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A novel dandelion-based bionic proppant and its transportation mechanism in different types of fractures

Petroleum Science 2024年第4期21卷 2583-2599页

作者： Jun Li ming-yi wu Xu Han Si-Yuan He Ze-Yu Lin State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum University Sichuan Particles Energy and Technology Co. Ltd Chongqing Industry Polytechnic College Petroleum Systems Engineering Faculty of Engineering and Applied Science University of Regina

Low-permeability reservoirs are generally characterized by low porosity and low permeability. Obtaining high production using the traditional method is technologically challenging because it yields a low reservoir recovery factor. In recent years, hydraulic fracturing technology is widely applied for efficiently exploiting and developing low-permeability reservoirs using a low-viscosity fluid as a fracturing ***, the transportation of the proppant is inefficient in the low-viscosity fluid, and the proppant has a low piling-up height in fracture channels. These key challenges restrict the fluid(natural gas or oil) flow in fracture channels and their functional flow areas, reducing the profits of hydrocarbon *** study aimed to explore and develop a novel dandelion-bionic proppant by modifying the surface of the proppant and the fiber. Its structure was similar to that of dandelion seeds, and it had high transport and stacking efficiency in low-viscosity liquids compared with the traditional ***, the transportation efficiency of this newly developed proppant was investigated experimentally using six different types of fracture models(tortuous fracture model, rough fracture model,narrow fracture model, complex fracture model, large-scale single fracture model, and small-scale single fracture model). Experimental results indicated that, compared with the traditional proppant, the transportation efficiency and the packing area of the dandelion-based bionic proppant significantly improved in tap water or low-viscosity fluid. Compared with the traditional proppant, the dandelionbased bionic proppant had 0.1-4 times longer transportation length, 0.3-5 times higher piling-up height, and 2-10 times larger placement area. The newly developed proppant also had some other extraordinary features. The tortuosity of the fracture did not influence the transportation of the novel proppant. This proppant could easily enter the branch fracture and n

关键词： Dandelion-based bionic proppant Low-viscosity fracturing fluid Unconventional reservoir Volumetric fracturing stimulation

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FPGA-based position reconstruction method for neutron beam flux spatial distribution measurement in BNCT

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Nuclear Science and Techniques 2024年第3期35卷 96-108页

作者： Wei Jiang Ping Cao yi-ming wu Xian-Ke Liu Zhu-Jun Fang Zhi-Yong Zhang Bin Shi Jun Chen State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China National Key Laboratory for Metrology and Calibration Techniques China Institute of Atomic EnergyBeijing 102413China

A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas *** address the issue of long processing times in traditional offline position reconstruction methods,this paper proposes a field programmable gate array based online position reconstruction method utilizing the micro-time projection chamber *** method encapsulates key technical aspects:a self-adaptive serial link technique built upon the dynamical adjustment of the delay chain length,fast sorting,a coordinate-matching technique based on the mapping between signal timestamps and random access memory(RAM)addresses,and a precise start point-merging technique utilizing a circular combined *** performance test of the selfadaptive serial link shows that the bit error rate of the link is better than 10-12 at a confidence level of 99%,ensuring reliable data *** experiment utilizing the readout electronics and Micromegas detector shows a spatial resolution of approximately 1.4 mm,surpassing the current method’s resolution level of 5 *** beam experiment confirms that the readout electronics system can obtain the flux spatial distribution of neutron beams online,thus validating the feasibility of the position reconstruction *** online position reconstruction method avoids traditional methods,such as bubble sorting and traversal searching,simplifies the design of the logic firmware,and reduces the time complexity from O(n2)to O(n).This study contributes to the advancement in measuring neutron beam flux for BNCT.

关键词： Position reconstruction FPGA Readout electronics Neutron flux spatial distribution

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Error-detected three-photon hyperparallel Toffoli gate with state-selective reflection

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Frontiers of physics 2022年第5期17卷 207-217页

作者： yi-ming wu Gang Fan Fang-Fang Du Science and Technology on Electronic Test and Measurement Laboratory North University of ChinaTaiyuan 030051China

We present an error-detected hyperparallel Toffoli(hyper-Toffoli)gate for a three-photon system based on the interface between polarized photon and cavity-nitrogen-vacancy(NV)center *** hyper-Toffoli gate can be used to perform double Toffoli gate operations simultaneously on both the polarization and spatial-mode degrees of freedom(DoFs)of a three-photon system with a low decoherence,shorten operation time,and less quantum resources required,in compared with those on two independent three-photon systems in one DoF *** the imperfect cavity-NVcenter interactions are transformed into the detectable failures rather than infidelity based on the heralding mechanism of detectors,a near-unit fidelity of the quantum hyper-Toffoli gate can be *** recycling the procedures,the efficiency of our protocol for the hyper-Toffoli gate is improved ***,the evaluation of gate performance with achieved experiment parameters shows that it is feasible with current experimental technology and provides a promising building block for quantum compute.

关键词： quantum photon system

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Self-error-rejecting multipartite entanglement purification for electron systems assisted by quantum-dot spins in optical microcavities

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Chinese Physics B 2022年第5期31卷 113-121页

作者： Yong-Ting Liu yi-ming wu Fang-Fang Du Science and Technology on Electronic Test and Measurement Laboratory North University of ChinaTaiyuan 030051China

We present a self-error-rejecting multipartite entanglement purification protocol(MEPP)for N-electron-spin entangled states,resorting to the single-side cavity-spin-coupling *** MEPP has a high efficiency containing two *** is to obtain high-fidelity N-electron-spin entangled systems with error-heralded parity-check devices(PCDs)in the same parity-mode outcome of three electron-spin pairs,as well as M-electron-spin entangled subsystems(2≤M

关键词： quantum communication entanglement purification electron-spin system

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Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy:a precise construction of structurally diverse azaspiro polycyclic scaffolds

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Science China Chemistry 2024年第2期67卷 576-586页

作者： Xiao-Bao wu Jun-Xiu Shi yi-ming Ou Hua-Jie Jiang yi-Jun Fang Qi-ming Wang Quan Gao Jie Yu Department of Applied Chemistry Anhui Province Engineering Laboratory for Green Pesticide Development and ApplicationAnhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Agricultural UniversityHefei230036China

A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic *** diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results(up to 99:1 e.r.,>95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(Ⅲ) complexes.

关键词： asymmetric catalysis post-Ugi transformation anionic stereogenic-at-cobalt(Ⅲ)complex azaspiro polycyclic scaffold one-pot synthesis

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A New Convenient Synthesis of Pyridine-N-oxides

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Chinese Chemical Letters 1996年第10期7卷 907-908页

作者： Tao LU Xin Zhong SHI yi ming wu(Dept.of Organic Chemistry, China Pharmaceutical University,Nanjing, Jiangsu 210009) CHINA PHARMACEUT UNIV DEPT ORGAN CHEMNANJING 210009JIANGSUPEOPLES R CHINA

This paper describes the direct oxidation of pyridines to pyridine-N-oxides by means of 30% H2O2 in aq media in the presence of Na2WO4.2H(2)O as catalyst instead of with per-acids or 30% H2O2 in acetic acid. Good yiel... 详细信息

关键词： A New Convenient Synthesis of Pyridine-N-oxides

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Targeting cytokine and chemokine signaling pathways for cancer therapy

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3381-3428页

作者： ming yi Tianye Li Mengke Niu Haoxiang Zhang Yuze wu Kongming wu Zhijun Dai Department of Breast Surgery The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310000People's Republic of China Department of Gynecology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000People's Republic of China Department of Oncology Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030People's Republic of China Department of Hepatopancreatobiliary Surgery Fujian Provincial HospitalFuzhou 350001People's Republic of China

Cytokines are critical in regulating immune responses and cellular behavior,playing dual roles in both normal physiology and the pathology of diseases such as *** molecules,including interleukins,interferons,tumor necrosis factors,chemokines,and growth factors like TGF-β,VEGF,and EGF,can promote or inhibit tumor growth,influence the tumor microenvironment,and impact the efficacy of cancer *** advances in targeting these pathways have shown promising therapeutic potential,offering new strategies to modulate the immune system,inhibit tumor progression,and overcome resistance to conventional *** this review,we summarized the current understanding and therapeutic implications of targeting cytokine and chemokine signaling pathways in *** exploring the roles of these molecules in tumor biology and the immune response,we highlighted the development of novel therapeutic agents aimed at modulating these pathways to combat *** review elaborated on the dual nature of cytokines as both promoters and suppressors of tumorigenesis,depending on the context,and discussed the challenges and opportunities this presents for therapeutic *** also examined the latest advancements in targeted therapies,including monoclonal antibodies,bispecific antibodies,receptor inhibitors,fusion proteins,engineered cytokine variants,and their impact on tumor growth,metastasis,and the tumor ***,we evaluated the potential of combining these targeted therapies with other treatment modalities to overcome resistance and improve patient ***,we also focused on the ongoing research and clinical trials that are pivotal in advancing our understanding and application of cytokine-and chemokine-targeted therapies for cancer patients.

关键词： cytokine chemokine overcome

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Beyond success: unveiling the hidden potential of radiotherapy and immunotherapy in solid tumors

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Cancer Communications 2024年第7期44卷 739-760页

作者： Yuze wu ming yi Mengke Niu Binghan Zhou Qi Mei Kongming wu Department of Oncology Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Breast Surgery Zhejiang University School of Medicine First Affiliated HospitalHangzhouZhejiangP.R.China Cancer Center Shanxi Bethune HospitalShanxi Academy of Medical ScienceTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxiP.R.China Cancer Center Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China

Immunotherapy,particularly with immune checkpoint inhibitors,has significantly transformed cancer *** its success,many patients struggle to respond adequately or sustain long-lasting clinical improvement.A growing consensus has emerged that radiotherapy(RT)enhances the response rate and overall efficacy of *** combining RT and immunotherapy has been extensively investigated in preclinical models and has shown promising results,establishing itself as a dynamic and thriving area of research,clinical evidence for this combination strategy over the past five years has shown both positive and disappointing results,suggesting the need for a more nuanced *** review provides a balanced and updated analysis of the combination of immunotherapy and *** summarized the preclinical mechanisms through which RT boosts antitumor immune responses andmainly focused on the outcomes of recently updated clinical trials,including those that may not have met *** investigated the optimization of the therapeutic potential of this combined strategy,including key challenges,such as fractionation and scheduling,lymph node irradiation,and ***,we offered insights into the prospects and challenges associated with the clinical translation of this combination therapy,providing a realistic perspective on the current state of research and potential future directions.

关键词： immunotherapy radiotherapy immune checkpoint inhibitor abscopal effect tumor microenvironment

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The Functional Redundancy of Neddylation E2s and E3s in Modulating the Fitness of Regulatory T Cells

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Research 2024年第2期2023卷 373-387页

作者： Di wu yi Sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Cancer Center of Zhejiang University Hangzhou 310029China Zhejang Provincial Clinical Research Center for Cancer Zhejang ProvinceChina Key Laboratory of Molecular Biology in Medical Sciences Zhejang ProvinceChina Research Center for Life Science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China

Neddylation is necessary for activation of Cullin-RING ligases(CRLs),which degrade various immune regulatory *** recent study showed that while depletion of neddylation E2-E3 pair Ube2f-Sag in regulatory T(T_(reg))cells had no obvious phenotype,the same depletion of either Ube2m or Rbx1 caused inflammation disorders with different *** these E2s or E3s compensate each other in functional regulations of T_(reg)cells is,however,previously *** this report,we generated Foxp3^(Cre);Ube2m^(fl/fl);Ube2f^(fl/fl)or Foxp3^(Cre);Rbx1^(fl/fl);Sag^(fl/fl)double-null mice by simultaneous deletion of both neddylation E2s or E3s in T_(reg)cells,***,Ube2m&Ube2f double-null mice developed much severe autoimmune phenotypes than did Ube2m-null mice,indicating that Ube2m markedly compensates Ube2f in T_(reg)*** minor worsened autoimmune phenotypes seen at the very early stage in Rbx1&Sag double-null than Rbx1-null mice is likely due to already severe phenotypes of the later,indicating a minor compensation of Rbx1 for *** RNA profiling-based analyses revealed that up-and down-regulations of few signaling pathways in T_(reg)cells are associated with the severity of autoimmune ***,severer inflammation phenotypes seen in mice with double E3-null than with double E2-null T_(reg)cells indicate a neddylation-independent mechanism of 2 E3s,also known to serve as the RING component of CRLs in regulation of T_(reg)cell fitness.

关键词： Foxp3 inflammation markedly

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Fractal model of spontaneous imbibition in low-permeability reservoirs coupled with heterogeneity of pore seepage channels and threshold pressure

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Petroleum Science 2024年第2期21卷 1002-1017页

作者： ming-Sheng Zuo Hao Chen Xi-Liang Liu Hai-Peng Liu yi wu Xin-Yu Qi National Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China College of Safety and Ocean Engineering China University of Petroleum(Beijing)Beijing102249China

Spontaneous imbibition(SI)is an important mechanism for enhancing oil recovery in low-permeability *** to the strong heterogeneity,and the non-Darcy flow,the construction of SI model for lowpermeability reservoirs is extremely ***,traditional SI models based on single or averaged capillary tortuosity ignore the influence of heterogeneity of pore seepage channels and the threshold pressure(TP)on ***,in this work,based on capillary model and fractal theory,a mathematical model of characterizing SI considering heterogeneity of pore seepage channels is *** this basis,the threshold pressure was introduced to determine the pore radius at which the wetted phase can displace *** proposed new SI model was verified by imbibition experimental *** study shows that for weakly heterogeneous cores with permeability of 0-1 m D,the traditional SI model can characterize the imbibition process relatively accurately,and the new imbibition model can increase the coefficient of determination by 1.05 ***,traditional model has serious deviations in predicting the imbibition recovery for cores with permeability of 10-50 m *** new SI model coupling with heterogeneity of pore seepage channels and threshold pressure effectively solves this problem,and the determination coefficient is increased from 0.344 to 0.922,which is increased by2.68 *** low-permeability reservoirs,the production of the oil in transitional pores(0.01-0.1μm)and mesopores(0.1-1μm)significantly affects the imbibition recovery,as the research shows that when the heterogeneity of pore seepage channels is ignored,the oil recovery in transitional pores and mesopores decreases by 7.54%and 4.26%,*** analysis shows that increasing interfacial tension,decreasing contact angle,oil-water viscosity ratio and threshold pressure will increase imbibition *** addition,there are critical values for the influence of these factors o

关键词： Spontaneous imbibition Low-permeability reservoir Fractal model Threshold pressure Capillary tube

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