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Reconfigurable logic and in-sensor encryption operations in an asymmetrically tunable van der Waals heterostructure

Nano Research 2024年第4期17卷 3113-3119页

作者： Fan Gong Wenjie Deng yi Wu Fengming Liu yihao Guo Zelin Che Jingjie Li Jingzhen Li Yang chai Yongzhe Zhang Key Laboratory of Optoelectronics Technology of Education Ministry of China Faculty of Information TechnologyBeijing University of TechnologyBeijing 100124China Key Laboratory of Advanced Functional Materials Ministry of EducationFaculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Department of Applied Physics Hong Kong Polytechnic UniversityKowloonHong KongChina

Reconfigurable devices can be used to achieve multiple logic operation and intelligent optical sensing with low power consumption,which is promising candidates for new generation electronic and optoelectronic integrated ***,the versatility is still limited and need to be extended by the device architectures ***,we report an asymmetrically gate two-dimensional(2D)van der Waals heterostructure with hybrid dielectric layer SiO_(2)/hexagonal boron nitride(h-BN),which enable rich function including reconfigurable logic operation and in-sensor information encryption enabled by both volatile and non-volatile optoelectrical *** the partial gate is grounded,the non-volatile light assisted electrostatic doping endowed partially reconfigurable doping between n-type and p-type,which allow the switching of logic XOR and not implication(NIMP).When the global gate is grounded,additionally taking the optical signal as another input signal,logic AND and OR is realized by combined regulation of the light and localized gate *** on the high on/off current ratio approaching 105 and reliable&switchable logic gate,in-sensor information encryption and decryption is demonstrated by manipulating the logic ***,these results provide strong extension for current reconfigurable electronic and optoelectronic devices.

关键词： in-sensor encryption reconfigurable logic van der Waals heterostructure asymmetrical tunable architecture

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Enzymatic recovery of glycopeptides from different industrial grades edible bird’s nest and its by-products:nutrient,probiotic and antioxidant activities,and physicochemical characteristics

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Food Science and Human Wellness 2022年第6期11卷 1555-1564页

作者： Hidayati Syamimi Mohd Noor Rafi dah Mohd Ariff Lee Sin Chang Xin yi chai Hui Yan Tan Nur’Aliah Daud Abdul Salam Babji Seng Joe Lim Faculty of Science and Technology Universiti Kebangsaan MalaysiaBangi 43600Malaysia International Institute for Halal Research and Training(INHART) International Islamic University Malaysia(IIUM)Jalan Gombak 53100Malaysia Faculty of Applied Sciences UCSI University Kuala LumpurCheras 56000Malaysia Faculty of Agriculture Science and Technology Universiti Putra Malaysia Bintulu CampusBintulu 97008Malaysia Innovative Centre for Confectionery Technology(MANIS) Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaBangi 43600Malaysia

This study was conducted to recover edible bird’s nest(EBN)hydrolysates from different grades of EBN,including the industrial by-products,using enzymatic *** nutrient,physicochemical properties and antioxidant activities of the recovered hydrolysates at different hydrolysis times were *** showed that the recovery yield of enzymatic hydrolysis was above 89%for all grades of EBN and the degree of hydrolysis increased over *** content(0.321-0.433 mg/L)was below the permissible tolerance level for all ***,the antioxidant activities(DPPH and ABTS scavenging activities and ferric reducing antioxidant powder(FRAP)activity)were significantly higher(P≤0.05)in hydrolysates recovered from EBN by-products(EBNhC and EBNhD)as compared to the high grade EBN hydrolysates(EBNhA and EBNhB).The in-vitro probiotic activity of EBN and its hydrolysates were examined using the probiotic bacterium Lactobacillus ***,EBN by-products hydrolysate(EBNhD)recorded the highest number of ***(1.1×1011 CFU/mL),indicating that low grade EBN has the potential as prebiotic material that promotes probiotic *** study demonstrated the concept of using EBN by-products hydrolysates for various applications,such as functional ingredients with enhanced bioactivities,to improve its economic value.

关键词： Edible bird’s nest by-products Enzymatic hydrolysis Glycopeptides Lactobacillus plantarum Probiotic activity

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Crosstalk between PC 12 cells and endothelial cells in an artificial neurovascular niche constructed by a dual-functionalized selfassembling peptide nanofiber hydrogel

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Nano Research 2022年第2期15卷 1433-1445页

作者： Zhe Zhang yi chai He Zhao Shuhui Yang Wei Liu Zihui Yang Weilong Ye Chenlong Wang Xiaohan Gao Xiangdong Kong Xiaodan Sun Lingyun Zhao Tuoyu Chen Yuqi Zhang Jiaju Lu Xiumei Wang State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Neurosurgery Yuquan HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 100084China Institute of Smart Biomedical Materials School of Materials Science and EngineeringZhejiang Sci-Tech UniversityHangzhou 310018China Department of orthopedics Dongzhimen hospitalBeijing University of Chinese MedicineBeijing 100700China Department of Neurosurgery The First Hospital of Hebei Medical UniversityShijiazhuang 050000China Department of Obstetrics and Gynecology Beijing Tsinghua Changgung HospitalBeijing 102218China Department of Chemistry Tsinghua UniversityBeijing 100084China

The coordination between neurogenesis and angiogenesis plays an important role in nerve tissue development and ***,using bioactive materials to drive neurogenic and angiogenic responses has gained increasing *** the neurovascular link between regulatory cues offers valuable insight into the mechanisms underlying nerve regeneration and the design of new bioactive *** this study,we utilized a dual-functionalized peptide nanofiber hydrogel presenting the brain-derived neurotrophic factor and vascular endothelial growth factor mimetic peptides RGIDKRHWNSQ(RGI)and KLTWQELYQLKYKGI(KLT)to construct an artificial neurovascular *** dual-functionalized peptide nanofiber hydrogel enhanced the neurite outgrowth of pheochromocytoma(PC12)cells and tube-like structures formation of human umbilical vein endothelial cells(HUVECs)in vitro,and promoted rapid lesion infiltration of neural and vascular cells in a rat brain injury *** indirect co-culture models,we found that the dual-functionalized peptide hydrogel effectively mediated neurovascular crosstalk by regulating secretion of paracrine factors from PC12 cells and *** the two cells types were directly co-cultured on the dua卜functionalized peptide hydrogel,the efficiency of cell-cell communication was enhanced,which further accelerated the differentiation and maturation of PC12 cells with an increased number of pseudopodia and spread morphology,and HUVECs tube-like structure *** summary,the dual-functionalized peptide nanofiber hydrogel successfully formed an artificial neurovascular niche to directly regulate the behaviors of neural and vascular cells and promote their neurovascular crosstalk through paracrine signaling and direct cell-cell contact.

关键词： neurovascular microenvironment self-assembling peptide co-culture nanofiber hydrogel brain injury

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Nonlinear fusion estimation for false data injection attack signals in cyber-physical systems

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Science China(Information Sciences) 2023年第7期66卷 309-310页

作者： Yawen TAN Pindi WENG Bo CHEN Li YU Department of Automation Zhejiang University of Technology Institute of Cyberspace Security Zhejiang University of Technology

Cyber-physical systems(CPSs) that integrate computation,network, and physical objects play essential roles in the era of Industry 4.0 [1, 2]. However, the introduction of networks makes it face the threat of cyber-attacks [3]. Among various types of cyber-attacks, a false data injection(FDI) attack degrades the estimation performance for CPSs by injecting wrong signals and is one of the most dangerous attacks [4,5]. Therefore, the joint estimation of FDI attacks and system states is of great significance to the security of CPSs.

关键词： Iterative methods

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LC-MS/MS analysis and pharmacokinetic study on five bioactive constituents of Tanreqing injection in rats

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Chinese Journal of Natural Medicines 2016年第10期14卷 769-775页

作者： ZHANG Feng SUN Liang GAO Shou-Hong CHEN Wan-Sheng chai yi-Feng Department of Pharmacy Changzheng HospitalSecond Military Medical University Department of Pharmaceutical Analysis School of Pharmacy Second Military Medical University Department of Pharmacy The 98th Hospital of PLA

Tanreqing injection(TRQ), a well-known traditional Chinese medicine formula, is commonly used to treat respiratory diseases. In the present study, a rapid, selective, and sensitive liquid chromatography-tandem mass spectrometry(LC-MS/MS) method was developed and validated to simultaneously determinate the plasma contents of 5 major constituents of TRQ, including chlorogenic acid(CHA), caffeic acid(CFA), baicalin(BA), ursodeoxycholic acid(UDCA) and chenodeoxycholic acid(CDCA) in rats after intravenous administration of TRQ. Chromatographic separation was performed on an Agilent Zorbax SB-C_(18) column(3.5 μm, 100 mm × 2.1 mm), with acetonitrile and 0.1% aqueous formic acid as mobile phase at a flow rate of 0.3 m L·min^(^(-1)). The calibration curves were linear over the ranges of 27.0–13 333.0 ng·m L^(-1) for CFA, 30.0–14 933.0 ng·m L^(-1) for CHA, 50.0–50 333.0 ng·m L^(-1) for BA, 550.0–55 000.0 ng·m L^(-1) for UDCA, and 480.0–48 000.0 ng·m L^(-1) for CDCA, respectively. Intra- and inter-day precisions(relative standard deviations, RSDs) were from 3.11% to 14.08%. The extraction recoveries were greater than 71% and accuracy(relative recovery) was from 89% to 137% for all analytes, except endogenous bile acids. This validated method was successfully applied to the first pharmacokinetic study of CFA, CHA, BA, UDCA and CDCA in rat plasma after intravenous administration of TRQ.

关键词： Tanreqing Injection Flavones Phenolic acids Bile acids Pharmacokinetics

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Ptip safeguards the epigenetic control of skeletal stem cell quiescence and potency in skeletogenesis

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Science Bulletin 2024年第13期69卷 2099-2113页

作者： Jianfei Liang Jing Wang Bingdong Sui yibo Tong Jihua chai Qin Zhou Chenxi Zheng Hao Wang Liang Kong Haojian Zhang yi Bai State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool&Hospital of StomatologyTaikang Center for Life and Medical SciencesWuhan UniversityWuhan 430079China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an 710004China Department of Implant Dentistry College of StomatologyXi’an Jiaotong UniversityXi’an 710004China State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyShaanxi International Joint Research Center for Oral DiseasesCenter for Tissue EngineeringSchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyDepartment of Oral and Maxillofacial SurgerySchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China Department of Hematology Zhongnan HospitalWuhan UniversityWuhan 430079China Frontier Science Center for Immunology and Metabolism Medical Research InstituteWuhan UniversityWuhan 430079China Taikang Center for Life and Medical Sciences Wuhan UniversityWuhan 430079China

Stem cells remain in a quiescent state for long-term maintenance and preservation of potency;this process requires fine-tuning regulatory *** this study,we identified the epigenetic landscape along the developmental trajectory of skeletal stem cells(SSCs)in skeletogenesis governed by a key regulator,Ptip(also known as Paxip1,Pax interaction with transcription-activation domain protein-1).Our results showed that Ptip is required for maintaining the quiescence and potency of SSCs,and loss of Ptip in type II collagen(Col2)^(+)progenitors causes abnormal activation and differentiation of SSCs,impaired growth plate morphogenesis,and long bone *** also found that Ptip suppressed the glycolysis of SSCs through downregulation of phosphoglycerate kinase 1(Pgk1)by repressing histone H3 lysine 27 acetylation(H3K27ac)at the promoter ***,inhibition of glycolysis improved the function of SSCs despite Ptip *** the best of our knowledge,this is the first study to establish an epigenetic framework based on Ptip,which safeguards skeletal stem cell quiescence and potency through metabolic *** framework is expected to improve SSC-based treatments of bone developmental disorders.

关键词： Skeletal stem cells Bone development Epigenetics Ptip Glycolysis

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浅议网上政府的房地产业管理

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重庆建筑大学学报 2000年第4期22卷 65-70页

作者：柴毅吴德夫重庆建筑大学管理学院重庆400045

政府是现代经济生活的主体 ,在世界各国积极倡导的“信息高速公路”的五个应用领域中 ,“电子政府”被列为第一位。本文对我国“电子政府”的房地产业管理的现状进行了分析 ,指出了存在的不足 ,提出了构建网上政府房地产业管理初步框架... 详细信息

政府是现代经济生活的主体 ,在世界各国积极倡导的“信息高速公路”的五个应用领域中 ,“电子政府”被列为第一位。本文对我国“电子政府”的房地产业管理的现状进行了分析 ,指出了存在的不足 ,提出了构建网上政府房地产业管理初步框架的建议 ,有助于促进房地产业管理的规范化和现代化建设。

关键词：政府互联网房地产管理

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The existence verification of barrier function with application to synchronous safety and stability

The existence verification of barrier function with applicat...

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第32届中国过程控制会议(CPCC2021)

作者： Zheren Zhu yi chai Zhihuan Song Xinmin Zhang IEEE State Key Laboratory of Industrial Control Technology College of Control Science and EngineeringZhejiang University State Key Laboratory of Power Transmission Equipment and System Security and New Technology and School of AutomationChongqing University

This paper mainly discusses the existence of barrier function which can guarantee a dynamic system synchronously safe and ***,scholars will use the terms "if there exists a barrier function" for most related *** this paper,we use a particular case to verify the existence of barrier function and whether it can realize stabilization with guaranteed safety,such as synchronously realizing safety and asymptotic stability,safety and uniform asymptotic stability,safety and exponential stability,and safety and finite-time *** think this paper can help to know the safety under the definitions of barrier functions and realize the safety-and-stability control.

关键词： Existence of barrier function synchronous safety and stability pre-compact forward invariant set and dynamic nonlinear system

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Research on Detection Method of UAV Based on micro-Doppler Effect

Research on Detection Method of UAV Based on micro-Doppler E...

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第三十九届中国控制会议

作者： Shuo Li yi chai Maoyun Guo Yunling Liu Key Laboratory of complex system safety and control Ministry of Education

With the wide application of small UAV, its negative effects begin to appear gradually. Therefore, it is of great significance to detect UAV. Because the micro Doppler effect of objects is different under the radar, the UAV can be detected by the time-frequency characteristics of the target micro Doppler signal. In this paper, the radar echo of the UAV rotor is simulated and analyzed by using the scattering point integral model. The results show that the UAV can be detected according to the time-frequency characteristics of the micro Doppler signal generated by the UAV rotor rotation. In this paper, Discrete Wavelet Transform is used to remove the environment clutter in radar signal, Singular Value Decomposition is used to extract the timefrequency characteristics of signal, and finally Support Vector Machine is used as classifier to detect UAV. The experiment shows that the detection accuracy can reach 85%.

关键词： UAV micro Doppler detection

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Identification of Early Esophageal Cancer Based on Data Augmentation

Identification of Early Esophageal Cancer Based on Data Augm...

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第三十九届中国控制会议

作者： Xinyi Li yi chai Weiqing Chen Fei Ao Complex system safety and control Key Laboratory of Ministry of EducationSchool of AutomationChongqing University Chongqing University Cancer Hospital

With the improvement of technology, computer-aided technology is playing an increasingly important role in medical diagnosis. Early detection of esophageal cancer has a high probability of cure, so reducing the rate of missed diagnosis is very important for patients. Due to the particularity of medical images, the image data of early esophageal cancer is very ***, we propose a new noise-filtered image augmentation method. After processing the original dataset using this method, a new image is generated to form the augmented the new dataset. The new dataset and the simple dataset are used in the early esophageal cancer recognition algorithm based on YOLOv3-Tiny for transfer learning to obtain training models. The experimental results show that the sensitivity of early esophageal cancer is improved after using the noise-filtered augmentation method. Therefore, the proposed noise-filtered image augmentation method can be applied in the recognition of early esophageal cancer.

关键词： Early esophageal cancer Data augmentation Noise-filtered augmentation method YOLOv3-Tiny

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