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Epithelial-mesenchymal transition effect of fine particulate matter from the Yangtze River Delta region in China on human bronchial epithelial cells

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Journal of Environmental Sciences 2018年第4期30卷 155-164页

作者： Yulang Chi Qiansheng Huang yi lin Guozhu Ye Huimin Zhu Sijun Dong Center for Excellence in Urban Atmospheric Environment Institute of Urban Environment Chinese Academy of Sciences Key Lab of Urban Environment and Health Institute of Urban Environment Chinese Academy of Sciences College of Resources and Environment University of Chinese Academy of Sciences

Epidemiological studies have demonstrated that fine particulate matter（PM（2.5）） exposure causes airway inflammation, which may lead to lung cancer. The activation of epithelial–mesenchymal transition（EMT） is assumed to be a crucial step in lung tumor metastasis and development. We assessed the EMT effect of low concentrations（0, 0.1, 1.0, and 5.0 μg/m L）of PM（2.5） organic extract on a human bronchial epithelial cell line（BEAS-2 B）. PM（2.5） samples were collected from three cities（Shanghai, Ningbo, and Nanjing） in the Yangtze River Delta（YRD） region in autumn 2014. BEAS-2 B cells were exposed to the PM（2.5） extract to assess cell viability, invasion ability as well as the relative m RNA and protein expressions of EMT markers. Our findings revealed that BEAS-2 B cells changed from the epithelial to mesenchymal phenotype after exposure. In all groups, PM（2.5） exposure dose-dependently decreased the expression of E-cadherin and increased the expression of Vimentin. The key transcription factors, including ZEB1 and Slug, were significantly up-regulated upon exposure. These results indicated that the PM（2.5） organic extract induced different degrees of EMT progression in BEAS-2 B cells. The cell invasion ability increased in a concentration-dependent manner after 48 hr of treatment with the extract. This study offers a novel insight into the effects of PM（2.5） on EMT and the potential health risks associated with PM（2.5） in the YRD region.

关键词： PM2.5 BEAS-2B Epithelial–mesenchymal transition Cell invasion

宁波市鄞州区2017-2022年6岁及以下儿童疱疹性咽峡炎流行特征及与手足口病发病的互相关分析

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中华流行病学杂志 2024年第5期45卷 714-720页

作者：王静娴殷玥琪沈鹏陈云鹏林鸿波王怡孙烨祥温州医科大学公共卫生学院温州325000 宁波市鄞州区疾病预防控制中心数据中心宁波315100 宁波市鄞州区病毒检测重点实验室宁波315100 宁波市鄞州区疾病预防控制中心宁波315100

目的了解宁波市鄞州区2017-2022年≤6岁儿童疱疹性咽峡炎(HA)流行特征并分析其与手足口病(HFMD)发病的互相关性。方法基于鄞州区域健康大数据平台2017-2022年的电子病历数据和公共卫生管理数据,分析≤6岁儿童HA流行特征。利用公共卫生... 详细信息

目的了解宁波市鄞州区2017-2022年≤6岁儿童疱疹性咽峡炎(HA)流行特征并分析其与手足口病(HFMD)发病的互相关性。方法基于鄞州区域健康大数据平台2017-2022年的电子病历数据和公共卫生管理数据,分析≤6岁儿童HA流行特征。利用公共卫生管理数据中传染病报告数据计算HFMD发病率,采用自回归移动平均模型与互相关函数分析HA和HFMD发病的相关性。结果2017-2022年鄞州区≤6岁儿童中累计监测HA病例25385例,男女性别比为1.12∶1。HA年均发病率为4986.67/10万,2018年最高(10477.09/10万),2020年最低(870.88/10万)。HA发病高峰为6、7月,1岁组发病率高于其他年龄组,发病率为7950.45/10万;云龙镇、姜山镇和下应街道发病率较高,发病率依次为8764.31/10万、8377.58/10万和7965.31/10万。HA发病率与滞后0、7、12、18 d的HFMD发病率互相关系数分别为0.199、0.139、0.090、0.086(均P<0.05)。结论2017-2022年鄞州区≤6岁儿童中HA呈高流行水平,发病率存在季节性和地区差异性,HA发病与HFMD发病存在相关性,且HFMD发病有一定滞后性。应重视HA监测,开展HA和HFMD的同期监测和管理,加强两者的综合防控。

关键词：疱疹性咽峡炎手足口病流行特征互相关

Nondestructive technique for identifying nuclides using neutron resonance transmission analysis at CSNS Back-n

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Nuclear Science and Techniques 2024年第1期35卷 178-187页

作者： Sheng-Da Tang Yong-Hao Chen Jing-Yu Tang Rui-Rui Fan Qiang Li Gong Li Dong Liu Zheng-Yao Jin Xing-Zhu Cui Tian-Xiang Chen yi-Wei Yang Rong Liu Han yi Yang Li Zhen Yang Qi An Hao-Fan Bai Jiang-Bo Bai Jie Bao Ping Cao Qi-Ping Chen Zhen Chen Zeng-Qi Cui An-Chuan Fan Chang-Qing Feng Fan-Zhen Feng Ke-Qing Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong yi-Wei Hu Han-Xiong Huang Wei-Hua Jia Hao-yu Jiang Wei Jiang Zhi-jie Jiang ling Kang Bo Li Chao Li Jia-Wen Li Xiao Li Jie Liu Shu-Bin Liu Guang-Yuan Luan Chang-Jun Ning Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Xin Tan Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Yong-Ji Yu Guo-Hui Zhang lin-Hao Zhang Mo-Han Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Yue Zhang Zhi-Yong Zhang Mao-Yuan Zhao Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute of High-Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China USTC Archaeometry Laboratory University of Science and Technology of ChinaHefei 230026China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China

Nondestructive and noninvasive neutron assays are essential applications of neutron *** resonance transmission analysis(NRTA)is a powerful nondestructive method for investigating the elemental composition of an *** back-streaming neutron line(Back-n)is a newly built time-of-flight facility at the China Spallation Neutron Source(CSNS)that provides neutrons in the eV to 300 MeV range.A feasibility study of the NRTA method for nuclide identification was conducted at the CSNS Back-n via two test *** results demonstrate that it is feasible to identify different elements and isotopes in samples using the NRTA method at *** study reveals its potential future applications.

关键词： CSNS White neutron beam NRTA Nuclide identification Nondestructive method

Coastal wind field retrieval from polarimetric synthetic aperture radar

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Acta Oceanologica Sinica 2014年第5期33卷 54-61页

作者： ZHANG yi JIANG Xingwei SONG Qingtao lin Mingsen XIE Xuetong National Satellite Ocean Application Service State Oceanic Administration Key Laboratory of Space Ocean Remote Sensing and Applications State Oceanic Administration

Coastal winds are strongly influenced by topology and discontinuity between land and sea surfaces. Wind assessment from remote sensing in such a complex area remains a challenge. Space-borne scatterometer does not provide any information about the coastal wind field, as the coarse spatial resolution hampers the radar backscattering. Synthetic aperture radar （SAR） with a high spatial resolution and all-weather observation abilities has become one of the most important tools for ocean wind retrieval, especially in the coastal area. Conventional methods of wind field retrieval from SAR, however, require wind direction as initial information, such as the wind direction from numerical weather prediction models （NWP）, which may not match the time of SAR image acquiring. Fortunately, the polarimetric observations of SAR enable independent wind retrieval from SAR images alone. In order to accurately measure coastal wind fields, this paper proposes a new method of using co-polarization backscattering coefficients from polarimetric SAR observations up to polarimetric correlation backscattering coefficients, which are acquired from the conjugate product of co-polarization backscatter and cross-polarization backscatter. Co-polarization backscattering coefficients and polarimetric correlation backscattering coefficients are obtained form Radarsat-2 single-look complex （SLC） *** maximum likelihood estimation is used to gain the initial results followed by the coarse spatial filtering and fine spatial filtering. Wind direction accuracy of the final inversion results is 10.67 with a wind speed accuracy of 0.32 m/s. Unlike previous methods, the methods described in this article utilize the SAR data itself to obtain the wind vectors and do not need external wind directional information. High spatial resolution and high accuracy are the most important features of the method described herein since the use of full polarimetric observations contains more information about the space

关键词： polarimetric synthetic aperture radar coastalwind field polarimetric correlation backscattering coefficients

genotoxicity evaluation and a primary risk assessment of organic pollutants in the drinking water sources of Nanjing, China

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Journal of Environmental Sciences 2006年第5期18卷 983-988页

作者： LI yi-qiang WU Yu-lin CHEN Yuan-gao KONG Zhi-ming The State Key Laboratory of Pollution Control and Resource Reuse School of Environmental Nanjing University Nanjing 210093 China National Accredited Laboratory Environmental Monitoring Center of Jiangsu Province Nanjing 210036 China

An increasing number of industrial, agricultural, and commercial chemicals in the aquatic environment leads to various deleterious effects on organisms, which is becoming an increasingly serious problem in China. In this study, the comet assay was conducted to investigate the genotoxicity to human body caused by organic concentrates in the drinking water sources of Nanjing City from Yangtze River of China, and health and ecology risk due to expose to these organic pollutants were evaluated with the multimedia environmental assessment system （MEAS）. For all the water samples, they were collected from four different locations in the drinking water sourcr samples, es of Nanjing City. The results of the comet assay showed that all the organic concentrates from the water samples could induce different levels DNA damages on human peripheral blood lymphocytes, and a statistically significant difference （p〈0.01） was observed compared with the solvent control, which demonstrated the genotoxicity was in existence. According to the ambient severity （AS） of individual compound, we had sorted out the main organic pollutants in the drinking water source of the four waterworks, and the results showed that there was some potential hazard to human body for all the source water, namely the total ambient severity （TAS） of health for each water source was more than 1. However, the TAS of ecology for each water source was less than 1, which indicated that it was safe to ecology. The results of this investigation demonstrate the application of the comet assay and the MEAS in aquatic environmental monitoring studies, and the comet assay found to be fast, sensitive, and suitable for genotoxicity monitoring programs of drinking water source.

关键词： genotoxicity comet assay risk assessment organic pollutants drinking water sources Nanjing City

Molten-salt chemical exfoliation process for preparing two-dimensional mesoporous Si nanosheets as high-rate Li-storage anode

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Nano Research 2018年第12期11卷 6294-6303页

作者： ying Han Jie Zhou Tieqiang Li Zheng yi Ning lin yitai Qian Hefei National Laboratory for Physical Science at Microscale and Department of Chemistry University of Science and Technology of ChinaHefei 230026China

Two-dimensional (2D) materials have attracted enormous attention due to their functional applications in energy storage. In this work, a low-temperature molten-salt chemical exfoliation methodology is developed for producing free-standing 2D mesoporous Si through deintercalation of CaSi2 in excess molten AlCl3 at 195 °C. The average dimension of these sheets is 1.5 μm, and the thickness of a single sheet is approximately 10 nm. The as-prepared 2D Si has a Brunauer-Emmett-Teller surface area of 154 m2·g−1 and an average pore size of 5.87 nm. With this unique structure, the 2D Si exhibits superior Li-storage performance, including a reversible capacity of 2,974 mA·h·g−1 at 0.2 C, reversible capacities of 2,162, 1,947, and 1,527 mA·h·g−1 at 0.8, 2, and 5 C after 200 cycles, and a capacity retention of 357 mA·h·g−1 even at 30 C (90 A·g−1).

关键词： Si nanosheets molten-salt exfoliation mesoporous structure Li-storage anode superior rate capability

基于鳄雀鳝议题的“生态系统的稳定性”SSI教学设计

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生物学通报 2024年第1期59卷 33-37页

作者：袁洪玉李展贤林媛伊珍珍华南师范大学生命科学学院广东广州510631

以鳄雀鳝(Atractosteus spatula)议题在“生态系统的稳定性”一节中的应用为例,借助一定的框架选择议题内容,使用情境教学和问题驱动教学,通过热点话题导入、构建概念模型、多重因果推理、整体分析现象、讨论社会议题、明确概念关系等... 详细信息

以鳄雀鳝(Atractosteus spatula)议题在“生态系统的稳定性”一节中的应用为例,借助一定的框架选择议题内容,使用情境教学和问题驱动教学,通过热点话题导入、构建概念模型、多重因果推理、整体分析现象、讨论社会议题、明确概念关系等教学环节,帮助学生逐步形成概念、应用概念、深化对概念的理解,促进学生核心素养的培养,探讨社会性科学议题在“生物与环境”模块中的应用。

关键词：社会性科学议题生态系统的稳定性问题驱动情境创设

自主教学模式在伤口造口培训小组中的应用效果

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中国继续医学教育 2024年第10期16卷 108-111页

作者：林小力左红群潘意广西结直肠癌临床医学研究中心/广西医科大学附属肿瘤医院结直肠肛门外科广西南宁530021

目的探讨自主教学模式在伤口造口培训小组中应用的效果。方法选取2019年10月—2022年10月参与广西医科大学附属肿瘤医院结直肠肛门外科伤口造口专科培训的29名学员作为研究对象。根据培训时间分为常规组(15名)和观察组(14名)。常规组... 详细信息

目的探讨自主教学模式在伤口造口培训小组中应用的效果。方法选取2019年10月—2022年10月参与广西医科大学附属肿瘤医院结直肠肛门外科伤口造口专科培训的29名学员作为研究对象。根据培训时间分为常规组(15名)和观察组(14名)。常规组的培训方式采用传统教学模式,培训时间为2019年10月—2020年10月;观察组的培训方式则采用自主教学模式,培训时间为2021年10月—2022年10月。比较2组学员在理论考核成绩、临床实践考核成绩、幻灯片制作及授课能力、综述书写自评以及他评评分和教学满意度等方面的差异。结果观察组学员的理论考核成绩及临床实践考核成绩[(97.82±2.13)分、(96.74±3.11)分]均高于常规组[(88.71±2.08)分、(86.76±2.81)分],差异有统计学意义(P <0.001)。观察组学员在幻灯片制作和授课能力方面的自评和他评评分也高于常规组,差异有统计学意义(P <0.05)。观察组学员对教学满意度100%,高于常规组76.92%,差异有统计学意义(P <0.05)。结论在伤口造口培训小组中实施自主教学模式可以提升学员的专业水平和实践能力,同时获得更高的教学满意度。

关键词：自主教学模式伤口造口培训小组教学满意度应用实施效果

心因性勃起功能障碍患者疾病不确定感现状及相关因素的Logistic回归分析

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中国性科学 2024年第2期33卷 14-17页

作者：孙晓乐林盈盈郑宜浙江丽水市中心医院泌尿外科浙江丽水323000

目的调查分析心因性勃起功能障碍(ED)患者疾病不确定感现状及影响因素。方法采用便利抽样法,选取2021年12月至2022年12月浙江丽水市中心医院诊治的123例心因性ED患者作为观察组,并按1∶1原则同期纳入同院123例器质性ED患者作为对照组。... 详细信息

目的调查分析心因性勃起功能障碍(ED)患者疾病不确定感现状及影响因素。方法采用便利抽样法,选取2021年12月至2022年12月浙江丽水市中心医院诊治的123例心因性ED患者作为观察组,并按1∶1原则同期纳入同院123例器质性ED患者作为对照组。调查项目包括疾病不确定感[疾病不确定感量表(MUIS)]及临床资料[包含焦虑自评量表(SAS)、抑郁自评量表(SDS)、社会支持评定量表(SSRS)]。重点分析心因性ED患者疾病不确定感现状及影响因素。结果观察组疾病不确定感总分、SAS评分和SDS评分均高于对照组,且SSRS评分低于对照组,差异具有统计学意义(P0,P<0.05);疾病不确定感与社会支持呈负相关性(r<0,P<0.05)。经多元线性回归分析显示,对疾病和治疗的了解程度、病情严重程度、焦虑和抑郁情绪、社会支持是心因性ED患者疾病不确定感的影响因素(P<0.05)。结论心因性ED患者存在疾病不确定感,临床应重点关注对疾病和治疗的了解程度匮乏、病情较重、有焦虑和抑郁情绪和社会支持偏低的心因性ED患者,加强干预来降低其疾病不确定感,提高生活质量。

关键词：心因性勃起功能障碍疾病不确定感影响因素