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The Influence of Ethyl Branch on Formation of Shish-Kebab Crystals in Bimodal Polyethylene under Shear at Low Temperature

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Chinese Journal of Polymer Science 2021年第8期39卷 1050-1058,I0008页

作者： Zong-Bao Wang yi-min mao Xu-Ke Li yi-Guo Li Chatchai Jarumaneeroj Boonyakeat Thitisak Piyawan Tiyapiboonchaiya Wonchalerm Rungswangd Benjamin S.Hsiao Ningbo Key Laboratory of Specialty Polymers School of Materials Science and Chemical EngineeringNingbo UniversityNingbo 315211China Department of Materials Science and Engineering University of MarylandCollege ParkMaryland 20742USA NIST Center for Neutron Research National Institute of Standards and TechnologyGaithersburgMaryland 20899USA SCG Chemicals Co. Ltd.Siam Cement Group(SCG).1 Siam Cement Rd.BangsueBangkok 10800Thailand USA Department of Chemistry Stony Brook UniversityStony BrookNY 11794-3400USA

Formation of shish-kebab crystals using a bimodal polyethylene system containing high molecular weight(HMW)component with different ethyl branch contents was *** situ small-angle X-ray scattering(SAXS)and wide-angle X-ray diffraction(WAXD)techniques were used to monitor the formation and evolution of shish-kebab structure sheared at low temperature in simple shear mode and low *** the bimodal PE with no branch formed shish-kebab crystals at the shear temperature of 129℃,and the shish length increased with the crystallization time,while bimodal PE with branch has no observable shish under the same *** degree of crystallization for bimodal PE with no branch increased with time up to above 7%,while those with ethyl branch increased continually up to above 23%.Furthermore,bimodal PE's Hermans orientation factor with no branch increased to 0.60,while those with ethyl branch only increased to a value below *** study indicated that the shish-kebab crystal formed at the low temperature of 129℃is due to the stretch of entangled chains under shear for the bimodal PE with no *** partly oriented lamellar crystals were formed for the bimodal PE with ethyl *** the results at the shear temperatures higher,closed to,and lower than the melting point,the modulation of shish crystals formation owing to different mechanisms of the coil-stretch transition and the stretched network by changing shear temperature was achieved in the bimodal PE samples.

关键词： Bimodal polyethylene Shish-kebab Ethyl branch Shear

Th17细胞在支气管哮喘小鼠发病机制中的作用研究

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中国现代医学杂志 2015年第25期25卷 21-24页

作者：单世民毛毅敏孙瑜霞河南科技大学第一附属医院河南洛阳471000

目的研究Th17细胞及其分泌的炎症因子(IL-17)在哮喘小鼠气道炎症中的作用机制,并初步探讨Th17和T-reg细胞的表达失衡的意义。方法将30只小鼠随机分为对照组和模型组,采用卵白蛋白(OVA)致敏的方法建立小鼠哮喘模型。对两组小鼠肺泡灌洗液... 详细信息

目的研究Th17细胞及其分泌的炎症因子(IL-17)在哮喘小鼠气道炎症中的作用机制,并初步探讨Th17和T-reg细胞的表达失衡的意义。方法将30只小鼠随机分为对照组和模型组,采用卵白蛋白(OVA)致敏的方法建立小鼠哮喘模型。对两组小鼠肺泡灌洗液(BALF)中炎症细胞进行计数,并采用酶联免疫吸附法检测BALF中IL-17和IL-10水平;流式细胞术检测小鼠外周血Th17和T-reg细胞占CD4+T淋巴细胞百分率情况;并分析Th17和T-reg细胞数与BALF中性粒细胞的相关性。结果哮喘组小鼠BALF中细胞总数和中性粒细胞、嗜酸性粒细胞、淋巴细胞百分率均明显高于对照组(P<0.05)。哮喘小鼠外周血Th17/T-reg细胞比例增大;BALF上清中IL-17水平明显升高,而IL-10水平明显降低(均P<0.05)。Th17细胞数与BALF中的中性粒细胞数呈正相关,而T-reg细胞数与BALF中的中性粒细胞数呈负相关。结论 Th17及其分泌的炎症因子IL-17在哮喘小鼠气道炎症反应中有着重要作用,同时Th17/T-reg细胞在小鼠哮喘模型中失衡表达,提示其参与了哮喘的发病过程,为治疗哮喘提供新的研究思路。

关键词：支气管哮喘 Th17 IL-17 T-reg

N-末端脑钠肽前体联合超声心动图对急性肺栓塞患者预后的评估

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中国现代医学杂志 2017年第25期27卷 115-118页

作者：徐慧李媛媛毛毅敏南阳医学高等专科学校第一附属医院呼吸内科河南南阳473058 河南科技大学第一附属医院呼吸内科河南洛阳471003

目的探讨N-末端脑钠肽前体(NT-pro BNP)和右心功能在急性肺栓塞(APE)患者中的变化,研究其在APE患者临床预后的评估作用。方法收集2010~2014年在河南科技大学第一附属医院住院,临床诊断为APE的患者135例。根据超声心动图检查结果将APE患... 详细信息

目的探讨N-末端脑钠肽前体(NT-pro BNP)和右心功能在急性肺栓塞(APE)患者中的变化,研究其在APE患者临床预后的评估作用。方法收集2010~2014年在河南科技大学第一附属医院住院,临床诊断为APE的患者135例。根据超声心动图检查结果将APE患者分为右心功能正常组(71例)、右心功能不全组(64例);根据APE住院期间是否发生死亡、病情恶化及不良事件将APE患者分为预后良好组(81例)、预后不良组(54例)。分析不同组别主要临床指标的差异,得出影响APE患者预后的因素。结果右心功能不全组不良事件、死亡的发生率与右心功能正常组比较,差异有统计学意义(P<0.05),右心功能不全组高于右心功能正常组;与右心功能正常组比较,右心功能不全组NT-pro BNP、c Tn I及Pa O2差异有统计学意义(P<0.05);预后不良组NT-pro BNP、c Tn I水平与预后良好组比较,差异有统计学意义(P<0.05),预后不良组高于预后良好组。Logistic逐步回归分析结果显示:右心功能不全、NT-pro BNP、c Tn I、深静脉血栓病史与APE患者住院期间预后不良相关,OR∧值分别为8.503、5.474、5.418和5.084。结论 NT-pro BNP与右心功能不全呈正相关,二者均是APE患者预后的预测因子,结合后的评估价值更大。

关键词：急性肺栓塞 N-末端脑钠肽前体右心功能不全

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di Zhao Lemei Zhu Zheyu Zhang min yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

启动子CpGs位点甲基化所致BRCA1基因转录抑制作用的位点特异性

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实用肿瘤杂志 2003年第6期18卷 444-447页

作者：朱益民来茂德浙江大学医学院公共卫生系浙江杭州310006 浙江大学医学院病理学教研室浙江杭州310006

目的　研究 BRCA1基因 Cp G岛内各个 Cp Gs位点甲基化与转录水平的关系 ,探讨甲基化所致转录抑制作用的特异性 Cp G位点 ,以阐明 DNA甲基化的作用方式。方法　以 Rice等研究数据为材料 ,用方差分析和多因素线性回归模型等方法进行统计... 详细信息

目的　研究 BRCA1基因 Cp G岛内各个 Cp Gs位点甲基化与转录水平的关系 ,探讨甲基化所致转录抑制作用的特异性 Cp G位点 ,以阐明 DNA甲基化的作用方式。方法　以 Rice等研究数据为材料 ,用方差分析和多因素线性回归模型等方法进行统计再分析。结果　 BRCA1基因 Cp G岛 +8～ +44、- 189～ - 19、- 379～ - 2 5 8、- 37～ - 19和 - 80～ - 19区段内 Cp Gs的甲基化与基因转录抑制有关 ,这些区段内 Cp Gs位点的甲基化数目越多 ,基因转录水平越低。多因素线性回归模型分析表明 ,- 80～ - 19区段的甲基化与转录抑制关系密切。并以 - 2 9Cp G位点甲基化引起的转录抑制作用最强。结论　 Cp G岛甲基化引起的转录抑制与 Cp Gs位点有关 ,具有位点的特异性。

关键词：启动子 CpGs位点甲基化 BRCA1基因转录抑制作用位点特异性

Silicon-based metal-organic frameworks(SiMOFs)for immunogenic cell death in cancer therapy

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Nano Research 2025年第1期18卷 628-641页

作者： min Han Zishan Chen Shiying Zhou Zunde Liao Xiangting yi Yao He yiling Zhong Kam W.Leong College of Pharmacy State Key Laboratory of Bioactive Molecules and Druggability AssessmentJinan UniversityGuangzhou 511443China Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA Institute of Functional Nano and Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123China

Silicon-based nanomaterials,known for their unique properties and favorable biocompatibility,significantly impact sectors like energy,electronics,and ***,metalorganic frameworks(MOFs)have emerged as promising candidates for biomedicine,characterized by adjustable chemical composition,high porosity,and ***,the combination of silicon with MOFs to create silicon-based MOF nanostructures(SiMOFs)remains ***,we establish a diverse library of SiMOFs with various nanostructures,including flower-like,capsule-like,hexagonal snowflake-like,and necklace-like morphologies via microwave-assisted *** SiMOFs,with their spacious interiors,are ideal for drug *** are used to load drugs and create drug-loaded SiMOFs(e.g.,SiFeO).SiFeO exhibits excellent photothermal effects and high reactive oxygen species(ROS)generation capacity,enabling synergistic treatments involving chemochemodynamic-photothermal *** approach efficiently triggers immunogenic cell death(ICD)and demonstrates excellent antitumor efficacy in *** staining reveals that the synergistic therapy can modulate the tumor microenvironment(TME)by reducing M2-phenotype macrophages,increasing the activation of antigen-presenting cells(APCs),enhancing the infiltration of CD4^(+)and CD8^(+)T cells,elevating Granzyme B production,and decreasing the presence of immunosuppressive regulatory T cells(Tregs).Consequently,drug-loaded SiMOFs-mediated combination therapy effectively reverses the immunosuppressive TME and activates robust antitumor immune responses by inducing ICD in tumor cells,ultimately achieving superior anticancer efficacy.

关键词： silicon-based nanomaterials nanocarriers immunogenic cell death antitumor immune responses

TIDAL EFFECTS ON GROUNDWATER DYNAMICS IN COASTAL AQUI-FER UNDER DIFFERENT BEACH SLOPES

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Journal of Hydrodynamics 2012年第1期24卷 97-106页

作者： LIU yi SHANG Song-hao mao Xiao-min College of Water Conservancy and Civil EngineeringChina Agricultural UniversityBeijing 100083China State Key Laboratory of Hydroscicncc and Engineering Department of Hydraulic EngineeringTsinghuaUniversityBeijing 100084China College of Water Conservancy and Civil Engineering China Agricultural UniversityBeijing 100083China

The tide induced groundwater fluctuation and the seawater intrusion have important effects on hydrogeology and ecology of coastal *** previous studies,there were few quantitative evaluations of the joint effects of the beach slope and the tide fluctuation on the groundwater *** this article,a numerical model is built by using the software FEFLOW with consideration of seawater intrusion,tide effects,density dependent flow and beach sloping *** simulation results are validated by laboratory experimental data in *** numerical scenarios are designed in a practical scale with different beach *** show that the groundwater fluctuation decays exponentially with the distance to the beach,i.e.,,and our simulation further shows that the beach slope influence can be expressed in the form of a logarithm *** for the same location,the amplitude increases logarithmically with the beach angle in the form,where and are related with the horizontal distance（）in the form of a logarithm *** beach slope has no influence on the phase lag,although the latter increases regularly with the distance from the *** beach slope effect on the seawater intrusion is investigated through the quantitative relationship among the relative intrusion length（）,the relative enhancement of the tide induced seawater intrusion（）and the beach angle（）.It is shown that the tide effects on a milder beach is much greater than on a vertical one,and both λ and κ can be expressed in logarithm functions *** tidal effect on the flow field in the transition zone for a particular mild beach is also studied,with results showing that the tide induced fluctuation of is similar to the groundwater table fluctuation while shows a distinct variation along both directions.

关键词： tidal effects salt wedges saline intrusion beach slope finite element method

Hydraulics and swimming behavior of schizothorax prenanti in vertical slot fishways

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Journal of Hydrodynamics 2019年第1期31卷 169-176页

作者： Rui-dong An Jia Li Wen-min yi Xi mao State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan UniversityChengdu 610065China College of Water Conservancy and Hydropower Engineering Sichuan Agricultural UniversityYaan 625014China

This paper presents a novel experiment for the correlation between the hydraulics and the swimming behavior of Schizothorax prenanti,a rare species of fish in southwest China,in passing a vertical slot *** an acoustic Doppler velocimeter,the velocities of a physical model in the equidimension fishway in the Shaping II power station are *** hydraulic parameters include the hydraulic head drop,the velocity patterns and the flow rate,and the swimming behavior includes the burst-coast,the sustained swimming and the migratory path,and they are analyzed under the test *** sustained swimming velocity is in the range from 0.65m/s to 1.09m/*** estimated hydraulic head drop of each pool is calculated and is in the range from 0.08-0.11 m,which means that 2.6% slope is *** the same slope,the maximum velocity is further reduced from 1.24 m/s to 1.14 m/s by using an L shape baffle *** above findings are used as the basis to evaluate the hydraulic performance of the fishways,where the L shape baffle structure is expected to be effective tor creating a preterencial flow for the *** the main stream of the pool,an "Ω" shape flow pattern is more fish-friendly,which can effectively extend the energy dissipation distance and avoid the bursting through a high velocity *** paper provides a useful complementary tool for practical designs.

关键词： Hydraulics swimming behavior vertical slot fishways burst-coast energy dissipation

An Inequality for the Perron Pair of an Irreducible and Symmetric Nonnegative Tensor with Application

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Journal of the Operations Research Society of China 2017年第1期5卷 65-82页

作者： mao-Lin Che yi-min Wei School of Mathematical Sciences Fudan UniversityShanghai 200433China School of Mathematical Sciences and Shanghai Key Laboratory of Contemporary Applied Mathematics Fudan UniversityShanghai 200433China

The main purpose of this paper is to consider the Perron pair of an irreducible and symmetric nonnegative tensor and the smallest eigenvalue of an irreducible and symmetric nonsingular *** analyze the analytical property of an algebraic simple eigenvalue of symmetric *** also derive an inequality about the Perron pair of nonnegative tensors based on plane stochastic *** finally consider the perturbation of the smallest eigenvalue of nonsingular M-tensors and design a strategy to compute its smallest *** verify our results via random numerical examples.

关键词： Nonnegative tensor Symmetric tensor Irreducible tensor M-Tensor H-Eigenpair An algebraic simple eigenvalue The Perron pair The smallest eigenvalue Perturbation