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Long-term outcomes of high-risk percutaneous coronary interventions under extracorporeal membrane oxygenation support:An observational study

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World Journal of Clinical Cases 2022年第16期10卷 5266-5274页

作者： yi-Xiong Huang Zheng-Ming Xu Li Zhao yi Cao Yu Chen yi-gang qiu ying-Ming Liu Peng-Yu Zhang Jiang-Chun He Tian-Chang Li Medical School of Chinese People’s Liberation Army Beijing 100853China Department of Cardiology Sixth Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100048China

BACKGROUND Venoarterial extracorporeal membrane oxygenation(VA-ECMO)offers hemodynamic support for patients undergoing high-risk percutaneous coronary interventions(PCIs).However,long-term outcomes associated with VA-ECMO have not previously been *** To explore long-term outcomes in high-risk cases undergoing PCI supported by *** In the present observational cohort study,61 patients who received VA-ECMOsupported high-risk PCI between April 2012 and January 2020 at the Sixth Medical Center of Chinese People’s Liberation Army General Hospital were *** endpoint characteristics such as all-cause mortality,repeated cardiovascular diseases,and cardiac death were *** Among 61 patients,three failed stent implantation due to chronic total occlusions with severely calcified *** patient showed VA-ECMO intolerance because of high left ventricular *** was successfully performed in 57 patients(93.4%).The in-hospital mortality was 23.0%,and the overall survival was 45.9%,with a median follow-up period of 38.6(8.6-62.1)*** VA-ECMO can be used as a support in patients undergoing high-risk PCI as it is associated with favorable long-term patient survival.

关键词： High-risk percutaneous coronary intervention Venoarterial extracorporeal membrane oxygenation Overall survival Long-term survival

Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： yi Qi Xueying Chen Bowen Liu Xuliang Lin Xueqing qiu Yanlin Qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

含2-氯-5-吡啶甲基的双氰基取代乙烯酮缩胺类化合物的合成及生物活性

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高等学校化学学报 1998年第10期 93-95页

作者： ZHAO yi gang, HUANG Run qiu *, CHENG Mu Ru, LI Hui ying, CHENG Jun Ran (Institute of Elemento Organic Chemistry, State Key Laboratory of Elemento Organic Chemistry, Nankai University, Tianjin, 300071)

新烟碱类杀虫剂由于具有高效、低毒、无交互抗性和内吸性等特点，成为杀虫剂领域新的研究热点［１］．本文以Ｎｉｔｅｎｐｙｒａｍ为母体，首次合成了２－氰基－３－（２－氯－５－吡啶甲氨基）－３－甲硫基丙烯腈（９），并以其为中间... 详细信息

新烟碱类杀虫剂由于具有高效、低毒、无交互抗性和内吸性等特点，成为杀虫剂领域新的研究热点［１］．本文以Ｎｉｔｅｎｐｙｒａｍ为母体，首次合成了２－氰基－３－（２－氯－５－吡啶甲氨基）－３－甲硫基丙烯腈（９），并以其为中间体合成了１９个双氰基取代的含２－氯...

关键词： 2-氯-5-吡啶甲基氰基乙烯酮缩胺生物活性

Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： yi Zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li Zhang Zheng gang Zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： Wen-Jin Yuan yi-Juan Zheng Bing-Rong Zhang yi-Jie Lin You Li Yan-Yan qiu Xue-Ping Yu Department of Infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

黑磷/黑砷异质结纳米器件热电性质应力调控研究

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原子与分子物理学报 2025年第1期42卷 69-74页

作者：戎杙邱乙峰张蓓新疆大学物理科学与技术学院乌鲁木齐830046

探索新型高性能低维热电纳米材料已成为国家重大发展策略.论文采用密度泛函理论结合非平衡态格林函数方法研究了由黑磷、黑砷纳米带构建异质结构在2%、4%、6%和8%四种拉伸应变作用下热电性能调控机理.研究结果表明,6%拉伸应变较其他情形... 详细信息

探索新型高性能低维热电纳米材料已成为国家重大发展策略.论文采用密度泛函理论结合非平衡态格林函数方法研究了由黑磷、黑砷纳米带构建异质结构在2%、4%、6%和8%四种拉伸应变作用下热电性能调控机理.研究结果表明,6%拉伸应变较其他情形,能够更有效抑制声子输运行为;与此同时,拉伸应变对于器件的电子输运的调控效果并不明显.在费米能附近,黑磷/黑砷异质结纳米器件在6%拉伸应变调控下热电优值达到最大值2.31.

关键词：黑磷黑砷异质结应力热电性质

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-yian Guo Jian-gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

基于石墨烯电极TCNQ分子结热/电输运性质理论研究

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原子与分子物理学报 2025年第3期42卷 135-140页

作者：刘仪伟邱乙峰张蓓新疆大学物理科学与技术学院乌鲁木齐830046

本文采用密度泛函理论和非格林平衡函数,对基于石墨烯电极的7,7,8,8-四氰基苯醌二甲烷(Tetracyanoquinodimethane,TCNQ)分子结热/电输运性质进行系统研究.研究结果表明:随着中心TCNQ分子个数的增加,声子透射系数明显降低,即声子透射行... 详细信息

本文采用密度泛函理论和非格林平衡函数,对基于石墨烯电极的7,7,8,8-四氰基苯醌二甲烷(Tetracyanoquinodimethane,TCNQ)分子结热/电输运性质进行系统研究.研究结果表明:随着中心TCNQ分子个数的增加,声子透射系数明显降低,即声子透射行为受到极大抑制.与此同时,电子透射系数也有一定程度的减小.在热/电参数的协同作用下,伴随分子数量的增加分子结热电转换性能呈上升趋势,1TCNQ热电优值(ZT)为0.016,而2TCNQ则上升了1个数量级,ZT值达到0.11.最后,我们对分子结依赖于分子结构个数的自旋输运性质进行研究,发现TCNQ分子结具有显著的自旋过滤效应,其过滤能力随着TCNQ分子数量的增加而增加.该工作可为实验制备分子热电器件提供理论依据和数据支持.

关键词：锯齿状石墨烯纳米带 TCNQ分子自旋输运性质自旋过滤效应

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