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Mesospheric tide comparisons at low latitudes observed by two collocated meteor radars

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Earth and Planetary Physics 2025年第1期9卷 54-68页

作者： Jian li Wen yi XiangHui Xue Jie Zeng HaiLun Ye JianYuan Wang JinSong Chen Na li TingDi Chen Chinese Academy of Sciences(CAS)Key Laboratory of Geospace Environment Department of Geophysics and Planetary SciencesUniversity of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology Anhui Mengcheng Geophysics National Observation and Research StationUniversity of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China National Key Laboratory of Electromagnetic Environment China Research Institute of Radiowave PropagationQingdao 266107China Yunnan Kunming Electromagnetic Environment National Observation and Research Station Qujing Kunming 655000China

Accurate knowledge of mesospheric winds and waves is essential for studying the dynamics and climate in the mesosphere and lower thermosphere(MLT)*** this study,we conduct a comparative analysis of the mesosphere tidal results obtained from two adjacent meteor radars at low latitudes in Kunming,China,from November 2013 to December *** two radars operate at different frequencies of 37.5 MHz and 53.1 MHz,***,overall good agreement is observed between the two radars in terms of horizontal winds and tide *** results show that the dominant tidal waves of the zonal and meridional winds are diurnal and semidiurnal ***,we conduct an exhaustive statistical analysis to compare the tidal amplitudes and vertical wavelengths recorded by the dual radar systems,which reveals a high degree of alignment in tidal *** investigation includes variances and covariances of tidal amplitudes,which demonstrate remarkable consistency across measurements from both *** finding highlights clear uniformity in the mesospheric tidal patterns observed at low latitudes by the two neighboring meteor *** of the comparative analysis specifically underscore the significant correlation in vertical wavelength measurements,validating the robustness of radar observations for tidal research.

关键词： mesosphere and lower thermosphere region meteor radar mesospheric winds tides

The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao Tai Meng-Lu liu Shuaipeng Ma Tianjin shen Yuhua Zou Chun-li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli li Jianhua Huang Di Zhao Lemei Zhu Zheyu Zhang Min yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong liu Xiaolin li Xiaowei Zhou Wei Chen Aidong Wen Minna liu yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

贵州省少数民族心脏代谢指数与高尿酸血症的关联性研究

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现代预防医学 2024年第16期51卷 2887-2891+2917页

作者：吴申燕张宇馨陈成周恩慧申毅力胡宇欣洪峰贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室

目的研究贵州省少数民族心脏代谢指数(CMI)对高尿酸血症(HUA)的关联关系。方法基于“中国多民族队列研究”,共纳入16 630名30～79岁苗族、侗族、布依族人群作为研究对象。Logistic回归模型分析CMI与HUA的关系，限制性立方样条分析CMI... 详细信息

目的研究贵州省少数民族心脏代谢指数(CMI)对高尿酸血症(HUA)的关联关系。方法基于“中国多民族队列研究”,共纳入16 630名30～79岁苗族、侗族、布依族人群作为研究对象。Logistic回归模型分析CMI与HUA的关系，限制性立方样条分析CMI与HUA的剂量-反应关系，采用ROC曲线分析CMI对HUA的预测价值。结果 HUA总体检出率为22.8%,苗族、侗族、布依族人群分别为22.8%、24.4%、25.2%、18.5%。在总人群、苗、侗、布依族人群中，调整协变量后，与Q1相比，CMI Q4组患HUA的OR分别为4.39(95%CI:3.76～5.12)、3.96(95%CI:3.03～5.18)、4.28(95%CI:3.36～5.46)、5.55(95%CI:4.08～7.54),CMI与HUA风险之间呈非线性剂量-反应关系(P for nonlinear <0.001)。ROC曲线分析显示，CMI在总人群、苗、侗、布依族人群中预测HUA患病风险的曲线下面积(最佳截断值、灵敏度、特异度)分别为0.742(0.641、68.3%、68.8%), 0.724(0.651、63.8%、70.8%)0.741(0.654、68.5%、68.1%)、0.775(0.555、68.8%、73.0%)。结论 CMI对不同民族人群HUA患病风险增加有关，可作为预测贵州省少数民族人群HUA的指标。

关键词：心脏代谢指数高尿酸血症剂量反应关系 ROC分析

贵州省少数民族人群体重矫正腰围指数与心血管疾病的关联性研究

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现代预防医学 2024年第15期51卷 2689-2694页

作者：申毅力吴申燕钟建琴胡宇欣陈成张宇馨洪峰贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室

目的了解贵州省少数民族人群体重矫正腰围指数（weight adjusted waist index,WWI）与心血管疾病之间的关联性。方法基于“西南区域少数民族聚集地世居自然人群队列研究”，于2018—2019年在贵州省黔东南、黔南地区对30～79岁侗族、... 详细信息

目的了解贵州省少数民族人群体重矫正腰围指数（weight adjusted waist index,WWI）与心血管疾病之间的关联性。方法基于“西南区域少数民族聚集地世居自然人群队列研究”，于2018—2019年在贵州省黔东南、黔南地区对30～79岁侗族、苗族、布依族人群开展基线调查。采用logistic回归分析贵州省少数民族人群WWI与心血管疾病及其亚型的关联，采用限制性立方样条（restricted cubic spline, RCS）探讨WWI与心血管疾病的剂量反应关系，采用相乘、相加模型分析WWI与饮酒情况、糖尿病交互作用对心血管疾病的影响。结果共纳入16 993人，贵州省少数民族人群心血管疾病检出率为3.1%。调整所有协变量后，与WWI最低分位（Q1）相比，WWI第三分位（Q3）、第四分位（Q4）患心血管疾病的OR值分别为1.448(95%CI:1.089～1.924)、1.350(95%CI:1.007～1.811)。RCS显示，WWI与心血管疾病呈近似“S”型非线性剂量反应关系（P for nonlinear=0.029）。相乘交互作用显示，WWI与饮酒存在正向相乘交互作用（OR=2.36, 95%CI:1.22～4.55）, WWI与糖尿病不存在相乘交互作用（OR=0.55, 95%CI:0.30～1.00）。结论贵州省少数民族人群WWI与心血管疾病呈正相关，且呈非线性剂量反应关系，WWI与饮酒对心血管疾病存在相乘交互作用。

关键词：体重矫正腰围指数心血管疾病少数民族剂量反应关系交互作用

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李传平辨治糖尿病肾病经验

中医药临床杂志 2017年第7期29卷 995-997页

作者：沈翊李传平安徽省铜陵市立医院安徽铜陵244000 安徽省六安市中医院安徽六安237000

糖尿病肾病（diabetic nephropathy,DN）是糖尿病最严重微血管病变并发症之一,也是导致终末期肾脏病的最常见的病因。根据数据统计在欧美国家,DN已成为尿毒症的首位病因,而随着我国人们生活水平的提高,DN的发病率越来越高,并且DN预后较... 详细信息

糖尿病肾病（diabetic nephropathy,DN）是糖尿病最严重微血管病变并发症之一,也是导致终末期肾脏病的最常见的病因。根据数据统计在欧美国家,DN已成为尿毒症的首位病因,而随着我国人们生活水平的提高,DN的发病率越来越高,并且DN预后较差,常较快进展为肾功能不全。对于其治疗西医无特别有效的治疗方法,一般以对症处理为主。特别是糖尿病肾病中、晚期患者,临床上多表现为蛋白尿及水肿.

关键词：李传平糖尿病肾病名医经验中医

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耐密玉米杂交种密度效应研究

玉米科学 2009年第3期17卷 107-112页

作者：杨贵兰李新海李红李爱军董红芬申毅力山西长治职业技术学院山西长治046000 中国农业科学院作物科学研究所北京100081 山西省农业科学院谷子研究所山西长治046011

研究了郑单958和先玉335在山西长治地区生态条件下的种植密度效应,分析了光合特性和产量及其构成因素。结果表明:郑单958的适宜栽培密度为7.50万～9.00万株/hm2,在此密度下产量为13056.0～13526.0kg/hm2,叶面积指数在抽雄至蜡熟期为4.2... 详细信息

研究了郑单958和先玉335在山西长治地区生态条件下的种植密度效应,分析了光合特性和产量及其构成因素。结果表明:郑单958的适宜栽培密度为7.50万～9.00万株/hm2,在此密度下产量为13056.0～13526.0kg/hm2,叶面积指数在抽雄至蜡熟期为4.2～6.2,蜡熟至完熟期保持在2.6左右,经济产量形成期的群体光合势占总光合势的67.53%,全生育期平均净同化率为7.2～8.3g/(m2·d);最佳产量结构为单位面积穗数7.50万～8.82万穗/hm2、穗粒数524～466粒、千粒重332.0～329.0g。先玉335的适宜栽培密度为7.50万株/hm2,在此密度下产量为13714.5kg/hm2,叶面积指数在抽雄至蜡熟期4.0～5.2,蜡熟至完熟保持在2.6左右,经济产量形成期的群体光合势占总光合势的66.42%,全生育期平均净同化率为7.9g/(m2·d);最佳产量结构为单位面积穗数7.50万穗/hm2、穗粒数538粒、千粒重339.9g。

关键词：玉米密度产量光合特性

Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai Feng Juanji li Tingting liu Shiqi Huang Xiangliang Chen shen liu Junshan Zhou Hongdong Zhao Ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization