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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3343-3349页

作者： Chun-Yan Niu Bang-tao Yao Hua-yi tao Xin-Gui Peng Qing-Hua Zhang Yue Chen Lu Liu Department of Gastroenterology Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing 211200Jiangsu ProvinceChina Department of Ophthalmology Nanjing Lishui People’s HospitalNanjing 211200Jiangsu ProvinceChina Department of Medical Imaging Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing 210009Jiangsu ProvinceChina

BACKGROUND Thrombocytopenia is a common complication of invasive liver abscess syndrome(ILAS)by Klebsiella pneumoniae(***)infection,which indicates severe infection and a poor ***,the presence of leukopenia is *** are rare reports on leukopenia and its clinical significance for ILAS,and there is currently no recognized treatment *** and broad-spectrum antimi-crobial therapy may be an effective therapy for treating ILAS and improving its *** SUMMARY A 55-year-old male patient who developed fever,chills,and abdominal distension without an obvious cause presented to the hospital for *** tests revealed thrombocytopenia,leukopenia,and multiple organ *** examinations revealed an abscess in the right lobe of the liver and thromboph-lebitis,and *** was detected in the blood *** the patient was diabetic and had multi-system involvement,he was diagnosed with ILAS accom-panied by leukopenia and *** antibiotic treatment and sys-temic supportive therapy,the symptoms disappeared,and the patient’s condition almost completely *** Leukopenia is a rare complication of ILAS,which serves as an indicator of adverse prognostic outcomes and the severity of infection.

关键词： Invasive liver abscess syndrome Klebsiella pneumoniae Leukopenia Thrombocytopenia Treatment Prognosis Case report

The remarkable effect of amino hydrogen on membrane permeability and organelle staining of 1,8-naphthalimide dyes

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Chinese Chemical Letters 2024年第2期35卷 347-351页

作者： Zhifeng Li Qinglong Qiao Ning Xu Kai An Wenchao Jiang yi tao Pengjun Bao yinchan Zhang Zhaochao Xu School of Chemistry Dalian University of TechnologyDalian 116024China CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China

Membrane permeability and intracellular diffusion of fluorescent probes determine staining selectivity of intracellular ***,the relationship between the molecular structure of fluorescent probes and their membrane permeability and intracellular distribution is poorly *** this paper,we reported a series of 1,8-naphthalimide dyes and carried out cell imaging experiments,and found that the presence of amino hydrogen in these dyes played a crucial role in their cell membrane permeability and intracellular *** secondary amino group containing compounds 1-4 show excellent membrane permeability and strong fluorescence in living *** the tertiary amine containing dyes 5 and 6 can hardly permeate the cell membrane though they show extremely similar structure with compounds *** 1 can selectively image lipid droplets by selecting the wavelength of excitation *** the specificity for lysosomes,2 and 4 have been used in long-term time-lapses imaging of lysosomal dynamics and tracking the process of lysosome-lysosome interaction,fusion and *** effect of hydrogen-containing amino substituent on the cell membrane permeability of fluorescent molecules is promising for the development of better biocompatible probes.

关键词： Amino hydrogen 1,8-Naphthalimide Cell permeability Lipid droplet Lysosome

Ni-B/TiO_2 Amorphous Catalyst Used in Heavy Arenes of Petrochemicals Hydrogenation

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Chinese Chemical Letters 2001年第12期12卷 1123-1126页

作者： Qing Yan CHENG Wei LI ying ZHOU Ming Hui ZHANG Nai Jia GUAN Ke yi tao Department of Material Chemistry Nankai UniversityTianjin 300071

A supported Ni-B/TiO2 amorphous catalyst was prepared by impregnation and reduction. It was characterized by XRD, SAED, DSC, XPS, etc.. The catalytic activity of catalyst was measured through the hydrogenation of he... 详细信息

关键词： Hydrogenation heavy arenas petrochemicals Ni-B/TiO2 amorphous catalyst.

Targeted migration of mesenchymal stem cells modified with CXCR4 to acute failing liver improves liver regeneration

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World Journal of Gastroenterology 2014年第40期20卷 14884-14894页

作者： Hu-Cheng Ma Xiao-Lei Shi Hao-Zhen Ren Xian-Wen Yuan yi-tao Ding Department of Hepatobiliary Surgery the Affiliated Drum Tower Hospital of Nanjing University Medical School Key Medical Center for Hepatobiliary Diseases of Jiangsu Province

AIM: To improve the colonization rate of transplanted mesenchymal stem cells (MSCs) in the liver and effect of MSC transplantation for acute liver failure (ALF).

关键词： Acute liver failure Cell transplantation Chemokine CXC receptor 4 Mesenchymal stem cells Cell mobilization

Infection within 2 weeks before liver transplantation closely related to prognosis of posttransplant infection:A single-center retrospective observational study in China

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Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 358-364页

作者： Yue ying Rui-Dong Li Jing-Wen Ai yi-Min Zhu Xian Zhou yi-yi Qian Xin-Chang Chen Xu-Yang Wang Hao-Cheng Zhang Yang Li Shan-Shan Weng yi-Qi Yu yi-Feng tao Yu-Xian Huang Zheng-Xin Wang Wen-Hong Zhang Department of Infectious Diseases Huashan HospitalFudan UniversityShanghai 200040China Department of General Surgery Huashan HospitalFudan UniversityShanghai 200040China

Background:Infections still represent the main factors influencing morbidity and mortality following liver *** study aimed to evaluate the incidence and risk factors for infection and survival after liver ***:We retrospectively examined medical records in 210 liver recipients who underwent liver transplantation between April 2015 and October 2017 in our *** manifestations and results of pathogen detection test were used to define *** analyzed the prevalence,risk factors and prognosis of patients with ***:The median follow-up was 214 days;the incidence of infection after liver transplantation was 46.7%(n=98)which included pneumonia(43.4%),biliary tract infection(21.9%),peritonitis(21.4%)and bloodstream infection(7.6%).Among the pathogens in pneumonia,the most frequently isolated was Acinetobacter baumanii(23.5%)and Klebsiella pneumoniae(21.2%).Model for end-stage liver disease(MELD)score(OR=1.083,95%CI:1.045–1.123;P<0.001),biliary complication(OR=4.725,95%CI:1.119–19.947;P=0.035)and duration of drainage tube(OR=1.040,95%CI:1.007–1.074;P=0.017)were independent risk factors for posttransplant ***-cause mortality was 11.0%(n=23).The prognostic factors for postoperative infection in liver recipients were prior-transplant infection,especially pneumonia within 2 weeks before ***-Meier curves of survival showed that recipients within 2 weeks prior infection had a significantly lower cumulative survival rate compared with those without infection(65.2%vs.90.0%;hazard ratio:4.480;P<0.001).Conclusions:Infection,especially pneumonia within 2 weeks before transplantation,complication with impaired renal function and MELD score after 7 days of transplantation was an independent prognostic factor for postoperative infection in liver transplant recipients.

关键词： Infection Liver transplantation Risk factors MELD score

Simulation-based optimization of inner layout of a theater considering the effect of pedestrians

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Chinese Physics B 2020年第3期29卷 285-291页

作者： Qing-Fei Gao yi-Zhou tao Yan-Fang Wei Cheng Wu Li-Yun Dong Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai UniversityShanghai 200072China College of Science Shanghai Institute of TechnologyShanghai 201418China College of Physical Science and Technology Yulin Normal UniversityYulin 537000China Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai 200072China

We propose an extended cellular automaton model based on the floor field. The floor field can be changed accordingly in the presence of pedestrians. Furthermore, the effects of pedestrians with different speeds are distinguished, i.e., still pedestrians result in more increment of the floor field than moving ones. The improved floor field reflects impact of pedestrians as movable obstacles on evacuation process. The presented model was calibrated by comparing with previous studies. It is shown that this model provides a better description of crowd evacuation both qualitatively and *** we investigated crowd evacuation from a middle-size theater. Four possible designs of aisles in the theater are studied and one of them is the actual design in reality. Numerical simulation shows that the actual design of the theater is *** we optimize the position of the side exit in order to reduce the evacuation time. It is shown that the utilization of the two exits at bottom is less than that of the side exits. When the position of the side exit is shifted upwards by about 1.6 m,it is found that the evacuation time reaches its minimum.

关键词： cellular automaton floor field crowd evacuation optimization of pedestrian facilities

Effect of early enteral combined with parenteral nutrition in patients undergoing pancreaticoduodenectomy

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World Journal of Gastroenterology 2013年第35期19卷 5889-5896页

作者： Xin-Hua Zhu Ya-Fu Wu Yu-Dong Qiu Chun-Ping Jiang yi-tao Ding Department of Hepatobiliary Surgery Affiliated Drum Tower Hospital Medical School of Nanjing University

AIM:To investigate the effect of early enteral nutrition(EEN)combined with parenteral nutritional support in patients undergoing pancreaticoduodenectomy(PD).METHODS:From January 2006,all patients were given EEN combined with parenteral nutrition(PN)(EEN/PN group,n=107),while patients prior to this date were given total parenteral nutrition(TPN)(TPN group,n=67).Venous blood samples were obtained for a nutrition-associated assessment and liver function tests on the day before surgery and 6 d after *** assessment of clinical outcome was based on postoperative ***-up for infectious and noninfectious complications was carried out for 30 d after hospital *** within 30 d afterdischarge was also ***:Compared with the TPN group,a significant decrease in prealbumin(PAB)(P=0.023)was seen in the EEN/PN *** bilirubin(TB),direct bilirubin(DB)and lactate dehydrogenase(LDH)were significantly decreased on day 6 in the EEN/PN group(P=0.006,0.004 and 0.032,respectively).The rate of gradeⅠcomplications,gradeⅡcomplications and the length of postoperative hospital stay in the EEN/PN group were significantly decreased(P=0.036,0.028and 0.021,respectively),and no hospital mortality was observed in our *** with the TPN group(58.2%),the rate of infectious complications in the EEN/PN group(39.3%)was significantly decreased(P=0.042).Eleven cases of delayed gastric emptying were noted in the TPN group,and 6 cases in the EEN/PN *** rate of delayed gastric emptying and hyperglycemia was significantly reduced in the EEN/PN group(P=0.031 and P=0.040,respectively).CONCLUSION:Early enteral combined with PN can greatly improve liver function,reduce infectious complications and delayed gastric emptying,and shorten postoperative hospital stay in patients undergoing PD.

关键词： Enteral nutrition Parenteral nutrition Pancreaticoduodenectomy Complications Metabolism

Gegen Qinlian decoction enhances immunity and protects intestinal barrier function in colorectal cancer patients via gut microbiota

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World Journal of Gastroenterology 2020年第48期26卷 7633-7651页

作者： Yang Li Zhong-Xin Li Chen-Yang Xie Jing Fan Ji Lv Xin-Jian Xu Jian Lv Wen-tao Kuai yi-tao Jia Department of Oncology Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina Department of Oncology Affiliated Hospital of Hebei UniversityBaoding 071000Hebei ProvinceChina Second Department of Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Surgery The First Hospital of QinhuangdaoQinhuangdao 066000Hebei ProvinceChina Department of Thoracic Surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Emergency Hebei General HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND We previously showed,using the Traditional Chinese Medicine System Pharmacology Database,that Gegen Qinlian decoction(GQD)had a direct antitumor effect,and was combined with programmed cell death protein(PD)-1 inhibitors to treat microsatellite stable(MSS)tumor-bearing ***,the effect of GQD on patients with colorectal cancer(CRC)is not *** To determine the therapeutic mechanism of GQD in improving immune function,reducing inflammation and protecting intestinal barrier *** Seventy patients with CRC were included in this study:37 in the control group and 33 in the treatment *** proportions of CD4+T,CD8+T,natural killer(NK),NKT and T regulatory cells were measured by flow *** of the cytokines tumor necrosis factor(TNF)-α,interferon(IFN)-γ,interleukin(IL)-2,IL-6,IL-10 and serotonin(5-hydroxytryptamine;5-HT)in serum were assessed by enzyme-linked immunosorbent assay(ELISA).The expression of zonula occludens(ZO)-1,occludin,nuclear factor(NF)-κB and TNF-αin tumor and normal tissues was measured by *** composition of gut microbiota from patients in the treatment group was assessed using 16S rDNA *** There were no adverse events in the treatment *** proportion of CD4+T cells and NKT cells in the post-treatment group was significantly higher than that in the pre-treatment and control groups(P<0.05).The level of TNF-αin the posttreatment group was significantly lower than that in the pre-treatment and control groups(P<0.05).The concentration of 5-HT in the post-treatment group was significantly lower than that in the pre-treatment group(P<0.05).The expression of ZO-1 and occludin in tumor tissues in the treatment group was significantly higher than that in the control group(P<0.05).The expression of ZO-1 in normal tissues of the treatment group was significantly higher than that in the control group(P=0.010).Compared with the control group,expression of NF-κB and TNF-αin tumor tis

关键词： Colorectal cancer Gegen Qinlian decoction Immunity Inflammation Intestinal barrier function Gut microbiota

SDC1 acts as a novel molecular marker and prevents rheumatoid arthritis and modulates inflammatory response by targeting the miR-4531/SDC1 axis

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Medical Data Mining 2023年第1期6卷 17-27页

作者： yi-Wen tao Jin-Song Su yi Zhang Yong Zeng Xian-Li Meng Shao-Hui Wang State Key Laboratory of Southwestern Chinese Medicine Resources School of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China State Key Laboratory of Southwestern Chinese Medicine Resources School of Ethnic MedicineChengdu University of Traditional Chinese MedicineChengdu 611137China

Objective:Rheumatoid arthritis(RA)is a systemic autoimmune disease characterized by chronic erosive *** to the lack of effective biomarkers for diagnosis and treatment,RA patients have many complications in the later stage,seriously affecting their quality of ***,this study was conducted to investigate new therapeutic targets and to discover diagnostic biomarkers in ***:In this study,the expression profiles of GSE55235 and GSE55457 were downloaded from the Gene Expression Omnibus database to obtain DEGs between RA and healthy *** Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed on the common genes existing in the RA-related ***,we used the STRING database to construct the protein‒protein interaction ***,we established the interaction analysis of Hub Genes and microRNA(miRNA)and verified the 10 Hub genes through the GSE77298 dataset and quantitative real-time polymerase chain reaction Results:276 and 69 DEGs were screened from the GSE55235 dataset and GSE55457 dataset,***,we obtained 42 up-regulated genes in two chip datasets *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of the 42 up-regulated genes showed that they were mainly concentrated in immune response-activating cell surface receptor signaling pathway,***,the protein-protein interaction network indicated that 10 hub genes are closely related to RA,including MS4A1,CD27,LCK,CD79A,SDC1,CXCL9,CXCL10,CXCL13,IGLL5,and *** addition,we found that miR-4531 is the same target miRNAs between MS4A1 and SDC1 through messenger RNA-miRNA co-expression ***,the GSE77298 gene chip and quantitative real-time polymerase chain reaction verified the expression of 10 Hub *** six Hub genes of CD27,SDC1,CXCL9,CXCL10,CXCL13,and IGJ are significantly ***:We found that SDC1 may be a novel molecular marker for the

关键词： SDC1 rheumatoid arthritis molecular marker microRNA miR-4531/SDC1 axis

L4-to-L4 nerve root transfer for hindlimb hemiplegia after hypertensive intracerebral hemorrhage

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Neural Regeneration Research 2022年第6期17卷 1278-1285页

作者： Teng-Da Qian Xi-Feng Zheng Jing Shi tao Ma Wei-Yan You Jia-Huan Wu Bao-Sheng Huang yi tao Xi Wang Ze-Wu Song Li-Xin Li Department of Neurosurgery Jintan HospitalAffiliated Hospital of Jiangsu Vocational College of MedicineJintanJiangsu ProvinceChina Department of Gastroenterology Jintan HospitalAffiliated Hospital of Jiangsu Vocational College of MedicineJintanJiangsu ProvinceChina Department of Neurosurgery Changzhou First People’s HospitalSuzhou UniversityChangzhouJiangsu ProvinceChina Deparment of Neurobiology Basic Medical CollegeNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurosurgery Sir Run Run Hospital Affiliated to Nanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurosurgery Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurosurgery First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina

There is no effective treatment for hemiplegia after hypertensive intracerebral *** that the branches of L4 nerve roots in the lumbar plexus root control the movement of the lower extremity anterior and posterior muscles,we investigated a potential method of nerve repair using the L4 nerve *** models of hindlimb hemiplegia after a hypertensive intracerebral hemorrhage were established by injecting autogenous blood into the posterior limb of internal *** L4 nerve root on the healthy side of model rats was transferred and then anastomosed with the L4 nerve root on the affected side to drive the extensor and flexor muscles of the *** investigated whether this method can restore the flexible movement of the hindlimbs of paralyzed rats after hypertensive intracerebral *** a beam-walking test and ladder rung walking task,model rats exhibited an initial high number of slips,but improved in accuracy on the paretic side over *** 17 weeks after surgery,rats gained approximately 58.2%accuracy from baseline performance and performed ankle motions on the paretic *** 9 weeks after surgery,a retrograde tracing test showed a large number of fluoro-gold-labeled motoneurons in the left anterior horn of the spinal cord that supports the L4-to-L4 nerve *** addition,histological and ultramicrostructural findings showed axon regeneration of motoneurons in the anterior horn of the spinal *** and paw print analysis showed that denervated hindlimb muscles regained reliable innervation and walking coordination *** findings suggest that the L4-to-L4 nerve root transfer method for the treatment of hindlimb hemiplegia after hypertensive intracerebral hemorrhage can improve the locomotion of hindlimb major joints,particularly of the distal *** from study support that the L4-to-L4 nerve root transfer method can effectively repair the hindlimb hemiplegia after hypertensive intracerebral hemorrh

关键词： central hemiplegia end-to-end anastomosis functional regeneration hypertensive intracerebral hemorrhage L4 nerve root neural regeneration neurotization rat model reinnervation skilled restoration