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Science China Chemistry 2025年

作者： Yuan Tian Jiang-Bo Chen Jie ying Ge Tian Yu-Xuan Xiao yi lu Si-Ming Wu Wei Geng Ling Shen Xiao-Yu Yang State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and School of Materials Science and Engineering and Shenzhen Research Institute & Laoshan Laboratory Wuhan University of Technology School of Chemical Engineering and Technology Sun Yat-Sen University National Energy Key Laboratory for New Hydrogen-Ammonia Energy Technologies Foshan Xianhu Laboratory

Seawater electrolysis is a highly promising method to produce high energy density hydrogen,especially in dry areas that have scarce freshwater ***,application of seawater electrolysis is confronted by two major problems associated with catalysts employed for the anodic oxygen evolution reaction （OER） including the competitive hypochlorite evolution reaction（HCER） and strong chloridion （Cl–） triggered *** studies aimed at overcoming these problems,a facile method has been developed to synthesize a homologous CoS2heterojunction as an OER *** to a difference in work functions at the interface and increased electron density,this material has directed electron transfer and strong chloridion repulsion properties,*** have shown that CoS2achieves low overpotentials of 289 and 322 mV at 10 mA cm-2current density in respective alkaline （1 M KOH） and alkaline simulated seawater ***,the outstanding stability of CoS2is reflected in a negligible decline in activity during promotion of the OER for 100 *** of density functional theory calculations reveal that the homologous CoS2heterojunction promotes directed electron transport for optimizing adsorption/desorption of reactive species and heightens the Cl-adsorption energy for strongly repulsing Cl-,phenomena that enhance OER performance in alkaline simulated seawater.

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PRKCQ-AS1通过Akt信号促进气道平滑肌细胞增殖的研究

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中国药理学通报 2025年第1期41卷 88-94页

作者：吴露依胡方启安庆医药高等专科学校临床科研中心安庆市立医院安徽安庆246000

目的探讨PRKCQ-AS1在气道平滑肌细胞(airway smooth muscle cells,ASMCs)的作用。方法首先通过转录组测序技术(RNA-seq)检测哮喘儿童肺泡灌洗液中的差异表达基因(differentially expressed genes,DEGs)。随后,分别构建PRKCQ-AS1慢病毒敲低和过表达载体并转染ASMCs。qRT-PCR方法检测了ASMCs中PRKCQ-AS1的表达;用CCK-8和流式细胞术分别检测ASMCs的增殖和凋亡;酶联免疫吸附测定(enzyme-linked immunosorbent assay,ELISA)检测ASMCs培养上清液中TNF-α和IL-1β的含量;lncRNA芯片检测PRKCQ-AS1敲低后的DEGs并进行KEGG通路富集;Western blot检测p-Akt和Akt的水平。结果RNA-seq结果显示,PRKCQ-AS1是上调最明显的DEGs之一。PRKCQ-AS1过表达促进了ASMCs的增殖和迁移并抑制了其凋亡,同时,PRKCQ-AS1过表达使上清液中炎性因子TNF-α和IL-1β的水平升高,而PRKCQ-AS1敲低则呈现相反的结果。对PRKCQ-AS1敲低后得到的606个DEGs进行KEGG信号通路富集分析,结果显示PI3K-Akt信号被明显富集。Western blot结果表明,PRKCQ-AS1敲低抑制了Akt的活化;相反,PRKCQ-AS1过表达则促进了Akt的水平。结论PRKCQ-AS1可能通过增强Akt信号促进ASMCs炎症反应,进而加剧了ASMCs的增殖和迁移,最终导致哮喘的发展。

关键词： PRKCQ-AS1 ASMCs 哮喘 Akt信号细胞实验炎性细胞因子

Development of Novel Hybrid Hand Formed by a Parallel Wrist and Three Soft-flexible Fingers

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Journal of Bionic Engineering 2022年第5期19卷 1349-1358页

作者： yi lu Zefeng Chang Yang lu College of Mechanical Engineering Yanshan UniversityQinhuangdao 066004China Harbin Electric Corporation(Qinhuangdao)Heavy Equipment Company Limited Qinhuangdao 066004China

A prototype of a novel hybrid hand is developed by combing a parallel wrist with three flexible *** dynamics model is established,its grabbed forces are measured,and its grabbing performances are ***,Jacobian and Hessian matrices of the moving platform in the parallel wrist are derived,the kinematics formulas for solving the general velocity and the general acceleration of the moving platform are *** its dynamics model is established for solving the dynamic actuation forces,the dynamic constrained forces of the developed hybrid ***,its simulation mechanism is constructed in Matlab,and the theoretical solutions of the kinematics and the dynamics of the developed hybrid hand are verified to be correct using its simulation ***,when objects with different mass are grabbed by prototype of hybrid hand in different poses,the grabbed forces are measured,and the grabbing performances are discovered and analyzed to verify its merits.

关键词： Hybrid hand Flexible finger mechanism Dynamics Parallel wrist Grabbing performance

Kinetostatics Analysis of a Novel 6-DOF Parallel Manipulator with Three Planar Limbs and Equipped with Three Fingers

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Chinese Journal of Mechanical Engineering 2014年第5期27卷 919-927页

作者： lu yi LI Xuepeng College of Mechanical Engineering Yanshan University Key Laboratory of Parallel Robot and Mechatronic System of Hebei Province Key Laboratory of Advanced Forging & Stamping Technology and Science of Ministry of National Education

It is significant to develop a robot hand with high rigidity by a 6-DOF parallel manipulator（PM）.However,the existing6-DOF PMs include spherical joint which has less capability of pulling force bearing,less rotation range and lower precision under alternately heavy loads.A novel 6-DOF PM with three planar limbs and equipped with three fingers is proposed and its kinematics and statics are analyzed systematically.A 3-dimension simulation mechanism of the proposed manipulator is constructed and its structure characteristics is *** kinematics formulae for solving the displacement,velocity,acceleration of the platform,the active legs and the fingers are *** statics formulae are derived for solving the active forces of PM and the finger *** analytic example is given for solving the kinematics and statics of proposed manipulator and the analytic solved results are verified by the simulation *** is proved from the error analysis of analytic solutions and simulation solutions that the derived analytic formulae are correct and provide the theoretical and technical foundations for its manufacturing,control and application.

关键词： parallel manipulator planar limbs finger kinematics statics

CYBERNETIC PARADIGM BASED INNOVATIVE APPROACHES TOWARDS COPING WITH CLIMATE CHANGE

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Journal of Systems Science and Systems Engineering 2017年第3期26卷 359-382页

作者： yi lu Jiuping Xu Uncertainty Decision-making Laboratory Sichuan University Chengdu 610064 China Engineering Research Center of Low Carbon Technology and Economy Sichuan University Chengdu 610064 China

Increasing carbon emissions from large-scale human activities have contributed to global climate change, which has resulted in an increase in significant human crises. Therefore, as carbon abatement is a public good, coping with climate change is also a public-good; however, it suffers from many free-rider incentives, leading to a tragedy of the commons. Overcoming this challenge from a systemic perspective, requires that all sectors such as industry, government, and citizens on global, national, and regional levels engage in low-carbon development and the implementation of fair and efficient climate policies. Through a theoretical exploration of carbon abatement and a systemic description of low-carbon systems, this paper developed a cybernetic framework for coping with climate change, which consists of a cloud platform for data analysis, meta-synthetic engineering for decision support, a polycentric approach to extensive consultation and various functional goal achievement modules. On this basis, by combining the ＂invisible hand＂ and ＂visible hand＂ and by integrating negotiation at the global level, cooperation at the national level and knowledge at the local level, a multilevel policymaking model is proposed to address complex climate change problems. This cybernetic paradigm based innovative approach could provide valuable illumination to stakeholders seeking to cope with climate change.

关键词： Cybernetics climate change carbon abatement public good low-carbon development

An experimental setup with controllable tuning parameters for studying the Kondo systems

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Science China(Physics,Mechanics & Astronomy) 2022年第4期65卷 121-122页

作者： Zhong-yi lu Department of Physics Renmin University of ChinaBeijing 100872China

The Kondo physics has been studied since the 1960 s in condensed matter physics[1,2],which is mainly determined by two competing factors namely the Kondo effect and the Ruderman-Kittel-Kasuya-Yosida(RKKY)interaction.

关键词： interaction Kondo condensed

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The role of oxygen vacancies in metal oxides for rechargeable ion batteries

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Science China Chemistry 2021年第11期64卷 1826-1853页

作者： Runzhe Wei yi lu Yang Xu Department of Chemistry University College LondonLondonWC1H 0AJUK

Rechargeable ion batteries are one of the most reliable energy storage technologies for the applications ranging from small portable devices and electric vehicles to renewable energy integration and large-scale stationary energy *** the roadmap of developing and understanding new electrode materials for rechargeable ion batteries,oxygen vacancies,known as defects in metal oxides,have shown a high impact on the final electrochemical performance of the *** present review aims to summarise the synthesis methods and characterisation techniques of oxygen vacancies as well as some of the most recent and exciting progress made to understand the role of oxygen vacancies in the electrochemical performance of Li-,Na-,K-and Zn-ion *** review discusses not only the role of oxygen vacancies directly in electrode materials and indirectly in the coating layers on electrode materials,but also the synergistic role of oxygen vacancies interplaying with other contributors such as carbonaceous materials,doping,amorphisation,structural transformation,nanostructuring and functional ***,perspectives are given to stimulate new ideas and open questions to facilitate the further development of oxygen deficient electrode materials in energy research landscape.

关键词： oxygen vacancies defect chemistry metal oxide rechargeable ion batteries ion diffusion intercalation reaction conversion reaction

SYMPLECTIC SCHEMES FOR TELEGRAPH EQUATIONS

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Journal of Computational Mathematics 2016年第3期34卷 285-299页

作者： yi lu Yaolin Jiang School of Mathematics and Statistics Xi'an Jiaotong University Shaanxi 710049 China

A new numerical algorithm for telegraph equations with homogeneous boundary con- ditions is proposed. Due to the damping terms in telegraph equations, there is no royal conservation law according to Noether＇s theorem. The algorithm origins from the discovery of a transform applied to a telegraph equation, which transforms the telegraph equation to a Klein-Gordon equation. The Symplectic method is then brought in this algorithm to solve the Klein-Gordon equation, which is based on the fact that the Klein-Gordon equation with the homogeneous boundary condition is a perfect Hamiltonian system and the symplectic method works very well for Hamiltonian systems. The transformation itself and the inverse transformation theoretically bring no error to the numerical computation. Therefore the error only comes from the symplectic scheme chosen. The telegraph equation is finally explicitly computed when an explicit symplectic scheme is utilized. A relatively long time result can be expected due to the application of the symplectic method. Mean- while, we present order analysis for both one-dimensional and multi-dimensional cases in the paper. The efficiency of this approach is demonstrated with numerical examples.

关键词： Telegraph equation Klein-Gordon equation Symplectic method Explicitmethod.

Pseudovirus-based neuraminidase inhibition assays reveal potential H5N1 drug-resistant mutations

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Protein & Cell 2013年第5期4卷 356-363页

作者： yi lu Taijiao Jiang Key Laboratory of Protein and Peptide Pharmaceuticals National Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China

The use of antiviral drugs such as influenza neuraminidase (NA) inhibitors is a critical strategy to prevent and control flu pandemic, but this strategy faces the challenge of emerging drug-resistant strains. For a highly pathogenic avian influenza (HPAI) H5N1 virus, biosafety restrictions have significantly limited the efforts to monitor its drug responses and mechanisms involved. In this study, a rapid and biosafe assay based on NA pseudovirus was developed to study the resistance of HPAI H5N1 virus to NA inhibitor drugs. The H5N1 NA pseudovirus was comprehensively tested using oseltamivir-sensitive strains and their resistant mutants. Results were consistent with those in previous studies, in which live H5N1 viruses were used. Several oseltamivir-resistant mutations reported in human H1N1 were also identified to cause decreased oseltamivir sensitivity in H5N1 NA by using the H5N1 NA pseudovirus. Thus, H5N1 NA pseudoviruses could be used to monitor HPAI H5N1 drug resistance rapidly and safely.

关键词： infl uenza virus H5N1 neuraminidase inhibi-tor drug resistance pseudovirus

Natural and human-induced decline and spatio-temporal differentiation of terrestrial water storage over the Lancang-Mekong River Basin

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Journal of Geographical Sciences 2025年第1期 112-138页

作者： CHEN Junxu WANG Yuan ZHAO Zhifang FAN Yunjiang luO Xiaochuan yi lu FENG Siqi YANG Liang Emlyn Yunnan Key Laboratory of Soil Erosion Prevention and Green Development Yunnan University International Joint Research Center for Karstology Yunnan University School of Engineering Westlake University Department of Geography Ludwig Maximilian University of Munich (LMU)

Due to water conflicts and allocation in the Lancang-Mekong River Basin(LMRB), the spatio-temporal differentiation of total water resources and the natural-human influence need to be clarified. This work investigated LMRB's terrestrial water storage anomaly(TWSA) and its spatio-temporal dynamics during 2002–2020. Considering the effects of natural factors and human activities, the respective contributions of climate variability and human activities to terrestrial water storage change(TWSC) were separated. Results showed that:(1) LMRB's TWSA decreased by 0.3158 cm/a.(2) TWSA showed a gradual increase in distribution from southwest of MRB to middle LMRB and from northeast of LRB to middle LMRB. TWSA positively changed in Myanmar while slightly changed in Laos and China. It negatively changed in Vietnam, Thailand and Cambodia.(3) TWSA components decreased in a descending order of soil moisture, groundwater and precipitation.(4) Natural factors had a substantial and spatial differentiated influence on TWSA over the LMRB.(5) Climate variability contributed 79% of TWSC in the LMRB while human activities contributed 21% with an increasing impact after 2008. The TWSC of upstream basin countries was found to be controlled by climate variability while Vietnam and Cambodia's TWSC has been controlled by human activities since 2012.

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