced gamma Adaptive correction Source-less density

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