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Ataxia-telangiectasia complicated with Hodgkin's lymphoma:A case report

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World Journal of Clinical Cases 2020年第11期8卷 2387-2391页

作者： Xiao-ling Li yi-lin wang Department of Pediatrics(III) The Linyi People’s HospitalLinyi 276000Shandong ProvinceChina

BACKGROUND Ataxia-telangiectasia(AT)is a rare,autosomal recessive,multisystem *** most clinicians have low awareness of the disease,only scarce reports of AT exist in the literature,especially of cases with lymphoma/*** SUMMARY A 7-year-old girl with a history of recurrent respiratory tract infections was referred to our department because of unstable walking for 5 years and enlarged neck nodes for 2-mo *** examination revealed scleral telangiectasia and cerebellar *** alpha-fetoprotein,decreased serum immunoglobulin,and decreased T cell function were the major findings of laboratory *** analysis of cervical lymph node biopsy was suggestive of classical Hodgkin's *** examination showed heterozygous nucleotide variation of c.6679C>T and heterozygous nucleotide variation of c.5773 delG in the ATM gene;her parents were *** final diagnosis was AT with Hodgkin's *** Clinicians should strengthen their understanding of AT *** diagnosis plays an important role in its diagnosis and treatment.

关键词： Ataxia-telangiectasia Hodgkin's lymphoma Child Case report ATM gene

An alternative aqueous synthetic route to preparing CdTe quantum dots with tunable photoluminescence

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Chinese Chemical Letters 2012年第3期23卷 359-362页

作者： yi lin wang Sheng Yan Liu Li Ya Zhou School of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004China

An aqueous synthetic route has been developed for the preparation of mercaptosuccinic acid（MSA）-capped CdTe quantum dots （QDs） using TeO_2 as tellurium source and sodium borohydride as *** size and the emission color of CdTe QDs can be tuned by varying the reflux *** obtained QDs were characterized by photoluminescence（PL） spectroscopy,X-ray powder diffraction（XRD） and high-resolution transmission electron microscopy（HRTEM）.The results show that the CdTe QDs were of zinc-blende crystal structure in a sphere-like shape.

关键词： Cadmium telluride Quantum dots Synthesis Photoluminescence

Cordyceps cicadae extracts ameliorate renal malfunction in a remnant kidney model

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第12期12卷 1024-1033页

作者： Rong ZHU yi-ping CHEN Yue-yi DENG Rong ZHENG yi-fei ZHONG lin wang Lan-ping DU Department of Nephrology Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai 200032 China

Background and Objectives:Chronic kidney disease(CKD) is a growing public health problem with an urgent need for new pharmacological *** cicadae is widely used in traditional Chinese medicine(TCM) and has potential renoprotective *** current study aimed to determine any scientific evidence to support its clinical ***:We analyzed the potential of two kinds of *** extract,total extract(TE) and acetic ether extract(AE),in treating kidney disease simulated by a subtotal nephrectomy(SNx) ***-Dawley rats were divided randomly into seven groups:sham-operated group,vehicle-treated SNx,Cozaar,2 g/(kg·d) TE SNx,1 g/(kg·d) TE SNx,92 mg/(kg·d) AE SNx,and 46 mg/(kg·d) AE *** injury was monitored using urine and serum analyses,and hematoxylin and eosin(HE) and periodic acid-Schiff(PAS) stainings were used to analyze the level of *** expression of type IV collagen(Col IV),fibronectin(FN),transforming growth factor-β1(TGF-β1),and connective tissue growth factor(CTGF) was detected by ***:Renal injury,reflected in urine and serum analyses,and pathological changes induced by SNx were attenuated by TE and AE *** depositions of Col IV and FN were also decreased by the treatments and were accompanied by reduced expression of TGF-β1 and *** some respects,2 g/(kg·d) of TE produced better effects than ***:For the first time,we have shown that *** may inhibit renal fibrosis in vivo through the TGF-β1/CTGF ***,we conclude that the use of *** could provide a rational strategy for combating renal fibrosis.

关键词： Chronic kidney disease Cordyceps cicadae TGF-β Traditional Chinese medicine

Quantum-chemical study on the catalytic activity of Ti_nRu_mO_2(110)surfaces on chlorine evolution

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Chinese Chemical Letters 2015年第5期26卷 595-598页

作者： Xiao-Hua Hu Jia-Chuan Pan Dan wang Wen Zhong Hao-Yuan wang lin-yi wang College of Chemistry and Chemical Engineering.Chongqing University Department of Biomedical and Chemical Engineering Syracuse University

Based on the generalized gradient approximation （GGA）, Perdew-wang-91 （PW91） combined with a periodic slab model has been applied to study the catalytic activity of chlorine evolution on TinRumO2 （1 1 0） surface. Metal oxide model TinRumO2 has been established with pure TiO2 and Ru02 on the basis set of Double Numerical plus polarization （DNP）, in which the proportion of n：m was 3：1, 1 ：l, or 1：3. Analysis on the reaction activity in the electrochemical reaction and the electrochemical desorption reaction was based on Frontier molecular orbital theory. The results show that the TinRumO2 with a ratio of Ti：Ru at 3：1 is best facilitates the electrochemical reaction and electrochemical desorption reaction to produce M-Clads intermediate and precipitate C12. In addition, the adsorption energy of Cl on the surface of Ti3RU102 possesses the minimum value of 2.514 eV, and thus electrochemical desorption reaction could occur most easily.

关键词： TinRumO2 (1 1 0) Frontier molecular orbitals Adsorption energy PW9 l DSA

DIAGNOSIS, TREATMENT, AND RESEARCH OF ETIOLOGY OF SPONTANEOUS NEONATAL GASTRIC PERFORATION

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Chinese Medical Sciences Journal 2006年第1期21卷 62-64页

作者： Zhi-bin Niu yi Yang Chang-lin wang Department of Pediatric Surgery Shengjing Hospital China Medical University Shenyang 110004

SPONTANEOUS neonatal gastric perforation (SNGP) is a rare and life-threatening disease, which has a high mortality *** study retrospectively reported 23 cases of SNGP treated in the Department of Pediatric Surgery of Shengjing Hospital of China Medical University from January 1993 to December 2003, and briefly discussed the diagnosis, treatment, and possible etiology.

关键词： gastric perforation neonate surgery

Free radicals trigger the closure of open pores in lignin-derived hard carbons toward improved sodium-storage capacity

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Journal of Energy Chemistry 2024年第7期94卷 551-559页

作者： Wen-Jun Ji Zong-lin yi Ming-Xin Song Xiao-Qian Guo yi-lin wang yi-Xuan Mao Fang-Yuan Su Jing-Peng Chen Xian-Xian Wei Li-Jing Xie Cheng-Meng Chen CAS Key Laboratory of Carbon Materials Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001ShanxiChina University of Chinese Academy of Sciences Beijing 100049China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China School of Environment and Safety Taiyuan University of Science and TechnologyTaiyuan 030001ShanxiChina

The chemical activation of various precursors is effective for creating additional closed pores in hard carbons for sodium ***,the formation mechanism of closed pores under the influence of pore-forming agents is not well ***,an effective chemical activation followed by a high-temperature self-healing strategy is employed to generate interconnected closed pores in lignin-derived hard carbon(HCs).By systematic experimental design combined with electron paramagnetic res-onance spectroscopy,it can be found that the content of free radicals in the carbon matrix influences the closure of open pores at high *** high activation temperature(>700 C)leads to a low free radical concentration,making it difficult to achieve self-healing of open pores at high *** activation at 700°C,a balance between pore making and self-healing is achieved in the final hard carbon.A large number of free radicals triggers rapid growth and aggregation of carbon microcrys-tals,blocking pre-formed open micropores and creating additional interconnected closed pores in as-obtained hard *** a result,the optimized carbon anode(LK-700-1300)delivers a high reversible capacity of 330.8 mA h g^(-1) at 0.03 A g^(-1),which is an increase of 86 mA h g^(-1) compared to the pristine lignin-derived carbon anode(L-700-1300),and exhibits a good rate performance(202.1 mA h g^(-1) at 1 A g^(-1)).This work provides a universal and effective guidance for tuning closed pores of hard carbons from otherprecursors.

关键词： Hard carbon Chemical activation Free radical Self-healing Closed pores Sodium ion batteries

Transparent micropatterned conductive films based on highlyordered nanowire network

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Nano Research 2024年第5期17卷 4288-4297页

作者： Xin-Ran Zhang Hai-Tao Deng Xu Zeng yi-lin wang Peng Huang Xiao-Sheng Zhang School of Integrated Circuit Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

Transparent conductive films that are based on nanowire networks are essential to construct flexible,wearable,and even stretchable ***,large-scale precise micropatterning,especially with regard to the controllability of the organizing orientation of nanowires,is a critical ***,we proposed a liquid film rupture self-assembly approach for manufacturing transparent conductive films with microstructure arrays based on a highly ordered nanowire *** large-scale microstructure conductive films were fabricated through air-liquid interface self-assembly and liquid film rupture *** typical micropattern morphologies,including square,hexagon,circle,serpentine,etc.,were prepared to reveal the universal applicability of the proposed *** homogeneity and controllability of this approach were verified for multiple *** the assembly cycles increasing,the optical transmittance decreases *** addition,theoretical model analysis is carried out,and the analytical formula of the speed of the film moving with the surface tension and the density of the liquid film is ***,the feasibility of this approach for piezoresistive strain sensors is *** fabrication approach demonstrated a cost-effective and efficient method for precisely arranging nanowires,which is useful in transparent and wearable applications.

关键词： flexible electronics transparent conductive network micropatterning nanowires micro electromechanical systems(MEMS)

Mitochonic acid 5 regulates mitofusin 2 to protect microglia

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Neural Regeneration Research 2021年第9期16卷 1813-1820页

作者： Jian Tan Shuang-Xi Chen Qing-Yun Lei Shan-Qing yi Na Wu yi-lin wang Zi-Jian Xiao Heng Wu Department of Neurology The First Affiliated Hospital of University of South ChinaHengyangHunan ProvinceChina

Microglial apoptosis is associated with neuroinflammation and no effective strategies are currently available to protect microglia against inflammation-induced apoptosis. Mouse microglial BV-2 cells(5 × 10^6) were incubated with 10 μg/mL lipopolysaccharides for 12 hours to mimic an inflammatory environment. Then the cells were co-cultured with mitochonic acid 5(MA-5) for another 12 hours. MA-5 improved the survival of lipopolysaccharide-exposed cells. MA-5 decreased the activity of caspase-3, which is associated with apoptosis. MA-5 reduced the number of terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling-positive cells, and increased adenosine triphosphate levels in cells. MA-5 decreased the open state of the mitochondrial permeability transition pore and reduced calcium overload and diffusion of second mitochondria-derived activator of caspase(Smac). MA-5 decreased the expression of apoptosis-related proteins(mitochondrial Smac, cytoplasmic Smac, pro-caspase-3, cleaved-caspase-3, and caspase-9), and increased the levels of anti-apoptotic proteins(Bcl2 and X-linked inhibitor of apoptosis protein), mitochondria-related proteins(mitochondrial fusion protein 2, mitochondrial microtubule-associated proteins 1 A/1 B light chain 3 B II), and autophagy-related proteins(Beclin1, p62 and autophagy related 5). However, MA-5 did not promote mitochondrial homeostasis or decrease microglial apoptosis when Mitofusin 2 expression was silenced. This shows that MA-5 increased Mitofusin 2-related mitophagy, reversed cellular energy production and maintained energy metabolism in BV-2 cells in response to lipopolysaccharide-induced inflammation. These findings indicate that MA-5 may promote the survival of microglial cells via Mitofusin 2-related mitophagy in response to lipopolysaccharide-induced inflammation.

关键词： apoptosis autophagy related 5 Beclin1 BV-2 cells caspase-3 inflammation lipopolysaccharide mitophagy Smac survival

High-performance hybrid nanogenerator for selfpowered wireless multi-sensing microsystems

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Microsystems & Nanoengineering 2023年第4期9卷 143-156页

作者： Dan-Liang Wen Peng Huang Hai-Tao Deng Xin-Ran Zhang yi-lin wang Xiao-Sheng Zhang School of Integrated Circuit Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

Wireless sensor network nodes are widely used in wearable devices,consumer electronics,and industrial electronics and are a crucial component of the Internet of Things(IoT).Recently,advanced power technology with sustainable energy supply and pollution-free characteristics has become a popular research ***,to realize an unattended and reliable power supply unit suitable for distributed IoT systems,we develop a high-performance triboelectricelectromagnetic hybrid nanogenerator(TEHNG)to harvest mechanical *** TEHNG achieves a high load power of 21.8 mW by implementing improvements of material optimization,configuration optimization and pyramid microstructure *** realize a self-powered integrated microsystem,a power management module,energy storage module,sensing signal processing module,and microcontroller unit are integrated into the ***,an all-in-one wireless multisensing microsystem comprising the TEHNG,the abovementioned integrated functional circuit and three sensors(temperature,pressure,and ultraviolet)is *** milliwatt microsystem operates continuously with the TEHNG as the only power supply,achieving self-powered operations of sensing environmental variables and transmitting wireless data to a terminal in real *** shows tremendous application potential in the IoT field.

关键词： generator mentioned operations