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Engineering surface framework TiO6 single sites for unprecedented deep oxidative desulfurization

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National Science Review 2024年第5期11卷 303-314页

作者： Shen Yu Zhan Liu Jia-Min Lyu Chun-Mu Guo Xiao-Yu Yang Peng Jiang yi-long wang Zhi-yi Hu Ming-Hui Sun Yu Li Li-Hua Chen Bao-Lian Su Laboratory of Living Materials at the State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Nanostructure Research Center Wuhan University of Technology School of Chemistry Chemical Engineering and Life ScienceWuhan University of Technology Laboratory of Inorganic Materials Chemistry University of Namur

Catalytic oxidative desulfurization（ODS） using titanium silicate catalysts has emerged as an efficient technique for the complete removal of organosulfur compounds from automotive fuels. However, the precise control of highly accessible and stable-framework Ti active sites remains highly challenging. Here we reveal for the first time by using density functional theory calculations that framework hexa-coordinated Ti（TiO6） species of mesoporous titanium silicates are the most active sites for ODS and lead to a lower-energy pathway of ODS. A novel method to achieve highly accessible and homogeneously distributed framework TiO6active single sites at the mesoporous surface has been developed. Such surface framework TiO6species exhibit an exceptional ODS performance. A removal of 920 ppm of benzothiophene is achieved at60°C in 60 min, which is 1.67 times that of the best catalyst reported so far. For bulky molecules such as4,6-dimethyldibenzothiophene（DMDBT）, it takes only 3 min to remove 500 ppm of DMDBT at 60°C with our catalyst, which is five times faster than that with the current best catalyst. Such a catalyst can be easily upscaled and could be used for concrete industrial application in the ODS of bulky organosulfur compounds with minimized energy consumption and high reaction efficiency.

关键词： electrostatic interactions framework hexa-coordinated Ti site oxidative desulfurization mesoporous materials self-assembly

Dual antiplatelet therapy may increase the risk of non-intracranial haemorrhage in patients with minor strokes: a subgroup analysis of the CHANCE trial

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Stroke & Vascular Neurology 2016年第2期1卷 29-36页

作者： David wang Li Gui yi Dong Hao Li Shujuan Li Huaguang Zheng Anxin wang Xia Meng Li-Ping Liu yi-long wang Guangyao wang Jing Jing Zixiao Li Xing-Quan Zhao Yong-Jun wang on behalf of the investigators for the CHANCE trial Illinois Neurological Institute Stroke Network Sisters of the Third Order of St.Francis Healthcare SystemUniversity of Illinois College of MedicinePeoriaIllinoisUSA Southwest Hospital Stroke Center Third Military University of Medical SciencesChongqingChina Department of Neurology Huashan HospitalFudan UniversityShanghaiChina China National Clinical Research Center for Neurological Diseases BeijingChina Chaoyang Hospital Neurology Department Capital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalTiantan Clinical Trial and Research Center for StrokeCapital Medical UniversityBeijingChina Neurological Intensive Care Unit Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalVascular NeurologyCapital Medical UniversityBeijingChina 不详

Aim:The aim of this study was to explore the difference between haemorrhagic events among those patients on either aspirin or aspirin plus clopidogrel who were enrolled in the Clopidogrel in High-Risk Patients with Acute Non-disabling Ischemic Cerebrovascular Events(CHANCE)***:This was an ad hoc analysis of the CHANCE trial;data on all patients with any haemorrhagic event were reviewed and *** proportional hazards regression was used to determine factors association with any ***:In the CHANCE trial,there were a total of 101(2%)haemorrhagic events reported from 50 different *** clopidogrel–aspirin group had 60(2.3%)cases and the aspirin group had 41(1.6%,p=0.09).Moderate or severe haemorrhagic events occurred in 7 patients(0.3%)in the clopidogrel–aspirin group and in 8(0.3%)in the aspirin group(p=0.73).Of 36(0.7%)cases of intracranial haemorrhages,20(0.4%)were in the clopidogrel–aspirin group and 16(0.3%)in the aspirin *** group had 8(0.3%)cases of symptomatic haemorrhagic *** common haemorrhagic events included 24(0.5%)cases of skin bruises,13(0.3%)gastrointestinal haemorrhages,9(0.2%)gum haemorrhages and 8(0.2%)intraocular ***:There was no overall significant difference in haemorrhagic events(p=0.29),especially in the rate of intracranial haemorrhages between the 2 treatment ***,patients enrolled with minor strokes had an increased risk of haemorrhagic events regardless of treatment group,not seen in patients with high-risk transient ischaemic *** elderly,of male gender and with a history of aspirin or proton pump inhibitor usage were associated with increased risk of *** with higher body mass index had lower risk of haemorrhagic events.

关键词： patients intracranial analysis

Potential preservative mechanisms of cardiac rehabilitation pathways on endothelial function in coronary heart disease

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Science China Life Sciences 2024年

作者： Wen-Tao Sun Jian-Yong Du Jia wang yi-long wang Er-Dan Dong Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital)School of Health and Life SciencesUniversity of Health and Rehabilitation Sciences Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalThe Institute of Cardiovascular SciencesPeking UniversityState Key Laboratory of Vascular Homeostasis and RemodelingPeking University

Cardiac rehabilitation, a comprehensive exercise-based lifestyle and medical management, is effective in decreasing morbidity and improving life quality in patients with coronary heart disease. Endothelial function, an irreplaceable indicator in coronary heart disease progression, is measured by various methods in traditional cardiac rehabilitation pathways, including medicinal treatment, aerobic training, and smoking cessation. Nevertheless, studies on the effect of some emerging cardiac rehabilitation programs on endothelial function are limited. This article briefly reviewed the endothelium-beneficial effects of different cardiac rehabilitation pathways, including exercise training, lifestyle modification and psychological intervention in patients with coronary heart disease, and related experimental models, and summarized both uncovered and potential cellular and molecular mechanisms of the beneficial roles of various cardiac rehabilitation pathways on endothelial function. In exercise training and some lifestyle interventions, the enhanced bioavailability of nitric oxide, increased circulating endothelial progenitor cells(EPCs), and decreased oxidative stress are major contributors to preventing endothelial dysfunction in coronary heart disease. Moreover, the preservation of endothelial-dependent hyperpolarizing factors and inflammatory suppression play roles. On the one hand, to develop more endothelium-protective rehabilitation methods in coronary heart disease, adequately designed and sized randomized multicenter clinical trials should be advanced using standardized cardiac rehabilitation programs and existing assessment methods. On the other hand, additional studies using suitable experimental models are warranted to elucidate the relationship between some new interventions and endothelial protection in both macro-and microvasculature.

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Establishment of an efficient reverse genetic system of Mumps virus S79 from cloned DNA

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World Journal of Pediatrics 2019年第5期15卷 499-505页

作者： Duo Zhou Meng-ying Zhu yi-long wang Xiao-Qiang Hao Dong-Ming Zhou Rong-Xian Liu Chu-Di Zhang Chu-Fan Qu Zheng-Yan Zhao Zhejiang University School of Medicine HangzhouChina Children's Hospital Zhejiang University School of MedicineHangzhou 310052China Department of Neurology Children's HospitalZhejiang University School of MedicineHangzhou 310052China

Background Mumps is a common type of respiratory infectious disease caused by mumps virus(MuV),and can be effectively prevented by *** this study,a reverse genetic system of MuV that can facilitate the rational design of safer,more efficient mumps vaccine candidates is *** MuV-S79 cDNA clone was assembled into a full-length plasmid by means of the GeneArtTM High-Order Genetic Assembly System,and was rescued via reverse genetic ***-PCR,sequencing,and immunofluorescence assays were used for rMuV-S79 *** replication kinetics and in vivo experimental models were used to evaluate the replication,safety,and immunogenicity of *** A full-length cDNA clone of MuV-S79 in the assembly process was generated by a novel plasmid assemble strategy,and a robust reverse genetic system of MuV-S79 was successfully *** established rMuV-S79 strain could reach a high virus titer in *** average viral titer of rMuV-S79 in the lung tissues was 2.68±0.14 log10PFU/g lung tissue,and rMuV-S79 group did not induce inflammation in the lung tissues in cotton *** antibody titers induced by rMuV-S79 were high,long-lasting and could provide complete protection against MuV wild strain *** We have established a robust reverse genetic system of MuV-S79 which can facilitate the optimization of mumps ***-S79 rescued could reach a high virus titer and the safety was proven in *** could also provide complete protection against MuV wild strain challenge.

关键词： Mumps virus Reverse genetics Plasmid Safety Immunogenicity

Shuxuetong for Prevention of recurrence in Acute Cerebrovascular events with Embolism(SPACE)trial:rationale and design

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Stroke & Vascular Neurology 2020年第3期5卷 311-314页

作者： Hong-Qiu Gu Xue-Wei Xie Jing Jing Xia Meng Wei Lv Jian-Dong Yu Xiang-Ping Lv Hao Li yi-long wang Yong-Jun wang China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease BeijingChina Center for Stroke Beijing Institute for Brain DisordersBeijingChina

Backgrounds Embolic stroke is one of the main mechanisms of ischaemic *** if treated with recommended antithrombotic agents,stroke recurrence remains *** Shuxuetong injection,a purified extract of traditional Chinese medicine widely used for thrombus diseases in clinical practice in China,could be a promising agent to prevent stroke *** To describe the design of the Shuxuetong injection for prevention of recurrence in acute ischaemic stroke with embolism *** The Shuxuetong for Prevention of recurrence in Acute Cerebrovascular events with Embolism(SPACE)trial is a multicentre,randomised,double-blind,placebo-controlled,parallel-group,superiority trial to evaluate the efficacy and safety of Shuxuetong injection in reducing recurrence or silent new ischaemic lesions on patients with acute embolic stroke within 10 *** estimated 2416 patients with embolic stroke within 72 hours of symptom onset from 80 hospitals will be randomly assigned to one of two groups receiving Shuxuetong injection or placebo injection for 10 *** primary endpoint is symptomatic or asymptomatic new cerebral infarction within 10 days after *** The SPACE Trial will provide valuable evidence for the efficacy and safety of Shuxuetong injection for the prevention of stroke recurrence in patients with imaging-defined embolic stroke.

关键词： prevention injection acute

Attenuated MuV-S79 as vector stably expressing foreign gene

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World Journal of Pediatrics 2019年第5期15卷 511-515页

作者： Duo Zhou Meng-ying Zhu yi-long wang Xiao-Qiang Hao Dong-Ming Zhou Rong-Xian Liu Chu-Di Zhang Chu-Fan Qu Zheng-Yan Zhao Zhejiang University School of Medicine HangzhouZhejiangChina Children's Hospital Zhejiang University School of MedicineHangzhou 310052China Department of Neurology Children's HospitalZhejiang University School of MedicineHangzhou 310052China

Background To describe mumps virus(MuV)used as a vector to express enhanced green fluorescent protein(EGFP)or red fluorescent protein(RFP)*** Molecular cloning technique was applied to establish the cDNA clones of recombinant mumps viruses(rMuVs).rMuVs were recovered based on our reverse genetic system of *** properties of rMuVs were determined by growth curve,plaque assay,fluorescent microscopy and determination of fluorescent *** Three recombinant viruses replicated well in Vero cells and similarly as parental rMuV-S79,expressed heterologous genes in high levels,and were genetically stable in at least 15 *** rMuV-S79 is a promising platform to accommodate foreign genes like marker genes,other antigens and immunomodulators for addressing various diseases.

关键词： Mumps virus Reverse genetic system Foreign genes

China Stroke Statistics 2019:A Report From the National Center for Healthcare Quality Management in Neurological Diseases,China National Clinical Research Center for Neurological Diseases,the Chinese Stroke Association,National Center for Chronic and Non-communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations

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Stroke & Vascular Neurology 2020年第3期5卷 211-239页

作者： Yong-Jun wang Zi-Xiao Li Hong-Qiu Gu yi Zhai Yong Jiang Xing-Quan Zhao yi-long wang Xin Yang Chun-Juan wang Xia Meng Hao Li Li-Ping Liu Jing Jing Jing Wu An-Ding Xu Qiang Dong David wang Ji-Zong Zhao On behalf of China Stroke Statistics 2019 Writing Committee China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Department of Neurology and Stroke Center The First Affiliated HospitalJinan UniversityGuangzhouGuangdongChina Department of Neurology Huashan HospitalFudan UniversityShanghaiChina Neurovascular Division Department of NeurologyBarrow Neurological InstituteSt.Joseph's Hospital and Medical CenterPhoenixArizonaUSA 不详

China faces the greatest challenge from stroke in the *** death rate for cerebrovascular diseases in China was 149.49 per 100000,accounting for 1.57 million deaths in *** ranked third among the leading causes of death behind malignant tumours and heart *** age-standardised prevalence and incidence of stroke in 2013 were 1114.8 per 100000 population and 246.8 per 100000 person-years,*** to the Global Burden of Disease Study 2017,the years of life lost(YLLs)per 100000 population for stroke increased by 14.6%;YLLs due to stroke rose from third highest among all causes in 1990 to the highest in *** absolute numbers and rates per 100000 population for all-age disability-adjusted life years(DALYs)for stroke increased substantially between 1990 and 2017,and stroke was the leading cause of all-age DALYs in *** main contributors to cerebrovascular diseases include behavioural risk factors(smoking and alcohol use)and pre-existing conditions(hypertension,diabetes mellitus,dyslipidaemia and atrial fibrillation(AF)).The most prevalent risk factors among stroke survivors were hypertension(63.0%-84.2%)and smoking(31.7%-47.6%).The least prevalent was AF(2.7%-7.4%).The prevalences for major risk factors for stroke are high and most have increased over *** on the latest national epidemiological data,26.6%of adults aged≥15 years(307.6 million adults)smoked tobacco *** those aged≥18 years,age-adjusted prevalence of hypertension was 25.2%;adjusted prevalence of hypercholesterolaemia was 5.8%;and the standardised prevalence of diabetes was 10.9%.For those aged≥40 years,the standardised prevalence of AF was 2.31%.Data from the Hospital Quality Monitoring System showed that 3010204 inpatients with stroke were admitted to 1853 tertiary care hospitals during *** those,2466785(81.9%)were ischaemic strokes(ISs);447609(14.9%)were intracerebral haemorrhages(ICHs);and 95810(3.2%)were subarachnoid haemorrhages(SAHs).The average age

关键词： admitted smoke insurance

Proteomic profiling of cerebrospinal fluid in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease

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World Journal of Pediatrics 2024年第3期20卷 259-271页

作者： yi-long wang Meng-ying Zhu Zhe-Feng Yuan Xiao-Yan Ren Xiao-Tong Guo yi Hua Lu Xu Cong-ying Zhao Li-Hua Jiang Xin Zhang Guo-Xia Sheng Pei-Fang Jiang Zheng-Yan Zhao Feng Gao Department of Neurology Children's HospitalZhejiang University School of MedicineHangzhou 310052China Children's Hospital Zhejiang University School of MedicineHangzhou 310052China Children's Hospital National Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhou 310052China

Background Myelin oligodendrocyte glycoprotein(MOG)antibody-associated disease(MOGAD)is an autoimmune demy-elinating disorder of the central nervous *** Extracted proteins from 34 cerebrospinal fluid(CSF)samples[patients with MOGAD(MOG group,n=12);healthy controls(HC group,n=12);patients with MOG seronegative and metagenomics next-generation sequencing-negative inflammatory neurological diseases(IND group,n=10)]were processed and subjected to label-free quantitative *** partial least squares-discriminant analysis(PLS-DA)and orthogonal PLS-DA(O-PLS-DA)models were also performed based on proteomics *** analysis of differentially expressed proteins(DEPs)was performed using Gene Ontology,InterPro,and Kyoto Encyclopedia Genes and *** enzyme-linked immunosorbent assay was used to determine the complement levels in serum from patients with *** Four hundred and twenty-nine DEPs(149 upregulated and 280 downregulated proteins)were identified in the MOG group compared to the HC group according to the P value and fold change(FC).Using the O-PLS-DA model,872 differentially abundant proteins were identified with variable importance projection(VIP)scores>*** proteins(gamma-glutamyl hydrolase,cathepsin F,interalpha-trypsin inhibitor heavy chain 5,latent transforming growth factor beta-binding protein 4 and leukocyte-associated immunoglobulin-like receptor 1)overlapping between the top 30 DEPs with top-ranked P value and FC and top 30 proteins in PLS-DA VIP lists were *** analysis revealed that the dysregulated proteins in the MOG group were primarily involved in complement and coagulation cascades,cell adhesion,axon guidance,and glycosphingolipid biosynthesis compared to the HC *** The proteomic alterations in CSF samples from children with MOGAD identified in the current study might provide opportunities for developing novel biomarker candidates.

关键词： Acute disseminated encephalomyelitis Cerebrospinal fluid Complement cascades Myelin oligodendrocyte glycoprotein-associated disease Proteomics

Temporal trends and rural-urban disparities in cerebrovascular risk factors,in-hospital management and outcomes in ischaemic strokes in China from 2005 to 2015:a nationwide serial cross-sectional survey

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Stroke & Vascular Neurology 2023年第1期8卷 34-50页

作者： Chun-Juan wang Hong-Qiu Gu Xin-Miao Zhang Yong Jiang Hao Li Janet Prvu Bettger Xia Meng Ke-Hui Dong Run-Qi wangqin Xin Yang Meng wang Chelsea Liu Li-Ping Liu Bei-Sha Tang Guo-Zhong Li Yu-Ming Xu Zhi-yi He yi Yang Winnie yip Gregg C Fonarow Lee H Schwamm ying Xian Xing-Quan Zhao yi-long wang Yongjun wang Zixiao Li China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeiingChina Center of Stroke Beijing Institute for Brain DisordersBeijngChina Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease BeijingChina Duke Clinical Research Institute Duke UniversityDurhamNorth CarolinaUSA Department of Neurology Duke Univeristy Medical CenterDurhamNorth CarolinaUSA Department of Epidemiology Harvard T H Chan School of Public HealthBostonMassachusettsUSA Neuro-intensive Care Unit Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Neurology The First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Key Laboratory of Cerebrovascular Disease Prevention and Treatment National Health Commission(Province and Ministry Co-constructed)ZhengzhouHenanChina Department of Neurology The First Affiliated Hospital of China Medical UniversityShenyangLiaoningChina Department of Neurology The First Hospital of Jilin UniversityChangchunJilinChina Department of Global Health and Population Harvard T.H.Chan School of Public HealthBostonMAUSA Ahmanson-UCLA Cardiomyopathy Center Ronald Reagan-UCLA Medical CenterLos AngelesCAUSA Department of Neurology Massachusetts General HospitalHarvard Medical SchoolBostonMAUSA Department of Neurology The University of Texas Southwestern Medical CenterDallasTexasUSA Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Chinese Inst

Background Stroke is the leading cause of mortality in China,with limited evidence of in-hospital burden obtained from nationwide *** aimed to monitor and track the temporal trends and rural-urban disparities in cerebrovascular risk factors,management and outcomes from 2005 to *** We used a two-stage random sampling survey to create a nationally representative sample of patients admitted for ischaemic stroke in 2005,2010 and *** sampled participating hospitals with an economic-geographical region-stratified random-sampling approach first and then obtained patients with a systematic sampling *** weighed our survey data to estimate the national-level results and assess changes from 2005 to *** We analysed 28277 ischaemic stroke admissions from 189 participating *** 2005 to 2015,the estimated national hospital admission rate for ischaemic stroke per 100000 people increased(from 75.9 to 402.7,Ptrend<0.001),and the prevalence of risk factors,including hypertension,diabetes,dyslipidaemia and current smoking,*** composite score of diagnostic tests for stroke aetiology assessment(from 0.22 to 0.36,Ptrend<0.001)and secondary prevention treatments(from 0.46 to 0.70,Ptrend<0.001)were improved.A temporal decrease was found in discharge against medical advice(DAMA)(from 15.2%(95%CI 13.7%to 16.7%)to 8.6%(8.1%to 9.0%);adjusted Ptrend=0.046),and decreases in in-hospital mortality(0.7%in 2015 vs 1.8%in 2005;adjusted OR(aOR)0.52;95%CI 0.32 to 0.85)and the composite outcome of in-hospital mortality or DAMA(8.4%in 2015 vs 13.9%in 2005;aOR 0.65;95%CI 0.47 to 0.89)were *** between rural and urban hospitals narrowed;however,disparities persisted in in-hospital management(brain MRI:rural-urban difference from−14.4%to−11.2%;cerebrovascular assessment:from−20.3%to−16.7%;clopidogrel:from−2.1%to−10.3%;anticoagulant for atrial fibrillation:from−10.9%to−8.2%)and in-hospital outcomes(DAMA:from 2.7%to 5.0%;composite outcome

关键词： admitted nationwide survey