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On-chip stackable dielectric laser accelerator

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Nuclear Science and Techniques 2023年第2期34卷 79-87页

作者： Bin Sun Yang‑fan He Ruo‑yun Luo Tai‑Yang Zhang Qiang Zhou Shao‑yi wang Jian zheng Zong‑Qing Zhao CAS Key Laboratory of Geospace Environment Department of Plasma Physics and Fusion EngineeringUniversity of Science and Technology of ChinaHefei 230026China Laser Fusion Research Center CAEPP.O.Box 919986Mianyang 621900China The Sciences and Technology on Plasma Physics Laboratory CAEPMianyang 621900China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Department of Nuclear Plasmaand Radiological EngineeringUniversity of Illinois at Urbana-Champaign104 South Wright StreetUrbanaIL 61801USA CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China IFSA Collaborative Innovation Center Shanghai Jiao Tong UniversityShanghai 200240China CAS Center for Excellence in Ultra-Intense Laser Science Shanghai 201800China

In this paper,we propose a novel stacked laser dielectric acceleration *** structure is based on the inverse Cherenkov effect and represented by a parametric design *** to existing dielectric laser accelerators relying on the inverse Smith–Purcell effect,the proposed structure provides an extended-duration synchronous acceleration field without requiring the pulse front tilting *** advantage significantly reduces the required pulse *** addition,the easy to integrate layered structure facilitates cascade acceleration,and simulations have shown that low-energy electron beams can be cascaded through high gradients over extended *** practical advantages demonstrate the potential of this new structure for future chip accelerators.

关键词： Dielectric laser accelerator Inverse Cherenkov effect Laser-driven particle acceleration

Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer

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Research 2021年第1期2021卷 689-703页

作者： yun Zhou Mian Yu Changjun Tie Yang Deng Junqing wang yunfei yi fan Zhang Chenyi Huang Hairong zheng Lin Mei Meiying Wu School of Pharmaceutical Sciences(Shenzhen) Sun Yat-sen UniversityShenzhen 518107China Paul C.Lauterbur Research Center for Biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China

Benefiting from treating diseases at the genetic level,gene therapy has been considered a new revolution in the biomedical ***,the extracellular and intracellular barriers during gene transport such as enzymatic degradation and endo-/lysosomal sequestration significantly compromise the therapeutic *** photochemical internalization(PCI)has emerged as a promising approach for causing endo-/lysosomal leakage with translocation of the internalized molecules into the cytosol,its effect is still unsatisfactory due to the insufficient light penetration ***,we develop tumor microenvironment-specific enhanced gene delivery by means of ROS generated from the in situ cascaded catalytic reactions in tumors involving GOx-mediated redox reaction and Mn2+-mediated Fenton-like *** efficient enzymatic protection and successful endo-/lysosomal escape of cargo gene complexes have been ***,anti-Twist siRNA-loaded G@MMSNs-P exhibit tumor-specific biodegradation,excellent T1-weighted MR imaging,and significant inhibitory effects against breast cancer growth and pulmonary metastasis.

关键词： Internal loaded emerged

Migration behavior of solid fuel particles during granulation process and its influence on combustion property

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Journal of Iron and Steel Research International 2023年第11期30卷 2153-2162页

作者： Zhi-yun Ji yi-fan wang Xiao-hui fan Gai-ge Zhao Min Gan Le-yun Tang Yong Tu Xiao-long wang Hao-xiang zheng Xu-ling Chen Xiao-xian Huang Zeng-qing Sun School of Minerals Processing and Bioengineering Central South UniversityChangsha410083HunanChina Hunan Valin Xiangtan Iron and Steel Co. Ltd.Xiangtan411101HunanChina

Iron ore sintering process is the main CO_(2) emission source throughout the integrate steelworks,which primarily comes from the combustion of solid *** the combustion efficiency and reducing the solid fuel consumption are important ways to reduce the CO_(2) emission in the sintering *** the efficient combustion of fuel,the migration behavior and combustion characteristics of solid fuel in the granulation process were *** results indicated that during the granulation process,fuel particles with size less than 0.5 mm mainly migrated into the granules with grain size of 1-3,3-5 and 5-8 mm;fuel particles with size of 0.5^(-1)mm mainly migrated into granules of 1-3 mm;fuel particles with size of 1-3,3-5 and 5-8 mm mainly entered the granules with the same grain *** the increase in fuel particles grain size from-0.5 to+8 mm,the combustion efficiency exhibited a firstly-increasing and then decreasing tendency,while the NO_(x) exhibited a decreasing *** reason can be described that finer fuel particles(-1 mm)easily distributed in the outer layer of the granules,which combusted fiercely due to its larger specific surface area,leading to the development of incomplete combustion and the conversion of fuel nitrogen;the combustion efficiency of larger fuel particles was restricted by the inner diffusion of O_(2),which then contributed to the reduction of NO_(x) under the inadequate combustion atmosphere.

关键词： Iron ore sintering Granulation Solid fuel distribution Pollutant emission Combustion efficiency

Synergistic Effect of Triple Ion Beams on Radiation Damage in CLAM Steel

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Chinese Physics Letters 2014年第4期31卷 93-95页

作者： YUAN Da-Qing zheng Yong-Nan ZUO yi fan Ping ZHOU Dong-Mei ZHANG qiao-Li MA Xiao-Qiang CUI Bao-Qun CHEN Li-Hua JIANG Wei-Sheng WU yi-Can ttUANG Qun-ying PENG Lei CAO Xing-Zhong wang Bao-yi WEI Long ZHU Sheng-yun China Institute of Atomic Energy Beijing 102413 Institute of Nuclear Energy Safety Technology Chinese Academy of Sciences Hefei 230031 Institute of High Energy Physics Chinese Academy of Sciences Beijing 100039

The synergistic effect of triple ion beams is investigated by simultaneous and scquential irradiations of gold, hydrogen and helium ions on the low activation martensitie steel （CLAM） developed in China. The depth profile measurements of the positron annihilation Doppler broadening S parameter are carried out as a function of slow- positron beam energy to examine the produced radiation damage. The synergistic effect of displacement damage and hydrogen and helium on the formation of radiation damage is clearly observed. In the preset case ,this effect suppresses the radiation damage in the CLAM steel due to the helium and/or hydrogen filling of vacancy clusters.

关键词： HELIUM ions HYDROGEN MARTENSITIC stainless steel POSITRON annihilation RADIATION damage

Effect of EGb761 on light-damaged retinal pigment epithelial cells

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 8-13页

作者： yun-yun Zhou Chang-zheng Chen Yu Su Lu Li Zuo-Hui-Zi yi Hang Qi Ming Weng yi-qiao Xing Department of Ophthalmology Renmin Hospital of Wuhan University Zhongshan Ophthalmic Center Sun Yat-sen University

AIM: To investigate the protective mechanism of Gingko Biloba extract(EGb761) on the ability of retinal pigment epithelial(RPE) cells to resist light-induced damage in a comparative proteomics study. · METHODS: Human RPE cells(ARPE-19) were randomly distributed to one of three groups: normal control(NC group) and light-damaged model without or with EGb761 group(M and ME groups,respectively). The light-damaged model was formed by exposing to white light(2 200 ±300)lx for 6h. The RPE cells in ME group were conducted with EGb761(100μg/mL) before light exposure. The soluble cellular proteins extracting from each groups were separated by two-dimensional electrophoresis and stained by silver staining. Different proteins in the profiles of the gels were analyzed by Image Master Software. Two-fold expressing protein spots were identified by Matrix-assisted laser desorption/ ionization tandem time-of-flight(MALDI-TOF/TOF) mass spectrometry. ·RESULTS: NC,M and ME groups displayed 1 892±71,2 145 ±23 and 2 216 ±85 protein spots,respectively. We identified 33 proteins with different expression levels between the NC and M groups,25 proteins between the M and ME groups,and 11 proteins between the NC and ME groups. MALDI-TOF/TOF mass spectrometry successfully identified 16 proteins,including metabolic enzymes,cytoskeletal proteins,anti-oxidation proteins,and others. ·CONCLUSION: Differences in some important proteins,such as cathepsin B,heat shock protein,and cytochrome C reductase,indicated that multiple pathways may be induced in light-damaged RPE cells and the protective effect of EGb761.

关键词： EGb761 retinal pigment epithelial cells light damage protein mass spectrographic analysis

Site-specific and seasonal variation in habitat use of Eurasian otters(Lutra lutra)in western China:implications for conservation

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Zoological Research 2021年第6期42卷 825-833页

作者： qiao-yun wang Kai-Dan zheng Xue-Song Han fang He Xiang Zhao Peng-Fei fan Lu Zhang School of Life Sciences Sun Yat-Sen UniversityGuangzhouGuangdong 510275China Shan Shui Conservation Center Beijing 100871China School of Life Sciences Peking UniversityBeijing 100871China Tangjiahe National Natural Reserve GuangyuanSichuan 628109China

As a top predator,the Eurasian otter(Lutra lutra)is an indicator of healthy freshwater ecosystems and a flagship species for *** widespread in China,the species is now distributed mainly in the upper reaches of the great rivers of western ***,a lack of knowledge on local otter populations continues to hinder their conservation in ***,we conducted a detailed study on habitat use of Eurasian otters in Yushu City and Tangjiahe National Nature Reserve in western China using transect *** both study sites,otters preferred to defecate on large rocks close to or protruding from the river and about 50 cm above the *** Yushu,no spraints were found along the 5 km river bank section in the downtown area,with otters preferring sprainting sites with natural banks,riparian zones,and lower human population ***,this pattern was not obvious at Tangjiahe,where river transformation and human disturbance are *** river use intensity was negatively correlated with elevation and human population density in Yushu in both *** Tangjiahe,otter river use intensity was positively correlated with prey mass and flow rate and negatively correlated with human population in spring,but positively correlated with human population and negatively correlated with flow rate in *** results reflect the flexible habitat use strategies of otters at different sites,underlining the necessity to study otters living in different regions and habitat *** provide suggestions for river modification and call for more site-specific studies to promote otter conservation in China.

关键词： Lutra lutra Sprainting site Habitat selection Conservation Local scale

Influence of oxygen-rich hot air composite gas medium on sintering performance and function mechanism

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Journal of Iron and Steel Research International 2024年第5期31卷 1071-1081页

作者： Min Gan Hao-xiang zheng Xiao-hui fan Zhi-yun Ji Qiang Li Ming Wu yi-fan wang Xiao-long wang Yu-feng Wu Xu-ling Chen Zeng-qing Sun Xiao-xian Huang School of Minerals Processing and Bioengineering Central South UniversityChangsha410083HunanChina Shanxi Taigang Stainless Steel Co. Ltd.Taiyuan030003ShanxiChina

Hot air sintering technology is used to improve the quality and production efficiency of sintered ***,the current thick layer condition highlights the disadvantage of the low oxygen potential of the hot air sintering ***,it is considered to use oxygen enrichment sintering to improve the environment of hot air *** sintering,hot air sintering,and oxygen-rich hot air sintering were compared through sintering cup experiments,and the influence of hot air and oxygen-rich hot air on sintering indexes was *** air reduced the vertical sintering velocity,while improved the yield and tumbler ***-rich hot air sintering contributed to improving the vertical sintering velocity while ensuring the quality of sintered ore,thus comprehensively improving production *** the action of hot air,the highest temperature of the sintering layer increased and the high-temperature holding time was *** oxygen enrichment,the combustion efficiency of fuels in the upper layer of materials was promoted,which optimized heat distribution in the middle and lower layers of materials and increased the content of calcium ferrite in the sintered ore,thus strengthening the sintering process.

关键词： Iron ore sintering Hot air sintering Oxygen enrichment Function mechanism

Laparoscopic resection and endoscopic submucosal dissection for treating gastric ectopic pancreas

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World Journal of Gastrointestinal Surgery 2023年第12期15卷 2799-2808页

作者： Hui-Da zheng qiao-yi Huang yun-Huang Hu Kai Ye Jian-Hua Xu Department of Gastrointestinal Surgery The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina Department of Gynaecology and Obstetrics The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

BACKGROUND Gastric ectopic pancreas(GEP)is a rare developmental abnormality that refers to the existence of pancreatic tissue in the stomach with no anatomical relationship with the main *** is usually difficult to diagnose through histological examination,and the choice of treatment method is *** To describe the endoscopic ultrasound characteristics of GEP and evaluate the value of laparoscopic resection(LR)and endoscopic submucosal dissection(ESD).METHODS Forty-nine patients with GEP who underwent ESD and LR in the Second Affiliated Hospital of Fujian Medical University from May 2018 to July 2023 were retrospectively *** on clinical characteristics,endoscopic ultrasonography(EUS),ESD,and LR were collected and *** characteristics of EUS and the efficacy of the two treatments were *** The average age of the patients was 43.31±13.50 years,and the average maximum diameter of the lesions was 1.55±0.70 *** lesion originated from the mucosa in one patient(2.04%),from the submucosa in 42 patients(85.71%),and from the muscularis propria in 6 patients(12.25%).Twenty-nine patients(59.20%)with GEP showed umbilical depression on *** most common initial symptom of GEP was abdominal pain(40.82%).Tumor markers,including carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9(CA19-9),were generally within the normal *** patient(2.04%)with GEP had increased CEA and CA-19-9 ***,no cancer tissue was found on postoperative pathological examination,and tumor markers returned to normal levels after resecting the *** was no significant difference in surgery duration(72.42±23.84 vs 74.17±12.81 min)or hospital stay(3.70±0.91 vs 3.83±0.75 d)between the two *** was more often used for patients with larger tumors and deeper *** amount of bleeding was significantly higher in LR than in ESD(11.28±16.87 vs 16.67±8.76 mL,P<0.05).Surgery was associated with complete resection of the lesion with

关键词： Ectopic pancreas Endoscopic ultrasonography Endoscopic submucosal dissection Laparoscopic resection

Detector performance of the Gamma-ray Transient Monitor onboard DRO-A satellite

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 75-90页

作者： Pei-yi Feng zheng-Hua An Da-Li Zhang Chen-Wei wang Chao zheng Sheng Yang Shao-Lin Xiong Jia-Cong Liu Xin-qiao Li Ke Gong Xiao-Jing Liu Min Gao Xiang-Yang Wen Ya-Qing Liu Xiao-yun Zhao fan Zhang Xi-Lei Sun Hong Lu Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China

The Gamma-ray Transient Monitor(GTM) is an all-sky monitor onboard the Distant Retrograde Orbit-A(DRO-A) satellite with the scientific objective of detecting gamma-ray transients ranging from 20 ke V to 1 MeV. The GTM was equipped with five Gamma-ray Transient Probe(GTP) detector modules utilizing a NaI(Tl) scintillator coupled with a SiPM array. To reduce the SiPM noise, GTP uses a dedicated dual-channel coincident readout design. In this work, we first studied the impact of different coincidence times on the detection efficiency and ultimately selected a 0.5 μs time coincidence window for offline data processing. To test the performance of the GTPs and validate the Monte-Carlo-simulated energy response, we conducted comprehensive ground calibration tests using the Hard X-ray Calibration Facility(HXCF) and radioactive sources, including the energy response, detection efficiency, spatial response, bias-voltage response, and temperature dependence. We extensively present the ground calibration results and validate the design and mass model of the GTP detector, thus providing the foundation for in-flight observations and scientific data analysis.

关键词： NaI(Tl)detector energy response ground calibration gamma-ray detector DRO-A satellite