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Monitoring the Progression of Renal Fibrosis by T2-weighted Signal Intensity and Diffusion Weighted Magnetic Resonance Imaging in Cisplatin induced Rat Models

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Chinese Medical Journal 2015年第5期128卷 626-631页

作者： Huan-Huan Wu Hui-Ru jia yi Zhang Le Liu Dong-Bo Xu Hao-Ran Sun Department of Radiology Tianjin Medical University Hospital Tianjin China Department of Radiology Northwest Women and Children's Hospital Tianjin Medical University Hospital Tianjin China Department of Radiology The Second Affiliated Hospital of Xi'an Jiaotong University Tianjin Medical University Hospital Tianjin China Department of Pathology Tianjin Medical University Hospital Tianjin China

Background：Diffusion weighted imaging （DWI）,with the applying of intravoxel incoherent motion model,has showed promising results in obtaining additional information about microperfusion and tubular flow associated with morphologic changes in chronic kidney *** study aims to evaluate the potential of T2-weighted signal intensity （SI） and DWI with mono-and bi-exponential models to reflect the serial changes on cisplatin （CP） induced rat renal fibrosis ***：Magnetic resonance exams were performed prior to and 2nd day,4th day,6th day,8th day,2nd week,3rd week and 4th week after CP injection at a 3.0T with an animal *** T2-weighted images （T2WI）,DWI of 13 b values from 0 to 1500 s/mm^2 was *** diffusion coefficient （ADC）,fluid fraction f,pure diffusivity D and pseudodiffusivity D＊ values were *** regions of interest were placed on cortex （CO）,outer stripe of the outer medulla （OM） and inner stripe of the outer medulla （OM）,parameters were measured and compared among different time *** rats were scarified at each time point for pathological ***：OM revealed remarkable hyperintense and broadened before it became an obscure thread,while CO demonstrated moderate hyperintense and IM didn＇t show significant change on *** all three stripes,ADC values decreased firstly then kept increasing since the 4th day;f values decreased on all stripes; D values had a tendency to increase with fluctuations but the changes didn＇t achieve statistical significance; D＊ values increased at the 2nd day then tended to be steady *** findings revealed tubules epitheliums swelling followed by inflammation cells infiltration,interstitial fibrosis was observed since the 2nd ***：All of T2-weighted SI,ADC,and biexponential models parameters vary during fibrotic process; biexponential model is superior to monoexponential model in separating changes of microperfusion together with tubular flow f

关键词： Apparent Diffusion Coefficient Animal Model Histopathology Chronic Kidney Disease Kidney Renal Fibrosis Diffusion Weighted Imaging

Association between composite dietary antioxidant index and stroke among individuals with diabetes

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World Journal of Diabetes 2024年第8期15卷 1742-1752页

作者： Hong-Qiang Zhang Jie Shi Tong Yue jia-Hao Weng Xu-Lin Wang Hao Wang Xiao-Yu Su Xue-ying Zheng Si-Hui Luo Yu Ding Chao-fan Wang Department of Cardiology Centre for Leading Medicine and Advanced Technologies of IHMThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Endocrinology Centre for Leading Medicine and Advanced Technologies of IHMThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Graduate School Bengbu Medical CollegeBengbu 233030Anhui ProvinceChina Department of Endocrinology and Metabolism The Third Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of DiabetologyGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Recent research has underscored the potentially protective role of dietary antioxidants against chronic conditions,such as cardiovascular diseases and *** composite dietary antioxidant index(CDAI),which reflects the overall intake of key dietary antioxidants,has been identified as a crucial metric for exploring this *** previous research has shown a negative correlation between CDAI levels and stroke risk in prediabetic individuals,there remains a substantial gap in understanding this association among individuals with diabetes,who are at an inherently greater risk for cerebrovascular *** To investigate the association between CDAI and stroke risk in individuals with *** Using a cross-sectional study design,this investigation analyzed data from the National Health and Nutrition Examination Survey spanning from 2003 to 2018 that included 6735 participants aged over 20 years with *** CDAI was calculated from 24-h dietary recalls to assess intake of key antioxidants:Vitamins A,C,and E;carotenoids;selenium;and *** logistic regression and restricted cubic spline analysis were used to rigorously examine the relationship between CDAI and stroke *** The participant cohort,with an average age of 59.5 years and a slight male majority,reflected the broader demographic characteristics of individuals with *** analysis revealed a strong inverse relationship between CDAI levels and stroke ***,those in the highest quintile of CDAI demonstrated a 43%lower prevalence of stroke compared to those in the lowest quintile,even after adjustments for various *** finding not only highlights the negative association between CDAI and stroke risk but also underscores the significant potential of antioxidant-rich diets in reducing stroke prevalence among patients with *** Our findings suggested that CDAI was inversely associated with stroke prevalence among pa

关键词： Stroke Diabetes Composite dietary antioxidant index National Health and Nutrition Examination Survey Crosssectional study

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X波段异向介质设计及其负折射特性研究

宇航学报 2007年第4期28卷 951-954页

作者：孟繁义吴群傅佳辉武明峰马伟哈尔滨工业大学航天学院哈尔滨150001 中国空间无线电技术研究所

通过对异向介质激发机理的深入分析,最终设计出了一种结构新颖的小单元、宽频带异向介质。其绝对带宽达到2.6GHz,远远优于传统异向介质。文中对这种异向介质的后向波特性和负折射特性进行了数值仿真,结果表明,在异向介质工作频段内观测... 详细信息

通过对异向介质激发机理的深入分析,最终设计出了一种结构新颖的小单元、宽频带异向介质。其绝对带宽达到2.6GHz,远远优于传统异向介质。文中对这种异向介质的后向波特性和负折射特性进行了数值仿真,结果表明,在异向介质工作频段内观测到明显的后向波效应和负折射效应,从而使该异向介质的存在性得到有力证明。本研究成果为基于异向介质的新型微波、毫米波器件在空间通信技术中的应用奠定了坚实的基础。

关键词：异向介质宽频带后向波负折射

Synthesis of novel nanomaterials and their application in efficient removal of radionuclides

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Science China Chemistry 2019年第8期62卷 933-967页

作者： Xiangxue Wang Long Chen Lin Wang Qiaohui fan Duoqiang Pan jiaxing Li fangting Chi yi Xie Shujun Yu Chengliang Xiao Feng Luo Jun Wang Xiaolin Wang Changlun Chen Wangsuo Wu Weiqun Shi Shuao Wang Xiangke Wang Key Laboratory of Resources and Environmental Systems Optimization Ministry of EducationCollege of Environmental Science and EngineeringNorth China Electric Power UniversityBeijing 102206China China Academy of Engineering Physics Mianyang 621900China State Key L aboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionCollaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education InstitutionsSoochow UniversitySuzhou 215123China Laboratory of Nuclear Energy Chemistry and Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Key Laboratory of Petroleum Resources Gansu ProvinceNorthwest Institute of Eco-Environment and Resources. Chinese Academy of SciencesLanzhou 730000China Radiochemistry Laboratory School of Nuclear Science and TechnologyLanzhou UniversityLanzhou 730000China CAS Key Laboratory of Photovoltaic and Energy Conservation Materials. Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031China Fundamental Science on Nuclear Wastes and Environmental Safety Laboratory Southwest University of Science and Technology Mianyang 621010China State Key Laboratory of Nuclear Resources and Environment School of BiologyChemistry and Material Science East China University of TechnologyFuzhou 344000China College of Materials Science and Chemical Engineering Harbin Engineering UniversityHarbin 150001China China Academy of Engineering Physics Mianyang 621900China

With the development of nuclear energy, large amounts of radionuclides are inevitably released into the natural environment. It is necessary to eliminate radionuclides from wastewater for the protection of environment. Nanomaterials have been considered as the potential candidates for the effective and selective removal of radionuclides from aqueous solutions under complicated conditions because of their high specific surface area, large amounts of binding sites, abundant functional groups, pore-size controllable and easily surface modification. This review mainly summarized the recent studies for the synthesis, fabrication and surface modification of novel nanomaterials and their applications in the efficient elimination and solidification of radionuclides,and discussed the interaction mechanisms from batch experiments, spectroscopy analysis and theoretical calculations. The sorption capacities with other materials, advantages and disadvantages of different nanomaterials are compared, and at last the perspective of the novel nanomaterials is summarized.

关键词： nanomaterials radionuclides removal preconcentration interaction mechanism

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饮食模式对多囊卵巢综合征的影响

现代预防医学 2020年第19期47卷 3497-3499+3535页

作者：岳月仪范雨佳鲁燕苏州大学附属第一医院内分泌科

目的研究不同饮食模式与多囊卵巢综合征(PCOS)的关系。方法在PubMed、Web of Science、万方、CNKI数据库中以"饮食"("diet")"多囊卵巢综合征"("Polycystic ovary syndrome"、"PCOS")为主题词检索2020年3月1日前文献。结果高脂饮食促进... 详细信息

目的研究不同饮食模式与多囊卵巢综合征(PCOS)的关系。方法在PubMed、Web of Science、万方、CNKI数据库中以"饮食"("diet")"多囊卵巢综合征"("Polycystic ovary syndrome"、"PCOS")为主题词检索2020年3月1日前文献。结果高脂饮食促进多囊卵巢综合征的发生发展,生酮饮食、低GI饮食、地中海饮食及Dash饮食则不同程度地改善多囊卵巢综合征的症状和结局。结论饮食与多囊卵巢综合征之间有一定相关性,某些饮食模式有治疗潜能,但仍需更多研究证实。

关键词：多囊卵巢综合征胰岛素抵抗高脂饮食生酮饮食地中海饮食

中小城市居民垃圾分类行为影响因素——以张家港市为例

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中国环境科学 2022年第10期42卷 4946-4953页

作者：张佳乐费凡温宗国清华大学环境学院工业节能与绿色发展评价中心北京100084

为识别中小城市居民分类行为的影响因素和决策机制,本文构建了中小城市居民垃圾分类行为决策模型,并以江苏省张家港市为例,运用结构方程拟合与修正,分析了主客观因素对居民分类行为的影响,并与大城市相关研究进行了比较.结果表明:张家... 详细信息

为识别中小城市居民分类行为的影响因素和决策机制,本文构建了中小城市居民垃圾分类行为决策模型,并以江苏省张家港市为例,运用结构方程拟合与修正,分析了主客观因素对居民分类行为的影响,并与大城市相关研究进行了比较.结果表明:张家港市垃圾分类参与率达95%,高于一、二线大城市.对于张家港市居民而言,“行为意愿”是影响其分类行为最显著的因素,其次是“环保意识”和“社会影响”;“经济回报”和“法规影响”的显著性较低,尚未发挥应有的激励作用;“分类知识掌握程度”和“时间花费”的影响不显著.总体来看,主观意识(敏感性系数:0.629)仍是影响中小城市居民分类行为的主导因素,但在强制垃圾分类背景下,随着分类设施的建设完善、法律法规的颁布和社区管制加强,其影响作用趋于减弱,而客观环境对应的显著观测变量更多,对居民分类行为的影响逐渐增强,将是政府制定管理政策的有效发力点.

关键词：生活垃圾分类环境行为城市居民结构方程模型中小城市张家港市

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基于改进图规划的机械臂任务规划方法

北京邮电大学学报 2018年第3期41卷 27-31页

作者：贾庆轩黄旭东陈钢王一帆北京邮电大学自动化学院

针对机械臂工作场景复杂、任务需求多样的特点,提出了一种基于改进图规划的机械臂任务规划方法.首先建立针对机械臂任务规划的通用数学表征模型;其次结合机械臂的任务特性与改进模拟退火算法,提出一种基于图规划的改进任务规划算法,将... 详细信息

针对机械臂工作场景复杂、任务需求多样的特点,提出了一种基于改进图规划的机械臂任务规划方法.首先建立针对机械臂任务规划的通用数学表征模型;其次结合机械臂的任务特性与改进模拟退火算法,提出一种基于图规划的改进任务规划算法,将传统算法单一的规划结果拓展为任务动作序列集合;最后,基于该集合求解融合不同目标的机械臂任务执行策略,并以七自由度机械臂为仿真对象对该方法的正确性和有效性进行了验证.结果表明,与传统规划方式相比,提出的方法具备优先考虑不同目标任务执行策略的能力,同时可以有效缩短规划时间.

关键词：机械臂图规划模拟退火算法目标融合

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肝癌精准治疗的研究前沿

中华肝脏病杂志 2020年第11期28卷 897-900页

作者：樊嘉高强黄润复旦大学附属中山医院肝肿瘤外科上海200030

肝癌是严重威胁我国人民生命健康的重大疾病。近年来,肝癌的临床诊治及创新研究取得了令人瞩目的进展。新型血清标志物的发现和转化应用,包括蛋白、miRNA以及外周血循环游离DNA甲基化等,促进了肝癌的早诊早治。影像学以及计算机技术的进... 详细信息

肝癌是严重威胁我国人民生命健康的重大疾病。近年来,肝癌的临床诊治及创新研究取得了令人瞩目的进展。新型血清标志物的发现和转化应用,包括蛋白、miRNA以及外周血循环游离DNA甲基化等,促进了肝癌的早诊早治。影像学以及计算机技术的进步,为精准肝脏外科的实现创造了便利条件。靶向与免疫治疗的进步,将为肝癌的精准治疗提供更多的手段。借助于基因组、转录组、蛋白组、代谢组等多组学技术,对肝癌发生和发展机制及其基因表型特征的认识越来越深入。单细胞、基因编辑、药物开发等技术的进步,使得肝癌创新研究的思路和方法越来越开阔。肝癌是一种复杂而难治的恶性肿瘤,通过不断揭示其恶性生物学行为的真正本质,进一步探寻制癌之道,从而助力肝癌精准治疗,使患者生存获益。

关键词：肝细胞癌早期诊断免疫靶向治疗精准外科

Analysis of Clinical Characteristics and Risk Factors of Pseudomonas aeruginosa Bloodstream Infection in 55 Cases

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Yangtze Medicine 2023年第3期7卷 162-170页

作者： Pengpeng Tian Shanshan Su Tian Wang Lisa Zhu Wen fan Huawei yi Department of Laboratory Medicine of the First Affiliated Hospital of Yangtze University Jingzhou China

Objective: Pseudomonas aeruginosa bloodstream infection presents a severe challenge to hospitalized patients. To investigate the clinical characteristics, risk factors and drug resistance of Pseudomonas aeruginosa bloodstream infection. Methods: Clinical data and laboratory results of patients with Pseudomonas aeruginosa bloodstream infection in the First Affiliated Hospital of Yangtze University from January 2019 to December 2022 were retrospectively analyzed. The factors associated with infection and death were analyzed by univariate analysis. Results: A total of 55 patients were enrolled in this study, The 28-day mortality rate was 14.5%. Univariate analysis showed that high procalcitonin, low albumin, ICU admission, central venous catheterization, indwelling catheter, and mechanical ventilation were associated with death. Multivariate Logistic regression analysis showed that hypoproteinemia and central venous catheters were independent risk factors for death in patients with Pseudomonas aeruginosa bloodstream infection. Conclusions: The drug resistance of P. aeruginosa bloodstream infection is not high, but the fatality rate is high. The combination of hypoalbuminemia after the onset of the disease and the use of central vein catheters can lead to increased mortality, suggesting that clinical identification of high-risk patients as early as possible, reducing the use of catheters, preventing the occurrence of P. aeruginosa bloodstream infection and improving the prognosis.

关键词： Pseudomonas aeruginosa Bloodstream Infections Resistance Risk Factors