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Journal of Integrative Plant Biology 2010年第9期52卷 829-843页

作者： yi deng wei wang wen-qing li chuan xia hong-ze liao xue-qin zhang de ye State Key-Laboratory of Pla-nt Physiology and Biochemistry College of Biological Sciences China Agricultural University Beijing 100193 China

Sialyltransferases （SlaTs） exist widely in vertebrates and play important roles in a variety of biological processes. In plants, several genes have also been identified to encode the proteins that share homology with the vertebrate SlaTs. However, very little is known about their functions in plants. Here we report the identification and characterization of a novel Arabidopsis gene, MALE GAMETOPHYTE deFECTIVE 2 （MGP2） that encodes a sialyltransferase-like protein. MGP2 was expressed in all tissues including pollen grains and pollen tubes. The MGP2 protein was targeted to Golgi apparatus. Knockout of MGP2 significantly inhibited the pollen germination and retarded pollen tube growth in vitro and in vivo, but did not affect female gametophytic functions. These results suggest that the sialyltransferase-like protein MGP2 is important for normal pollen germination and pollen tube growth, giving a novel insight into the biological roles of the *** proteins in plants.

关键词： Plants Planting Proteins Protein products Imports Genes Vertebrates Pollen tubes Growth Germinability

10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang li li‑Jiao wang Jing‑Yu Tang xiang‑Biao Qiu Zhen Chen Mao‑Yuan Zhao Chang‑Jun Ning Kai Pan wei Xu Tao li Su‑Peng Lu Han yi Rui‑Rui Fan Chang‑qing Feng Rong zhang xiao‑Yang Sun Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Yong‑Hao Chen zeng‑Qi Cui An‑chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang hong yi‑wei Hu Han‑Xiong Huang wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin ling Kang Bo li Gong li xiao li Yang li Jie liu Rong liu Shu‑Bin liu yi‑Na liu Guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Kang Sun Zhi‑Xin Tan Sheng‑Da Tang Jin‑Cheng wang Peng‑Cheng wang Zhao‑Hui wang Zhong‑wei wen xiao‑Guang Wu Xuan Wu Cong xia Yong‑Ji Yu Guo‑Hui zhang Hang‑Chang zhang lin‑Hao zhang Qi‑wei zhang xian‑Peng zhang Yu‑liang zhang Yue zhang Zhi‑Yong zhang Zhi‑Hao Zhou Ke‑Jun Zhu Chong Zou Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research Institute Co.Ltd Nanjing 211106China department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China China Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China China Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the China Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

CEPC Technical design Report

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Radiation detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili deng Binglin denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai wenyong Cai Wujun Cai yijian Cai yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance xuejun Chang Yue Chang Zhe Chang Xinyuan Chang wei Chao Auttakit Chatrabhuti yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen wei Chen xiang Chen xiaoyu Chen Xin Chen Xun Chen Xurong Chen ye Chen ying Chen Yukai Chen zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti wen Han Chiu Guk Cho Ming-Chung Chu xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio de Maria Nicola de Filippis Christophe de La Taille Francesca de Mori Chiara de Sio Elisa del Core Shuangxue deng wei-Tian deng Zhi deng Ziyan deng Bhupal dev Tang dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian deutsches Elektronen-Synchrotron deSY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical design Report(TDR)follows the Preliminary Conceptual design Report(Pre-CDR,2015)and the Conceptual design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

The first data release(DR1) of the LAMOST regular survey

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Research in Astronomy and Astrophysics 2015年第8期15卷 1095-1124页

作者： A-li Luo Yong-Heng Zhao Gang Zhao li-Cai deng xiao-wei liu yi-Peng Jing Gang wang Hao-Tong zhang Jian-Rong Shi xiang-Qun Cui Yao-Quan Chu Guo-Ping li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen li Chen xue-Lei Chen xiao-Yan Chen ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui yi-Qiao Dong Bing Du Dong-wei Fan Lei Feng Jian-Ning Fu Peng Gao xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-wen Han Bo-liang He Jin-liang Hou Yong-Hui Hou wen Hou hong-Zhuan Hu Ning-Sheng Hu Zhong-wen Hu Zhi-ying Huo Lei Jia Fang-Hua Jiang xiang Jiang Zhi-Bo Jiang Ge Jin xiao Kong Xu Kong Ya-Juan Lei Ai-Hua li Chang-Hua li Guang-wei li Hai-Ning li Jian li Qi li Shuang li Sha-Sha li Xin-Nan li Yan li yin-Bi li ye-Ping li Yuan liang Chien-Cheng lin Chao liu Gen-Rong liu Guan-Qun liu Zhi-Gang liu wen-Zhi Lu Yu Luo yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-xiang Qi Yong-Jun Qi Shi-yin Shen Huo-Ming Shi Jing Song yi-Han Song Ding-Qiang Su hong-Jun Su Zheng-hong Tang qing-Sheng Tao Yuan Tian Dan wang Da-Qi wang Feng-Fei wang Guo-Min wang Hai wang hong-Chi wang Jian wang Jia-Ning wang Jian-ling wang Jian-Ping wang Jun-xian wang Lei wang Meng-Xin wang Shou-Guan wang Shu-qing wang xia wang Ya-Nan wang You wang Yue-Fei wang You-Fen wang Peng wei Ming-Zhi wei hong Wu Ke-Fei Wu xue-Bing Wu Yu-Zhong Wu xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan de-Hua Yang Hai-Feng Yang Hui-qin Yang Ming Yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan wei-Min Yuan Chao Zhai En-Peng zhang Hua-wei zhang Jian-Nan zhang li-Pin zhang wei zhang Yong zhang Yan-xia zhang Zheng-Chao zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo National Astronomical Observatories Chinese Academy of Sciences department of Astronomy Peking University Shanghai Astronomical Observatory Chinese Academy of Sciences Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences University of Science and Technology of China department of Physics Applied Physics and AstronomyRensselaer Polytechnic InstituteTroyNY 12180USA department of Physics and Astronomy Earlham CollegeRichmondIN 47374USA Universitt Heidelberg Zentrum für AstronomieLandessternwarteKnigstuhl 1269117 HeidelbergGermany department of Astronomy Beijing Normal University Yunnan Observatories Chinese Academy of Sciences Purple Mountain Observatory Chinese Academy of Sciences

The Large sky Area Multi-Object Fiber Spectroscopic Telescope（LAMOST） general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio（SNR） ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters： late A,FGK-type stars with high quality spectra（1 061 918 entries）, A-type stars（100 073 entries）, and M-type stars（121 522 entries）. This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided.

关键词： techniques: spectroscopic survey—data release—catalog

detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun liu Dan-Dan li wei Dong Yu-Qi liu Yang Wu Da-Xuan Tang Fu-Chun zhang Meng Qiu Qi Hua Jing-Yu He Jun li Bai Du Ting-Hai Du lin-lin Niu xue-Jun Jiang Bo Cui Jiang-Bin Chen Yang-Gan wang Hai-Rong wang qin Yu Jing He yi-lin Mao xiao-Fang Bin Yue deng Yu-Dan Tian qing-Hua Han Da-Jin liu li-qin Duan Ming-Jun Zhao Cui-ying zhang Hai-ying Dai ze-Hua li ying xiao You-Zhi Hu xiao-Yu Huang Kun Xing Xin Jiang Chao-Feng liu Jing An Feng-Chun li Tao Tao Jin-Fa Jiang ying Yang Yao-Rong Dong Lei zhang Guang Fu ying li Shu-wei Huang li-Ping Dou Lan-Jun Sun ying-Qiang Zhao Jie li Yun xia Jun liu Fan liu wen-Jin He ying li Jian-Cong Tan Yang lin Ya-Bin Zhou Jian-Fei Yang Guo-qing Ma Hui-Jun Chen He-Ping liu Zong-Wu liu Jian-Xiong liu xiao-Jia Luo xiao-hong Bin Ya-Nan Yu Hai-xia Dang Bing li Fei Teng wang-Min Qiao xiao-Long Zhu Bing-wei Chen Qi-Guang Chen Chun-Ti Shen Yong-Yan wang Yun-Dai Chen Zhong wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina department of Cardiology Chinese PLA General HospitalBeijingChina department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina department of Geratology Peking University Third HospitalBeijingChina department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian University DalianLiaoningChina department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina department of Cardiology Changsha Central HospitalChangshaHunanChina department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina department of Cardiology Shanghai Tongji HospitalShanghaiChina department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina department of Cardiology The First Hospital of ChangshaChangshaHunanChina department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(deMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline(updated version)

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Military Medical Research 2020年第3期7卷 249-282页

作者： ying-Hui Jin qing-Yuan Zhan Zhi-Yong Peng xue-Qun Ren Xun-Tao yin lin Cai Yu-Feng Yuan Ji-Rong Yue xiao-Chun zhang Qi-wen Yang Jianguang Ji Jian xia yi-Rong li Fu-xiang Zhou Ya-Dong Gao Zhui Yu Feng Xu Ming-li Tu li-Ming Tan Min Yang Fang Chen xiao-Ju zhang Mei zeng Yu Zhu Xin-Can liu Jian Yang Dong-Chi Zhao Yu-Feng Ding Ning Hou Fu-Bing wang Hao Chen Yong-Gang zhang wei li wen Chen Yue-xian Shi Xiu-Zhi Yang xue-Jun wang Yan-Jun Zhong Ming-Juan Zhao Bing-Hui li lin-Lu Ma Hao Zi Na wang Yun-Yun wang Shao-Fu Yu Lu-Yao li Qiao Huang hong weng xiang-ying Ren li-Sha Luo Man-Ru Fan Di Huang hong-Yang xue lin-Xin Yu Jin-Ping Gao Tong deng xian-Tao zeng hong-Jun li Zhen-Shun Cheng xiao-Mei Yao Xing-Huan wang Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical Research Center for Respiratory Diseases China-Japan Friendship HospitalBeijing 100029China department of Pulmonary and Critical Care Medicine China-Japan Friendship HospitalBeijing 10029China Leishenshan Hospital in Wuhan Wuhan 430200China department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institutes of Evidence-based Medicine and Knowledge Translation Henan UniversityKaifeng 475000HenanChina department of Medical Imaging Guizhou Provincial People’s HospitalGuiyang 550002China departments of Orthopedics Zhongnan Hospital of Wuhan UniversityWuhan 430071China department of Hepatobiliary Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Clinical Research Center for Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China department of Geriatrics West China Hospital of Sichuan UniversityChengdu 610041China department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China department of Clinical Laboratory Peking Union Medical College Hospital(PUMCH)Peking Union Medical CollegeChinese Academy of Medical Sciences(CAMS)Beijing 100730China Center for Primary Health Care Research Lund University and Region Skåne25002 MalmöSweden Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 403371China department of Allergology Zhongnan Hospital of Wuhan UniversityWuhan 430071China department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 43071China department of Critical Care Medicine Renmin Hospital of Wuhan UniversityWuhan 430060China department of Emergency Medicine and Chest Pain Center Qilu Hospital of Shandong UniversityJinan 250002China department of Respiratory and Critical Care Medicine Suizhou Central HospitalHubei University of MedicineSuizhou 441300HubeiChina department of Clinic Pharmacy Second People’s Hospital of Huaihua Ci

The novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the cause of a rapidly spreading illness,coronavirus disease 2019(COVID-19),affecting more than seventeen million people around the *** and treatment guidelines for clinicians caring for patients are *** the early stage,we have issued"A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV)infected pneumonia(standard version)";now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based *** formed a working group of clinical experts and *** steering group members proposed 29 questions that are relevant to the management of COVID-19 covering the following areas:chemoprophylaxis,diagnosis,treatments,and discharge *** searched the literature for direct evidence on the management of COVID-19,and assessed its certainty generated recommendations using the Grading of Recommendations,Assessment,development and Evaluation(GRAde)*** were either strong or weak,or in the form of ungraded consensus-based ***,we issued 34 *** them,6 were strong recommendations for,14 were weak recommendations for,3 were weak recommendations against and 11 were ungraded consensus-based *** covered topics of chemoprophylaxis(including agents and Traditional Chinese Medicine(TCM)agents),diagnosis(including clinical manifestations,reverse transcription-polymerase chain reaction(RT-PCR),respiratory tract specimens,IgM and IgG antibody tests,chest computed tomography,chest X-ray,and CT features of asymptomatic infections),treatments(including lopinavirritonavir,umifenovir,favipiravir,interferon,remdesivir,combination of antiviral drugs,hydroxychloroquine/chloroquine,interleukin-6 inhibitors,interleukin-1 inhibitors,glucocorticoid,qingfei paidu decoction,lianhua qingwen granules/capsules,convalescent plasma,lung

关键词： COVID-19 SARS-CoV-2 Recommendation Chemoprophylaxis Diagnosis Treatment Discharge management Traditional Chinese medicine guideline

The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST

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Research in Astronomy and Astrophysics 2019年第11期19卷 33-48页

作者： Bo Chen Hui li Ke-Fei Song Quan-Feng Guo Pei-Jie zhang ling-Ping He Shuang Dai xiao-Dong wang Hai-Feng wang Chun-Long liu hong-Ji zhang Guang zhang Yunqi wang Shi-Jie liu hong-Xin zhang Lei liu Shi-Lei Mao Yang liu Jia-Hao Peng Peng wang liang Sun Yang liu Zhen-wei Han Yan-Long wang Kun Wu Guang-Xing Ding Peng Zhou Xin Zheng Ming-yi xia qing-wen Wu Jin-Jiang Xie Ya Chen Shu-Mei Song hong wang Bo Zhu Chang-Bo Chu wen-Gang Yang li Feng Yu Huang wei-Qun Gan ying li Jing-wei li Lei Lu Jian-Chao xue Bei-li ying Ming-Zhe Sun Cheng Zhu wei-Min Bao Lei deng zeng-Shan yin Changchun Institute of Optics FineMechanics and PhysicsChinese Academy of SciencesChangchun 130033China State Key Laboratory of Applied Optics Changchun 130033China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China Shandong University Weihai 264209China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201210China

As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,*** maximum exposure time can be up to20 s due to precise pointing and image stabilization *** the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attainline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal *** present the up-to-date design for the LST payload.

关键词： telescopes—instrumentation high angular resolution—Sun flares—Sun coronal mass ejections(CMEs)—Sun UV radiation

The DIRECT consortium and the REST-meta-MDD project:towards neuroimaging biomarkers of major depressive disorder

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Psychoradiology 2022年第1期2卷 32-42页

作者： xiao Chen Bin Lu Hui-xian li xue-ying li Yu-wei wang Francisco Xavier Castellanos li-Ping Cao Ning-Xuan Chen wei Chen Yu-Qi Cheng Shi-xian Cui Zhao-Yu deng yi-Ru Fang Qi-Yong Gong wen-Bin Guo Zheng-Jia-yi Hu li Kuang Bao-Juan li Le li Tao li Tao lian yi-Fan liao Yan-Song liu Zhe-Ning liu Jian-Ping Lu qing-Hua Luo Hua-qing Meng Dai-Hui Peng Jiang Qiu Yue-Di Shen Tian-Mei Si Yan-qing Tang chuan-Yue wang Fei wang Hua-Ning wang Kai wang xiang wang ying wang Zi-Han wang xiao-Ping Wu Chun-Ming Xie Guang-Rong Xie Peng Xie Xiu-Feng Xu hong Yang Jian Yang Shu-Qiao Yao Yong-Qiang Yu Yong-Gui Yuan Ke-Rang zhang wei zhang Zhi-Jun zhang Jun-Juan Zhu Xi-Nian Zuo Jing-Ping Zhao Yu-Feng Zang the DIRECT consortium Chao-Gan Yan CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China International Big-Data Center for depression Research Chinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China department of Psychology University of Chinese Academy of SciencesBeijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Graduate University of Chinese Academy of SciencesBeijing 101408China department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew YorkNY 10016USA Nathan Kline Institute for Psychiatric Research OrangeburgNew YorkNY 10962USA 9Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370China Capital Normal University Beijing 100089China department of Psychiatry Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020ZhejiangChina department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China Huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengduSichuan 610044China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengduSichuan 610052China department of Psychiatry and National Clinical Research Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011HunanChina department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Xijing Hospital of Air Force Military Medical University Xi’anShaanxi 710032China Center for Cognitive Science of Language Beijing Language and Culture UniversityBeijing 100083China Affiliated Mental Health Center&Hangzhou Seventh People’s Hospital Zhejiang University School of

despite a growing neuroimaging literature on the pathophysiology of major depressive disorder(MDD),repro-ducible findings are lacking,probably reflecting mostly small sample sizes and heterogeneity in analytic *** address these issues,the depression Imaging REsearch ConsorTium(DIRECT)was *** REST-meta-MDD project,pooling 2428 functional brain images processed with a standardized pipeline across all participating sites,has been the first effort from *** this review,we present an overview of the moti-vations,rationale,and principal findings of the studies so far from the REST-meta-MDD *** from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network,in whole-brain topological properties,in dynamic features,and in functional *** well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven *** these fruitful explorations,DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations.A state-of-the-art,surface-based preprocessing pipeline has also been introduced to improve *** images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diag-nosis *** addition,large-scale longitudinal studies targeting brain network alterations following antidepressant treatment,aggregation of diffusion tensor images,and the development of functional magnetic resonance imaging-guided neuromodulation approaches are *** these endeavours,we hope to accelerate the translation of functional neuroimaging findings to clinical use,such as evaluating longitudinal effects of antidepressant medications and developing individualized

关键词： major depressive disorder DIRECT R-fMRI database neuroimaging

Malnutrition and Quality of life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects

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Journal of Nutritional Oncology 2021年第1期6卷 16-32页

作者： hong xia Xu Chun Hua Song Zhen Ming Fu Chang wang zeng qing Guo Yuan lin ying ying Shi wen Hu yi Ba Su yi li zeng Ning li Kun Hua wang Jing Wu ying He Jia Jun Yang Cong Hua Xie Fu xiang Zhou Xin xia Song Gong Yan Chen wen Jun Ma Su xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun ling Zhou wei wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang wen xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao li Jun wen Ou qing chuan Zhao Jian Xiong Wu Min weng qing Hua Yao Jiu wei Cui wei li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group department of Nutrition Daping Hospital&Research Institute of SurgeryThird Military Medical UniversityChongqing 400042China department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Cancer Center Renmin Hospital of Wuhan UniversityWuhan 430060HubeiChina Cancer Center of the First Hospital of Jilin University Changchun 130021JilinChina department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014FujianChina department of Gastrointestinal Surgery Cancer Hospital Affiliated to Guangxi Medical UniversityNanning 530021GuangxiChina department of Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080GuangdongChina department of Clinical Nutrition West China Hospital of Sichuan UniversityChengdu 610041SichuanChina department of Gastrointestinal Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin Key Laboratory of Cancer Prevention and TherapyTianjin 300060China department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical UniversityHefei 230031AnhuiChina department of Clinical Nutrition the First Hospital of Hebei Medical UniversityShijiazhuang 050031HebeiChina department of Gastrointestinal Surgery Institute of Gastroenterologythe First Affiliated Hospital of Kunming Medical University 650032KunmingYunnanChina department of Clinical Nutrition the First People's Hospital of KashiKashi 844000XinjiangChina department of Clinical Nutrition Chongqing General HospitalChongqing 400014China department of Colorectal and Anal Surgery Huizhou Municipal Central HospitalHuizhou 516001GuangdongChina department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan UniversityWuhan 430071HubeiChina department of Oncology Xingtai People’s HospitalHebei Medical UniversityXingtai 054031HebeiChina Harbin Medical University Cancer Hospital Harbin 150085HeilongjiangChina

Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even ***,there is currently no large data available on the prevalence of malnutrition in Chinese cancer *** study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic *** We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)*** of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal *** patients were enrolled from 72 hospitals located in different regions of *** patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)*** cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,*** From december 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the *** patients included 12,494(52.9%)males and 11,124(47.1%)*** mean age was 55.8±13.7 *** proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,*** the 23,994 inpatients,the proportions of patients who were underweight(BMIweight(24 kg/m2≤BMI<28 kg/m2)and obese(BMI≥2

关键词： Nutritional status Nutritional assessment Malnutrition Patient generated subjective global assessment Body mass index Body weight loss Karnofsky Performance Status score Quality of life

Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients

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Journal of Nutritional Oncology 2016年第1期1卷 52-58页

作者： Zhen Ming Fu hong xia Xu Chun Hua Song wei li zeng qing Guo Yuan lin ying ying Shi wen Hu yi Ba Su yi li zeng Ning li Kun Hua wang Jing Wu ying He Jia Jun Yang Cong Hua Xie Xin xia Song Gong Yan Chen wen Jun Ma Su xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun ling Zhou wei wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang wen xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao li Jun wen Ou qing chuan Zhao Jian Xiong Wu Chang wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group Cancer Center Renmin Hospital of Wuhan University Wuhan Hubei 430060 China department of Nutrition and Metabolism of Oncology Affiliated Provincial Hospital of Anhui Medical University Hefei Anhui 230031 China department of Clinical Nutrition The First Hospital of Hebei Medical University Shijiazhuang Hebei 050031 China department of Gastrointestinal Surgery Institute of Gastroenterology The First Affiliated Hospital of Kunming Medical University Kunming Yunnan 650032 China department of Clinical Nutrition The First People's Hospital of Kashi Xinjiang 844000 China department of Clinical Nutrition Chongqing General Hospital Chongqing 400014 China department of Colorectal and Anal Surgery Huizhou Municipal Central Hospital Huizhou Guangdong 516001 China department of Radiation and Medical Oncology Zhongnan Hospital of Wuhan University Wuhan Hubei 430071 China department of Oncology Xingtai People’s Hospital Hebei Medical University Xingtai Hebei 054031 China The First department of the Tumor Hospital of Harbin Medical University Harbin Heilongjiang 150085 China department of Nutrition Guangdong General Hospital Guangdong Academy of Medical Sciences Guangzhou Guangdong 510080 China department of Nutrition Daping Hospital & Research Institute of Surgery Third Military Medical University Chongqing 400042 China department of Oncology Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital Zhengzhou Henan 450008 China department of General Surgery Xiangya Hospital Central South University Changsha Hunan 410008 China Comprehensive Oncology department Cancer Hospital Chinese Academy of Medical Sciences Beijing 100021 China department of Oncology Affiliated Hospital of Zunyi Medical University Zunyi Guizhou 563000 China The Fourth Affiliated Hospital Harbin Medical University Harbin Heilongjiang 150001 China Cancer center The First People's Hospital of Foshan Foshan Guangdong 528000 China department of Gastrointestinal Tumor Surge

The prevalence of malnutrition is high among oncology patients in China. Although the Patient- Generated Subjective Global Assessment (PG-SGA) is widely recognized as an important nutritional assessment tool, it has not been validated for Chinese cancer patients. The purpose of this study was to conduct an analysis of nutrition screening and assessment data to validate the Chinese version of the PG-SGA in Chinese patients with lung cancer. This was an observational, cross-sectional study of 2,000 consecutive adult patients with lung cancer treated at several tertiary hospitals in China. Anthropometric and patient descriptive data were collected. The PG-SGA generated a score for the nutritional risk and a global rating for the nutritional status. The internal consistency, external consistency, and construct validity were evaluated, and a known-groups comparison and principal component analyses were conducted to evaluate the reliability and validity of the PG-SGA. The known-groups comparison demonstrated the ability of the PG-SGA to differentiate lung cancer patients of different nutritional and body mass index (BMI) groups. A confirmatory factor analysis supported the original four-factor structure of the PG-SGA. In terms of the internal and external consistency, the PG-SGA demonstrated intra-class correlation coefficients (ICC) up to 0.987. Alternative form validity was also demonstrated between Box 4 of the PG-SGA and the Karnofsky Performance Status score, with excellent external consistency (r = 0.972, P lidity was supported, and selected questionnaire dimensions were evident in the principal component analysis. Significant Spearman correlations (P demonstrated. The Chinese version of the PG-SGA demonstrated significant reliability and sufficient exploratory properties to support its validity. It seems to be a valid tool that can be used to access the nutritional status of Chinese lung cancer patients. The validity of the P

关键词： Validation Nutrition status PG-SGA Chinese version Cancer