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Babao Dan Inhibits Gastric Cancer Progression in vivo Through Multiple Signaling Pathways

World Journal of Traditional Chinese Medicine 2024年第1期10卷 14-21页

作者： Hai-Xia shang yi Fang Bin Guan Jian-Hua Guan Jun Peng Jin-Yan Zhao Jiu-Mao Lin Institute of Oncology of Academy of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhouFujianChina Key Laboratory of Integrative Medicine of Fujian Province University Fujian University of Traditional Chinese MedicineFuzhouFujianChina Fujian Key Laboratory of Integrative Medicine on Geriatric Fujian University of Traditional Chinese MedicineFuzhouFujianChina Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhouFujianChina Xiamen Traditional Chinese Medicine Co. Ltd.XiamenFujianChina

Objective:The aim of this study was to explore the effects of Babao dan(BBD),a traditional Chinese medicine,on gastric cancer(GC)progression in *** and Methods:A subcutaneous xenograft mouse model of GC was established using MGC80-3 *** terminal deoxynucleotidyl transferase-mediated dUTP:2'-deoxyuridine 5'-triphosphate-biotin nick-end labeling method was adopted to detect cell apoptosis in *** expression levels of proteins associated with proliferation,apoptosis,and angiogenesis were measured by immunohistochemical staining or western blotting(WB).The activation and protein levels of p-c-Jun N-terminal kinase(JNK),p-p38,p-extracellular-regulated kinase 1/2,p-nuclear factor-κB(NF-κB),and p-STAT3 were examined by Bio-plex and ***:BBD significantly inhibited tumor growth in GC mouse models with no adverse effect on body weight or organ *** was also found that BBD significantly suppressed the proliferation of GC tumor cells,induced the apoptosis of tumor cells,and inhibited angiogenesis through inactivating with mitogen-activated protein kinase,NF-κB,and STAT3 ***:BBD exerts suppressive effects on GC tumor growth by regulating multiple pathways in vivo,which may provide a novel treatment option for GC therapy.

关键词： Babao dan gastric cancer multiple signaling pathways proliferation traditional Chinese medicine

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Optical and electrical anisotropy regulation engineering of low-dimensional materials toward polarized detection and imaging applications

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Rare Metals 2024年第7期43卷 2968-2993页

作者： Jian-Bin Zhang Nan Zhou Li-Hui Zhang Cong-Hui shang Jia-Xuan Li yi Zhao Guo-Hui Jia Ru-Sen Yang Hua Xu Xiao-Bo Li Shaanxi Joint Key Laboratory of Graphene Shaanxi Key Laboratory of High-Orbits-Electron Materials and Protection Technology for AerospaceShaanxi Joint Key Laboratory of GrapheneSchool of Advanced Materials and NanotechnologyXidian UniversityXi'an710126China Guangzhou Institute of Technology Xidian UniversityGuangzhou 710068China Xi'an Thermal Power Research Institute Co. LtdXi'an 710054China Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationShaanxi Key Laboratory for Advanced Energy DevicesShaanxi Engineering Lab for Advanced Energy TechnologySchool of Materials Science and EngineeringShaanxi Normal UniversityXi'an Xi'an 710119China

Polarized-sensitive image sensors are a kind of photodetector with great development potential due to their enhanced ability to detect and identify the target objects from the aspect of spatial,spectral and polarized ***,low-dimensional anisotropic materials with inherent anisotropic properties,ultrathin thickness,tunable bandgap and feasible integration with complementary metal oxide semiconductor(CMOS)fabrication processes have attracted great interest for their facilitation of polarized photodetector devices *** the polarized detection performance of low-dimensional materials to satisfy realistic needs stimulates the exploration of modulation of anisotropic *** this review,we comprehensively introduce the latest research progress in modulating the optical and optoelectronic anisotropy characteristics of low-dimensional *** strategy of anisotropy regulation through crystal structure engineering and coupling system is discussed ***,the latest progress in image recognition applications using anisotropic low-dimensional materials is reviewed in ***,we summarize the challenge and propose future opportunities in the practical application of polarized-sensitive imaging photodetectors based on low-dimensional anisotropic materials.

关键词： Anisotropy Polarized detection Image recognition Low-dimensional materials

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New insights into substrate folding preference of plant OSCs

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Science Bulletin 2016年第18期61卷 1407-1412页

作者： Yongshuo Ma Yuan Zhou Sergey Ovchinnikov Per Jr.Greisen Sanwen Huang yi shang Institute of Vegetables and Flowers Chinese Academy of Agricultural Sciences Key Laboratory of Biology and Genetic Improvement of Horticultural Crops of the Ministry of Agriculture Sino-Dutch Joint Laboratory of Horticultural Genomics Department of Biochemistry University of Washington Department of Modelling Novo Nordisk A/S 2760 Ml?vDenmark Agricultural Genomic Institute at Shenzhen Chinese Academy of Agricultural Sciences

Sterols and triterpenes are structurally diverse bioactive molecules generated through cyclization of linear2,3-oxidosqualene. Based on carbocationic intermediates generated during initial substrate preorganization step,oxidosqualene cyclases(OSCs) are roughly segregated into protosteryl cation group that mainly catalyzes tetracyclic products and dammarenyl cation group which mostly generates pentacyclic products. However, in contrast to well-studied cascade of ring-forming reactions, little is known about the mechanism underlying the initial substrate folding process. Previously, we have identified a cucurbitadienol synthase(Bi) and its null allele bi(C393Y)from cucumber. By integration of homology modeling,residue coevolution and site-directed mutagenesis, we discover that four covarying amino acids including C393 constitute a dynamic domain that may be involved in substrate folding process for Bi. We also reveal a group of co-conserved residues that closely associated with the segregation of plant OSCs. These residues may act collaboratively in choice of specific substrate folding intermediate for OSCs. Thus, our findings open a door to engineer plant OSCs from four-ringed skeleton catalysts into five-ringed producer.

关键词：折叠过程有机基板植物偏好生物活性分子三萜类化合物无效等位基因离子基团

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戴着地理眼镜读书——《空间的生产与重塑——流动中的文化古镇》书评

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人文地理 2023年第5期38卷 191-192页

作者：周尚意北京师范大学地理科学学部北京100875

《空间的生产与重塑》一书选择的空间单元是镇。这个空间尺度容易让读者产生带入感,因为每位读者都有关于“镇”的直接和间接了解,并能够以之为基础,进入本书作者讲述的“江南文化古镇”。镇是一级行政地理空间单元,在中国城市大致对应... 详细信息

《空间的生产与重塑》一书选择的空间单元是镇。这个空间尺度容易让读者产生带入感,因为每位读者都有关于“镇”的直接和间接了解,并能够以之为基础,进入本书作者讲述的“江南文化古镇”。镇是一级行政地理空间单元,在中国城市大致对应街道(社区)。人们鲜活的日常生活经验。

关键词：日常生活经验空间单元书评行政地理文化古镇空间尺度空间的生产重塑

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Interactions between dislocations and twins in deformed titanium aluminide crystals

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Journal of Materials Science & Technology 2019年第3期35卷 402-408页

作者： Guang Yang shang-yi Ma Kui Du Dong-Sheng Xu Sen Chen Yang Qi Heng-Qiang Ye School of Materials Science and Engineering Northeastern University Shenyang National Laboratory for Materials Science Institute of Metal Research Chinese Academy of Sciences Division of Titanium Alloys Institute of Metal Research Chinese Academy of Sciences Department of Materials Physics and Chemistry School of Materials Science and Engineering Northeastern University

Using scanning, transmission electron microscopy and aberration-corrected scanning transmission electron microscopy, we have studied the interactions between dislocations and twins in impact deformed polysynthetic twinned TiAl crystal. The 1/3 dislocations with the coherent twin *** abnormal stacking fault was found adjacent to the coherent twin boundary. It has the same stacking sequence but different atom species in the [110] direction with an additional displacement of 1/4[110]in two neighboring {111} layers, and is likely induced by the slip of a 1/12[112](i.e. 1/4[110] + 1/6[211])dislocation.

关键词： TiAl Dynamic deformation Twins Dislocations Abnormal stacking fault

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Pathotypes and Genetic Diversity of Blumeria graminis *** in the Winter Barley Regions in China

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Agricultural Sciences in China 2010年第12期9卷 1787-1798页

作者： ZHU Jing-huan WANG Jun-mei JIA Qiao-jun YANG Jian-ming ZHOU yi-jun LIN Feng HUA Wei shang yi College of Plant Protection Nanjing Agricultural University Nanjing 210095 P.R.China National Barley Improvement Center Zhejiang Academy of Agricultural Sciences Hangzhou 310021 P.R. China Institute of Plant Protection Jiangsu Academy of Agricultural Sciences Nanjing 210014 P.R. China

Barley powdery mildew caused by Blumeria graminis f. sp. hordei （Bgh） is one of the most destructive foliar diseases of barley in the winter barley region of China. The evaluation and assessment of the virulence and diversity of Bgh populations help to determine effective sources of resistance to the pathogen. 515 isolates were collected from seven populations of Bgh on cultivated barley in seven geographically distant locations in 2006. Their virulence was determined by inoculation onto 26 differential host lines. All of the isolates belonged to 58 pathotypes and 13 of which included 81% of these isolates. The most abundant pathotype was pathotype 0047 （18.3%）, the second most abundant was pathotype 0045 （11.8%） and the third most abundant was pathotype 0057 （7.8%）. Most of virulent genes investigated in this study showed similar frequencies in the seven different areas. These indicate that the seven locations may be in a uniform epidemiological region and barley cultivars in these areas may have similar genetic background. Diversities within these populations and distances between these populations measured by KOIND package were different. Correlations were not found between the genetic distance and the geographical distances between different locations. This suggested that long distance spread and local epidemics existed in the major winter barley growing regions in China.

关键词： Blumeria graminis f. sp. hordei powdery mildew pathotype virulence frequency diversity barley China

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Study on the response of wheat to lead, cadmium and zinc

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Journal of Environmental Sciences 1998年第2期10卷 111-117页

作者： Meng Ling Tan De-yong Wang Huan-xiao Duan Chang-qun Duan Pei-shang Gao shang-yi Department of Biology Yunnan UniversityKunming 650091China

Ｓｔｕｄｙｏｎｔｈｅｒｅｓｐｏｎｓｅｏｆｗｈｅａｔｔｏｌｅａｄ，ｃａｄｍｉｕｍａｎｄｚｉｎｃＭｅｎｇＬｉｎｇ，ＴａｎＤｅｙｏｎｇ，ＷａｎｇＨｕａｎｘｉａｏ，ＤｕａｎＣｈａｎｇｑｕｎ，ＤｕａｎＰｅｉｓｈａｎｇ... 详细信息

Ｓｔｕｄｙｏｎｔｈｅｒｅｓｐｏｎｓｅｏｆｗｈｅａｔｔｏｌｅａｄ，ｃａｄｍｉｕｍａｎｄｚｉｎｃＭｅｎｇＬｉｎｇ，ＴａｎＤｅｙｏｎｇ，ＷａｎｇＨｕａｎｘｉａｏ，ＤｕａｎＣｈａｎｇｑｕｎ，ＤｕａｎＰｅｉｓｈａｎｇ，ＧａｏＳｈａｎｇｙｉＤｅｐａｒ...

关键词： lead cadmium zinc wheat gene transcription.

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How about the reporting quality of case reports in nursing field?

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World Journal of Clinical Cases 2019年第21期7卷 3505-3516页

作者： Ke-Lu Yang Cun-Cun Lu Yue Sun yi-Tong Cai Bo Wang yi shang Jin-Hui Tian Evidence-Based Nursing Center School of NursingLanzhou UniversityLanzhou 730000Gansu ProvinceChina Evidence-Based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000Gansu ProvinceChina Gansu Province Hospital Rehabilitation Center Lanzhou 730000Gansu ProvinceChina Lanzhou University Second Hospital Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

BACKGROUND As a significantly important part of clinical practice,the professional nursing process can be advanced in many *** the fact that case reports are regarded to be of a lower quality grade in the hierarchy of evidence,one of the principles of evidence-based medicine is that decision-making should be based on a systematic summary of ***,the evidence on the reporting characteristics of case reports in the nursing field is *** To use the CARE guidelines to assess reporting quality and factors influencing the quality of case reports in the nursing *** Nursing science citation indexed(SCI-indexed)journals were identified from the professional *** of the identified journals was searched on their website for articles published before December ***-one sub-items on the CARE checklist were recorded as“YES”,“PARTLY”,or“NO”according to information reported by the included *** responses were assigned corresponding scores of 1,0.5,and 0,*** overall score was the sum of the 21 sub-items and was defined as“high”(more than 15),“medium”(10.5 to 14.5),and“low”(less than 10).The means,standard deviations,odds ratios(OR),and the associated 95%confidence interval(CI)were determined using Stata 12.0 *** Ultimately,184 case reports from 16 SCI-indexed journals were identified,with overall scores ranging from 6.5 to 18(mean=13.6±2.3).Of the included case reports,10.3%were regarded low-quality,52.7%were considered middle-quality,and 37%were regarded *** were statistical differences in the mean overall scores of the included case reports with funding versus those without funding(14.2±1.7 vs 13.6±2.4,respectively;P=0.4456)and journal impact factor<1.8 versus impact factor≥1.8(13.3±2.3 vs 13.6±2.4,respectively;P=0.4977).Five items from the CARE guidelines,5a(Patient),6(Clinical findings),8c(Diagnostic reasoning),9(Therapeutic intervention),and 11d(The main take-away lessons)were

关键词： Systematic review Case reports Case report guidelines Nursing Reporting quality Science citation indexed journals

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2D and 3D milled surface roughness of high volume fraction Si Cp/Al composites

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Defence Technology（防务技术） 2015年第2期11卷 104-109页

作者： Tao WANG Li-jing XIE Xi-bin WANG Teng-yi shang School of Mechanical Engineering Beijing Institute of Technology

This paper presents a study on surface roughness generated by high speed milling of high volume fraction(65%) silicon carbide particlereinforced aluminum matrix(Si Cp/Al) *** 2D(Raand Rz) and 3D(Saand Sq) surface roughness parameters were selected to evaluate the influence of the milling parameters on the surface quality in comparison with aluminum *** 3D topography of the milled surface was studied as *** results indicate that 3D parameters(Saand Sq) are more capable to describe the influence of the milling parameters on the surface quality,and among them Sqis preferable due to its good *** with milling speed and increases with feed *** influence of axial depth of cut(ADOC) is negligible.

关键词：表面粗糙度参数 SiC颗粒高速铣削体积分数复合材料三维形貌二维中国兵工学会

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Fracture mode identification of low alloy steels and cast irons by electron back-scattered diffraction misorientation analysis

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Journal of Materials Science & Technology 2017年第12期33卷 1582-1595页

作者： Shao-Shi Rui yi-Bo shang Wenhui Qiu Li-Sha Niu Hui-Ji Shi Shunsaku Matsumoto Yasuharu Chuman Applied Mechanics Laboratory School of Aerospace EngineeringTsinghua UniversityBeijing 100084China Residential Air Conditioning Division MIDEAFoshan528311China Strength Research Department Research&Innovation CenterMitsubishi Heavy IndustriesLtd.Nagasaki 851-0392Japan

The fracture modes of low alloy steels and cast irons under tensile and fatigue conditions were identified by electron back-scattered diffraction（EBSD） misorientation analysis in this research. The curves of grain reference orientation deviation（GROD） distribution perpendicular to the fracture surface were obtained by EBSD observation, and the characteristics of each fracture mode were identified. The GROD value of the specimen fractured in tension decreases to a constant related to the elongation of corresponding specimen in the far field（farther than 5 mm away from the fracture surface）. The peak exhibits in GROD curves of two smooth specimens and a notched specimen near the fracture surface（within 5 mm away from the fracture surface）, and the formation mechanisms were discussed in detail based on the influences of specimen geometries（smooth or notched） and material toughness. The GROD value of fatigue fractured specimen is close to that at undeformed condition in the whole field, except the small area near the crack path. The loading conditions（constant stress amplitude loading or constant stress intensity factor range K loading） and the EBSD striation formation during fatigue crack propagation were also studied by EBSD observation parallel to the crack path.

关键词： Fracture mode identification Low alloy steels Cast irons Electron back-scattered diffraction (EBSD) Misorientation

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