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Modelling and validation of flash flood inundation in drylands

Journal of Geographical Sciences 2024年第1期34卷 185-200页

作者： gao Dan yiN Jie WANG Dandan YANG Yuhan LU yi CHEN Ruishan School of Geographic Sciences East China Normal UniversityShanghai 200241China Key Laboratory of Geographic Information Science of Ministry of Education East China Normal UniversityShanghai 200241China National Disaster Reduction Center of China Ministry of Emergency Management of People's Republic of ChinaBeijing 100124China School of Design Shanghai Jiao Tong UniversityShanghai 200240China

In the context of climate change and human activities,flood disasters in arid mountainous areas have become increasingly frequent,and seriously threatened the safety of people's lives and *** and accurate flash flood inundation modelling is an essential foundational research area,which can aid in the reduction of casualties and the minimization of disaster losses;however,this modelling is also very difficult,and models need to be urgently developed to address flash flood forecasting and *** objective of this study is to construct a numerical modelling method for flash floods in *** on a 2D high-resolution flood numerical model(Flood Map-Hydro Inundation2D),we hindcasted the dynamic process of flash flooding and show the spatio-temporal characteristics of flash flood inundation for the“8·18”flash flood disaster that occurred in Datong county,Qinghai *** results showed that the model output effectively agreed with the observed inundation after the event in terms of both spatial extent and temporal *** flooding mainly occurred between 00:00 and 01:00 on August 18,***,Hejiazhuang and Longwo villages were affected most *** further conducted model sensitivity analysis and found that the model was highly sensitive to both roughness and hydraulic conductivity in drylands,and the effect of hydraulic conductivity was more *** study confirmed the good performance of our model for the simulation of flash flooding in arid areas and provides a potential method for flash flood assessment and management in arid areas.

关键词： flash flood numerical modelling arid areas Datong county Flood Map-Hydro Inundation2D

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Novel insights into immune-related genes associated with type 2 diabetes mellitus-related cognitive impairment

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World Journal of Diabetes 2024年第4期15卷 735-757页

作者： Jing gao ying Zou Xiao-Yu lv Li Chen Xin-Guo Hou Department of Endocrinology Qilu Hospital of Shandong UniversityCheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina Institute of Endocrine and Metabolic Diseases Shandong UniversityJinan 250012Shandong ProvinceChina Key Laboratory of Endocrine and Metabolic Diseases Shandong Province Medicine&HealthJinan 250012Shandong ProvinceChina Department of Endocrinology Jinan Clinical Research Center for Endocrine and Metabolic DiseaseJinan 250012Shandong ProvinceChina

BACKGROUND The cognitive impairment in type 2 diabetes mellitus(T2DM)is a multifaceted and advancing state that requires further exploration to fully ***-roinflammation is considered to be one of the main mechanisms and the immune system has played a vital role in the progression of the *** To identify and validate the immune-related genes in the hippocampus associated with T2DM-related cognitive *** To identify differentially expressed genes(DEGs)between T2DM and controls,we used data from the Gene Expression Omnibus database *** identify T2DM module genes,we used Weighted Gene Co-Expression Network *** the genes were subject to Gene Set Enrichment ***-protein interaction network construction and machine learning were utilized to identify three hub *** cell infiltration analysis was *** three hub genes were validated in GSE152539 via receiver operating characteristic curve *** experiments including reverse transcription quantitative real-time PCR,Western blotting and immunohistochemistry were conducted both in vivo and in *** identify potential drugs associated with hub genes,we used the Comparative Toxicogenomics Database(CTD).RESULTS A total of 576 DEGs were identified using *** taking the intersection of DEGs,T2DM module genes,and immune-related genes,a total of 59 genes associated with the immune system were ***,machine learning was utilized to identify three hub genes(H2-T24,Rac3,and Tfrc).The hub genes were associated with a variety of immune *** three hub genes were validated in *** experiments were conducted at the mRNA and protein levels both in vivo and in vitro,consistent with the bioinformatics ***,11 potential drugs associated with RAC3 and TFRC were identified based on the *** Immune-related genes that differ in expression in the hippocampus are closely linked to microgli

关键词： Bioinformatics analysis Type 2 diabetes mellitus Cognitive impairment Hippocampus Immune Microglia

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Honokiol Prevents Intestinal Barrier Dysfunction in Mice with Severe Acute Pancreatitis and Inhibits JAK/STAT1 Pathway and Acetylation of HMGB1

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Chinese Journal of Integrative Medicine 2024年第6期30卷 534-542页

作者： LI Jie CHEN Ya-feng gao Lei LI yi-jie FENG Dian-xu Department of General Surgery Putuo HospitalShanghai University of Traditional Chinese MedicineShanghai200062China

Objective To investigate the effect of honokiol(HON)and the role of high-mobility group protein B1(HMGB1)on the pathogenesis of severe acute pancreatitis(SAP).Methods Thirty mice were numbered according to weight,and randomly divided into 5 groups using a random number table,including control,SAP,SAP and normal saline(SAP+NS),SAP and ethyl pyruvate(SAP+EP),or SAP+HON groups,6 mice in each *** of pancreas,intestine,and blood were collected 12 h after SAP model induction for examination of pathologic changes,immune function alterations by enzyme linked immunosorbent assay(ELISA),and Western *** vitro experiments,macrophages were divided into 5 groups,the control,lipopolysaccharide(LPS),LPS+DMSO(DMSO),LPS+anti-HMGB1 monoclonal antibody(mAb),and LPS+HON *** tight connection level was determined by transmission electron microscopy and fluorescein *** location and acetylation of HMGB1 were measured by Western ***,pyridone 6 and silencing signal transducer and activator of the transcription 1(siSTAT1)combined with honokiol were added to determine whether the Janus kinase(JAK)/STAT1 participated in the regulation of honokiol on *** protein expression levels of HMGB1,JAK,and STAT1 were detected using Western *** Mice with SAP had inflammatory injury in the pancreas,bleeding of intestinal tissues,and cells with disrupted *** in the SAP+HON group had significantly fewer pathological *** with SAP also had significant increases in the serum levels of amylase,lipase,HMGB1,tumor necrosis factor-α,interleukin-6,diamine oxidase,endotoxin-1,and *** in the SAP+HON group did not show these abnormalities(P<0.01).Studies of Caco-2 cells indicated that LPS increased the levels of occludin and claudin-1 as well as tight junction permeability,decreased the levels of junctional adhesion molecule C,and elevated intercellular permeability(P<0.01).HON treatment blocked these *** of

关键词： severe acute pancreatitis intestinal barrier dysfunction honokiol high-mobility group protein B1 Januskinase signal transducerand activatorof transcription1

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Investigation of the Effect of the Force Arm on the Bending Capability of Prestressed Glulam Beam

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Structural Durability & Health Monitoring 2024年第5期18卷 641-661页

作者： Yan Zhao Yuanyuan Wu Shengliang He Zhenglu gao Ziyan Huang Chenzheng lv Department of Civil Engineering and Architecture Wuyi UniversityWuyishan354300China Experimental Forest Farm in Qingyuan County Lishui323000China Fujian Zhuanghe Bamboo Industry Technology Co. Ltd.Nanping353000China Fujian Liuzheng New Materials Technology Co. Ltd.Nanping353000China

Prestress enables the Glulam beam could make full use of the compression strength,and then increase the span,but it still could not reduce all drawbacks,such as cross-section weakening and small force *** avoid slotting and ensure suitable tension and compression couple,one kind of novel anchor has been proposed,which could meet the bearing capacity *** then the bending test of prestressed Glulam beams with a geometric scale ratio of 1:2 was simulated,to investigate the effect of the force arm on bending capacities,failure modes,and deformation *** show that increasing the force arm could improve the ultimate bending per-formance of the beam signiﬁcantly,and the anchor arm length has a certain effect on the performance,but it is not ***,based on Finite element method analysis,the practice design suggestions have been offered.

关键词： Force arm prestressed Glulam beam ﬁnite element method bearing capacity

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Current Status and Perspectives of Dual-Atom Catalysts Towards Sustainable Energy Utilization

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Nano-Micro Letters 2024年第7期16卷 402-440页

作者： yizhe Li Yajie Li Hao Sun Liyao gao Xiangrong Jin Yaping Li Zhi lv Lijun Xu Wen Liu Xiaoming Sun State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science EngineeringCollege of ChemistryBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China Xinjiang Coal Mine Mechanical and Electrical Engineering Technology Research Center Xinjiang Institute of EngineeringUrumqi 830023Xinjiang Uygur Autonomous RegionPeople’s Republic of China

The exploration of sustainable energy utilization requires the imple-mentation of advanced electrochemical devices for efficient energy conversion and storage,which are enabled by the usage of cost-effective,high-performance ***,heterogeneous atomically dispersed catalysts are considered as potential candidates for a wide range of *** to conventional cata-lysts,atomically dispersed metal atoms in carbon-based catalysts have more unsatu-rated coordination sites,quantum size effect,and strong metal-support interactions,resulting in exceptional catalytic *** these,dual-atomic catalysts(DACs)have attracted extensive attention due to the additional synergistic effect between two adja-cent metal *** have the advantages of full active site exposure,high selectiv-ity,theoretical 100%atom utilization,and the ability to break the scaling relationship of adsorption free energy on active *** this review,we summarize recent research advancement of DACs,which includes(1)the comprehensive understanding of the synergy between atomic pairs;(2)the synthesis of DACs;(3)characterization meth-ods,especially aberration-corrected scanning transmission electron microscopy and synchrotron spectroscopy;and(4)electrochemical energy-related *** last part focuses on great potential for the electrochemical catalysis of energy-related small molecules,such as oxygen reduction reaction,CO_(2) reduction reaction,hydrogen evolution reaction,and N_(2) reduction *** future research challenges and opportunities are also raised in prospective section.

关键词： Dual-atom catalysts Synergetic effect Electrocatalysis Oxygen reduction reaction CO_(2)reduction reaction Hydrogen evolution reaction N2 reduction reaction

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Efficient photocatalytic NADH regeneration with Rh-loaded Z-scheme mediator-free system

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Chinese Chemical Letters 2024年第2期35卷 496-500页

作者： yi Zhou yiling He Ming gao Ningkai Ding Juying Lei Yanbo Zhou State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process East China University of Science and TechnologyShanghai 200237China National Engineering Research Center of Industrial Wastewater Detoxication and Resource Recovery East China University of Science and TechnologyShanghai 200237China Shanghai Engineering Research Center for Multi-media Environmental Catalysis and Resource Utilization East China University of Science and TechnologyShanghai 200237China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092China

Nicotinamide adenine dinucleotide(NADH)regeneration is necessary for the sustainable application of enzymatic *** Rh-based complex[Cp^(*)Rh(bpy)(H)]+has been widely used as an important mediator in NADH regeneration systems,but it is limited by complexity and high ***,a Z-scheme was constructed by loading Rh onto carbon nitride nanosheets/carbon nitride quantum dots(CN-CNQD).The resultant catalyst achieved a high yield of NADH in a mediator-free(M-free)system of 0.283 mmol L^(−1) g^(−1) min^(−1),which is 5.29 times that of pure *** enzyme introduction experiments confirmed that the enzyme active product 1,4-NADH could reach 34.21%selectivity in the M-free *** research revealed that the heterojunction between CNs and CNQDs improved the NADH regeneration activity in the traditional M-involved system,while Rh loading was proved to optimize the yield and selectivity of 1,4-NADH in M-free *** immobilized Rh shows more competitiveness than[Cp^(*)Rh(bpy)(H)]^(+).This study contributes to the construction of an M-free system for further application in greener,lower-cost enzymatic processes.

关键词： Photocatalysis NADH regeneration Mediator-free Carbon nitride Z-scheme

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Oral pyroptosis nanoinhibitor for the treatment of inflammatory bowel disease

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Nano Research 2024年第3期17卷 1748-1759页

作者： Zhenxing Zhu Dongtao Zhou yi yin Zhun Li Zhen Guo Yongchun Pan Yanfeng gao Jingjing Yang Weiming Zhu Yujun Song yi Li Department of General Surgery Affiliated Jinling HospitalMedical SchoolNanjing UniversityNanjing 210093China College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjing 210023China Department of General Surgery Affiliated Drum Tower HospitalMedical SchoolNanjing UniversityNanjing 210008China Department of Biochemistry and Molecular Biology School of Medicine&Holistic Integrative MedicineJiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Inflammatory bowel disease(IBD)is an autoimmune gastrointestinal disease characterized by chronic relapsing inflammation of the *** pyroptosis that exists in the inflamed intestine can activate damage signals and aggravate local inflammation in ***,we designed an oral pyroptosis nanoinhibitor,DXMS@CuM@PPADT@PSS(DCMP),which can target intestinal lesions,and respond to reactive oxygen species(ROS)to release active sites and drugs at the *** can inhibit the activation of the nucleotide-binding domain and leucine-rich repeat family pyrin domain containing 3(NLRP3)inflammasomes by scavenging ROS,resulting in the down-regulation of gasdermin D(GSDMD)cleavage thus inhibiting *** also improved intestinal barrier function,decreased inflammatory cytokine levels,and increased the diversity of gut microbiota in mice with *** work is believed to expand the biomedical application of nanomaterials for innate immunity modulation.

关键词： inflammatory bowel disease nanoinhibitors pyroptosis synergistic therapy antioxidant

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Comprehensive evaluation of rare case:From diagnosis to treatment of a sigmoid Schwannoma:A case report

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 244-250页

作者： Jing-yi Li Xi-Zhuang gao Jian Zhang Xiang-Zheng Meng yi-Xian Cao Kun Zhao Clinical Medical College of Jining Medical University Jining Medical UniversityJining 272000Shandong ProvinceChina Department of Gastroenterology The First People's Hospital of JiningJining 272000Shandong ProvinceChina

BACKGROUND Schwannomas are uncommon tumors originating from Schwann cells,forming the neural *** account for approximately 2%-6%of all mesenchymal tumors and are most commonly identified in peripheral nerve trunks,with rarity in the gastrointestinal *** gastrointestinal locations,the stomach harbors the majority of nerve sheath tumors,while such occurrences in the sigmoid colon are exceptionally *** SUMMARY This study presented a clinical case involving a 60-year-old female patient who,during colonoscopy,was diagnosed with a submucosal lesion that was later identified as a nerve sheath *** patient underwent surgical resection,and the diagnosis was confirmed through *** study highlighted an exceptionally uncommon occurrence of a nerve sheath tumor in the sigmoid colon,which was effectively managed within our ***,a comprehensive review of relevant studies was *** The preoperative diagnosis of nerve sheath tumors poses challenges,as the definitive diagnosis still relies on pathology and *** categorized as benign,these tumors have the potential to demonstrate malignant ***,the optimal treatment approach entails the complete surgical excision of the tumor,ensuring the absence of residual lesions at the margins.

关键词： Schwannoma Gastrointestinal stromal tumors Treatment Sigmoid colon Case report

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Aero-Hydro-Elastic-Servo Modeling and Dynamic Response Analysis of A Monopile Offshore Wind Turbine Under Different Operating Scenarios

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China Ocean Engineering 2024年第3期38卷 379-393页

作者： XIE Shuang-yi gao Jian LI Yong-ran JIANG Shu-xin ZHANG Cheng-lin HE Jiao College of Mechanical Engineering Chongqing University of TechnologyChongqing 400044China Beijing Institute of Precision Mechatronics and Controls Beijing 100076China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing 400044China Fishery Machinery and Instrument Research Institute Chinese Academy of Fishery SciencesShanghai 200092China School of Mechanical and Power Engineering Chongqing University of Science&TechnologyChongqing 401331China

This paper constructs a coupled aero-hydro-elastic-servo simulation framework for a monopile offshore wind turbine(OWT).In this framework,a detailed multi-body dynamics model of the monopile OWT including the gearbox,blades,tower and other components(nacelle,hub,bedplate,etc.)has been explicitly *** effects of pile−soil interaction,controller and operational conditions on the turbine dynamic responses are studied systematically in time domain and frequency *** results show that(1)a comprehensive drivetrain model has the capability to provide a more precise representation of the complex dynamic characteristics exhibited by drivetrain components,which can be used as the basis for further study on the dynamic characteristics of the drivetrain.(2)The pile−soil interaction can influence the wind turbine dynamic responses,particularly under the parked condition.(3)The effect of the pile−soil interaction on tower responses is more significant than that on blade responses.(4)The use of the controller can substantially affect the rotor characteristics,which in turn influences the turbine dynamic responses.(5)The tower and blade displacements under the operational condition are much larger than those under the parked *** model and methodology presented in this study demonstrate potential for examining complex dynamic behaviors of the monopile *** ensure accuracy and precision,it is imperative to construct a detailed model of the wind turbine system,while also taking into account simulation efficiency.

关键词： offshore wind turbine(OWT) pile−soil interaction dynamic response parked condition operating condition

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LLMs in medicine:The need for advanced evaluation systems for disruptive technologies

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The Innovation 2024年第3期5卷 1-2页

作者： yi-Da Tang Er-Dan Dong Wen gao Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalBeijing 100191China State Key Laboratory of Vascular Homeostasis and Remodeling Peking UniversityBeijing 100191China University of Health and Rehabilitation Sciences Qingdao 266000China Peking University Beijing 100871China

In an era of rapid advancements in artificial intelligence(AI),the potential role of large language models(LLMs)in the medical field is receiving increasing *** progression of this technology not only highlights upcoming revolutionary changes in medical services but also offers unprecedented opportunities for the health care sector.1 LLMs’formidable capability to process natural language opens vast prospects for application in the medical field,including in the contexts of emergency triage,geriatric care,and digital medical workflows.

关键词： dis highlights services

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