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Intranasal temperature-sensitive hydrogels of cannabidiol inclusion complex for the treatment of post-traumatic stress disorder

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Acta Pharmaceutica Sinica B 2021年第7期11卷 2031-2047页

作者： Lulu Pang Siqing Zhu Jinqiu Ma Lin Zhu yijing Liu Ge Ou Ruiteng Li Yaxin Wang yi liang Xu Jin Lina Du yiguang Jin Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China College of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China College of Pharmacy Anhui Medical UniversityHefei 230001China Pharmacy Department Chinese PLA General HospitalBeijing 100853China Department of Anesthesiology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

Post-traumatic stress disorder(PTSD)is a psychiatric disease that seriously affects brain ***,selective serotonin reuptake inhibitors(SSRIs)are used to treat PTSD clinically but have decreased efficiency and increased side *** this study,nasal cannabidiol inclusion complex temperature-sensitive hydrogels(CBD TSGs)were prepared and evaluated to treat *** model of PTSD was established with conditional fear *** TSGs could significantly improve the spontaneous behavior,exploratory spirit and alleviate tension in open field box,relieve anxiety and tension in elevated plus maze,and reduce the freezing *** and eosin and c-FOS immunohistochemistry slides showed that the main injured brain areas in PTSD were the prefrontal cortex,amygdala,and hippocampus *** TSGs could reduce the level of tumor necrosis factor-a caused by *** blot analysis showed that CBD TSGs increased the expression of the 5-HT1 A *** administration of CBD TSGs was more efficient and had more obvious brain targeting effects than oral administration,as evidenced by the pharmacokinetics and brain tissue distribution of CBD ***,nasal CBD TSGs are safe and effective and have controlled *** are a novel promising option for the clinical treatment of PTSD.

关键词： Post-traumatic stress disorder Cannabidiol Hydroxypropyl-β-cyclodextrin Inclusion complex Hydrogels Brain targeting Blood-brain barrier Intranasal administration

Correlation of Skp2 overexpression to prognosis of patients with nasopharyngeal carcinoma from South China

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Chinese Journal of Cancer 2011年第3期30卷 204-212页

作者： Hui-Min Xu yi liang Qiong Chen Qi-Nian Wu Yun-Miao Guo Guo-Ping Shen Ru-Hua Zhang Zhi-Wei He yi-Xin Zeng Fang-Yun Xie Tie-Bang Kang State Key Laboratory of Oncology in South China Guangzhou Guangdong 510060 P. R. China Department of Radiation Oncology Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Department of Experimental Research Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Department of Pathology Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China iuangdong Medical College Cancer Center Dongguan Guangdong 523808 P. R. China.

S-phase kinase-associated protein 2 (Skp2), which plays a role in cell cycle regulation, is commonly overexpressed in a variety of human cancers and associated with poor prognosis. However, its role in nasopharyngeal carcinoma (NPC) is not well understood. In this study, we examined the clinical significance of Skp2, with a particular emphasis on overall survival (OS) and disease-free survival (DFS), in NPC cases in South China, where NPC is an epidemic. Additionally, we explored the function of Skp2 in maintaining a cancer stem cell -like phenotype in NPC cell lines. Skp2 expression was assessed for 127 NPC patients using tissue microarrays and immunohistochemistry and analyzed together with clinicopathologic features, OS, and DFS. Skp2 expression was detectable, or positive, in 75.6% of patients. Although there was no correlation between Skp2 and any clinicopathologic factor, Skp2 expression significantly portended inferior OS (P = 0.013) and DFS (P = 0.012). In the multivariate model, Skp2 expression remained significantly predictive of poor OS [P = 0.009, risk ratio (RR) = 4.06] and DFS (P = 0.008, RR = 3.56), and this was also true for clinical stage (P = 0.012 and RR=3.201 for OS; P = 0.002 and RR=1.94 for DFS) and sex (P = 0.016 and RR=0.31 for OS; P = 0.006 and RR = 0.27 for DFS). After Skp2 knockdown, a colony formation assay was used to evaluate the self-renewal property of stem-like cells in the NPC cell lines CNE-1 and CNE-2. The colony formation efficiency in CNE-1 and CNE-2 cells was decreased. In Skp2-transfected CNE-1 and CNE-2 cells, side population (SP) proportion was increased as detected by flow cytometry. Skp2 is an independent prognostic marker for OS and DFS in NPC. Skp2 may play a role in maintaining the cancer stem cell-like phenotype of NPC cell lines.

关键词： Skp2 蛋白表达鼻咽癌预后患者中国全国人民代表大会细胞周期调控

Game-Based Learning for Competency Abilities in Blended Museum Contexts for Diverse Learners

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Psychology Research 2020年第9期10卷 338-348页

作者： Hsin-yi liang Tien-Yu Hsu National Taiwan University of Science and Technology TaipeiTaiwan National Museum of Natural Science TaichungTaiwan

Museums offer a lifelong edutainment environment with flexible choices for the public and provide fruitful interdisciplinary learning resources to support competency-based ***,the lack of proper scaffolding and supports in museums negatively affect learner ***,the individual differences need to be considered to effectively support the diverse learners learning in *** this study,an innovative learning model to support competency education for lifelong learning in museums is proposed.A game-based learning service named CoboFun that offers various types of problem-solving activities was developed to facilitate learners’interaction with exhibits and their peers in the *** examine the service design of CoboFun,learners’perceptions were evaluated and the differences in their cognitive styles were examined(Field Independent(FI)and Field Dependent(FD)).The results showed that both FI and FD learners enjoyed learning with CoboFun but that flexible learning tools needed to be provided to satisfy the different needs for the learners with different cognitive styles.

关键词： competency-based learning museum learning game-based learning virtual and physical lifelong learning

Sediment variability and transport in the littoral area of the abandoned Yellow River Delta, northern Jiangsu

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Journal of Geographical Sciences 2014年第4期24卷 717-730页

作者： ZHANG Lin CHEN Shenliang PAN Shunqi yi liang JIANG Chao State Key Lab of Estuarine and Coastal Research East China Normal University Shanghai 200062 China School of Engineering Cardiff University Cardiff CF24 2AA UK Institute of Geology and Geophysics CAS Beijing 100029 China

The delta evolution and erosion process of the abandoned Yellow River Delta （AYRD） have been extensively studied. However, the variation of sediment at a large littoral scale along the north coast of Jiangsu is less understood. In this study, the data of surface sediment samples obtained in the littoral area of the Yellow River Delta in 2006 and 2012 is used to study the sediment variability and sediment transport trends by using the geostatistics analysis tool and the grain size trend analysis model, In order to ensure the applicability of the model, the geostatistics method is used to determine the characteristic distance （De） with the average range value （Ao） of grain size parameter. Filtering method （removing data that not at a sampling station） is used to improve accuracy of data selection. The results show that sedimentary spatial correlation in Lianyun Port area and southern part of the abandoned Yellow River Delta （AS） is better than that in the northern part of the abandoned Yellow River Delta （AN）. Sediment in the area is found to be anisotropy at the northeast-southeast direc- tion. The grain size trend analysis reveals that the sediment trend is towards bayhead and southerly in the Haizhou Bay, southeasterly along the shoreline in the south Lianyun Port, northwesterly in AN and easterly-southeasterly in AS respectively. The investigation of possible relationships between Do, Ao, sediment transport and delta evolution shows a close link between Do and Ao of one sediment combination. It is also found that sediment transport trends could reasonably represent the delta evolution to a certain degree.

关键词： sediment variability sediment transport geostatistics analysis grain size parameters abandoned Yellow River Delta

Staged lensectomy and vitrectomy in the management of stage 5C retinopathy of prematurity with corneal opacification:long-term follow up

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1437-1443页

作者： Ping Fei Ting-yi liang Jie Peng Yu Xu Jia Luo Qi Zhang Jia-Kai Li Jiao Lyu Pei-Quan Zhao Department of Ophthalmology Xinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

·AIM:To verify the feasibility and safety of staged lensectomy and vitrectomy in stage 5 C retinopathy of prematurity(ROP)with corneal opacification.·METHODS:This was a retrospective,interventional,consecutive case ***-two eyes of 18 stage 5 C ROP patients with corneal opacification were *** combined lensectomy and vitrectomy were not prescribed due to the invisible *** lensectomy and posterior vitrectomy were *** anatomical and visual outcomes were reviewed at the final follow-up visit.·RESULTS:The mean gestational age of ROP patients was29.3±1.6 wk(range:27-32 wk),comprising 8 males and 10 *** average birth weight was 1363.0±300.0 *** the eyes had corneal opacity and flat or disappeared anterior chambers *** eyes had complicated cataract and 7 eyes had retrolental *** eyes had posterior pupillary synechiae or ***(31.8%)eyes had vascularly active *** average interval between two procedures was 6.8±4.6 mo(2.5-18.5 mo).After surgeries,all the patients had normal anterior *** eyes had clear *** intraocular pressure of 3 eyes with glaucoma was controlled by *** eyes had ocular *** retina was reattached in 3 eyes and partially attached in 11 *** acuity ranged from no light perception to hand motion.·CONCLUSION:Staged lensectomy and vitrectomy are procedures that can halt progression to further complications and preserve some useful eyesight in stage5 C ROP patients with corneal *** earlier the lensectomy is performed,the better the prognosis is.

关键词： lensectomy vitrectomy staged surgery retinopathy of prematurity corneal opacification retinal detachment

一种机载合成孔径成像激光雷达聚束模式成像算法

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光学学报 2008年第6期28卷 1183-1190页

作者：郭亮邢孟道梁毅唐禹西安电子科技大学雷达信号处理国家重点实验室陕西西安710071

合成孔径成像激光雷达是一种新的主动式有源的成像系统,可以获得比合成孔径雷达更高的分辨率,和更接近光学图片的效果。首先,在理想条件下分析了调频连续波的信号模型,推导出在连续波系统聚束模式下一种适用于机载合成孔径成像激光雷达... 详细信息

合成孔径成像激光雷达是一种新的主动式有源的成像系统,可以获得比合成孔径雷达更高的分辨率,和更接近光学图片的效果。首先,在理想条件下分析了调频连续波的信号模型,推导出在连续波系统聚束模式下一种适用于机载合成孔径成像激光雷达系统的频率变标算法。然后,使用傅里叶变换法对符合von Karman谱的随机相位屏模拟大气湍流,并分析了Fried参量和合成孔径长度之间的关系。最后,仿真说明真空中采用方位预处理可以消除图像重影,并且补偿多普勒频移项可以消除8.6～9.3dB的能量损失和使图像散焦的现象。而在有大气影响时,合成孔径长度的选择小于Fried参量时,图像方位向可以良好聚焦。

关键词：激光雷达合成孔径调频连续波聚束式方位解模糊成像算法随机相位屏 Fried参量

Improving the peak current density of resonant tunneling diode based on InP substrate

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Journal of Semiconductors 2017年第6期38卷 75-78页

作者： Zhiqiang Li Hailin Tang Haitao Liu yi liang Qian Li Ning An Jianping Zeng Wenjie Wang Yongzhong Xiong Microsystem and Terahertz Research Centre China Academy of Engineering Physics Chengdu 610299 China

Resonant tunneling diodes（RTD）have the potential for compact and coherent terahertz（THz）sources operating at room temperature,but their low output power severely restricts their application in THz frequency *** this paper,two methods are adopted to increase the peak current of RTD for enhancing its output ***,different metal contact systems（including Pt/Ti/Pt/Au and Au Ge/Ni/Au）for RTD contact are introduced,and a higher current of RTD with Pt/Ti/Pt/Au contact demonstrates the superior contact characteristic of Pt/Ti/Pt/Au contact ***,the double barrier structure（DBS）of RTD is well designed to further improve the characteristic of RTD,and a high peak current of 154 kA/cm^2 is achieved at room *** improved peak current is very beneficial for increasing the output power of RTD oscillator.

关键词： resonant tunneling diode terahertz sources ohmic contact output power

ISAR imaging via sparse frequency-stepped chirp signal

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Science China(Information Sciences) 2012年第4期55卷 877-888页

作者： WANG HongXian,liang yi,XING MengDao & ZHANG ShouHong National Key Laboratory of Radar Signal Processing,Xidian University,Xi’an 710071,China National Key Laboratory of Radar Signal Processing Xidian University Xi’an China

Frequency-stepped chirp signal can simplify the designation of radar ***,it has a shortcoming of Doppler ambiguity for high-speed moving ***,it is of great significance to study how to increase its equivalent pulse repeat *** back scattering field of the ISAR target has strong sparsity;that is to say,most energy is contributed merely by a few scattering ***,based on the theory of the sparse signal representation,a novel method for ISAR imaging via sparse frequency-stepped chirp signals is proposed by analyzing the signal model of the *** the proposed method,part of sub-pulses of the frequency-stepped chirp signal is randomly selected to transmit,and then the 2D high-resolution image of the target can be constructed by sparse signal *** the cost of computational resources,the method can effectively resolve the problem of Doppler ambiguity,decrease the sidelobes and obtain a super-resolution ***,the validity of the proposed approach is confirmed by the results of numerical simulations and real data.

关键词： inverse synthetic aperture radar (ISAR) radar imaging sparse signal representation frequency-stepped (FS)

Intramolecular α-Oxygenation of Amines via N-Heterocyclic Carbene-Catalyzed Domino Reaction of Aryl Aldehyde: Experiment and DFT Calculation

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CCS Chemistry 2019年第4期1卷 343-351页

作者： Xiang-Yu Chen Chao-Shen Zhang liang yi Zhong-Hua Gao Zhi-Xiang Wang Song Ye Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of the Chinese Academy of SciencesBeijing 100049China Marine College Shandong University at WeihaiWeihai 264209China

We have developed an N-heterocyclic carbene(NHC)-catalyzed domino reaction with aryl alde-hyde through a simple acyl azolium intermediate using phenyliodine(III)diacetate(PIDA)as an *** experiments and density functional theory calculations supported a domino two-stage mechanism from aldehyde/amine to anα-oxygen-ation product,including NHC-catalyzed oxidation of the aldehyde to carboxylic acid via acyl azolium intermediate,and further,an addition of carboxyl-ate to iminium *** study reveals a new model for the oxidation of Breslow intermedi-ate via electrophilic attack of the hydroxyl group by PIDA.

关键词： N-heterocyclic carbene domino reactions simple acyl azolium intermediates α-oxygen-ation DFT calculations