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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： shengyang Zhou Ting li Wei Zhang Jian Wu Hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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流体脉宽调制控制系统的建模与仿真

系统仿真学报 2003年第2期15卷 171-172,178页

作者：杨云沈毅力李天石西安交通大学机械工程学院陕西西安710049

流体脉宽调制PWM(Pulse Width Modulation)控制系统是一类本质非线性控制系统,并且由于流体控制阀的响应速度限制,调制频率不可能很高,系统的分析和设计比较困难。本文对流体双极性PWM控制系统,基于谐波平衡原理,建立了系统的线性化谐... 详细信息

流体脉宽调制PWM(Pulse Width Modulation)控制系统是一类本质非线性控制系统,并且由于流体控制阀的响应速度限制,调制频率不可能很高,系统的分析和设计比较困难。本文对流体双极性PWM控制系统,基于谐波平衡原理,建立了系统的线性化谐波模型,便于用成熟的线性系统理论对系统进行分析和综合。系统仿真试验显示,建立的模型具有较好的逼近能力,能够较好的反映系统的特性。

关键词：流体脉宽调制控制系统建模仿真非线性控制系统

Inter-Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding, Sensing and Thermal Management

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NANO-MICRO LETTERS 2025年第1期17卷 1-18页

作者： li, Xufeng Chen, Chunyan li, Zhenyang yi, Peng Zou, Haihan Deng, Gao Fang, Ming He, Junzhe Sun, Xin Yu, Ronghai Shui, Jianglan Pan, Caofeng liu, Xiaofang Beihang Univ Sch Mat Sci & Engn Beijing 100191 Peoples R China Beihang Univ Inst Atom Mfg Beijing 100191 Peoples R China Tianmushan Lab Xixi Octagon City Hangzhou 310023 Peoples R China Beijing Inst Environm Features Sci & Technol Electromagnet Scattering Lab Beijing 100854 Peoples R China

Unique inter-skeleton conductive films are constructed in polymer *** resistance change of the foam can reach four orders of magnitude under *** foam exhibits strain-adaptive electromagnetic interference shielding performance, anti-interference pressure sensor with high sensitivity over a wide pressure range and compression-regulated Joule heating function. Conductive polymer foam (CPF) with excellent compressibility and variable resistance has promising applications in electromagnetic interference (EMI) shielding and other integrated functions for wearable electronics. However, its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during deformation. Here, an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under compression. Unique inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton (denoted as AMLM-PM foam). Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive films. Therefore, the resistance change of AMLM-PM reaches four orders of magnitude under compression. Moreover, the inter-skeleton conductive films can improve the mechanical strength of foam, prevent the leakage of liquid metal and increase the scattering area of EM wave. AMLM-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness, solving the problem of traditional CPFs upon compression. The upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam liquid metal Electromagnetic interference shielding

有为政府与有效市场下的我国职业教育治理:理论逻辑与实践路径

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高校教育管理 2025年第1期19卷 62-73页

作者：李政邱懿华东师范大学职业教育与成人教育研究所上海200062 中华人民共和国教育部职业教育与成人教育司北京100816 北京大学教育学院北京100871

政府与市场的关系是职业教育内外部治理关系的核心,先后经历了政府主导论、市场基础论、有为政府与有效市场论的演变。在有为政府与有效市场的关系形塑下,职业教育治理改革应实现三大转变,即政府治理方式应从事后响应转变为事前布局,职... 详细信息

政府与市场的关系是职业教育内外部治理关系的核心,先后经历了政府主导论、市场基础论、有为政府与有效市场论的演变。在有为政府与有效市场的关系形塑下,职业教育治理改革应实现三大转变,即政府治理方式应从事后响应转变为事前布局,职业院校治理角色应从代理主体转变为改革先锋,市场主体参与治理的动机应从短期利益转变为战略投资。政府、职业院校和市场的关系应由单向的“影响回应”关系转变为双向的“并行互动”关系。当前,我国政府参与职业教育治理的权责边界不清,职业院校办学自主权无法满足发展需求,市场主体参与职业教育缺乏战略自觉。为此,我国应加强各级政府的政策协作,提升政府政策的精准度和前瞻性;优化职业院校组织定位和内部治理模式,提升学校治理的灵活性和有效性;深度分析企业发展的外部条件和内部需求,提升企业发展的积极性和适应性。

关键词：职业教育治理有为政府有效市场全面深化改革办学自主权

贵州省少数民族人群胆结石与心血管疾病的关联及肾小球滤过率的中介效应分析

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现代预防医学 2024年第18期51卷 3434-3441页

作者：申毅力钟建琴胡宇欣杨婷婷王媛肖斐洪峰贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室

目的探讨贵州省少数民族人群胆结石与心血管疾病的关联及肾小球滤过率在关联中的中介效应，为减轻心血管疾病负担提供参考建议。方法本研究基于“西南区域少数民族聚集地世居自然人群队列研究”数据库，采用分层、多阶段整群抽样，于2... 详细信息

目的探讨贵州省少数民族人群胆结石与心血管疾病的关联及肾小球滤过率在关联中的中介效应，为减轻心血管疾病负担提供参考建议。方法本研究基于“西南区域少数民族聚集地世居自然人群队列研究”数据库，采用分层、多阶段整群抽样，于2018—2019年在贵州省黔东南州、黔南州对30～79岁少数民族人群展开基线调查，通过多因素logistic回归分析胆结石与心血管疾病的关联，中介效应模型评估肾小球滤过率在关联中的中介效应。结果贵州省少数民族人群心血管疾病检出率为3.16%,其中侗族、苗族、布依族检出率分别为3.27%、3.07%、3.12%,胆结石总检出率为9.03%。Logistic回归分析显示，调整所有协变量后(模型3),在总人群[OR(95%CI):1.633(1.269～2.102)]、侗族[OR(95%CI):1.567(1.077～2.280)]、苗族[OR(95%CI):1.679(1.055～2.673)]中，胆结石与心血管疾病呈正相关。在布依族人群，胆结石与心血管疾病之间不存在关联。亚组分析显示，侗族<60岁胆结石患者与心血管疾病呈正相关[OR(95%CI):1.825(1.022～3.258)]、未患高脂血症的胆结石患者[OR(95%CI):2.151(1.352～3.422)]、未患高血压的胆结石患者[OR(95%CI):1.612(1.013～2.565)]与心血管疾病存在正相关。苗族≥60岁[OR(95%CI):1.878(1.038～3.397)]、男性[OR(95%CI):1.546(1.212～5.586)]、BMI≥24[OR(95%CI):1.972(1.160～3.354)]、有高血压的胆结石患者[OR(95%CI):2.264(1.297～5.429)]与心血管疾病呈正相关。中介分析发现，在总人群、侗族、苗族、布依族人群中，肾小球滤过率在胆结石与心血管疾病之间的中介效应占比分别为16.96%、12.08%、17.43%、14.52%。结论贵州省侗族、苗族人群中胆结石与心血管疾病呈正相关，尤其在苗族超重、高血压人群。在布依族人群中胆结石与心血管疾病之间不存在关联。肾小球滤过率在胆结石与心血管疾病之间存在部分中介效应。

关键词：心血管疾病胆结石中介分析关联亚组分析

Merging bound states in the continuum in an open acoustic resonator

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem S.Pilipchuk Sibo Huang Chen shen Almas F.Sadreev Yong li Andrey E.Miroshnichenko School of Physics and Electronic Sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University School of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and Friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of Fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

带挠性附件三轴稳定卫星姿态动力学状态空间模型研究

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上海航天 2016年第3期33卷 55-60页

作者：梁永红李建勋沈毅力上海交通大学电子信息与电气工程学院上海200240 上海卫星工程研究所上海200240

对带挠性附件三轴稳定卫星姿态动力学状态空间模型建立进行了研究。用混合坐标法建立带挠性附件的卫星的动力学方程,对挠性体的高阶模态作截断处理以简化模型。用小角度近似获得了以姿态角表示的刚体卫星线性化姿态动力学方程,给出了卫... 详细信息

对带挠性附件三轴稳定卫星姿态动力学状态空间模型建立进行了研究。用混合坐标法建立带挠性附件的卫星的动力学方程,对挠性体的高阶模态作截断处理以简化模型。用小角度近似获得了以姿态角表示的刚体卫星线性化姿态动力学方程,给出了卫星姿态动力学方程状态空间方程,将卫星的挠性附件振动耦合作用作为一种外部干扰力矩叠加到线性方程中,建立了完整的带挠性附件三轴卫星姿态动力学方程的状态空间模型。以某带单翼太阳电池板的卫星作为算例,设计了基于状态空间模型的控制器,结果表明基于状态空间模型设计的高阶线性控制器能对具非线性时变特性的卫星进行有效控制,对帆板等挠性附件的振动有主动抑制功能。

关键词：三轴稳定卫星挠性附件姿态混合坐标法动力学方程状态空间模型线性方程外部干扰力矩控制器

The Support of a Refinable Vector Satisfying an Inhomogeneous Refinement Equation

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Acta Mathematica Sinica,English Series 2010年第4期26卷 691-698页

作者： Song li yi shen Department of Mathematics Zhejiang University Hangzhou 310027 P. R. China

In this paper, we investigate the support of a refinable vector satisfying an inhomoge- neous refinement equation. By using some methods introduced by So and Wang, an estimate is given for the support of each component function of a compactly supported refinable vector satisfying an inhomogeneous matrix refinement equation with finitely supported masks.

关键词： support inhomogeneous refnement equation refinable vector

Near optimal condition of OMP algorithm in recovering sparse signal from noisy measurement

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Journal of Systems Engineering and Electronics 2014年第4期25卷 547-553页

作者： Jia li Qiang Wang yi shen School of Astronautics Harbin Institute of Technology

This paper analyzes the performance of the orthogonal matching pursuit （OMP） algorithm in recovering sparse signals from noisy measurement. Considering the fact that some matrices satisfy some restricted isometry properties （RIPs） but not the coherence condition, a superior RIP-based condition is proposed, which means that if the measurement matrix satisfies δk＋1 〈 1/（2 ＋ √k） and the minimum component signal-to-noise ratio （MCSNR） is bounded, the OMP algorithm can exactly identify the support of the original sparse signal within k iterations. Finally, the theoretical results are verified by numerical simulations con- cerning different values of MCSNR and noise levels.

关键词： compressive sensing (CS) orthogonal matching pur-suit (OMP) measurement matrix sufficient condition.