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Acta Mathematica Sinica,English Series 2005年第6期21卷 1377-1390页

作者： yi wen jiang Li Ming WU Department of Mathematics Military Economics Academy Wuhan 430035 P. R. China Laboratoire de Mathématiques Appliqudes CNRS UMR 6620 Universitd Blaise Pascal 63177 Aubière France Department Mathematics Wuhan University Wuhan 430072 P. R. China

All known results on large deviations of occupation measures of Markov processes are based on the assumption of （essential） irreducibility. In this paper we establish the weak＊ large deviation principle of occupation measures for any countable Markov chain with arbitrary initial measures. The new rate function that we obtain is not convex and depends on the initial measure, contrary to the （essentially） irreducible case.

关键词： Large deviations Markov processes (chains)

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一种跳频信号跳周期联合估计算法

科学技术与工程 2012年第6期20卷 1260-1262,1267页

作者：易江文唐艳西南交通大学信息科学与技术学院成都610031

针对通信对抗中的实际应用,给出了一种联合算法估计跳频信号跳周期,与传统跳周期估计方法不同,该方法通过对信号进行谱图重排变换,然后提取时频脊线并对其进行小波变换,精确定位跳变时刻,最后得到跳周期的准确估计。仿真结果表明,该方... 详细信息

针对通信对抗中的实际应用,给出了一种联合算法估计跳频信号跳周期,与传统跳周期估计方法不同,该方法通过对信号进行谱图重排变换,然后提取时频脊线并对其进行小波变换,精确定位跳变时刻,最后得到跳周期的准确估计。仿真结果表明,该方法具有较好的抗噪性能,在信噪比大于-1 db时能得到准确的参数估计。

关键词：跳频时频重排小波变换

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牛蒡热风干燥工艺研究

食品研究与开发 2017年第13期38卷 132-135页

作者：义雯蒋红芝中南大学土木工程学院湖南长沙410075 广西农业职业技术学院广西南宁530007

以牛蒡为原料,采用热风干燥,对干燥温度、铺料厚度、干燥风速对牛蒡干燥的影响进行了研究,通过绘出干燥曲线及干燥速率曲线,并测定a、b、L值,进行分析。结果表明,选用热风干燥牛蒡,干燥温度为75℃,选料100 g,铺料一层,中风速干燥5 h,其... 详细信息

以牛蒡为原料,采用热风干燥,对干燥温度、铺料厚度、干燥风速对牛蒡干燥的影响进行了研究,通过绘出干燥曲线及干燥速率曲线,并测定a、b、L值,进行分析。结果表明,选用热风干燥牛蒡,干燥温度为75℃,选料100 g,铺料一层,中风速干燥5 h,其色泽最佳、时间较短。

关键词：牛蒡热风干燥干燥曲线干燥速率曲线工艺研究

The detection, extraction and parameter estimation of extreme-mass-ratio inspirals with deep learning

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun Yun wen-Biao Han yi-Yang Guo He Wang Minghui Du Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Shanghai Astronomical Observatory Chinese Academy of Sciences School of Physics and Astronomy Shanghai Jiao Tong University School of Astronomy and Space Science University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences Lanzhou Center for Theoretical Physics Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Institute of Theoretical Physics & Research Center of Gravitation Lanzhou University International Centre for Theoretical Physics Asia-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals of space-borne gravitational wave detectors is to detect and analyze extreme-mass-ratio inspirals(EMRIs). This task is particularly challenging because EMRI signals are complex, lengthy, and faint. In this work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI signals for space-borne detectors, achieving a true positive rate(TPR) of 96.9% at a 1% false positive rate(FPR) for signal-to-noise ratio(SNR) from 50 to 100. Especially, the key intrinsic parameters of EMRIs such as the mass, spin of the supermassive black hole(SMBH) and the initial eccentricity of the orbit can also be inferred directly by employing a neural network. The mass and spin of the SMBH can be determined at 99% and 92% respectively. This will greatly reduce the parameter spaces and computing cost for the following Bayesian parameter *** model also has a low dependency on the accuracy of the waveform model. This study underscores the potential of deep learning methods in EMRI data analysis, enabling the rapid detection of EMRI signals and efficient parameter estimation.

关键词： gravitational wave EMRIs deep-learing

柔性显示盖板用耐弯折无色透明聚酰亚胺薄膜的制备与性能

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高分子学报 2024年第10期55卷 1393-1404页

作者：白帆江怡雯李琇廷董杰赵昕张清华纤维材料改性国家重点实验室东华大学材料科学与工程学院上海201620

随着显示领域的不断发展,柔性显示盖板用无色透明聚酰亚胺(CPI)薄膜的研发备受关注.本研究中,通过使用商业化酸酐和二胺单体,调控主链结构、氟含量和分子间氢键,进而实现了薄膜透明性、尺寸稳定性、耐热性和机械性能之间的平衡;制备的CP... 详细信息

随着显示领域的不断发展,柔性显示盖板用无色透明聚酰亚胺(CPI)薄膜的研发备受关注.本研究中,通过使用商业化酸酐和二胺单体,调控主链结构、氟含量和分子间氢键,进而实现了薄膜透明性、尺寸稳定性、耐热性和机械性能之间的平衡;制备的CPI-2-TF薄膜有优异的平均光学透过率(T_(av))(>88%),同时具有较低的线性膨胀系数(CTE)(<1.3×10^(-5) K^(-1))、较高的玻璃化转变温度(T_(g))(≥380℃)和优良的机械性能,为CPI的商业化进程和大规模制备提供基础.此外,本研究重点考察了CPI-2-TF的耐弯折稳定性,弯折20万次后的薄膜基本没有任何变化,其T_(av)保持率在99%以上,力学性能仅下降4%;进一步弯折40万次后,薄膜的光学性能基本不变,力学性能保持率在92%以上,在折叠屏手机等领域展示出较高的应用潜力.

关键词：无色透明聚酰亚胺耐弯折性能柔性显示盖板耐高温

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3-巯基香豆素及其衍生物的研究

化学学报 1987年第4期45卷 344-353页

作者：邢其毅王文江何大淹北京大学化学系北京大学化学系北京

本文报道了3-巯基香豆素(8)、3,3′-二硫代双香豆素(9)的合成及8与一系列Michael受体的反应。按受体结构不同,除都能发生分子间的加成反应外,有些还可进一步发生第二次分子内的加成反应,关环后得到一系列四氢噻吩并[2,3-C][1]苯并吡喃-4... 详细信息

本文报道了3-巯基香豆素(8)、3,3′-二硫代双香豆素(9)的合成及8与一系列Michael受体的反应。按受体结构不同,除都能发生分子间的加成反应外,有些还可进一步发生第二次分子内的加成反应,关环后得到一系列四氢噻吩并[2,3-C][1]苯并吡喃-4(H)-酮的衍生物。对这些化合物的立体化学及结构进行了鉴定。8分别和烯丙基溴、肉桂基溴缩合,前者在N,N-二甲苯胺内发生正常的Claisen重排,得到1,2-二氢-2-甲基噻吩并[2,3-C][1]苯并吡喃-4(H)-酮(27)及1,2,3,5-四氢硫代吡喃并[2,3-C][1]苯并吡喃-5-酮(28),但后者的反应产物是3-(p-N,N-二甲氨基)苄硫基香豆素(32)。

关键词：香豆素受体邻氧萘酮苯并吡喃化合物反应丙烯睛甲基链烷基甲苯胺关环重结晶再结晶(冶金) 甲基丙烯酸马丁烯酸实测值巯基

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong wen Minna Liu yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

Photothermal probiotics delivery of photodynamic agents for enhanced immunogenic cell death within hypoxia center of solid tumors

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Nano Research 2025年第1期18卷 642-652页

作者： wen Luo Shiyu Du Yateng jiang Bangshun He Jun Tang Jingjing Yang Yujun Song jiangsu Key Laboratory of Artificial Functional Materials State Key Laboratory of Analytical Chemistry for Life ScienceNational Laboratory of Solid State MicrostructuresCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210023China Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Department of Anesthesiology Jinling HospitalMedical School of Nanjing UniversityNanjing 210000China Department of Biochemistry and Molecular Biology School of Medicine&Holistic Integrative MedicineJiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

Resulting from harsh hypoxic environmental conditions,central cells in the core of solid tumors are usually more aggressive and malignant with a less stable ***,therapeutic agents with improved penetration for the activation of immunity in tumor centers exhibit promising potential in ***,polydopamine-coated Escherichia coli Nissle 1917(EcN)bearing chlorin e6(Ce6)-loaded and polyethyleneimine(PEI)-coated hollow manganese dioxide(shorted as EP-ChP)are applied for enhanced immunotherapy in deep *** accumulation in tumor center through hypoxia targeting,manganese dioxide is degradated under the tumor microenvironment with released Ce6 and thus generates reactive oxygen species(ROS)upon 660 nm laser irradiation,which can further lower thermalresistance of cancer cells via HSP90α*** to that,heating induced by polydopamine upon 808 nm laser irradiation can achieve effective tumor *** upon dual laser induces enhanced immunogenic cell death,while bacterial infections in tumor tissues also trigger innate *** bacteria-based approach provides enhanced antitumor immune responses in deep tumors with great potential in the reshaping of immunosuppression tumor microenvironment.

关键词： bacteria phototherapies immunotherapy hypoxia targeting tumor penetration

青少年1型糖尿病患者疾病自我管理能力现状及其干预的研究进展

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中国全科医学 2013年第30期16卷 3594-3596页

作者：文益江郭佳何国平中南大学护理学院湖南省长沙市410013 益阳医学高等专科学校护理系

本文总结了青少年1型糖尿病(T1DM)患者疾病自我管理能力现状及近10年来国内外的相关干预研究成果,发现青少年T1DM患者疾病自我管理能力的现状不容乐观。国外学者主要采取以糖尿病常规健康教育、糖尿病夏令营、认知行为训练、远程干预等... 详细信息

本文总结了青少年1型糖尿病(T1DM)患者疾病自我管理能力现状及近10年来国内外的相关干预研究成果,发现青少年T1DM患者疾病自我管理能力的现状不容乐观。国外学者主要采取以糖尿病常规健康教育、糖尿病夏令营、认知行为训练、远程干预等形式为主的多种干预方案,提高了患者的自我管理能力,同时改善了生活质量和代谢控制状况,但国内此类干预效果的评价报道较少。笔者认为有必要在借鉴国外干预方法的基础上,开发出一套适合我国国情的青少年T1DM患者疾病自我管理干预方案。

关键词：糖尿病 1型青少年疾病管理血糖自我监测

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应激生理指标皮质醇和α-淀粉酶的研究进展

军事医学 2017年第2期41卷 146-149页

作者：张懿苏文君蒋春雷第二军医大学心理与精神卫生学系精神病学教研室上海200433

随着社会竞争的日益激烈,工作和生活节奏加快,人们所承受的压力和挑战越来越多,暴露于日常生活应激的频率和强度也越来越大。持续、过强的应激暴露能破坏人体的生物学保护机制,并产生一系列生理、神经内分泌、神经生化、免疫功能及心理... 详细信息

随着社会竞争的日益激烈,工作和生活节奏加快,人们所承受的压力和挑战越来越多,暴露于日常生活应激的频率和强度也越来越大。持续、过强的应激暴露能破坏人体的生物学保护机制,并产生一系列生理、神经内分泌、神经生化、免疫功能及心理行为等方面的变化,最终引发一系列危害身心健康的疾病。鉴于应激已成为多种慢性疾病的重要病因或诱因,对应激生理指标特别是反映应激水平的客观检测指标的应用研究,将为应激相关疾病的防治提供依据。文献报道有多种应激生理指标,如皮质醇、α-淀粉酶、儿茶酚胺、热休克蛋白、促炎细胞因子等,该文针对应激反应最主要的两条通路:下丘脑-垂体-肾上腺(HPA)轴和交感通路,将代表性的皮质醇和α-淀粉酶作为应激生理指标作一综述。

关键词：应激生理指标皮质醇 α-淀粉酶应激性疾病