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Thrombus migration in patients with acute ischaemic stroke undergoing endovascular thrombectomy

Stroke & Vascular Neurology 2024年第2期9卷 126-133,I0006-I0395页

作者： ZeFeng Tan Lei Zhang Li'an Huang Hongyu Qiao Min Guan Bing yang Pengfei yang Yongwei Zhang Hongjian Shen Yu Zhou bo Hong Huaizhang Shi Hongxing Han Xinyi Leng yi Dong Changlin Lian Wenhuo Chen Anding Xu Jianmin Liu Neurology First People's Hospital of FoshanFoshanGuangdongChina Department of Neurology Jinan University First Affiliated HospitalGuangzhouGuangdongChina Neurovascular Center Changhai HospitalNaval Medical UniversityShanghaiChina Department of Neurosurgery First Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Neurology Linyi People's HospitalLinyiShandongChina Medicine&Therapeutics The Chinese University of Hong KongHong KongChina Neurology Huashan Hospital Fudan UniversityShanghaiChina Neurology Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouFujianChina Stroke Center Jinan University First Affiliated HospitalGuangzhouGuangdongChina

Objective The impact of thrombus migration(TM)prior to endovascular thrombectomy(EVT)on clinical outcomes and revascularisation rates remains *** aimed to examine whether preinterventional TM modifies the treatment effects of direct EVT versus bridging EVT in acute large vessel occlusion *** All patients undergoing catheter angiography in the Direct Intra-arterial thrombectomy in order to Revascularise acute ischaemic stroke patients with large vessel occlusion Efficiently in Chinese Tertiary hospitals:A Multicentre randomised clinical Trial were *** was determined by radiologists unaware of the study by analysing discrepancies between computed tomographic angiography at baseline and first-run digital subtraction angiography before *** primary outcome was the score on the modified Rankin scale(mRS)assessed at 90 *** Of 627 included patients,the TM rate was 11.3%(71/627).In the multivariable logistic regression model,baseline National Institutes of Health Stroke Scale score(adjusted OR 0.956,95%CI 0.916 to 0.999;p=0.043)and intravenous thrombolysis(adjusted OR 2.614,95%CI 1.514 to 4.514;p<0.001)were independently associated with *** patients with TM were less likely to be completely recanalised than those without TM(21.27%vs 36.23%,p=0.040).The interaction of TM and the EVT treatment effect did not significantly affect mRS shift analysis(p=0.687)or mRS scores of 0 to 1(p=0.436).Conclusion Preinterventional TM does not modify the treatment effects of direct versus bridging EVT on functional outcomes in patients with acute ischaemic stroke with anterior large vessel *** leads to a lower complete recanalisation rate.

关键词： patients throm acute

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Iron and ferritin effects on intensive care unit mortality:A metaanalysis

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World Journal of Clinical Cases 2024年第16期12卷 2803-2812页

作者： Deng-Can yang bo-Jun Zheng Jian Li yi Yu Department of Anesthesiology The Central Hospital of ShaoyangShaoyang 422000Hunan ProvinceChina Department of Critical Care Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina Department of Critical Care Medicine Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510006Guangdong ProvinceChina

BACKGROUND The effect of serum iron or ferritin parameters on mortality among critically ill patients is not well *** To determine the association between serum iron or ferritin parameters and mortality among critically ill *** Web of Science,Embase,PubMed,and Cochrane Library databases were searched for studies on serum iron or ferritin parameters and mortality among critically ill *** reviewers independently assessed,selected,and abstracted data from studies reporting on serum iron or ferritin parameters and mortality among critically ill *** on serum iron or ferritin levels,mortality,and demographics were *** Nineteen studies comprising 125490 patients were eligible for *** observed a slight negative effect of serum ferritin on mortality in the United States population[relative risk(RR)1.002;95%CI:1.002-1.004].In patients with sepsis,serum iron had a significant negative effect on mortality(RR=1.567;95%CI:1.208-1.925).CONCLUSION This systematic review presents evidence of a negative correlation between serum iron levels and mortality among patients with ***,it reveals a minor yet adverse impact of serum ferritin on mortality among the United States population.

关键词： Iron Ferritin Mortality Critically ill Meta analysis

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Influence of different magnetic forces on the effect of colonic anastomosis in rats

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 860-870页

作者： bo-Yan Tian Miao-Miao Zhang Jia Ma yi Lyu Xiao-Peng Yan Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Surgical Oncology Shaanxi Provincial People's HospitalXi'an 710068Shaanxi ProvinceChina

BACKGROUND Despite much work having been conducted on magnetic compression anastomo-sis(MCA)in the digestive tract,there are no reports on the influence of magnetic force on the *** To investigate the effect of different magnetic force magnets on the MCA of the digestive *** Two groups of magnets of the same sizes but different magnetic forces were designed and produced.A total of 24 Sprague-Dawley rats were randomly assigned into two groups(powerful magnet group and common magnet group),with 12 rats in each *** types of magnets were used to complete the colonic side-to-side anastomosis of the *** operation time and magnet discharge time were *** anastomotic specimens were obtained 4 wk after the operation and then the burst pressure and diameter of the anastomosis were measured,and the anastomosis was observed via the naked eye and subjected to histological *** The magnetic forces of the powerful and common magnet groups at zero distance were 8.26 N and 4.10 N,*** colonic side-to-side anastomosis was completed in all 24 rats,and the operation success rate and postoperative survival rate were 100%.No significant difference was noted in the operation time between the two *** magnet discharge time of the powerful magnet group was slightly longer than that of the common magnet group,but the difference was not statistically significant(P=0.513).Furthermore,there was no statistical difference in the burst pressure(P=0.266)or diameter of magnetic anastomosis(P=0.095)between the two *** gross specimens of the two groups showed good anastomotic healing,and histological observation indicated good mucosal continuity without differences on *** In the rat colonic side-to-side MCA model,both the powerful magnet with 8.26 N and the common magnet with 4.10 N showed no significant impact on the anastomosis establishment process or its effect.

关键词： Magnetosurgery Magnetic compression anastomosis Colonic anastomosis Magnetic force Rats

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Pollutant emissions from biomass burning:A review on emission characteristics,environmental impacts,and research perspectives

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Particuology 2024年第2期85卷 296-309页

作者： Ke Jiang Ran Xing Zhihan Luo Wenxuan Huang Fan yi Yatai Men Nan Zhao Zhaofeng Chang jinfeng Zhao bo Pan Guofeng shen College of Urban and Environmental Sciences Peking UniversityBeijing100871China Beijing Key Lab Plant Resources Research and Development Beijing Technology and Business UniversityBeijing100048China College of Ecology and Environment Zhengzhou UniversityZhengzhou450001China Facultyof Environmental Sciences and Engineering Kunming University of Science and TechnologyYunnan Provincial Key Laboratoryof Soil Carbon Sequestration and Pollution ControlKunming650500China Institute of Carbon Neutrality Peking UniversityBeijing100871China

Biomass is one most abundant resource on the earth providing important energies in support of so-cioeconomic development in many *** of biomass fuels comprises to nearly 10%of the total energy from anthropogenic combustion processes:however,as the burning is usually incomplete,this process yields products of incomplete combustion posing consequently significant impacts on air quality,human health,and climate ***,we analyzed spatiotemporal characteristics in intentional and unintentional biomass burning from different sectors,discussed impacts of biomass burning emissions on indoor and outdoor air quality,and consequent influences on human *** global total con-sumption amount of biomass including both natural and anthropogenic sources was approximately 7900 Tg in 2019,with significantly large regional and sectorial discrepancies among ***,anthropogenic biomass burning amounts increased gradually,but notably in some developing countries like China residential consumption of biomass fuels,as one large sector of biomass use,decreased over *** biomass consumption needs to be accurately *** are relatively rich datasets of pollutant emission factors from biomass burning,including laboratory and field tests,but still large variations exit and contribute substantially to the uncertainty in emission *** pri-mary PM2.5,black carbon and organic carbon emissions from biomass burning were about 51,4.6,and 29 Tg,respectively,contributing to nearly 70%,55%,and 90%of the total emission from all sources,and emissions from the residential sector and open fires are major *** carbon emissions from biomass burning attracts growing interests but available studies adopted different methodologies challenging the comparability of those *** burning emissions polluted not only ambient air but more severely indoor air quality,adversely affecting human *** studies that should be emphasiz

关键词： Biomass burning Carbonaceous aerosol Emission Air quality Human health

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Predicting hepatocellular carcinoma: A new non-invasive model based on shear wave elastography

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World Journal of Gastroenterology 2024年第25期30卷 3166-3178页

作者： Dong Jiang yi Qian yi-Jun Gu Ru Wang Hua Yu Hui Dong Dong-Yu Chen Yan Chen Hao-Zheng Jiang Bi-bo Tan Min Peng yi-Ran Li Department of Ultrasound Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of Pathology Shanghai Eastern Hepatobiliary Surgery HospitalThird Affiliated Hospital of Naval Medical UniversityShanghai 200433China Department of College of Art and Science Case Western Reserve UniversityClevelandOH 44106United States Ultrasound Diagnosis PLA Naval Medical CenterShanghai 200437China

BACKGROUND Integrating conventional ultrasound features with 2D shear wave elastography(2D-SWE)can potentially enhance preoperative hepatocellular carcinoma(HCC)*** To develop a 2D-SWE-based predictive model for preoperative identification of *** A retrospective analysis of 884 patients who underwent liver resection and pathology evaluation from February 2021 to August 2023 was conducted at the Oriental Hepatobiliary Surgery *** patients were divided into the modeling group(n=720)and the control group(n=164).The study included conventional ultrasound,2D-SWE,and preoperative laboratory *** logistic regression was used to identify independent predictive factors for RESULTS In the modeling group analysis,maximal elasticity(Emax)of tumors and their peripheries,platelet count,cirrhosis,and blood flow were independent risk indicators for *** factors yielded an area under the curve of 0.77(95%confidence interval:0.73-0.81)with 84%sensitivity and 61%*** model demonstrated good calibration in both the construction and validation cohorts,as shown by the calibration graph and Hosmer-Lemeshow test(P=0.683 and P=0.658,respectively).Additionally,the mean elasticity(Emean)of the tumor periphery was identified as a risk factor for microvascular invasion(MVI)in malignant liver tumors(P=0.003).Patients receiving antiviral treatment differed significantly in platelet count(P=0.002),Emax of tumors(P=0.033),Emean of tumors(P=0.042),Emax at tumor periphery(P<0.001),and Emean at tumor periphery(P=0.003).CONCLUSION 2D-SWE’s hardness value serves as a valuable marker for enhancing the preoperative diagnosis of malignant liver lesions,correlating significantly with MVI and antiviral treatment efficacy.

关键词： Shear wave elastography Predicting model Microvascular invasion Antiviral treatment Hepatocellular carcinoma

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Typhoon-Induced Ocean Waves and Stokes Drift:A Case Study of Typhoon Mangkhut(2018)

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China Ocean Engineering 2024年第4期38卷 711-724页

作者： WU Zhi-yuan GAO Kai CHEN Jie ZHANG Hao-jian DENG Bin JIANG Chang-bo LIU yi-zhuang LYU Zhao YAN Ren School of Hydraulic and Environmental Engineering Changsha University of Science&TechnologyChangsha 410114China Key Laboratory of Water-Sediment Sciences and Water Disaster Prevention of Hunan Province Changsha 410114China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai UniversityNanjing 210024China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China School of Civil Engineering Hunan University of TechnologyZhuzhou 412007China

Ocean waves and Stokes drift are generated by *** study investigated the characteristics of ocean waves and wave-induced Stokes drift and their effects during Typhoon Mangkhut using European Centre for MediumRange Weather Forecasts(ECMWF)ERA5 datasets and observational *** results revealed that the typhoon generated intense cyclones and huge typhoon waves with a maximum wind speed of 45 m/s,a minimum pressure of955 h Pa,and a maximum significant wave height of 12 *** Stokes drift caused by typhoon waves exceeded 0.6m/s,the Stokes depth scale exceeded 18 m,and the maximum Stokes transport reached 6 m^(2)/*** spatial distribution of 10-m wind speed,typhoon wave height,Stokes drift,Stokes depth,and Stokes transport during the typhoon was highly correlated with the typhoon *** distribution along the typhoon track showed significant zonal asymmetry,with greater intensity on the right side of the typhoon track than on the left *** findings provide important insights into the impact of typhoons on ocean waves and Stokes drift,thus improving our understanding of the interactions between typhoons and the ocean *** study also investigated the contribution of Stokes transport to the total net transport during typhoons using Ekman-Stokes Numbers as a comparative *** results indicated that the ratio of Stokes transport to the total net transport reached up to 50%within the typhoon radius,while it was approximately 30%outside the *** Stokes transport induced by typhoon waves led to divergence in the transport direction,which resulted in upwelling of the lower ocean as a compensation ***,Stokes transport played a crucial role in the vertical mixing of the ocean during *** findings suggested that Stokes transport should be paid more attention to,particularly in high latitude ocean regions,where strong winds can amplify its effects.

关键词： Stokes drift typhoon waves Ekman-Stokes transport vertical mixing Typhoon Mangkhut

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RNF187 governs the maintenance of mouse GC-2 cell development by facilitating histone H3 ubiquitination at K57/80

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Asian Journal of Andrology 2024年第3期26卷 272-281页

作者： Bing-Ya Xu Xiang-Ling Yu Wen-Xin Gao Ting-Ting Gao Hao-Yue Hu Tian-Tian Wu Cong Shen Xiao-Yan Huang bo Zheng yi-bo Wu Human Reproductive and Genetic Center Affiliated Hospital of Jiangnan UniversityWuxi 214122China State Key Laboratory of Reproductive Medicine Department of Histology and EmbryologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing 211166China Changzhou Maternal and Child Health Care Hospital Changzhou Medical CenterNanjing Medical UniversityChangzhou 213000China State Key Laboratory of Reproductive Medicine Center for Reproduction and GeneticsSuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversityGusu SchoolNanjing Medical UniversitySuzhou 215002China

RING finger 187(RNF187),a ubiquitin-ligating(E3)enzyme,plays a crucial role in the proliferation of cancer ***,it remains unclear whether RNF187 exhibits comparable functionality in the development of germline *** investigate thepotential involvement of RNF187 in germ cell development,we conducted interference and overexpression assays using GC-2 cells,a mouse spermatocyte-derived cell *** findings reveal that the interaction between RNF187 and histone H3 increases theviability,proliferation,and migratory capacity of GC-2 ***,we provide evidence demonstrating that RNF187 interactswith H3 and mediates the ubiquitination of H3 at lysine 57(K57)or lysine 80(K80),directly or indirectly resulting in increasedcellular *** is a study to report the role of RNF187 in maintaining the development of GC-2 cells by mediatinghistone H3 ubiquitination,thus highlighting the involvement of the K57 and K80 residues of H3 in the epistatic regulation of *** discoveries provide a new theoretical foundation for further comprehensive investigations into the functionof RNF187 in the reproductive system.

关键词： GC-2 cell histone H3 RNF187 ubiquitination

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Upcycling of Poly(butylene adipate-co-terephthalate)into Dual Covalent Adaptable Networks through Chain Breaking-Crosslinking Strategy

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Chinese Journal of Polymer Science 2024年第10期42卷 1505-1513,I0011页

作者： Bin-bo Wang Rong Huang Xin Wang Tao Jiang yi Wang Shuai Du Fa-Lin Li Jin Zhu Song-Qi Ma Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi214122China Key Laboratory of Bio-based Polymeric Materials Technology and Application of Zhejiang Province Divisions of Polymers and CompositesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo315201China University of Chinese Academy of Sciences Beijing100049China

Poly(butylene adipate-co-terephthalate)(PBAT),a widely studied biodegradable material,has not effectively addressed the problem of plastic *** into consideration the cost-effectiveness,upcycling PBAT should take precedence over direct composting *** present work adopts a chain breaking-crosslinking strategy,upcycling PBAT into dual covalent adaptable networks(CANs).During the chainbreaking stage,the ammonolysis between PBAT and polyethyleneimine(PEI)established the primary crosslinked ***,styrene maleic anhydride copolymer(SMA)reacted with the hydroxyl group,culminating in the formation of dual covalent adaptable *** contrast to PBAT,the PBAT-dual-CANs exhibited a notable Young's modulus of 239 MPa,alongside an inherent resistance to creep and *** to catalysis from neighboring carboxyl group and excess hydroxyl groups,the PBAT-dual-CANs exhibited fast stress ***,they could be recycled through extrusion and hot-press reprocessing,while retaining their *** straightforward strategy offers a solution for dealing with plastic waste.

关键词： Poly(butylene adipate-co-terephthalate) Dynamic crosslinked networks Chain breaking-crosslinking strategy Upcycle Recycle

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Regulating metal-acid double site balance on mesoporous SiO2-Al2O3 composite oxide for supercritical n-decane cracking

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Petroleum Science 2024年第4期21卷 2881-2891页

作者： Liu-Ling Chen Jun Zhang Chun-Guang Li Li-Qun Fei bo Wang Chen-Qi Zhang yi Jiao Jian-Li Wang Institute of New Energy and Low-Carbon Technology Sichuan University Engineering Research Center of Combustion and Cooling for Aerospace Power Ministry of Education School of Chemical Engineering Sichuan University State Key Laboratory of Industrial Vent Gas Reuse Southwest Institute of Chemical Co. Ltd Science and Technology on Scramjet Laboratory Beijing Power Machinery Research Institute

The balance between metal and acid sites directly affects the preparation of high-performance cracking catalysts with high heat sink and low ***,how to control acid-metal sites balance and its relationship with cracking performance are reported *** this work,a series of Pt/Al2O3-SiO2dual sites catalysts with different metal to acid active sites ratio(CM/CSA) were constructed by ethanolassisted impregnation method and the impact on n-decane cracking under supercritical conditions was systematically and deeply *** results showed that the conversion and carbon deposition increased gradually with varied CM/CSAand reached the balance at CM/CSAof *** proper ratio CM/CSA（0.13） can balance the deep dehydrogenation coking over metal active sites and high heat sink of cracking over acid active sites,the chemical heat sink reaches amazing 1.75 MJ/kg and carbon deposition is only22.03 mg/cm2at 750℃.Meanwhile,the few metal sites at low CM/CSAand the few strong acid sites at high CM/CSAare the main factors limiting the cracking *** CM/CSAlimit the activation of C-H bond and deep dehydrogenation of coking precursor,resulting in relative low cracking activity and carbon deposition,while high CM/CSAlimit the activation of C-C bond and increase the deep *** this contribution,design and construction of metal-acid dual sites can not only provide the technical solution for the preparation of high heat sink and low coking cracking catalyst,but also deepen the understanding of the cracking path of hydrocarbon fuel.

关键词： Metal-acid dual sites balance Catalytic cracking Hydrocarbon fuels Chemical heat sink Carbon deposition

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Network Defense Decision-Making Based on Deep Reinforcement Learning and Dynamic Game Theory

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China Communications 2024年第9期21卷 262-275页

作者： Huang Wanwei Yuan bo Wang Sunan Ding yi Li Yuhua College of Software Engineering Zhengzhou University of Light IndustryZhengzhou 450001China The Third Construction Co. Ltd of China CREC Railway Electrification Engineering GroupZhengzhou 450052China Electronic and Communication Engineering Shenzhen Polytechnic UniversityShenzhen 518055China

Existing researches on cyber attackdefense analysis have typically adopted stochastic game theory to model the problem for solutions,but the assumption of complete rationality is used in modeling,ignoring the information opacity in practical attack and defense scenarios,and the model and method lack *** such problem,we investigate network defense policy methods under finite rationality constraints and propose network defense policy selection algorithm based on deep reinforcement *** on graph theoretical methods,we transform the decision-making problem into a path optimization problem,and use a compression method based on service node to map the network *** this basis,we improve the A3C algorithm and design the DefenseA3C defense policy selection algorithm with online learning *** experimental results show that the model and method proposed in this paper can stably converge to a better network state after training,which is faster and more stable than the original A3C *** with the existing typical approaches,Defense-A3C is verified its advancement.

关键词： A3C cyber attack-defense analysis deep reinforcement learning stochastic game theory

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