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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin zhou Dan Ma yi-Xiang He jing jin Hong-lian Wang Yun-Feng Wang fan Yang Jian-Qin liu Jie Chen Zhi li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

Einstein Probe discovery of EP240408a: A peculiar X-ray transient with an intermediate timescale

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 222-240页

作者： Wenda zhang Weimin Yuan Zhixing ling Yong Chen Nanda Rea Arne Rau Zhiming Cai Huaqing Cheng Francesco Coti Zelati lixin Dai jingwei Hu Shumei Jia Chichuan jin Dongyue li Paul O’Brien Rongfeng Shen Xinwen Shu Shengli Sun Xiaojin Sun Xiaofeng Wang Lei Yang Bing zhang Chen zhang Shuang-Nan zhang Yonghe zhang Jie An David Buckley Alexis Coleiro Bertrand Cordier liming Dou Rob Eyles-Ferris zhou fan Hua Feng Shaoyu Fu Johan P.U.Fynbo Lluis Galbany Saurabh W.Jha Shuaiqing Jiang Albert Kong Erik Kuulkers Weihua Lei Wenxiong li Bifang liu Mingjun liu Xing liu Yuan liu Zhu liu Chandreyee Maitra Alessio Marino Itumeleng Monageng Kirpal Nandra Jeremy Sanders Roberto Soria lian Tao Junfeng Wang Song Wang Tinggui Wang Zhongxiang Wang Qingwen Wu Xuefeng Wu Dong Xu Yanjun Xu Suijian Xue Yongquan Xue Zijian zhang Zipei Zhu Hu Zou Congying Bao fansheng Chen Houlei Chen Tianxiang Chen Wei Chen Yehai Chen yifan Chen Chenzhou Cui Weiwei Cui Yanfeng Dai Dongwei fan Ju Guan Dawei Han Dongjie Hou Haibo Hu Maohai Huang Jia Huo Zhenqing Jia Bowen Jiang Ge jin Chengkui li Junfei li Longhui li Maoshun li Wei li Zhengda li Tianying lian Congzhan liu Heyang liu Huaqiu liu fangjun Lu Laidan Luo Jia Ma Xuan Mao Haiwu Pan Xin Pan liming Song Hui Sun Yunyin Tan Qingjun Tang yihan Tao Hao Wang Juan Wang Lei Wang Wenxin Wang yilong Wang Yusa Wang Qinyu Wu Haitao Xu jingjing Xu Xinpeng Xu Yunfei Xu Zhao Xu Changbin Xue Yulong Xue Ailiang Yan Haonan Yang Xiongtao Yang Yanji Yang Juan zhang Mo zhang Wenjie zhang Zhen zhang Zhen zhang Ziliang zhang Donghua Zhao Haisheng Zhao Xiaofan Zhao Zijian Zhao Hongyan zhou yilin zhou Yuxuan Zhu Zhencai Zhu National Astronomical Observatories Chinese Academy of Sciences School of Astronomy and Space Sciences University of Chinese Academy of Sciences Key Laboratory of Particle Astrophysics Institute of High Energy Physics Chinese Academy of Sciences Institute of Space Sciences (ICE) CSIC Institut d’Estudis Espacials de Catalunya (IEEC) Max Planck Institute for Extraterrestrial Physics Innovation Academy for Microsatellites Chinese Academy of Sciences Department of Physics University of Hong Kong School of Physics and Astronomy University of Leicester School of Physics and Astronomy Sun Yat-sen University Department of Physics Anhui Normal University Shanghai Institute of Technical Physics Chinese Academy of Sciences Physics Department Tsinghua University Nevada Center for Astrophysics University of Nevada Las Vegas Department of Physics and Astronomy University of Nevada Las Vegas South African Astronomical Observatory Department of Astronomy University of Cape Town Department of Physics University of the Free State Université Paris Cité CNRS Astroparticule et Cosmologie Université Paris Cité CEA Paris-Saclay IRFU/DAp-AIM Department of Astronomy Guangzhou University Cosmic Dawn Center (DAWN) Niels Bohr Institute University of Copenhagen Department of Physics and Astronomy Rutgers the State University of New Jersey Institute for Cosmic Ray Research The University of Tokyo ESA/ESTEC Department of Astronomy School of Physics Huazhong University of Science and Technology INAF-Osservatorio Astrofisico di Torino Sydney Institute for Astronomy School of Physics The University of Sydney Department of Astronomy Xiamen University Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University Department of Astronomy University of Science and Technology School of Astronomy and Space Sciences University of Science and Technology of China Institute of Deep Space Sciences Deep Space Exploration Laboratory Department of Astronomy School of Physics and Astronomy Yunnan University Shanghai Astronomical Observatory Chi

We report the discovery of a peculiar X-ray transient,EP240408a,by Einstein Probe （EP） and follow-up studies made with EP,Swift,NICER,GROND,ATCA and other ground-based multiwavelength *** new transient was first detected with Wide-field X-ray Telescope （WXT） on board EP on April 8th,2024,manifested in an intense yet brief X-ray flare lasting for *** flare reached a peak flux of 3.9×10-9erg cm-2s-1in 0.5-4 ke V,～300 times brighter than the underlying X-ray emission detected throughout the *** and more precise follow-up observations by EP/FXT,Swift and NICER confirmed the finding of this new *** X-ray spectrum is non-thermal in 0.5-10 ke V,with a power-law photon index varying *** X-ray light curve shows a plateau lasting for ～4 d,followed by a steep decay till becoming undetectable ～10 d after the initial *** on its temporal property and constraints from previous EP observations,an unusual timescale in the range of 7-23 d is found for EP240408a,which is intermediate between the commonly found fast and long-term *** counterparts have been found in optical and near-infrared,with the earliest observation at 17 h after the initial X-ray detection,suggestive of intrinsically weak emission in these *** demonstrate that the remarkable properties of EP240408a are inconsistent with any of the transient types known so far,by comparison with,in particular,jetted tidal disruption events,gamma-ray bursts,X-ray binaries and fast blue optical *** nature of EP240408a thus remains an *** suggest that EP240408a may represent a new type of transients with intermediate timescales of the order of～10 *** detection and follow-ups of more of such objects are essential for revealing their origin.

关键词： X-ray transients ${\bm~{Einstein~~Probe}}$

Sodium tanshinone ⅡA sulfonate prevents radiation-induced damage in primary rat cardiac fibroblasts

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Chinese Journal of Natural Medicines 2020年第6期18卷 436-445页

作者： zhou Dan YANG Wen-Ke zhang yi-fan XIE jin-Hui MA li YANG Hui-Dong li yi XIE Ping Department of Cardiology Gansu Provincial HospitalLanzhou 730000China School of Clinical Medicine Gansu University of Chinese MedicineLanzhou 730000China School of Basic Medical Science Lanzhou UniversityLanzhou 730000China Ningxia Medical University Yinchuan 750004China Gansu Provincial Hospital Lanzhou 730000China School of Stomatology Lanzhou UniversityLanzhou 730000China

This study investigated the effects of X-ray irradiation on primary rat cardiac fibroblasts(CFs) and its potential mechanism, as well as whether sodium tanshinone ⅡA sulfonate(STS) has protective effect on CFs and its possible mechanism. Our data demonstrated that X-rays inhibited cell growth and increased oxidative stress in CFs, and STS mitigated X-ray-induced injury. Enzyme-linked immuno-sorbent assay showed that X-rays increased the levels of secreted angiotensin Ⅱ(Ang Ⅱ) and brain natriuretic peptide(BNP). STS inhibited the X-ray-induced increases in Ang Ⅱ and BNP release. Apoptosis and cell cycle of CFs were analyzed using flow cytometry. X-rays induced apoptosis in CFs, whereas STS inhibited apoptosis in CFs after X-ray irradiation. X-rays induced S-phase cell cycle arrest in CFs, which could be reversed by STS. X-rays increased the expression of phosphorylated-P38/P38,cleaved caspase-3 and caspase-3 as well as decreased the expression of phosphorylated extracellular signal-regulated kinase 1/2(ERK1/2)/ERK 1/2 and B cell lymphoma 2(Bcl-2)/Bcl-2 associated X protein(BAX) in CFs, as shown by Western blotting. STS mitigated the X-ray radiation-induced expression changes of these proteins. In conclusion, our results demonstrated that STS may potentially be developed as a medical countermeasure to mitigate radiation-induced cardiac damage.

关键词： Sodium tanshinone IIA sulfonate Cardiac fibroblasts Radiation Oxidative Stress Apoptosis

Numerical and Experimental Study on Aerodynamic Performance of Small Axial Flow fan with Splitter Blades

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Journal of Thermal Science 2013年第4期22卷 333-339页

作者： Zhu lifu jin yingzi li yi jin Yuzhen Wang Yanping zhang li The Province Key Laboratory of Fluid Transmission Technology Zhejiang Sci-Tech University

To improve the aerodynamic performance of small axial flow fan, in this paper the design of a small axial flow fan with splitter blades is studied. The RNG k-e turbulence model and SIMPLE algorithm were applied to the steady simulation calculation of the flow field, and its result was used as the initial field of the large eddy simulation to calculate the unsteady pressure field. The FW-H noise model was adopted to predict aerodynamic noise in the six monitoring points. Fast Fourier transform algorithm was applied to process the pressure signal. Experiment of noise testing was done to further investigate the aerodynamic noise of fans. And then the results obtained from the numerical simulation and experiment were described and analyzed. The results show that the static characteristics of small axial fan with splitter blades are similar with the prototype fan, and the static characteristics are improved within a certain range of flux. The power spectral density at the six monitoring points of small axial flow fan with splitter blades have decreased to some extent. The experimental results show sound pressure level of new fan has reduced in most frequency bands by comparing with prototype fan. The research results will provide a proof for parameter optimization and noise prediction of small axial flow fans with high performance.

关键词： small axial flow fan splitter blades noise frequency

Nanomaterial Assisted Exosome Analysis Using Mass Spectrometry

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Chemical Research in Chinese Universities 2024年第2期40卷 237-254页

作者： zhang yi zhou Bokai li Qiuning jin Mingshi BAI Yu Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing100871P.R.China Department of Chemistry Yanbian UniversityYanji133002P.R.China

Exosomes,extracellular vesicles(EVs)that play crucial roles in biological processes,have emerged as attractive targets for noninvasive disease diagnosis and *** spectrometry(MS)offers high sensitivity,high throughput,and excellent qualification and quantification capacity,which is the ideal approach for exosome ***’unique physiochemical properties,controllable morphology,and large surface area make them promising in biological sample pretreatment and *** contributed diverse functions to the exosome MS analysis,encompassing substrates for exosome isolation and cargos enrichment,matrices for laser desorption/ionization(LDI),read-out signals and supporters for signal amplification strategies,*** this review,recent progress in the applications of nanomaterial in the exosome MS analysis was summarized and a comprehensive discussion on the challenges and perspectives was proposed for the development of an advancing analysis approach of exosomes for the accurate diagnosis and monitoring of diseases.

关键词： Exosome Nanomaterial Enrichment Matrix Mass spectrometry

IDL: Evaluating software quality based on PageRank algorithm

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The Journal of China Universities of Posts and Telecommunications 2020年第1期27卷 10-25页

作者： zhou Guoqiang fan yi zhang Shuai Wang yilun li Peng Dai Guilan School of Computer Science Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China Southwest China Institute of Electronic Technology Chengdu 610036China Institute of Information Technology Tsinghua UniversityBeijing 100084China

In the traditional method, the software quality is measured by various metrics of the software, such as decoupling level(DL), which can be used to predict software defect. However, DL, which treats all the files equally, has not taken file importance into consideration. Therefore, a novel software quality metric, named as improved decoupling level(IDL), based on the importance of documents was proposed. First, the PageRank algorithm was used to calculate the importance of files to obtain the weights of the dependencies, and then defect prediction models was established by combining the software scale, dependencies, scores and software defects to assess the software quality. Compared to most existing module-based software quality evaluation methods, IDL has similar or even superior performance in the prediction of software quality. The results indicate that IDL measures the importance of each file in the software more accurately by combining the PageRank algorithm in DL, which indirectly reflects the quality of software by predicting the bug information in software and improves the accuracy of prediction result of software bug information.

关键词： decoupling level(DL) PageRank improved decoupling level(IDL) software architecture software matrix software quality

Flexible carbon fiber-based composites for electromagnetic interference shielding

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Rare Metals 2022年第11期41卷 3612-3629页

作者： Hong-Yan zhang jin-Yao li ying Pan yi-fan liu Nasir Mahmood Xian Jian School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu611731China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China RMIT University School of EngineeringMelbourneVic3001Australia

With the rapid development of electronic information technology,the waste electromagnetic radiation generated by the wireless and various other electronic devices has caused serious harm to human *** development of high-efficiency flexible electromagnetic interference(EMI)shielding materials has become one of the most effective ways to mitigate the increasingly serious problem of electromagnetic *** carbon fiber composites possess most of the physical requirements needed for EMI shielding applications,including high electrical conductivity,large specific surface area,light weight,flexibility,porous structure,and adjustable physical and chemical properties,and various morphology of carbon fibers-based composites applied *** this review,the primary EMI shielding mechanism of carbonfiber-based materials is *** carbon fiber suffers from a low absorption efficiency when used for EMI shielding by itself,it is usually combined with additional EMI filling ***,the methods of adding EMI filler materials to the carbon fiber framework and the influence of different fillers on the EMI shielding performance are also *** addition,the novel structural designs of flexible carbon fiber-based EMI shielding materials,including fiber orientation,core-shell structure,and multilayer heterostructure,are summarized in terms of their classification,which includes composites with metal,polymer,nano-carbon,and *** review concludes with a brief discussion of the challenges,research directions,and future prospects of carbon-fiber-based EMI shielding materials.

关键词： Carbon fibers Electromagnetic interference shielding Flexible Composites

Integration of human papillomavirus 18 DNA in esophageal carcinoma 109 cells

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World Journal of Gastroenterology 2011年第37期17卷 4242-4246页

作者： Ke zhang jin-Tao li Shu-ying li li-Hua Zhu ling zhou yi Zeng College of Basic Medicine Hebei United University Tangshan 063000 Hebei Province China College of life Science and Bio-engineering Beijing University of Technology Beijing 10024 China National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention and State Key Laboratory for Infectious Disease Prevention and Control Beijing 100052 China

AIM:To detect human papillomavirus(HPV) DNA in esophageal carcinoma(EC) 109 cells and investigate the relationship between HPV and ***:Genomic DNA and total RNA from EC109 cells were *** DNA was detected by polymerase chain reaction(PCR) with the general primer sets of My09/11 and GP5 +/6 + for the HPV L1 gene and type-specific primer sets for HPV18 E6 and HPV18 *** transcription(RT) of mRNA isolated from EC109 cells was performed to produce a *** then a PCR-based protocol for the amplification of papillomavirus oncogene transcripts was used to analyze HPV18 DNA and integrated transcripts of HPV18 in the chromosomes of EC109 *** final nested PCR products were cloned into a pMD-18T vector and sequenced to analyze the chromosomal location of HPV ***:HPV18 DNA was detected in EC109 cells by PCR using the general primer sets of My09/11 and GP5 +/6 + for HPV L1 and the type-specif ic primer sets for HPV18 E6 and E6-E7 to generate products of 450 bp,150 bp,335 bp and 944 bp,*** 600 bp of integrated HPV18-specific transcript was *** final nested PCR product of integrated HPV18 DNA was cloned into a pMD-18T vector and sequenced to analyze the chromosomal location of HPV *** alignment showed that the HPV18 sequence from EC109 cells was identical to that of the encoded early protein E7-E1 of the standard HPV18 strain X05015,and another partial gene sequence was identical to a partial sequence of human chromosome ***:Integration of the HPV genome into the host cell chromosome suggests that persistent HPV infection is vital for malignant cell transformation and carcinogenesis.

关键词： Esophageal carcinoma Human papillomavirus Integration Infection Genome

Detection of maize tassels for UAV remote sensing image with an improved YOLOX Model

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Journal of Integrative Agriculture 2023年第6期22卷 1671-1683页

作者： SONG Chao-yu zhang fan li Jian-sheng XIE jin-yi YANG Chen zhou Hang zhang Jun-xiong College of Engineering China Agricultural UniversityBeijing 100083P.R.China College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100083P.R.China

Maize tassel detection is essential for future agronomic management in maize planting and breeding,with application in yield estimation,growth monitoring,intelligent picking,and disease ***,detecting maize tassels in the field poses prominent challenges as they are often obscured by widespread occlusions and differ in size and morphological color at different growth *** study proposes the SEYOLOX-tiny Model that more accurately and robustly detects maize tassels in the ***,the data acquisition method ensures the balance between the image quality and image acquisition efficiency and obtains maize tassel images from different periods to enrich the dataset by unmanned aerial vehicle(UAV).Moreover,the robust detection network extends YOLOX by embedding an attention mechanism to realize the extraction of critical features and suppressing the noise caused by adverse factors(e.g.,occlusions and overlaps),which could be more suitable and robust for operation in complex natural *** results verify the research hypothesis and show a mean average precision(mAP_(@0.5)) of 95.0%.The mAP_(@0.5),mAP_(@0.5-0.95),mAP_(@0.5-0.95(area=small)),and mAP_(@0.5-0.95(area=medium)) average values increased by 1.5,1.8,5.3,and 1.7%,respectively,compared to the original *** proposed method can effectively meet the precision and robustness requirements of the vision system in maize tassel detection.

关键词： maize tassel detection remote sensing deep learning attention mechanism