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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren yi liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

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Frontiers of Medicine 2015年第1期9卷 57-62页

作者： yi liang Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China ' Collaborative Innovation Center for CancerMedicine Department of Experimental Research Department of Medical Oncology Sun Yat-sen University Cancer Center Guangzhou 510060 China Department of Hepatobiliary Oncology Affiliated Tumor Hospital Guangzhou Medical University Guangzhou 510095 China Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100730 China

The existence of cancer stem cells, stem-like cancer cells （SLCCs）, or tumor-initiating cells is considered as the cause of tumor formation and recurrence, indicating the importance of studying novel therapy that targets SLCCs. The origin of SLCCs is controversial because of two competing hypotheses： SLCCs are either transformed from tissue adult stem cells or dedifferentiated from transformed progenitor cells. Our previous research demonstrates that SLCCs are inducible by increasing genomic instability in cancer cells. In this study, to block the emergence of SLCCs, aminoethyl isothiourea （AET）, a compound that clears free radicals and is used to protect patients from radioactive exposure, was used as an agent that maintains genomic stability in combination with mitomycin C （MMC）, a commonly used chemotherapeutic drug that damages DNA. Using a rabbit tumor model with VX2 hepatic carcinoma, we found that MMC alone increased lung metastases and disadvantaged survival outcome, but the combination of MMC and AET reversed this effect and even prolonged overall survival. Moreover, in a VX2 xenograft model by immunocompromised mice, MMC alone enriched tumor-initiating cells, but the administration of MMC in combination with AET eliminated tumor cells effectively. Furthermore, MMC alone enhanced genomic instability, but MMC combined with AET attenuated the extent of genomic instability in primary VX2 tumor tissue. Taken together, our data suggest that the genomic protector AET can inhibit the induction of SLCCs, and this combination treatment by AET and cytotoxic agents should be considered as a promising strategy for future clinical evaluation.

关键词： rabbit VX2 liver tumor mitomycin C AET stem-like cancer cells genomic instability

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Bainite isothermal transformation of Si–Mn–Mo alloy by phase structure factor calculation under different rare earth contents

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Rare Metals 2014年第4期33卷 427-432页

作者： Yan-liang yi yi-Long liang Qi-Bing Tan The Key Laboratory for Mechanical Behavior and Microstructure of Materials School of Materials and MetallurgyGuizhou University

The effect of rare earth （RE） on bainite trans- formation mechanism is not yet unified in the academia. Therefore, further studying the effect of RE on bainite transformation mechanism will have important guiding significance for the development of bainite steels. In this paper, using differential dilatometer （DIL805A/D）, heat treatment was performed and C-curve was drawn. The effect of phase structure factor on bainite transformation under two different fractions of RE in Si-Mn-Mo bainite steels was investigated by the empirical electron theory （EET） of solids, molecules, dilatometry, and metallogra- phy. Experimental results show that RE makes Fe-C- RE segregation structural unit of Si-Mn-Mo bainite steels increase, i.e., the values of phase structure factor （na, FDC） increase, and delay bainite transformation due to the drag effect resulting from the segregation of RE ferrite island interphase and the retardation of RE to carbon diffusion in Si-Mn-Mo bainite steels. Beside this, C-curve is shifted to right and down, and microstructures of bainite ferrite and substructures are finer.

关键词： Phase structure factor C-curve Substructure Rare earths

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Interface characteristics and wear resistance of Ni-B_(4)C plated ZTA reinforced high chromium cast iron composite

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China Foundry 2023年第3期20卷 253-262页

作者： Ke-liang Li Wei Li Yan-liang yi Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou 510632China National Joint Engineering Research Center of High Performance Metal Wear Resistant Materials Technology Jinan UniversityGuangzhou 510632China

A chemical composite plating of Ni-B_(4)C was used to prepare the surface-modified zirconia toughened alumina(ZTA)ceramic *** ceramic preforms were prepared by the plated ZTA and sodium silicate solution binder,followed by casting infiltration to prepare the ZTA particles reinforced high chromium cast iron(HCCI)*** result reveals that a distinct interface layer forms at the ZTA/HCCI interface,which consists of phases of ZrB_(2),FeB,Fe_(2)B,and NaSiO_(4).The interfacial wettability between ZTA and HCCI is improved by the diffusion and reaction of Ni and B_(4)*** wear test reveals that the Ni-B_(4)C plated ZTA particles can effectively improve the wear resistance of the ZTA/HCCI composite,and the wear rate of the composite is decreased to 11.6%of HCCI.

关键词： ZTA composite high chromium cast iron interface layer three-body abrasive wear

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Introduction to the Special Issue on Hybrid Intelligent Methods for Forecasting in Resources and Energy Field

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Computer Modeling in Engineering & Sciences 2023年第2期134卷 763-766页

作者： Wei-Chiang Hong yi liang Department of Information Management Asia Eastern University of Science and TechnologyNew Taipei22061Taiwan School of Management Hebei GEO UniversityShijiazhuang050031China

Precise resources and energy forecasting are important to facilitate the decision-making process in order to achieve higher efficiency and reliability in energy system planning,maintenance,operation,security,and so *** the past decades,many resources and energy forecasting models have been continuously proposed to increase the forecasting accuracy,especially intelligence models(e.g.,artificial neural networks,support vector regression,evolutionary computation models,etc.).Meanwhile,due to the great development of optimization methods(e.g.,quadratic programming method,differential empirical mode method,evolutionary algorithms,etc.),many novel hybrid methods combined with the above-mentioned intelligent-optimization-based methods have also been proposed to achieve satisfactory forecasting accuracy *** is worthwhile to explore the tendency and development of intelligent-optimization-based hybrid methodologies and to enrich their practical performances,particularly for resources and energy forecasting.

关键词： artificial forecasting optimization

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A Survey of Truck-Drone Routing Problem:Literature Review and Research Prospects

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Journal of the Operations Research Society of China 2022年第2期10卷 343-377页

作者： yi-Jing liang Zhi-Xing Luo School of Traffic and Transport Engineering Changsha University of Science and TechnologyChangsha 410114HunanChina School of Management and Engineering Nanjing UniversityNanjing 210093JiangsuChina

The vehicle routing problem(VRP)has been an important research topic in operations research for *** major applications of the VRP arise in transportation,especially the last-mile *** recent years,a growing number of logistic companies introduce drones or unmanned aerial vehicles in the delivery ***,the truck-drone routing problem(TDRP),where trucks and drones are scheduled and coordinated to serve customers,vitalizes a new research stream in the *** this paper,we provide a comprehensive review on the ***,two basic models for the traveling salesman problem with drones and vehicle routing problem with drones are ***,researches devoted to the TDRP are classified according to their addressed constraints and ***,prevalent algorithms that have been widely used in the existing literature are reviewed and ***,potential research opportunities are identified for future study.

关键词： Drone Unmanned aerial vehicle Truck-drone routing Traveling salesman routing Vehicle routing

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On Double Degenerate Quasilinear Parabolic Variational Inequalities

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Acta Mathematicae Applicatae Sinica 2013年第4期29卷 861-868页

作者： Gui-fang LIU yi-liang LIU Department of Mathematics Hunan City University College of Sciences Guangxi University for Nationalities

We deal with the existence of weak solutions of double degenerate quasilinear parabolic inequalities with a Signorini-Dirichlet-Neumann type mixed boundary condition, which may degenerate in certain subset of the boundary or on a segment in the interior of the domain and in time. The main tools in our study are the maximM monotone property of the derivative operator with zero-initial valued conditions and the theory of pseudomonotone perturbations of maximal monotone mappings.

关键词： double degeneration quasilinear parabolic variational inequalities existence results

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Preparation of InYO_3 catalyst and its application in photodegradation of molasses fermentation wastewater

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Journal of Environmental Sciences 2011年第7期23卷 1219-1224页

作者： Zuzeng Qin yi liang Zili Liu Weiqing Jiang School of Chemistry and Chemical Engineering Guangxi University Nanning 530004 China School of Chemistry and Chemical Engineering Guangzhou University Guangzhou 510006 China

An InYO 3 photocatalyst was prepared through a precipitation method and used for the degradation of molasses fermentation wastewater. The InYO 3 photocatalyst characterized by X-ray diffraction （XRD）, UV-Vis diffuse reflectance spectroscopy, surface area and porosimetry. Energy band structures and density of states were achieved using the Cambridge Serial Total Energy package （CASTEP）. The results indicated that the photodegradation of molasses fermentation wastewater was significantly enhanced in the presence of InYO 3 when compared with PbWO 4 . The calcination temperature was found to have a significant effect on the photocatalytic activity of InYO 3 . Specifically, InYO 3 calcined at 700°C had a considerably larger surface area and lower reflectance intensity and showed higher photocatalytic activity. The mathematical simulation results indicated that InYO 3 is a direct band gap semiconductor, and its conduction band is composed of In 5p and Y 4d orbitals, whereas its valence band is composed of O 2p and In 5s orbitals.

关键词： indium yttrium oxide molasses fermentation wastewater photocatalytic degradation

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The blueberry(iron nodule)from the Shark Bay area, Western Australia and its implication to the genetic environments of iron nodules on Mars

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Science China Earth Sciences 2016年第3期59卷 640-650页

作者： LI Jun CHAN Lung Sang LI yi liang Department of Earth Sciences The University of Hong Kong

Fist-sized iron nodules, extensively found on the ground of Western Australia, were investigated by element analysis(XRF, ICP-MS and ICP-AES), electron microscopes, X-ray diffraction and M?ssbauser spectroscopy. Loosely-packed pisoidic structures of a few to >10 mm in size were observed in the cross-section of nodules. Chemically, the nodules are majorly made of O, Si, Fe and Al, and share similar REE pattern with the loess sourced Greatford concretions from New Zealand. Angular quartz particles, nano-sized goethite and hematite are found to be the major mineral phases. Other minerals, such as detrital zircon, barite and Ce-containing particles can also be observed but of very low abundance. No detectable carbonate or amorphous silica implies that these nodules have experienced little underground fluid alteration. The quartz particles showing particularly three sections of fractal size-distributions, together with their extensive broken features and conchoidal fractures, strongly suggest in situ fragmentation of the host rock with minimum later dynamic sorting. These observations indicate the genetic environment of those nodules is always close to the surface of the tectonically stable ground since their formation. Because of the similarity of climatic and geological features, the genesis and preservation environment of these nodules in Western Australia may provide clues on the formation of Martian iron concretions.

关键词： Iron nodules Western Australia Fractal dimensions In situ fragmentation Mars

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Highly efficient photocatalytic NO removal and in situ DRIFTS investigation on SrSn(OH)_(6)

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Chinese Chemical Letters 2022年第3期33卷 1259-1262页

作者： Wendong Zhang Yun Wang yi Wang yi liang Fan Dong Chongqing Key Laboratory of Inorganic Functional Materials Chongqing Key Laboratory of Green Synthesis and ApplicationChongqing Normal UniversityChongqing 401331China Yangtze Delta Region Institute(Huzhou)&Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaHuzhou 313001China State Centre for International Cooperation on Designer Low-carbon and Environmental Materials(CDLCEM) School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China

A novel SrSn(OH)_(6) photocatalyst with large plate and particle size were synthesized via a facile chemical precipitation method. The photocatalytic activity of the SrSn(OH)_(6) was evaluated by the removal of NO at ppb level under UV light irradiation. Based on the ESR measurements, SrSn(OH)_(6) photocatalyst was found to have the ability to generate the main active species of O_(2)^(·-), ^(·)OH and ^(1)O_(2) during the photocatalytic process. Moreover, SrSn(OH)_(6) photocatalyst not only exhibits high photocatalytic activity for NO removal (79.6%), but also has good stability after five cycles. The in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) was used to investigate the NO_(x) transfer pathway and the intermediate products distribution during the adsorption and photocatalytic NO oxidation process. The present work not only provides an efficient material for air pollutants purification at room temperature but also in-depth understanding of the mechanism involved in the photocatalytic NO removal process.

关键词： Highly efficient NO removal In situ DRIFTS investigation SrSn(OH)_(6) Reaction mechanism

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